GREMLIN Database
DUF932 - Domain of unknown function (DUF932)
PFAM: PF06067 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 228 (213)
Sequences: 12746 (9559)
Seq/√Len: 655.0
META: 0.938

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_S76_S2.9611.00
36_G45_F2.7571.00
77_A104_K2.5561.00
71_S75_S2.4261.00
88_V92_T2.4101.00
90_S94_V2.3651.00
39_R42_R2.3251.00
132_F136_A2.2731.00
142_T196_A2.2391.00
49_R63_E2.1971.00
14_N72_H2.1551.00
149_A199_A2.1351.00
145_T148_E2.0981.00
133_E137_E2.0731.00
139_L196_A2.0631.00
70_N78_L2.0171.00
175_L179_F2.0141.00
16_E19_E1.9401.00
14_N70_N1.8851.00
136_A197_W1.8761.00
87_V92_T1.8751.00
79_T104_K1.8571.00
148_E151_E1.8381.00
55_E61_E1.8241.00
149_A153_A1.7961.00
131_E134_E1.7681.00
117_E120_E1.7491.00
12_V111_F1.7301.00
204_T208_D1.7211.00
69_T79_T1.6761.00
9_Y71_S1.6741.00
188_D198_G1.6711.00
144_L199_A1.6691.00
62_V84_P1.6461.00
39_R43_R1.6441.00
55_E59_G1.6211.00
47_L67_L1.5671.00
60_D86_R1.5641.00
12_V78_L1.5551.00
69_T76_S1.5411.00
22_D26_G1.5361.00
19_E22_D1.5131.00
174_A178_L1.5051.00
195_T198_G1.5041.00
205_E210_G1.4971.00
13_Q16_E1.4851.00
176_L180_E1.4761.00
64_P129_F1.4481.00
86_R201_N1.4411.00
174_A177_E1.4361.00
33_E49_R1.4201.00
81_A102_S1.4181.00
152_F199_A1.4101.00
50_L53_E1.4091.00
68_L80_V1.4071.00
135_Q138_R1.4041.00
138_R142_T1.4031.00
138_R141_S1.3951.00
79_T102_S1.3881.00
151_E155_K1.3771.00
116_E119_K1.3741.00
150_E154_K1.3651.00
92_T96_A1.3631.00
93_L200_Y1.3501.00
184_D188_D1.3381.00
67_L83_T1.3371.00
87_V96_A1.3171.00
42_R73_D1.3021.00
146_D150_E1.2971.00
97_D100_A1.2911.00
81_A96_A1.2831.00
149_A202_A1.2781.00
32_Y35_A1.2781.00
39_R90_S1.2781.00
184_D187_N1.2751.00
192_A198_G1.2701.00
62_V197_W1.2661.00
67_L87_V1.2631.00
16_E112_D1.2621.00
110_N113_E1.2491.00
49_R65_Y1.2421.00
43_R76_S1.2291.00
18_F46_A1.2281.00
194_G198_G1.2271.00
5_V74_G1.2191.00
64_P84_P1.2171.00
21_L48_A1.2141.00
144_L196_A1.2071.00
10_K109_G1.2041.00
63_E87_V1.1981.00
165_K168_K1.1961.00
134_E137_E1.1891.00
65_Y83_T1.1841.00
77_A106_R1.1821.00
105_I111_F1.1821.00
78_L111_F1.1741.00
134_E138_R1.1711.00
185_R188_D1.1671.00
130_D134_E1.1631.00
172_R176_L1.1581.00
188_D191_G1.1471.00
131_E135_Q1.1451.00
142_T148_E1.1441.00
185_R205_E1.1441.00
137_E140_A1.1271.00
137_E141_S1.1131.00
15_E19_E1.1101.00
54_I133_E1.1041.00
87_V93_L1.0991.00
69_T81_A1.0991.00
83_T96_A1.0771.00
174_A210_G1.0761.00
188_D193_G1.0761.00
164_E167_Q1.0741.00
205_E208_D1.0671.00
193_G198_G1.0601.00
173_E176_L1.0581.00
170_R173_E1.0541.00
166_K169_K1.0401.00
150_E176_L1.0381.00
67_L81_A1.0291.00
151_E154_K1.0161.00
53_E63_E1.0081.00
172_R178_L1.0021.00
189_L192_A1.0021.00
31_E51_P0.9991.00
147_E151_E0.9951.00
186_G198_G0.9801.00
13_Q72_H0.9731.00
153_A202_A0.9621.00
128_Y131_E0.9601.00
147_E150_E0.9591.00
159_L162_E0.9441.00
184_D189_L0.9421.00
197_W201_N0.9401.00
14_N44_V0.9281.00
153_A199_A0.9271.00
187_N198_G0.9251.00
47_L65_Y0.9251.00
135_Q139_L0.9201.00
186_G189_L0.9121.00
76_S79_T0.9111.00
43_R73_D0.9091.00
62_V140_A0.9071.00
203_V207_L0.9061.00
112_D116_E0.9011.00
35_A38_L0.8981.00
179_F202_A0.8911.00
85_I90_S0.8901.00
88_V93_L0.8841.00
9_Y72_H0.8801.00
127_E130_D0.8771.00
171_A175_L0.8771.00
196_A199_A0.8771.00
41_G44_V0.8741.00
23_D26_G0.8701.00
199_A202_A0.8651.00
144_L149_A0.8611.00
185_R189_L0.8611.00
114_R117_E0.8561.00
37_S44_V0.8541.00
152_F203_V0.8541.00
73_D76_S0.8511.00
64_P82_F0.8501.00
170_R174_A0.8481.00
57_K137_E0.8471.00
