GREMLIN Database
DUF945 - Bacterial protein of unknown function (DUF945)
PFAM: PF06097 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 460 (453)
Sequences: 2009 (1671)
Seq/√Len: 78.5
META: 0.604

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_P58_W6.2381.00
30_E56_R5.1511.00
183_G209_G5.0731.00
244_G267_D4.6481.00
30_E34_D4.3841.00
389_K434_R3.7561.00
204_G228_D3.5631.00
18_W22_P3.4631.00
65_T88_H3.2031.00
137_T147_S3.1861.00
384_D442_S3.0571.00
289_D333_G3.0161.00
61_S92_H3.0061.00
112_T137_T2.9541.00
86_L112_T2.9391.00
182_K210_D2.9311.00
257_L287_N2.9051.00
289_D292_A2.9001.00
7_A10_V2.8481.00
286_N336_E2.8051.00
435_D440_V2.7731.00
111_H136_T2.6941.00
243_K268_S2.6711.00
280_K341_P2.6551.00
53_S64_R2.6251.00
346_T349_G2.5241.00
284_S340_D2.4651.00
345_K350_E2.4281.00
57_G61_S2.4161.00
30_E54_Y2.4051.00
449_Q456_P2.4051.00
94_P141_Y2.4021.00
184_D208_D2.3661.00
202_L205_L2.3381.00
63_A90_I2.3281.00
205_L227_L2.3181.00
155_D164_S2.2591.00
135_I149_L2.2411.00
26_G92_H2.2341.00
336_E358_D2.1651.00
351_S388_P2.1261.00
88_H110_V2.1251.00
32_E35_E2.1231.00
206_T226_S2.1181.00
189_G203_S2.1161.00
88_H112_T2.1161.00
353_G385_L2.0921.00
166_S189_G2.0781.00
63_A88_H2.0761.00
118_P121_K2.0651.00
278_S345_K2.0471.00
263_D282_D2.0381.00
22_P26_G2.0301.00
64_R87_D2.0211.00
88_H137_T1.9731.00
125_A129_G1.9651.00
167_G187_L1.9651.00
229_S243_K1.9531.00
228_D244_G1.9501.00
451_T456_P1.9251.00
386_S438_N1.9151.00
282_D340_D1.9151.00
222_D250_D1.9091.00
246_S265_S1.9001.00
54_Y63_A1.8661.00
280_K343_S1.8601.00
62_T89_T1.8351.00
203_S229_S1.8051.00
28_Q32_E1.8041.00
96_P105_P1.7851.00
354_N384_D1.7611.00
147_S172_V1.7581.00
67_L84_L1.7581.00
286_N338_S1.7471.00
54_Y92_H1.7421.00
287_N335_P1.7411.00
380_D446_A1.6831.00
355_L383_A1.6711.00
163_L192_L1.6611.00
24_Y28_Q1.6571.00
351_S391_L1.6561.00
145_T174_V1.6551.00
279_L344_L1.6481.00
254_D259_D1.6271.00
259_D286_N1.6051.00
154_F165_F1.5981.00
54_Y61_S1.5981.00
28_Q31_Q1.5901.00
19_L22_P1.5801.00
191_S201_T1.5771.00
371_N374_Q1.5761.00
6_V10_V1.5660.99
149_L170_G1.5550.99
331_L335_P1.5520.99
389_K437_D1.5470.99
29_A90_I1.5420.99
157_E162_K1.5410.99
64_R85_V1.5260.99
268_S275_D1.5160.99
266_L269_L1.5140.99
88_H147_S1.5130.99
8_L15_G1.5000.99
427_V434_R1.4940.99
27_K56_R1.4910.99
200_L232_V1.4860.99
388_P391_L1.4810.99
117_D120_T1.4780.99
