GREMLIN Database
DUF934 - Bacterial protein of unknown function (DUF934)
PFAM: PF06073 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (105)
Sequences: 8649 (5050)
Seq/√Len: 492.8
META: 0.894

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_E73_A3.6551.00
25_L35_G3.0001.00
5_A26_D2.7301.00
24_A55_V2.5631.00
40_R44_E2.5091.00
41_L45_R2.2971.00
51_E72_D2.1481.00
5_A8_D1.8861.00
3_R24_A1.8831.00
27_F35_G1.8671.00
60_R84_A1.6951.00
64_F95_V1.6631.00
10_P38_Q1.6581.00
6_P28_P1.6351.00
63_L74_F1.5981.00
88_A91_D1.5801.00
16_D20_L1.5521.00
3_R55_V1.5231.00
27_F54_A1.5221.00
3_R26_D1.5211.00
63_L85_A1.4671.00
36_Y58_V1.4441.00
25_L38_Q1.4431.00
53_R73_A1.4421.00
9_D12_A1.4221.00
68_R101_D1.4201.00
59_L62_Q1.3951.00
66_M74_F1.3951.00
66_M71_F1.3911.00
11_E46_Y1.3591.00
76_L80_Q1.3331.00
26_D55_V1.3311.00
60_R91_D1.2921.00
57_D77_R1.2901.00
14_A46_Y1.2591.00
1_G22_L1.2491.00
60_R88_A1.2381.00
44_E100_A1.2271.00
15_P18_D1.2111.00
82_A86_L1.1931.00
64_F92_F1.1851.00
6_P38_Q1.1581.00
35_G38_Q1.1551.00
36_Y59_L1.1411.00
36_Y62_Q1.1151.00
77_R80_Q1.0991.00
76_L85_A1.0881.00
14_A17_L1.0811.00
2_V20_L1.0771.00
8_D12_A1.0771.00
58_V66_M1.0741.00
84_A87_A1.0551.00
67_R89_L1.0511.00
43_R72_D1.0481.00
83_E86_L1.0431.00
8_D38_Q1.0421.00
22_L53_R1.0321.00
16_D19_R1.0241.00
54_A71_F1.0121.00
30_F59_L1.0071.00
68_R97_Q1.0031.00
27_F66_M1.0021.00
68_R99_A0.9901.00
22_L73_A0.9881.00
52_L71_F0.9881.00
4_L8_D0.9841.00
39_A52_L0.9701.00
4_L10_P0.9661.00
64_F91_D0.9641.00
63_L76_L0.9611.00
59_L77_R0.9541.00
85_A89_L0.9481.00
86_L90_A0.9011.00
81_D84_A0.8961.00
18_D21_A0.8951.00
30_F62_Q0.8951.00
78_D81_D0.8771.00
94_V102_G0.8741.00
83_E87_A0.8701.00
60_R80_Q0.8661.00
25_L39_A0.8611.00
81_D85_A0.8591.00
7_D38_Q0.8201.00
40_R69_C0.8131.00
9_D38_Q0.8101.00
6_P35_G0.8071.00
17_L20_L0.8071.00
35_G71_F0.7971.00
84_A88_A0.7931.00
58_V74_F0.7851.00
2_V13_L0.7811.00
95_V103_P0.7721.00
98_P102_G0.7641.00
24_A75_E0.7641.00
62_Q66_M0.7621.00
55_V75_E0.7591.00
95_V102_G0.7521.00
41_L46_Y0.7521.00
80_Q85_A0.7521.00
23_I42_L0.7261.00
86_L89_L0.7151.00
98_P103_P0.7111.00
79_D83_E0.7111.00
27_F71_F0.7091.00
79_D85_A0.6991.00
64_F67_R0.6911.00
23_I52_L0.6901.00
39_A71_F0.6851.00
30_F57_D0.6791.00
68_R95_V0.6731.00
36_Y57_D0.6671.00
63_L67_R0.6581.00
38_Q41_L0.6571.00
67_R74_F0.6571.00
85_A88_A0.6541.00
13_L46_Y0.6531.00
63_L81_D0.6411.00
63_L89_L0.6361.00
80_Q84_A0.6361.00
44_E69_C0.6321.00
31_T59_L0.6301.00
30_F66_M0.6241.00
60_R63_L0.6211.00
53_R75_E0.6191.00
95_V99_A0.6080.99
76_L82_A0.6030.99
98_P105_P0.6020.99
95_V101_D0.5880.99
14_A18_D0.5850.99
3_R6_P0.5810.99
97_Q101_D0.5760.99
20_L23_I0.5750.99
13_L20_L0.5740.99
102_G105_P0.5660.99
94_V98_P0.5650.99
10_P46_Y0.5630.99
64_F68_R0.5600.99
32_D59_L0.5600.99
63_L66_M0.5580.99
15_P19_R0.5570.99
18_D49_K0.5510.99
63_L68_R0.5510.99
100_A103_P0.5460.99
60_R87_A0.5430.99
17_L48_Y0.5390.99
37_S61_D0.5370.99
43_R47_G0.5360.99
64_F89_L0.5310.99
28_P35_G0.5310.99
37_S65_F0.5230.98
87_A91_D0.5170.98
94_V97_Q0.5150.98
12_A15_P0.5150.98
63_L84_A0.5150.98
59_L65_F0.5050.98
58_V76_L0.5020.98
37_S41_L0.5020.98
67_R102_G0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3inpA 6 0.8972 79.2 0.877 Contact Map
3ctlA 4 0.9065 77.8 0.879 Contact Map
4nu7A 5 0.9346 76.7 0.88 Contact Map
1h1yA 2 0.9065 76.5 0.88 Contact Map
1tqxA 2 0.9065 75.2 0.882 Contact Map
3ceuA 1 0.9439 72.2 0.884 Contact Map
1tqjA 4 0.8505 70 0.886 Contact Map
1rpxA 4 0.9159 66.5 0.889 Contact Map
4r9xA 2 0.8224 64.4 0.89 Contact Map
4ldaA 3 0.9252 63.7 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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