GREMLIN Database
DUF951 - Bacterial protein of unknown function (DUF951)
PFAM: PF06107 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (54)
Sequences: 6340 (3116)
Seq/√Len: 424.0
META: 0.885

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_S35_G2.7841.00
21_E34_L2.3601.00
8_R18_N2.3121.00
30_G39_R2.2731.00
8_R53_K2.1281.00
12_P18_N2.0221.00
19_E34_L1.8871.00
21_E32_K1.8671.00
6_I34_L1.8381.00
43_P46_K1.7431.00
4_G21_E1.7401.00
6_I19_E1.7181.00
46_K50_R1.6561.00
7_V47_F1.5601.00
32_K37_G1.5071.00
8_R19_E1.4731.00
23_V39_R1.4201.00
42_L47_F1.4161.00
23_V30_G1.3291.00
31_L47_F1.3071.00
3_L25_L1.2021.00
32_K39_R1.1861.00
25_L29_I1.1441.00
6_I21_E1.0611.00
2_R5_D1.0461.00
45_R48_E1.0441.00
20_W38_R1.0301.00
7_V22_V1.0231.00
47_F51_I1.0151.00
23_V32_K0.9491.00
30_G41_M0.9361.00
1_Y51_I0.9311.00
27_A45_R0.9111.00
20_W40_V0.9071.00
51_I54_I0.8951.00
27_A41_M0.8891.00
16_G38_R0.8741.00
9_L50_R0.8711.00
1_Y48_E0.8511.00
31_L40_V0.8321.00
46_K49_K0.8231.00
24_R41_M0.7711.00
9_L31_L0.7591.00
22_V31_L0.7531.00
12_P16_G0.7421.00
8_R52_K0.7371.00
12_P17_S0.7281.00
3_L23_V0.7061.00
33_C36_C0.6921.00
44_R48_E0.6731.00
18_N52_K0.6500.99
48_E51_I0.6450.99
40_V50_R0.6400.99
9_L44_R0.6300.99
28_D43_P0.6190.99
22_V25_L0.6080.99
28_D44_R0.6040.99
17_S34_L0.6020.99
5_D54_I0.5960.99
31_L42_L0.5950.99
9_L47_F0.5930.99
1_Y22_V0.5890.99
28_D41_M0.5730.99
7_V54_I0.5680.98
29_I48_E0.5660.98
34_L37_G0.5650.98
42_L46_K0.5640.98
24_R27_A0.5610.98
14_P17_S0.5560.98
3_L41_M0.5470.98
25_L45_R0.5440.98
33_C37_G0.5440.98
43_P48_E0.5430.98
16_G20_W0.5360.98
24_R28_D0.5340.98
29_I44_R0.5310.98
29_I41_M0.5310.98
2_R25_L0.5200.97
11_K49_K0.5130.97
27_A43_P0.5120.97
15_C33_C0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zey9 1 0.7091 22.7 0.866 Contact Map
4hw9A 3 0.8909 20.3 0.869 Contact Map
2k4xA 1 0.8364 18.8 0.871 Contact Map
4ujpg 1 0.7455 17.2 0.873 Contact Map
3udcA 3 0.8727 16.9 0.874 Contact Map
5ajiA 3 0.8909 15.8 0.875 Contact Map
1neeA 1 0.8 13.6 0.879 Contact Map
4cuyf 1 0.7455 13.1 0.879 Contact Map
4uer9 1 0.7455 13.1 0.879 Contact Map
2e9hA 1 1 12.5 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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