35_E38_A1.4770.99
410_E413_K1.4570.99
135_I147_S1.4560.99
403_L418_Q1.4320.99
55_E62_T1.4100.99
37_V41_N1.4060.99
26_G54_Y1.4050.99
170_G185_G1.4030.99
227_L230_L1.4020.99
96_P106_G1.3980.99
441_S452_L1.3910.99
13_A17_A1.3910.99
277_G344_L1.3760.99
203_S228_D1.3750.99
87_D113_E1.3700.99
284_S338_S1.3590.99
146_S173_D1.3560.99
66_R83_E1.3530.98
185_G207_L1.3520.98
412_A416_E1.3500.98
101_G106_G1.3480.98
26_G56_R1.3360.98
123_L126_A1.3330.98
382_D444_E1.3180.98
67_L86_L1.3170.98
429_Q458_P1.3160.98
106_G109_S1.3120.98
23_W58_W1.3080.98
94_P335_P1.3010.98
7_A13_A1.2930.98
386_S440_V1.2900.98
46_L49_V1.2890.98
175_D180_K1.2750.98
33_L88_H1.2740.98
101_G105_P1.2470.97
33_L63_A1.2450.97
231_S241_S1.2400.97
18_W58_W1.2320.97
68_T83_E1.2310.97
11_V15_G1.2250.97
168_L185_G1.2170.97
435_D438_N1.2140.97
210_D222_D1.2090.97
15_G19_L1.2030.97
20_G24_Y1.2010.97
443_L452_L1.1970.97
7_A227_L1.1960.97
433_K440_V1.1950.97
422_Q426_L1.1930.97
410_E414_L1.1880.97
427_V432_L1.1870.97
105_P277_G1.1850.96
61_S349_G1.1790.96
423_L439_Y1.1740.96
33_L65_T1.1710.96
214_G220_L1.1620.96
166_S188_P1.1530.96
276_L279_L1.1490.96
66_R85_V1.1360.96
170_G207_L1.1240.95
423_L452_L1.1200.95
23_W30_E1.1130.95
448_G458_P1.1050.95
110_V137_T1.1040.95
392_L396_A1.1040.95
62_T87_D1.1020.95
298_Q302_E1.0950.95
214_G253_E1.0920.94
8_L12_V1.0920.94
292_A333_G1.0910.94
22_P28_Q1.0910.94
357_L381_L1.0890.94
23_W27_K1.0880.94
23_W59_F1.0810.94
137_T145_T1.0770.94
87_D115_E1.0740.94
382_D442_S1.0480.93
429_Q432_L1.0460.93
388_P438_N1.0450.93
154_F167_G1.0410.93
267_D278_S1.0400.93
21_A25_T1.0390.93
186_S206_T1.0380.93
257_L289_D1.0370.93
44_L47_S1.0300.93
294_E298_Q1.0290.92
401_A405_G1.0270.92
94_P108_A1.0270.92
381_L443_L1.0240.92
424_A428_Q1.0230.92
20_G58_W1.0220.92
41_N48_V1.0220.92
96_P141_Y1.0190.92
89_T113_E1.0160.92
253_E290_A1.0140.92
45_G48_V1.0130.92
383_A443_L1.0110.92
405_G411_A1.0100.92
226_S246_S1.0060.92
258_L323_L1.0050.92
148_T171_T1.0040.92
216_G290_A0.9960.91
120_T124_F0.9950.91
258_L290_A0.9930.91
36_L39_Q0.9920.91
25_T141_Y0.9910.91
387_L392_L0.9910.91
217_G221_G0.9880.91
112_T135_I0.9860.91
70_A73_A0.9820.91
287_N336_E0.9800.91
217_G294_E0.9740.90
247_L251_S0.9730.90
291_A295_A0.9670.90
450_L458_P0.9640.90
386_S435_D0.9580.90
338_S356_S0.9570.89
163_L451_T0.9560.89
443_L450_L0.9520.89
425_M428_Q0.9520.89
322_A326_A0.9520.89
