GREMLIN Database
TraH - Conjugative relaxosome accessory transposon protein
PFAM: PF06122 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 361 (356)
Sequences: 1282 (1035)
Seq/√Len: 54.9
META: 0.754

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_C98_C11.4721.00
302_K313_E8.6191.00
107_A111_K3.7231.00
92_K99_A3.6681.00
123_A127_V3.2381.00
267_D278_P3.2321.00
298_S313_E3.1731.00
85_Y98_C3.1221.00
267_D277_N3.1161.00
99_A103_K3.0781.00
290_A294_T2.9821.00
224_I241_I2.8901.00
310_T313_E2.7621.00
196_V220_V2.7021.00
311_A314_K2.5231.00
66_I105_L2.5041.00
295_L316_F2.5001.00
201_K213_A2.4821.00
194_N197_W2.4431.00
67_N70_Q2.4271.00
295_L313_E2.4261.00
218_S244_L2.4061.00
71_L84_G2.3431.00
147_G153_F2.3041.00
88_Q99_A2.3031.00
299_I309_L2.2421.00
77_N81_N2.1481.00
286_K294_T2.1371.00
68_A71_L2.1141.00
71_L105_L2.1091.00
88_Q103_K2.1001.00
196_V200_L2.0931.00
81_N84_G2.0871.00
92_K100_N2.0571.00
217_M222_T2.0321.00
303_I328_L2.0291.00
92_K96_P2.0121.00
88_Q102_M1.9801.00
74_L109_A1.9731.00
118_N121_E1.9661.00
143_C163_C1.9641.00
298_S302_K1.9451.00
303_I325_Y1.8861.00
49_I58_L1.8840.99
52_G56_I1.8830.99
92_K97_Q1.8270.99
106_Q110_Q1.8240.99
151_G155_D1.7450.99
321_P353_D1.7350.99
244_L264_Y1.7220.99
155_D158_A1.7120.99
111_K114_Q1.7000.99
81_N127_V1.6750.99
268_D271_D1.6730.99
119_S123_A1.6700.99
94_L98_C1.6560.99
92_K101_I1.6470.99
266_C275_C1.6440.99
289_R348_E1.6190.98
16_A25_Y1.6080.98
39_I74_L1.5900.98
293_R344_E1.5850.98
92_K103_K1.5690.98
51_A84_G1.5680.98
85_Y95_C1.5600.98
98_C105_L1.5440.98
194_N217_M1.5440.98
113_N116_N1.5360.98
100_N104_E1.5360.98
64_S155_D1.5280.98
81_N123_A1.5270.98
69_D72_V1.5230.98
83_P123_A1.5210.98
85_Y105_L1.5000.97
197_W217_M1.4890.97
131_A134_K1.4860.97
217_M278_P1.4830.97
19_G24_Y1.4790.97
67_N83_P1.4780.97
71_L75_L1.4530.97
256_E289_R1.4510.97
91_L99_A1.4460.97
74_L106_Q1.4440.97
193_G198_K1.4430.97
36_V118_N1.4390.97
346_L350_I1.4310.97
20_Q23_G1.4210.96
295_L298_S1.4100.96
155_D159_A1.3770.96
25_Y326_K1.3560.95
241_I264_Y1.3540.95
252_K256_E1.3500.95
194_N222_T1.3410.95
72_V87_F1.3400.95
75_L88_Q1.3260.95
84_G88_Q1.3230.95
70_Q73_Q1.3200.95
44_I62_S1.3170.95
37_K77_N1.3060.94
271_D274_K1.3030.94
11_V30_L1.2850.94
89_L127_V1.2820.94
268_D278_P1.2780.94
201_K210_D1.2690.93
222_T241_I1.2660.93
118_N122_A1.2640.93
302_K307_T1.2610.93
169_A173_L1.2530.93
91_L102_M1.2530.93
18_Q21_T1.2520.93
75_L87_F1.2520.93
84_G105_L1.2510.93
255_L355_A1.2350.92
298_S310_T1.2320.92
241_I278_P1.2310.92
293_R297_D1.2210.92
89_L98_C1.2100.92
257_G287_G1.2080.92
158_A162_G1.1980.91
326_K330_V1.1980.91
38_N118_N1.1950.91
70_Q106_Q1.1910.91
197_W200_L1.1860.91
33_R57_D1.1820.91
58_L65_F1.1760.90
314_K325_Y1.1620.90
268_D277_N1.1600.90
198_K201_K1.1600.90
117_I121_E1.1510.89
267_D271_D1.1430.89
