GREMLIN Database
DUF947 - Domain of unknown function (DUF947)
PFAM: PF06102 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 165 (165)
Sequences: 647 (515)
Seq/√Len: 40.1
META: 0.243

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_I85_L4.5901.00
112_E120_K3.6111.00
46_K50_N3.5541.00
111_E115_A2.7901.00
48_R99_E2.5171.00
107_E111_E2.4991.00
114_E118_Q2.4091.00
103_E107_E2.2811.00
142_L148_L2.1820.99
59_E92_L2.1090.99
135_L139_F2.0720.99
43_D46_K2.0710.99
137_E140_E2.0250.99
112_E115_A1.9870.99
106_K110_K1.9630.99
97_R101_E1.9480.99
129_E132_K1.7740.98
62_I88_M1.7520.97
12_S20_R1.7520.97
62_I92_L1.6960.97
45_D49_K1.6940.97
66_K89_E1.6780.97
139_F144_K1.6680.96
160_A164_K1.6510.96
135_L159_N1.6240.96
144_K147_K1.6000.95
130_K133_L1.5990.95
124_Y133_L1.5940.95
142_L147_K1.5760.95
40_G47_F1.5650.95
42_F47_F1.5590.95
134_L154_K1.5080.94
27_K70_K1.5020.94
126_K129_E1.5000.94
3_N6_A1.4960.93
68_Q77_E1.4770.93
90_S93_K1.4730.93
69_L81_L1.4450.92
112_E123_F1.4340.92
161_G164_K1.4250.92
148_L163_E1.4180.91
85_L92_L1.4180.91
40_G43_D1.3540.89
78_K82_K1.3480.89
148_L151_A1.3460.89
57_Y60_K1.3410.89
18_R112_E1.3230.88
9_E13_K1.3210.88
159_N165_K1.3130.88
22_V25_V1.2930.87
135_L142_L1.2600.86
151_A155_K1.2590.86
48_R95_R1.2510.85
55_D99_E1.2480.85
19_K66_K1.2410.85
96_K100_R1.2370.85
138_K151_A1.2330.84
39_S42_F1.2200.84
55_D58_R1.2150.84
69_L85_L1.1910.82
78_K110_K1.1860.82
80_E84_L1.1720.81
52_S76_E1.1680.81
100_R137_E1.1640.81
120_K158_K1.1420.80
139_F156_R1.1410.80
79_E83_R1.1350.79
129_E133_L1.1240.78
104_V134_L1.1180.78
2_S6_A1.1130.78
6_A62_I1.1040.77
64_E68_Q1.1000.77
159_N164_K1.0970.77
45_D50_N1.0840.76
100_R104_V1.0820.76
144_K148_L1.0750.75
77_E80_E1.0710.75
21_E27_K1.0660.75
14_K117_K1.0500.74
31_R36_D1.0450.73
31_R39_S1.0340.72
88_M92_L1.0270.72
116_V122_P1.0260.72
72_T78_K1.0230.72
25_V29_K1.0150.71
129_E138_K1.0020.70
97_R138_K0.9900.69
108_H125_L0.9860.69
1_R6_A0.9850.69
105_L116_V0.9830.68
155_K158_K0.9830.68
55_D95_R0.9820.68
125_L129_E0.9800.68
142_L151_A0.9760.68
74_D165_K0.9590.67
110_K113_R0.9570.66
76_E79_E0.9530.66
20_R54_L0.9460.65
56_D59_E0.9380.65
88_M91_Q0.9340.64
7_P11_S0.9290.64
83_R87_R0.9280.64
58_R95_R0.9250.64
155_K161_G0.9190.63
56_D64_E0.9150.63
108_H130_K0.9110.63
123_F126_K0.9030.62
82_K86_Q0.8900.61
63_K165_K0.8870.60
112_E116_V0.8870.60
45_D106_K0.8870.60
143_K151_A0.8770.60
50_N124_Y0.8760.59
35_F81_L0.8750.59
119_G122_P0.8700.59
15_P18_R0.8560.58
104_V108_H0.8540.57
1_R15_P0.8540.57
70_K160_A0.8540.57
136_V139_F0.8520.57
86_Q90_S0.8480.57
70_K86_Q0.8470.57
94_A98_K0.8460.57
68_Q84_L0.8380.56
1_R66_K0.8310.55
73_K150_K0.8240.55
47_F148_L0.8230.55
36_D62_I0.8140.54
65_L81_L0.8060.53
45_D102_R0.8050.53
149_D153_E0.8050.53
