GREMLIN Database
Phenol_hyd_sub - Phenol hydroxylase subunit
PFAM: PF06099 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 57 (54)
Sequences: 723 (490)
Seq/√Len: 66.7
META: 0.787

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_T25_E3.1551.00
16_E41_R3.0781.00
13_V44_F2.8331.00
40_P43_A2.4801.00
23_E30_D1.8191.00
48_C53_V1.7831.00
41_R45_E1.7501.00
14_T37_L1.7221.00
8_R54_V1.7000.99
4_F30_D1.6950.99
15_G19_D1.6490.99
9_R51_N1.6470.99
25_E34_F1.5740.99
34_F37_L1.4750.99
14_T35_V1.4430.98
7_L10_Y1.3930.98
15_G23_E1.3730.98
43_A46_E1.3420.97
5_D8_R1.3380.97
46_E50_A1.1600.94
30_D37_L1.1110.92
45_E49_A1.0880.91
25_E35_V1.0810.91
21_F38_V1.0510.90
46_E49_A1.0470.90
26_F31_P1.0420.90
27_A34_F1.0370.89
27_A31_P1.0300.89
10_Y28_I0.9950.87
30_D34_F0.9920.87
27_A56_L0.9900.87
11_V48_C0.9330.84
42_A46_E0.9160.82
20_G56_L0.9080.82
44_F48_C0.8800.80
9_R53_V0.8720.79
23_E38_V0.8620.78
42_A45_E0.8490.77
9_R21_F0.7920.72
9_R54_V0.7730.70
26_F35_V0.7720.70
13_V45_E0.7370.67
39_L43_A0.7330.66
9_R31_P0.7240.65
15_G20_G0.7170.65
21_F40_P0.7160.65
11_V28_I0.7090.64
15_G18_A0.7080.64
9_R26_F0.7040.63
27_A54_V0.7030.63
23_E34_F0.6730.60
3_A22_V0.6590.58
17_R20_G0.6570.58
42_A52_R0.6540.58
30_D38_V0.6540.58
10_Y27_A0.6460.57
29_G52_R0.6350.55
13_V16_E0.6290.55
49_A52_R0.6180.53
12_R25_E0.6170.53
16_E32_E0.6150.53
43_A51_N0.6080.52
22_V41_R0.6020.51
17_R30_D0.6000.51
12_R42_A0.5860.50
33_L50_A0.5820.49
30_D44_F0.5800.49
17_R38_V0.5780.49
28_I51_N0.5720.48
14_T27_A0.5580.46
33_L54_V0.5510.45
22_V50_A0.5510.45
11_V16_E0.5490.45
9_R29_G0.5360.44
18_A41_R0.5350.44
4_F7_L0.5260.43
21_F53_V0.5190.42
36_E44_F0.5110.41
3_A7_L0.5100.41
36_E52_R0.5050.40
16_E45_E0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o34A 1 1 12.2 0.889 Contact Map
3ng0A 5 0.3333 4.2 0.91 Contact Map
1eswA 1 0.9298 4.1 0.911 Contact Map
3zdfC 1 0.3158 3.7 0.912 Contact Map
3biyA 1 0.8596 3.7 0.912 Contact Map
4bhwA 2 1 3.5 0.914 Contact Map
4bgpA 1 0.5439 3.2 0.915 Contact Map
3doaA 1 0.8246 3.1 0.916 Contact Map
4mo3M 1 0.5789 3.1 0.916 Contact Map
1werA 1 0.3333 3.1 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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