ArAE_1 - PFAM28P - GREMLIN Contacts

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ArAE_1 - Aromatic acid exporter family member 1

PFAM:	PF06081	Sequences: MKIGARTLKTALAAVLALLIARLLGLPEPYWAAITAILVVQPTVGASLRKALQRLLGTVIGALLGALLALLFGQNPWALGLAVLLAILLCVLLRLGEGIRVAAVTALILLLAPGDSWALALNRFLETLIGIAVALLVNLLM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	141 (132)
Sequences:	9428 (6535)
Seq/√Len:	568.8
META:	0.747

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
123_R	126_E	3.017	1.00
105_T	108_I	2.695	1.00
101_V	105_T	2.689	1.00
15_V	80_G	2.689	1.00
20_I	133_V	2.505	1.00
13_A	36_A	2.423	1.00
106_A	110_L	2.169	1.00
105_T	109_L	2.094	1.00
116_S	119_L	2.061	1.00
64_L	89_L	1.993	1.00
17_A	32_A	1.976	1.00
55_L	128_L	1.905	1.00
121_L	125_L	1.883	1.00
103_A	106_A	1.846	1.00
62_A	124_F	1.845	1.00
11_A	84_L	1.776	1.00
17_A	21_A	1.696	1.00
52_L	56_L	1.689	1.00
86_A	90_C	1.675	1.00
50_K	53_Q	1.668	1.00
16_L	133_V	1.650	1.00
51_A	131_I	1.639	1.00
128_L	132_A	1.594	1.00
105_T	110_L	1.558	1.00
101_V	104_V	1.542	1.00
11_A	15_V	1.535	1.00
123_R	127_T	1.508	1.00
18_L	33_A	1.495	1.00
21_A	29_P	1.486	1.00
49_R	53_Q	1.478	1.00
54_R	127_T	1.477	1.00
35_T	39_V	1.444	1.00
35_T	127_T	1.431	1.00
100_R	103_A	1.425	1.00
104_V	107_L	1.421	1.00
53_Q	97_E	1.378	1.00
113_P	116_S	1.363	1.00
104_V	108_I	1.355	1.00
51_A	135_L	1.335	1.00
15_V	19_L	1.295	1.00
107_L	110_L	1.280	1.00
120_A	123_R	1.272	1.00
14_A	83_V	1.263	1.00
67_L	71_L	1.262	1.00
106_A	109_L	1.251	1.00
28_E	31_W	1.247	1.00
26_L	126_E	1.246	1.00
19_L	23_L	1.230	1.00
114_G	118_A	1.208	1.00
19_L	22_R	1.188	1.00
75_N	78_A	1.157	1.00
131_I	135_L	1.126	1.00
122_N	125_L	1.105	1.00
114_G	119_L	1.105	1.00
88_L	91_V	1.101	1.00
17_A	36_A	1.096	1.00
58_T	127_T	1.093	1.00
102_A	106_A	1.092	1.00
122_N	126_E	1.086	1.00
103_A	107_L	1.080	1.00
15_V	76_P	1.071	1.00
48_L	51_A	1.063	1.00
68_L	82_A	1.063	1.00
114_G	117_W	1.056	1.00
102_A	105_T	1.056	1.00
21_A	26_L	1.055	1.00
133_V	136_L	1.038	1.00
9_K	137_V	1.031	1.00
29_P	32_A	1.020	1.00
31_W	35_T	1.013	1.00
17_A	133_V	1.012	1.00
77_W	81_L	1.011	1.00
58_T	123_R	1.007	1.00
115_D	118_A	1.005	1.00
13_A	137_V	0.992	1.00
97_E	100_R	0.990	1.00
76_P	80_G	0.973	1.00
66_A	120_A	0.970	1.00
108_I	123_R	0.965	1.00
32_A	36_A	0.950	1.00
115_D	119_L	0.949	1.00
100_R	108_I	0.941	1.00
41_Q	46_A	0.941	1.00
79_L	107_L	0.927	1.00
111_L	114_G	0.919	1.00
35_T	54_R	0.915	1.00
120_A	124_F	0.904	1.00
31_W	39_V	0.901	1.00
107_L	111_L	0.895	1.00
93_L	96_G	0.895	1.00
90_C	95_L	0.891	1.00
19_L	76_P	0.889	1.00
23_L	27_P	0.879	1.00
63_L	67_L	0.877	1.00
112_A	119_L	0.876	1.00
39_V	50_K	0.873	1.00
99_I	102_A	0.856	1.00
105_T	111_L	0.856	1.00
51_A	55_L	0.851	1.00