229_S241_S0.9500.89
445_Y450_L0.9490.89
227_L245_L0.9460.89
346_T351_S0.9430.89
315_L319_L0.9430.89
289_D329_K0.9410.89
10_V14_L0.9410.89
292_A329_K0.9390.89
155_D162_K0.9350.88
287_N333_G0.9320.88
242_L297_S0.9270.88
270_K275_D0.9210.88
282_D341_P0.9200.88
256_D291_A0.9170.87
13_A16_A0.9170.87
339_I342_L0.9150.87
281_L339_I0.9090.87
122_K126_A0.9060.87
202_L431_L0.9020.87
144_S283_L0.9020.87
91_D98_S0.8980.86
168_L187_L0.8960.86
139_V395_L0.8960.86
274_Q277_G0.8950.86
124_F127_L0.8930.86
424_A427_V0.8900.86
153_P167_G0.8890.86
249_S260_G0.8860.86
27_K30_E0.8810.85
404_G407_D0.8810.85
13_A23_W0.8810.85
423_L432_L0.8780.85
436_G440_V0.8770.85
373_L377_K0.8740.85
122_K125_A0.8730.85
364_L368_D0.8680.84
137_T143_G0.8660.84
393_E420_E0.8650.84
208_D224_S0.8640.84
53_S63_A0.8610.84
451_T457_M0.8600.84
188_P204_G0.8590.84
19_L59_F0.8580.84
422_Q432_L0.8550.83
414_L418_Q0.8510.83
260_G285_L0.8500.83
311_D314_A0.8490.83
450_L457_M0.8490.83
190_L202_L0.8490.83
224_S248_D0.8470.83
22_P25_T0.8460.83
343_S350_E0.8460.83
15_G20_G0.8430.83
96_P99_R0.8430.83
140_G144_S0.8420.82
150_T169_T0.8410.82
189_G204_G0.8400.82
158_D161_G0.8320.82
193_T199_Q0.8310.82
6_V11_V0.8290.81
295_A329_K0.8270.81
295_A326_A0.8240.81
109_S138_R0.8240.81
150_T229_S0.8200.81
131_S152_P0.8190.81
57_G92_H0.8140.80
449_Q457_M0.8120.80
286_N339_I0.8090.80
17_A22_P0.8080.80
84_L190_L0.8070.80
169_T204_G0.8070.80
116_L121_K0.8060.80
316_Q319_L0.8050.80
323_L327_L0.8030.79
340_D353_G0.8010.79
296_L300_Y0.7960.79
331_L359_L0.7950.79
163_L244_G0.7930.79
452_L457_M0.7920.78
54_Y90_I0.7910.78
363_G368_D0.7890.78
414_L417_Q0.7890.78
151_L165_F0.7880.78
269_L391_L0.7860.78
433_K443_L0.7860.78
434_R439_Y0.7850.78
19_L332_A0.7840.78
35_E39_Q0.7820.78
106_G230_L0.7810.77
253_E256_D0.7800.77
186_S231_S0.7800.77
157_E160_G0.7790.77
174_V178_G0.7780.77
331_L381_L0.7770.77
139_V145_T0.7750.77
200_L207_L0.7750.77
251_S392_L0.7720.77
218_L221_G0.7680.76
401_A404_G0.7660.76
276_L347_P0.7640.76
243_K266_L0.7620.76
146_S381_L0.7600.76
19_L58_W0.7580.75
339_I355_L0.7580.75
415_A418_Q0.7580.75
280_K354_N0.7570.75
186_S249_S0.7570.75
314_A317_Q0.7560.75
92_H108_A0.7530.75
260_G264_Y0.7520.75
23_W54_Y0.7510.75
90_I108_A0.7480.74
330_L349_G0.7470.74
165_F168_L0.7470.74
23_W26_G0.7470.74
12_V17_A0.7450.74
22_P27_K0.7430.74
430_G448_G0.7430.74
26_G59_F0.7430.74