82_K89_E0.8030.53
7_P32_D0.8010.53
59_E96_K0.8010.53
48_R124_Y0.7980.52
24_P27_K0.7980.52
153_E156_R0.7950.52
74_D78_K0.7940.52
148_L152_I0.7940.52
22_V106_K0.7900.52
133_L136_V0.7890.52
32_D35_F0.7840.51
146_G163_E0.7830.51
147_K151_A0.7820.51
159_N163_E0.7800.51
98_K101_E0.7760.50
84_L87_R0.7760.50
28_K76_E0.7730.50
4_K7_P0.7700.50
108_H112_E0.7630.49
44_E48_R0.7630.49
71_K107_E0.7590.49
101_E134_L0.7540.48
112_E121_K0.7450.48
68_Q81_L0.7430.47
109_K126_K0.7410.47
56_D111_E0.7400.47
13_K152_I0.7370.47
105_L130_K0.7280.46
62_I158_K0.7210.45
60_K122_P0.7170.45
24_P30_A0.7130.45
65_L85_L0.7090.44
81_L112_E0.7090.44
110_K116_V0.7010.44
145_S148_L0.7000.43
78_K94_A0.7000.43
154_K158_K0.6970.43
63_K140_E0.6850.42
72_T77_E0.6840.42
62_I69_L0.6800.42
155_K163_E0.6750.41
43_D131_K0.6730.41
125_L133_L0.6710.41
85_L93_K0.6680.41
47_F142_L0.6680.41
4_K126_K0.6640.40
86_Q93_K0.6600.40
150_K153_E0.6500.39
125_L132_K0.6480.39
18_R23_V0.6410.38
6_A92_L0.6390.38
44_E64_E0.6370.38
154_K161_G0.6370.38
99_E103_E0.6330.38
18_R57_Y0.6320.37
57_Y87_R0.6320.37
120_K123_F0.6300.37
62_I102_R0.6300.37
146_G151_A0.6280.37
102_R107_E0.6250.37
3_N8_M0.6240.37
82_K93_K0.6180.36
52_S56_D0.6160.36
107_E137_E0.6140.36
151_A163_E0.6100.36
61_E155_K0.6100.36
37_P140_E0.5990.35
18_R65_L0.5990.35
82_K115_A0.5960.34
41_E105_L0.5950.34
86_Q152_I0.5940.34
132_K157_K0.5920.34
44_E100_R0.5910.34
17_S23_V0.5880.34
46_K102_R0.5870.34
89_E93_K0.5840.33
74_D77_E0.5840.33
56_D60_K0.5790.33
10_M14_K0.5760.33
69_L78_K0.5760.33
87_R108_H0.5720.32
3_N79_E0.5720.32
139_F152_I0.5690.32
48_R55_D0.5650.32
100_R131_K0.5640.32
54_L58_R0.5630.32
16_V35_F0.5610.32
111_E114_E0.5570.31
67_K75_P0.5550.31
17_S154_K0.5540.31
18_R60_K0.5540.31
77_E84_L0.5530.31
56_D67_K0.5530.31
33_P119_G0.5480.31
5_H20_R0.5430.30
47_F50_N0.5410.30
127_K130_K0.5360.30
35_F69_L0.5350.30
19_K23_V0.5340.29
73_K126_K0.5300.29
116_V123_F0.5280.29
156_R161_G0.5270.29
116_V149_D0.5270.29
1_R4_K0.5270.29
58_R130_K0.5230.29
67_K139_F0.5230.29
62_I66_K0.5210.28
17_S29_K0.5210.28
9_E56_D0.5140.28
112_E119_G0.5110.28
86_Q138_K0.5100.28
87_R90_S0.5080.28
66_K133_L0.5080.28
108_H133_L0.5050.27
67_K83_R0.5030.27
135_L156_R0.5010.27
105_L125_L0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ziaJ 1 0.2182 5.6 0.95 Contact Map
4elyA 2 0.5515 4.8 0.952 Contact Map
2wujA 2 0.303 4.5 0.952 Contact Map
1uk5A 1 0.5939 3.2 0.956 Contact Map
2akfA 3 0.1939 2.7 0.957 Contact Map
3vp9A 3 0.4 2.5 0.958 Contact Map
4d2hA 5 0.2303 2.4 0.958 Contact Map
2a26A 4 0.297 2.2 0.959 Contact Map
1gmjA 2 0.3818 2.2 0.959 Contact Map
2rt6A 1 0.5818 2.1 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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