42_P	46_A	0.847	1.00
92_L	96_G	0.844	1.00
78_A	81_L	0.842	1.00
14_A	37_I	0.821	1.00
82_A	86_A	0.820	1.00
57_G	61_G	0.818	1.00
96_G	99_I	0.803	1.00
22_R	29_P	0.803	1.00
36_A	40_V	0.803	1.00
112_A	116_S	0.802	1.00
98_G	101_V	0.802	1.00
56_L	59_V	0.800	1.00
74_Q	78_A	0.799	1.00
43_T	46_A	0.792	1.00
100_R	105_T	0.791	1.00
91_V	96_G	0.789	1.00
87_I	91_V	0.779	1.00
99_I	103_A	0.778	1.00
68_L	78_A	0.775	1.00
30_Y	34_I	0.774	1.00
44_V	47_S	0.773	1.00
18_L	22_R	0.769	1.00
21_A	24_L	0.764	1.00
33_A	36_A	0.763	1.00
22_R	27_P	0.763	1.00
127_T	131_I	0.760	1.00
17_A	33_A	0.757	1.00
123_R	130_G	0.730	1.00
84_L	88_L	0.728	1.00
88_L	92_L	0.728	1.00
77_W	80_G	0.721	1.00
118_A	122_N	0.720	1.00
38_L	54_R	0.712	1.00
60_I	63_L	0.711	1.00
67_L	70_L	0.710	1.00
112_A	115_D	0.705	1.00
30_Y	33_A	0.704	1.00
32_A	35_T	0.702	1.00
125_L	128_L	0.700	1.00
39_V	131_I	0.693	1.00
59_V	63_L	0.691	1.00
48_L	135_L	0.690	1.00
22_R	25_G	0.686	1.00
90_C	96_G	0.683	1.00
70_L	74_Q	0.681	1.00
106_A	111_L	0.681	1.00
108_I	111_L	0.680	1.00
106_A	113_P	0.677	1.00
54_R	58_T	0.676	1.00
13_A	133_V	0.675	1.00
46_A	50_K	0.674	1.00
9_K	47_S	0.666	1.00
90_C	94_R	0.661	1.00
101_V	106_A	0.659	1.00
61_G	65_G	0.651	1.00
16_L	19_L	0.640	1.00
29_P	35_T	0.628	1.00
102_A	108_I	0.626	1.00
31_W	126_E	0.625	1.00
86_A	89_L	0.622	1.00
59_V	124_F	0.618	1.00
80_G	83_V	0.610	1.00
98_G	103_A	0.598	1.00
92_L	95_L	0.595	1.00
13_A	134_A	0.595	1.00
133_V	137_V	0.593	1.00
35_T	131_I	0.591	1.00
21_A	126_E	0.587	1.00
28_E	112_A	0.581	1.00
112_A	117_W	0.579	1.00
95_L	98_G	0.574	1.00
10_T	36_A	0.569	0.99
123_R	134_A	0.568	0.99
108_I	113_P	0.565	0.99
126_E	129_I	0.565	0.99
85_L	88_L	0.564	0.99
21_A	32_A	0.563	0.99
20_I	129_I	0.559	0.99
66_A	70_L	0.551	0.99
89_L	93_L	0.550	0.99
73_G	78_A	0.546	0.99
8_L	12_L	0.541	0.99
111_L	119_L	0.537	0.99
129_I	132_A	0.536	0.99
101_V	107_L	0.531	0.99
33_A	65_G	0.530	0.99
62_A	120_A	0.529	0.99
84_L	87_I	0.529	0.99
51_A	127_T	0.524	0.99
73_G	76_P	0.520	0.99
56_L	95_L	0.519	0.99
43_T	138_N	0.511	0.99
132_A	136_L	0.511	0.99
18_L	25_G	0.510	0.99
55_L	131_I	0.505	0.99
41_Q	50_K	0.505	0.99
15_V	23_L	0.504	0.99
129_I	133_V	0.502	0.99
111_L	117_W	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4u9nA	2	0.7234	9.4	0.91	Contact Map
3nd0A	2	0.9007	4.5	0.922	Contact Map
4wgvA	2	0.9858	2.8	0.93	Contact Map
3ge3B	2	0.2837	2.3	0.933	Contact Map
4umwA	1	0.3404	2	0.936	Contact Map
2incB	2	0.4255	1.8	0.937	Contact Map
2i88A	1	0.4113	1.7	0.938	Contact Map
2k3cA	1	0.2199	1.2	0.943	Contact Map
2mpnA	2	0.1915	1.1	0.944	Contact Map
4f35D	2	0.6454	1.1	0.944	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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