62_S109_A1.1360.89
74_L78_I1.1340.89
316_F350_I1.1330.89
135_T139_S1.1300.89
194_N266_C1.1100.88
197_W214_E1.1100.88
268_D274_K1.1090.88
141_K261_K1.1050.87
85_Y89_L1.0920.87
258_G263_V1.0890.87
14_P28_G1.0850.86
98_C101_I1.0840.86
291_R295_L1.0630.85
47_P61_G1.0600.85
48_S59_F1.0590.85
88_Q104_E1.0520.85
79_A95_C1.0510.85
322_L327_I1.0480.84
231_D234_G1.0340.84
173_L176_A1.0280.83
316_F319_S1.0260.83
16_A23_G1.0250.83
224_I276_L1.0190.83
210_D262_V1.0180.83
18_Q22_R1.0170.83
206_L209_D1.0110.82
112_L116_N1.0090.82
68_A72_V1.0080.82
73_Q321_P1.0030.82
65_F110_Q0.9950.81
302_K309_L0.9910.81
21_T24_Y0.9910.81
299_I313_E0.9900.81
79_A102_M0.9890.81
76_R80_S0.9850.81
68_A209_D0.9850.81
249_D252_K0.9820.80
69_D73_Q0.9770.80
81_N119_S0.9740.80
66_I70_Q0.9690.79
343_I347_A0.9670.79
87_F94_L0.9640.79
122_A125_A0.9600.79
44_I109_A0.9570.79
63_F90_A0.9570.79
5_F10_N0.9560.79
342_L346_L0.9550.78
172_T176_A0.9510.78
197_W266_C0.9430.78
71_L79_A0.9410.77
171_S175_K0.9390.77
326_K329_N0.9370.77
295_L299_I0.9350.77
267_D272_T0.9350.77
217_M266_C0.9300.77
93_T99_A0.9280.76
59_F86_A0.9270.76
62_S112_L0.9240.76
45_Q48_S0.9190.76
74_L119_S0.9190.76
242_P259_T0.9160.76
60_L63_F0.9140.75
6_N27_G0.9130.75
65_F84_G0.9120.75
93_T97_Q0.9100.75
117_I122_A0.9090.75
353_D357_Q0.9080.75
40_Q46_P0.9060.75
268_D273_D0.9050.75
131_A136_D0.9020.74
29_S33_R0.8970.74
104_E108_L0.8880.73
73_Q76_R0.8880.73
209_D212_L0.8870.73
79_A83_P0.8860.73
121_E125_A0.8860.73
95_C99_A0.8800.73
79_A296_L0.8790.72
20_Q24_Y0.8780.72
145_A308_A0.8690.72
141_K145_A0.8650.71
197_W213_A0.8630.71
298_S342_L0.8590.71
87_F90_A0.8580.71
282_I285_N0.8580.71
219_L359_L0.8570.71
300_V339_A0.8570.71
170_D173_L0.8550.70
95_C105_L0.8550.70
49_I76_R0.8500.70
339_A343_I0.8500.70
22_R39_I0.8490.70
309_L313_E0.8490.70
259_T307_T0.8470.70
38_N41_L0.8450.69
2_D6_N0.8400.69
153_F162_G0.8400.69
136_D139_S0.8340.68
73_Q81_N0.8300.68
291_R312_E0.8300.68
287_G290_A0.8290.68
51_A81_N0.8290.68
138_A142_I0.8250.68
324_V350_I0.8220.67
180_P183_K0.8210.67
147_G151_G0.8190.67
169_A174_A0.8190.67
88_Q91_L0.8170.67
209_D292_V0.8150.67
295_L312_E0.8120.66
74_L117_I0.8120.66
290_A293_R0.8100.66
222_T276_L0.8090.66
228_P239_R0.8070.66
15_G19_G0.8030.66
27_G345_Q0.8020.65
80_S86_A0.8020.65
141_K144_A0.8010.65
218_S266_C0.8010.65
11_V291_R0.7870.64
65_F106_Q0.7870.64
148_T159_A0.7860.64
303_I329_N0.7850.64
15_G26_T0.7840.64
102_M306_D0.7840.64
171_S174_A0.7830.64
54_G65_F0.7780.63
286_K307_T0.7770.63
67_N162_G0.7760.63
183_K259_T0.7760.63
76_R85_Y0.7750.63
24_Y62_S0.7730.63
103_K107_A0.7720.62
332_A349_V0.7710.62
99_A105_L0.7700.62
118_N147_G0.7700.62
299_I317_L0.7690.62
226_D229_G0.7670.62
123_A128_G0.7650.62
31_S57_D0.7650.62
16_A29_S0.7630.62
85_Y101_I0.7600.61
309_L314_K0.7600.61
196_V217_M0.7580.61