207_L225_L0.7390.73
180_K212_K0.7380.73
175_D179_G0.7380.73
313_E316_Q0.7380.73
444_E451_T0.7370.73
214_G290_A0.7360.73
244_G382_D0.7360.73
58_W94_P0.7340.73
353_G383_A0.7330.73
44_L48_V0.7330.73
56_R92_H0.7320.73
411_A415_A0.7300.73
379_L432_L0.7300.73
234_D348_E0.7260.72
91_D111_H0.7230.72
320_L387_L0.7220.72
261_S286_N0.7220.72
119_E124_F0.7210.72
86_L124_F0.7210.72
365_D368_D0.7210.72
8_L254_D0.7200.72
426_L429_Q0.7190.71
283_L339_I0.7190.71
107_L141_Y0.7190.71
102_N106_G0.7190.71
254_D330_L0.7180.71
93_G221_G0.7180.71
369_L372_P0.7140.71
51_S66_R0.7130.71
288_L330_L0.7130.71
183_G210_D0.7120.71
349_G388_P0.7120.71
61_S266_L0.7120.71
195_A198_G0.7100.70
121_K125_A0.7100.70
204_G244_G0.7090.70
398_Q401_A0.7090.70
152_P436_G0.7090.70
153_P165_F0.7080.70
53_S62_T0.7080.70
21_A24_Y0.7080.70
84_L227_L0.7070.70
208_D226_S0.7060.70
346_T394_E0.7050.70
116_L119_E0.7050.70
413_K416_E0.7030.70
218_L306_A0.7030.70
7_A14_L0.7020.70
443_L451_T0.7000.69
102_N109_S0.6980.69
20_G59_F0.6980.69
162_K302_E0.6980.69
34_D54_Y0.6950.69
406_A410_E0.6930.69
427_V439_Y0.6920.69
26_G29_A0.6890.68
19_L25_T0.6890.68
351_S387_L0.6870.68
213_R219_Y0.6870.68
14_L457_M0.6860.68
277_G349_G0.6860.68
295_A298_Q0.6860.68
94_P107_L0.6860.68
422_Q425_M0.6840.68
426_L432_L0.6820.67
31_Q288_L0.6820.67
186_S212_K0.6780.67
149_L344_L0.6770.67
403_L411_A0.6760.67
269_L358_D0.6730.66
413_K417_Q0.6730.66
10_V15_G0.6720.66
340_D354_N0.6720.66
93_G108_A0.6720.66
133_L170_G0.6700.66
404_G411_A0.6700.66
11_V227_L0.6690.66
90_I110_V0.6670.66
446_A457_M0.6660.66
21_A58_W0.6650.65
4_S7_A0.6650.65
405_G414_L0.6630.65
340_D355_L0.6630.65
67_L268_S0.6620.65
34_D38_A0.6620.65
84_L248_D0.6610.65
117_D152_P0.6600.65
445_Y452_L0.6580.65
94_P98_S0.6580.65
23_W65_T0.6570.65
110_V139_V0.6570.65
354_N382_D0.6550.64
364_L367_D0.6550.64
318_A359_L0.6520.64
188_P203_S0.6510.64
200_L236_G0.6500.64
404_G414_L0.6500.64
129_G289_D0.6500.64
418_Q422_Q0.6490.64
230_L435_D0.6480.63
50_I65_T0.6480.63
383_A386_S0.6470.63
23_W56_R0.6460.63
317_Q321_A0.6440.63
245_L249_S0.6440.63
446_A451_T0.6440.63
390_A393_E0.6430.63
165_F169_T0.6420.63
165_F188_P0.6420.63
90_I348_E0.6410.63
441_S444_E0.6410.63
173_D182_K0.6380.62
2_K9_G0.6380.62
85_V115_E0.6370.62
59_F93_G0.6370.62
29_A92_H0.6360.62
285_L337_L0.6350.62
369_L374_Q0.6330.62
259_D432_L0.6310.61
102_N105_P0.6290.61