85_I92_T0.8461.00
171_A179_F0.8451.00
139_L200_Y0.8441.00
10_K112_D0.8411.00
124_L127_E0.8351.00
116_E120_E0.8291.00
155_K158_P0.8261.00
97_D101_G0.8251.00
84_P129_F0.8231.00
173_E177_E0.8211.00
174_A179_F0.8181.00
34_T37_S0.8111.00
11_P72_H0.8061.00
146_D180_E0.7981.00
163_E167_Q0.7951.00
130_D133_E0.7921.00
171_A174_A0.7791.00
45_F48_A0.7741.00
165_K169_K0.7741.00
2_L5_V0.7701.00
205_E209_H0.7691.00
35_A39_R0.7691.00
57_K140_A0.7691.00
164_E168_K0.7671.00
153_A175_L0.7621.00
206_Y211_R0.7601.00
172_R175_L0.7581.00
120_E123_G0.7571.00
152_F196_A0.7561.00
144_L148_E0.7531.00
53_E61_E0.7481.00
113_E116_E0.7481.00
85_I95_A0.7421.00
55_E58_G0.7401.00
44_V70_N0.7311.00
171_A178_L0.7271.00
154_K158_P0.7271.00
163_E166_K0.7271.00
10_K111_F0.7231.00
32_Y38_L0.7211.00
68_L78_L0.7181.00
21_L68_L0.7161.00
202_A206_Y0.7151.00
170_R178_L0.7141.00
171_A177_E0.7091.00
27_A30_F0.7011.00
32_Y46_A0.6971.00
144_L152_F0.6951.00
175_L178_L0.6831.00
65_Y85_I0.6811.00
38_L41_G0.6811.00
178_L205_E0.6801.00
136_A140_A0.6801.00
35_A46_A0.6731.00
177_E180_E0.6661.00
34_T92_T0.6631.00
157_L161_K0.6621.00
28_G31_E0.6601.00
36_G40_G0.6601.00
17_V78_L0.6591.00
87_V90_S0.6591.00
110_N114_R0.6591.00
187_N192_A0.6581.00
146_D194_G0.6541.00
17_V68_L0.6461.00
33_E38_L0.6431.00
31_E49_R0.6421.00
3_G74_G0.6401.00
173_E178_L0.6381.00
146_D149_A0.6351.00
199_A203_V0.6331.00
23_D119_K0.6311.00
82_F125_A0.6291.00
78_L115_L0.6221.00
41_G48_A0.6141.00
81_A99_S0.6111.00
201_N204_T0.6081.00
17_V70_N0.6081.00
10_K110_N0.6081.00
124_L128_Y0.6071.00
48_A68_L0.6041.00
49_R52_D0.6041.00
149_A179_F0.6021.00
34_T38_L0.6001.00
42_R75_S0.5981.00
65_Y92_T0.5911.00
84_P136_A0.5901.00
103_V118_A0.5891.00
33_E65_Y0.5861.00
132_F135_Q0.5821.00
86_R197_W0.5811.00
160_P163_E0.5801.00
37_S40_G0.5791.00
173_E179_F0.5771.00
19_E23_D0.5761.00
88_V96_A0.5761.00
80_V103_V0.5751.00
33_E37_S0.5731.00
189_L198_G0.5731.00
159_L163_E0.5721.00
120_E124_L0.5721.00
143_K194_G0.5711.00
121_A125_A0.5701.00
127_E131_E0.5701.00
198_G202_A0.5701.00
33_E36_G0.5691.00
37_S42_R0.5691.00
143_K146_D0.5681.00
6_S108_T0.5671.00
186_G191_G0.5661.00
111_F114_R0.5641.00
200_Y204_T0.5611.00
14_N78_L0.5611.00
154_K159_L0.5601.00
83_T87_V0.5591.00
172_R177_E0.5581.00
126_L130_D0.5571.00
92_T95_A0.5551.00
83_T92_T0.5531.00
178_L210_G0.5521.00
108_T111_F0.5491.00
14_N17_V0.5491.00
170_R177_E0.5471.00
12_V17_V0.5461.00
86_R192_A0.5461.00
172_R179_F0.5461.00
206_Y210_G0.5451.00
177_E183_E0.5431.00
174_A180_E0.5421.00
22_D32_Y0.5381.00
55_E137_E0.5381.00
213_T217_D0.5331.00
21_L25_L0.5331.00
136_A139_L0.5300.99
133_E136_A0.5280.99
88_V94_V0.5210.99
173_E180_E0.5210.99
183_E187_N0.5210.99
118_A121_A0.5170.99
125_A129_F0.5160.99
91_N201_N0.5160.99
123_G127_E0.5150.99
85_I96_A0.5140.99
33_E47_L0.5140.99
43_R46_A0.5130.99
21_L24_L0.5130.99
21_L32_Y0.5130.99
8_R108_T0.5100.99
67_L93_L0.5090.99
43_R71_S0.5080.99
17_V21_L0.5040.99
66_L80_V0.5030.99
38_L92_T0.5000.99
161_K167_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l76A 1 0.3026 10.3 0.941 Contact Map
3goeA 1 0.2851 9.7 0.941 Contact Map
2ekeC 1 0.2939 6.7 0.945 Contact Map
4mgeA 3 0.1491 5.9 0.947 Contact Map
4pdbA 1 0.4737 5.6 0.948 Contact Map
3kydD 1 0.3026 5.4 0.948 Contact Map
4bkgA 1 0 5.3 0.948 Contact Map
3bbnH 1 0.4912 5.2 0.948 Contact Map
4npnA 4 0.2807 4.9 0.949 Contact Map
1seiA 2 0.4693 4.8 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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