229_G234_G0.7580.61
172_T175_K0.7560.61
84_G119_S0.7560.61
65_F82_A0.7560.61
77_N100_N0.7540.61
131_A142_I0.7530.61
58_L326_K0.7520.60
161_Q165_T0.7490.60
95_C102_M0.7470.60
2_D5_F0.7460.60
77_N95_C0.7380.59
106_Q109_A0.7370.59
51_A103_K0.7370.59
88_Q92_K0.7370.59
212_L220_V0.7320.58
14_P26_T0.7310.58
75_L79_A0.7310.58
66_I79_A0.7300.58
130_L227_K0.7270.58
87_F91_L0.7260.58
197_W222_T0.7260.58
344_E347_A0.7250.58
316_F320_T0.7250.58
83_P291_R0.7250.58
94_L97_Q0.7240.57
88_Q106_Q0.7230.57
352_L356_Y0.7220.57
52_G63_F0.7210.57
239_R242_P0.7170.57
156_W160_R0.7160.57
57_D113_N0.7160.57
62_S65_F0.7140.56
43_S62_S0.7140.56
12_T15_G0.7140.56
259_T311_A0.7140.56
264_Y278_P0.7130.56
51_A55_G0.7120.56
302_K310_T0.7110.56
210_D272_T0.7100.56
138_A141_K0.7090.56
39_I119_S0.7090.56
268_D276_L0.7080.56
125_A137_A0.7080.56
74_L112_L0.7060.56
25_Y75_L0.7060.56
214_E222_T0.7040.55
162_G165_T0.7040.55
6_N331_A0.7020.55
66_I217_M0.7020.55
97_Q104_E0.6990.55
261_K309_L0.6960.55
10_N31_S0.6950.54
121_E124_Q0.6940.54
46_P95_C0.6930.54
15_G24_Y0.6920.54
127_V332_A0.6910.54
322_L326_K0.6900.54
224_I266_C0.6900.54
102_M128_G0.6880.54
123_A126_L0.6880.54
62_S72_V0.6860.53
102_M199_A0.6860.53
200_L203_N0.6850.53
91_L104_E0.6820.53
45_Q59_F0.6800.53
4_F15_G0.6780.53
85_Y123_A0.6760.52
109_A116_N0.6750.52
53_C61_G0.6730.52
41_L44_I0.6720.52
18_Q298_S0.6720.52
97_Q101_I0.6670.51
11_V14_P0.6650.51
62_S322_L0.6630.51
53_C56_I0.6620.51
194_N200_L0.6620.51
19_G26_T0.6610.51
222_T266_C0.6610.51
8_M11_V0.6610.51
25_Y330_V0.6610.51
182_L219_L0.6590.51
147_G167_G0.6590.51
320_T350_I0.6580.50
265_K268_D0.6570.50
20_Q317_L0.6540.50
31_S37_K0.6540.50
136_D142_I0.6540.50
16_A20_Q0.6530.50
66_I83_P0.6520.50
47_P53_C0.6500.50
20_Q323_P0.6490.49
258_G281_T0.6460.49
156_W163_C0.6460.49
79_A99_A0.6410.49
97_Q100_N0.6400.49
189_V192_N0.6390.48
121_E151_G0.6370.48
214_E217_M0.6350.48
94_L109_A0.6320.48
25_Y292_V0.6310.48
217_M224_I0.6290.47
21_T94_L0.6240.47
66_I266_C0.6240.47
214_E218_S0.6230.47
299_I328_L0.6200.46
63_F82_A0.6200.46
174_A191_D0.6180.46
41_L117_I0.6170.46
227_K231_D0.6150.46
327_I349_V0.6130.46
79_A108_L0.6130.46
203_N332_A0.6120.46
46_P98_C0.6110.45
58_L327_I0.6100.45
118_N212_L0.6090.45
108_L112_L0.6090.45
39_I59_F0.6090.45
7_A34_T0.6090.45
11_V259_T0.6080.45
100_N351_A0.6080.45
36_V110_Q0.6070.45
59_F275_C0.6060.45
186_P190_P0.6050.45
325_Y330_V0.6040.45
112_L115_M0.6020.44
64_S142_I0.6010.44
15_G18_Q0.6010.44
100_N105_L0.6000.44
74_L118_N0.5970.44
229_G271_D0.5960.44
147_G150_S0.5960.44
80_S138_A0.5950.44
69_D91_L0.5920.43
293_R347_A0.5910.43
11_V29_S0.5890.43
144_A148_T0.5890.43
70_Q218_S0.5870.43
288_L355_A0.5870.43
95_C101_I0.5850.43
76_R339_A0.5850.43
337_G341_S0.5850.43
70_Q76_R0.5840.43
16_A30_L0.5830.42
84_G123_A0.5820.42