432_L449_Q0.6280.61
10_V47_S0.6270.61
88_H108_A0.6270.61
43_Q51_S0.6260.61
7_A11_V0.6250.61
108_A142_D0.6240.61
151_L167_G0.6210.60
443_L459_L0.6200.60
3_K16_A0.6190.60
347_P351_S0.6190.60
122_K235_P0.6180.60
222_D437_D0.6160.60
265_S288_L0.6160.60
31_Q435_D0.6160.60
341_P350_E0.6160.60
29_A56_R0.6150.59
33_L37_V0.6150.59
299_A303_L0.6140.59
212_K295_A0.6130.59
248_D263_D0.6130.59
430_G433_K0.6110.59
334_G363_G0.6110.59
422_Q429_Q0.6110.59
426_L439_Y0.6090.59
109_S292_A0.6080.59
146_S230_L0.6080.59
310_A313_E0.6060.58
346_T376_L0.6050.58
434_R449_Q0.6040.58
433_K436_G0.6030.58
158_D392_L0.6030.58
144_S242_L0.6020.58
265_S280_K0.6020.58
86_L163_L0.6020.58
406_A411_A0.6020.58
105_P141_Y0.5990.57
104_L109_S0.5980.57
315_L318_A0.5970.57
45_G346_T0.5970.57
48_V51_S0.5970.57
167_G190_L0.5970.57
260_G319_L0.5970.57
401_A406_A0.5960.57
255_G258_L0.5950.57
411_A414_L0.5940.57
59_F266_L0.5930.57
10_V13_A0.5920.57
221_G290_A0.5920.57
63_A183_G0.5920.57
60_S200_L0.5920.57
252_S259_D0.5910.56
24_Y27_K0.5910.56
261_S340_D0.5900.56
401_A415_A0.5900.56
187_L205_L0.5900.56
397_A412_A0.5890.56
108_A112_T0.5890.56
79_G228_D0.5890.56
410_E418_Q0.5880.56
407_D411_A0.5870.56
161_G194_D0.5860.56
13_A30_E0.5860.56
198_G209_G0.5860.56
283_L337_L0.5850.56
280_K337_L0.5850.56
151_L168_L0.5850.56
127_L156_Y0.5810.55
314_A318_A0.5810.55
160_G180_K0.5810.55
16_A24_Y0.5810.55
192_L321_A0.5800.55
26_G93_G0.5790.55
171_T184_D0.5770.55
406_A413_K0.5760.55
161_G249_S0.5750.54
191_S248_D0.5750.54
335_P448_G0.5750.54
368_D372_P0.5730.54
14_L327_L0.5730.54
262_L285_L0.5720.54
215_S395_L0.5710.54
152_P167_G0.5710.54
37_V433_K0.5710.54
171_T288_L0.5700.54
16_A323_L0.5700.54
22_P141_Y0.5690.54
51_S163_L0.5690.54
154_F166_S0.5690.54
367_D371_N0.5680.54
26_G57_G0.5670.53
149_L172_V0.5660.53
332_A344_L0.5660.53
10_V18_W0.5660.53
225_L230_L0.5660.53
10_V17_A0.5660.53
387_L424_A0.5650.53
44_L49_V0.5650.53
292_A328_P0.5650.53
358_D380_D0.5650.53
21_A27_K0.5650.53
9_G42_Q0.5640.53
444_E454_G0.5640.53
247_L420_E0.5630.53
190_L363_G0.5610.53
96_P292_A0.5600.52
407_D415_A0.5600.52
95_L367_D0.5590.52
336_E341_P0.5590.52
18_W21_A0.5590.52
26_G58_W0.5590.52
150_T259_D0.5580.52
5_L244_G0.5570.52
278_S347_P0.5570.52
202_L208_D0.5570.52
292_A332_A0.5560.52
200_L311_D0.5550.52
311_D317_Q0.5540.52
407_D410_E0.5530.52
245_L278_S0.5530.52
