GREMLIN Database
ArAE_1 - Aromatic acid exporter family member 1
PFAM: PF06081 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 141 (132)
Sequences: 9428 (6535)
Seq/√Len: 568.8
META: 0.747

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_R126_E3.0171.00
105_T108_I2.6951.00
101_V105_T2.6891.00
15_V80_G2.6891.00
20_I133_V2.5051.00
13_A36_A2.4231.00
106_A110_L2.1691.00
105_T109_L2.0941.00
116_S119_L2.0611.00
64_L89_L1.9931.00
17_A32_A1.9761.00
55_L128_L1.9051.00
121_L125_L1.8831.00
103_A106_A1.8461.00
62_A124_F1.8451.00
11_A84_L1.7761.00
17_A21_A1.6961.00
52_L56_L1.6891.00
86_A90_C1.6751.00
50_K53_Q1.6681.00
16_L133_V1.6501.00
51_A131_I1.6391.00
128_L132_A1.5941.00
105_T110_L1.5581.00
101_V104_V1.5421.00
11_A15_V1.5351.00
123_R127_T1.5081.00
18_L33_A1.4951.00
21_A29_P1.4861.00
49_R53_Q1.4781.00
54_R127_T1.4771.00
35_T39_V1.4441.00
35_T127_T1.4311.00
100_R103_A1.4251.00
104_V107_L1.4211.00
53_Q97_E1.3781.00
113_P116_S1.3631.00
104_V108_I1.3551.00
51_A135_L1.3351.00
15_V19_L1.2951.00
107_L110_L1.2801.00
120_A123_R1.2721.00
14_A83_V1.2631.00
67_L71_L1.2621.00
106_A109_L1.2511.00
28_E31_W1.2471.00
26_L126_E1.2461.00
19_L23_L1.2301.00
114_G118_A1.2081.00
19_L22_R1.1881.00
75_N78_A1.1571.00
131_I135_L1.1261.00
122_N125_L1.1051.00
114_G119_L1.1051.00
88_L91_V1.1011.00
17_A36_A1.0961.00
58_T127_T1.0931.00
102_A106_A1.0921.00
122_N126_E1.0861.00
103_A107_L1.0801.00
15_V76_P1.0711.00
48_L51_A1.0631.00
68_L82_A1.0631.00
114_G117_W1.0561.00
102_A105_T1.0561.00
21_A26_L1.0551.00
133_V136_L1.0381.00
9_K137_V1.0311.00
29_P32_A1.0201.00
31_W35_T1.0131.00
17_A133_V1.0121.00
77_W81_L1.0111.00
58_T123_R1.0071.00
115_D118_A1.0051.00
13_A137_V0.9921.00
97_E100_R0.9901.00
76_P80_G0.9731.00
66_A120_A0.9701.00
108_I123_R0.9651.00
32_A36_A0.9501.00
115_D119_L0.9491.00
100_R108_I0.9411.00
41_Q46_A0.9411.00
79_L107_L0.9271.00
111_L114_G0.9191.00
35_T54_R0.9151.00
120_A124_F0.9041.00
31_W39_V0.9011.00
107_L111_L0.8951.00
93_L96_G0.8951.00
90_C95_L0.8911.00
19_L76_P0.8891.00
23_L27_P0.8791.00
63_L67_L0.8771.00
112_A119_L0.8761.00
39_V50_K0.8731.00
99_I102_A0.8561.00
105_T111_L0.8561.00
51_A55_L0.8511.00
42_P46_A0.8471.00
92_L96_G0.8441.00
78_A81_L0.8421.00
14_A37_I0.8211.00
82_A86_A0.8201.00
57_G61_G0.8181.00
96_G99_I0.8031.00
22_R29_P0.8031.00
36_A40_V0.8031.00
112_A116_S0.8021.00
98_G101_V0.8021.00
56_L59_V0.8001.00
74_Q78_A0.7991.00
43_T46_A0.7921.00
100_R105_T0.7911.00
91_V96_G0.7891.00
87_I91_V0.7791.00
99_I103_A0.7781.00
68_L78_A0.7751.00
30_Y34_I0.7741.00
44_V47_S0.7731.00
18_L22_R0.7691.00
21_A24_L0.7641.00
33_A36_A0.7631.00
22_R27_P0.7631.00
127_T131_I0.7601.00
17_A33_A0.7571.00
123_R130_G0.7301.00
84_L88_L0.7281.00
88_L92_L0.7281.00
77_W80_G0.7211.00
118_A122_N0.7201.00
38_L54_R0.7121.00
60_I63_L0.7111.00
67_L70_L0.7101.00
112_A115_D0.7051.00
30_Y33_A0.7041.00
32_A35_T0.7021.00
125_L128_L0.7001.00
39_V131_I0.6931.00
59_V63_L0.6911.00
48_L135_L0.6901.00
22_R25_G0.6861.00
90_C96_G0.6831.00
70_L74_Q0.6811.00
106_A111_L0.6811.00
108_I111_L0.6801.00
106_A113_P0.6771.00
54_R58_T0.6761.00
13_A133_V0.6751.00
46_A50_K0.6741.00
9_K47_S0.6661.00
90_C94_R0.6611.00
101_V106_A0.6591.00
61_G65_G0.6511.00
16_L19_L0.6401.00
29_P35_T0.6281.00
102_A108_I0.6261.00
31_W126_E0.6251.00
86_A89_L0.6221.00
59_V124_F0.6181.00
80_G83_V0.6101.00
98_G103_A0.5981.00
92_L95_L0.5951.00
13_A134_A0.5951.00
133_V137_V0.5931.00
35_T131_I0.5911.00
21_A126_E0.5871.00
28_E112_A0.5811.00
112_A117_W0.5791.00
95_L98_G0.5741.00
10_T36_A0.5690.99
123_R134_A0.5680.99
108_I113_P0.5650.99
126_E129_I0.5650.99
85_L88_L0.5640.99
21_A32_A0.5630.99
20_I129_I0.5590.99
66_A70_L0.5510.99
89_L93_L0.5500.99
73_G78_A0.5460.99
8_L12_L0.5410.99
111_L119_L0.5370.99
129_I132_A0.5360.99
101_V107_L0.5310.99
33_A65_G0.5300.99
62_A120_A0.5290.99
84_L87_I0.5290.99
51_A127_T0.5240.99
73_G76_P0.5200.99
56_L95_L0.5190.99
43_T138_N0.5110.99
132_A136_L0.5110.99
18_L25_G0.5100.99
55_L131_I0.5050.99
41_Q50_K0.5050.99
15_V23_L0.5040.99
129_I133_V0.5020.99
111_L117_W0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u9nA 2 0.7234 9.4 0.91 Contact Map
3nd0A 2 0.9007 4.5 0.922 Contact Map
4wgvA 2 0.9858 2.8 0.93 Contact Map
3ge3B 2 0.2837 2.3 0.933 Contact Map
4umwA 1 0.3404 2 0.936 Contact Map
2incB 2 0.4255 1.8 0.937 Contact Map
2i88A 1 0.4113 1.7 0.938 Contact Map
2k3cA 1 0.2199 1.2 0.943 Contact Map
2mpnA 2 0.1915 1.1 0.944 Contact Map
4f35D 2 0.6454 1.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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