20_Q320_T0.5820.42
80_S331_A0.5820.42
194_N224_I0.5810.42
218_S222_T0.5790.42
299_I316_F0.5790.42
240_Y243_P0.5790.42
153_F331_A0.5770.42
206_L216_I0.5770.42
9_S32_A0.5760.42
200_L206_L0.5750.42
94_L310_T0.5750.42
85_Y127_V0.5740.42
58_L71_L0.5730.41
159_A163_C0.5720.41
31_S34_T0.5720.41
30_L148_T0.5670.41
288_L358_Y0.5660.41
239_R359_L0.5650.41
192_N296_L0.5650.41
94_L101_I0.5620.40
192_N251_L0.5610.40
45_Q95_C0.5580.40
39_I117_I0.5580.40
17_Y20_Q0.5580.40
193_G196_V0.5580.40
132_P140_Q0.5580.40
204_G314_K0.5570.40
194_N275_C0.5570.40
67_N341_S0.5570.40
201_K273_D0.5560.40
292_V350_I0.5540.39
295_L310_T0.5540.39
134_K143_C0.5530.39
292_V354_L0.5530.39
214_E266_C0.5520.39
32_A355_A0.5510.39
146_I201_K0.5510.39
92_K157_A0.5500.39
163_C224_I0.5490.39
62_S113_N0.5490.39
106_Q358_Y0.5490.39
230_A340_D0.5480.39
67_N102_M0.5470.39
222_T278_P0.5470.39
116_N160_R0.5470.39
88_Q108_L0.5460.39
300_V343_I0.5460.39
70_Q194_N0.5460.39
296_L350_I0.5450.39
32_A145_A0.5440.38
132_P136_D0.5440.38
93_T100_N0.5440.38
324_V331_A0.5430.38
65_F102_M0.5410.38
49_I162_G0.5400.38
123_A306_D0.5400.38
104_E107_A0.5400.38
316_F354_L0.5400.38
7_A80_S0.5400.38
106_Q113_N0.5390.38
160_R163_C0.5390.38
19_G73_Q0.5370.38
20_Q65_F0.5370.38
115_M328_L0.5370.38
213_A217_M0.5360.38
78_I85_Y0.5350.38
194_N218_S0.5350.38
30_L150_S0.5340.37
216_I220_V0.5330.37
356_Y360_S0.5330.37
169_A172_T0.5320.37
139_S143_C0.5320.37
154_S158_A0.5310.37
268_D272_T0.5290.37
135_T143_C0.5290.37
124_Q298_S0.5270.37
129_G132_P0.5270.37
80_S317_L0.5270.37
327_I331_A0.5270.37
17_Y349_V0.5270.37
162_G173_L0.5260.37
52_G55_G0.5260.37
281_T284_A0.5260.37
241_I245_A0.5250.37
330_V342_L0.5230.36
67_N202_K0.5230.36
75_L126_L0.5230.36
159_A236_V0.5220.36
229_G232_G0.5200.36
42_V112_L0.5180.36
108_L111_K0.5170.36
189_V193_G0.5160.36
196_V218_S0.5150.36
331_A343_I0.5150.36
67_N115_M0.5130.35
289_R292_V0.5130.35
314_K318_N0.5120.35
74_L193_G0.5090.35
46_P80_S0.5090.35
31_S35_P0.5090.35
95_C100_N0.5090.35
220_V250_L0.5070.35
22_R64_S0.5070.35
183_K216_I0.5070.35
329_N334_Y0.5060.35
31_S292_V0.5050.35
182_L185_C0.5050.35
354_L357_Q0.5050.35
8_M14_P0.5040.34
306_D314_K0.5040.34
41_L74_L0.5030.34
151_G291_R0.5030.34
140_Q149_S0.5030.34
282_I287_G0.5020.34
79_A146_I0.5010.34
194_N198_K0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b34A 1 0.3352 20 0.966 Contact Map
1whsA 2 0.3102 18.7 0.966 Contact Map
4x2uA 1 0.3352 13.7 0.968 Contact Map
4qhpA 1 0.3352 12.5 0.969 Contact Map
1vk4A 1 0.2548 11.2 0.97 Contact Map
1vm7A 2 0.277 9.2 0.971 Contact Map
4gm6A 5 0.277 6.8 0.973 Contact Map
3pl2A 2 0.2465 6.4 0.973 Contact Map
3jywF 1 0.2022 6.1 0.973 Contact Map
4grhA 1 0.2188 5.6 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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