320_L342_L0.5530.52
424_A441_S0.5520.51
61_S97_L0.5520.51
206_T355_L0.5520.51
26_G30_E0.5520.51
110_V127_L0.5510.51
46_L50_I0.5510.51
92_H143_G0.5490.51
21_A67_L0.5490.51
93_G331_L0.5480.51
97_L114_L0.5480.51
383_A441_S0.5480.51
161_G197_G0.5470.51
226_S244_G0.5470.51
300_Y423_L0.5460.51
9_G14_L0.5460.51
30_E61_S0.5450.51
288_L347_P0.5450.51
402_L406_A0.5450.51
281_L342_L0.5430.50
133_L149_L0.5420.50
312_P316_Q0.5410.50
281_L317_Q0.5390.50
30_E63_A0.5390.50
29_A152_P0.5390.50
96_P101_G0.5380.50
371_N375_L0.5380.50
427_V433_K0.5370.50
232_V325_A0.5360.49
194_D233_T0.5360.49
189_G192_L0.5350.49
371_N378_K0.5350.49
270_K273_G0.5350.49
238_E327_L0.5350.49
401_A411_A0.5340.49
191_S199_Q0.5330.49
276_L430_G0.5330.49
106_G138_R0.5330.49
15_G268_S0.5330.49
321_A325_A0.5320.49
119_E200_L0.5300.49
32_E37_V0.5290.49
7_A35_E0.5290.49
257_L335_P0.5250.48
96_P166_S0.5240.48
191_S318_A0.5240.48
16_A28_Q0.5230.48
402_L405_G0.5230.48
184_D194_D0.5230.48
86_L185_G0.5230.48
348_E392_L0.5220.48
149_L385_L0.5220.48
57_G256_D0.5220.48
244_G377_K0.5220.48
172_V188_P0.5220.48
263_D267_D0.5210.47
215_S447_D0.5200.47
89_T114_L0.5190.47
180_K210_D0.5190.47
319_L342_L0.5180.47
170_G355_L0.5180.47
314_A445_Y0.5170.47
209_G369_L0.5160.47
8_L341_P0.5160.47
114_L230_L0.5150.47
155_D204_G0.5150.47
38_A344_L0.5140.47
255_G290_A0.5140.47
95_L105_P0.5140.47
45_G51_S0.5140.47
325_A455_K0.5130.46
313_E371_N0.5120.46
59_F141_Y0.5120.46
110_V147_S0.5100.46
115_E185_G0.5100.46
248_D265_S0.5080.46
58_W346_T0.5080.46
139_V147_S0.5070.46
348_E394_E0.5060.46
392_L443_L0.5060.46
317_Q325_A0.5050.45
432_L452_L0.5040.45
389_K393_E0.5030.45
192_L256_D0.5030.45
175_D431_L0.5030.45
164_S245_L0.5030.45
78_P82_L0.5030.45
302_E306_A0.5020.45
213_R264_Y0.5020.45
133_L151_L0.5010.45
303_L306_A0.5010.45
447_D451_T0.5010.45
403_L406_A0.5000.45
33_L54_Y0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j5lA 1 0 11.3 0.964 Contact Map
3zbiC 1 0.0587 10.9 0.964 Contact Map
3dh3A 1 0.1283 6.6 0.967 Contact Map
3j46n 1 0.1891 6.5 0.967 Contact Map
3zm8A 1 0.1587 6.3 0.968 Contact Map
1spfA 1 0.0565 5.9 0.968 Contact Map
1m56D 1 0.0435 5.3 0.969 Contact Map
3bbnI 1 0.0739 5.3 0.969 Contact Map
1dm9A 1 0.1326 5.3 0.969 Contact Map
1qleD 1 0.0435 5.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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