GREMLIN Database
UPF0231 - Uncharacterised protein family (UPF0231)
PFAM: PF06062 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (121)
Sequences: 529 (345)
Seq/√Len: 31.3
META: 0.456

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_F113_L5.2921.00
68_L73_V4.3201.00
97_Y100_E4.1911.00
28_L32_V3.2821.00
50_K111_L2.7861.00
18_S21_H2.7281.00
3_Y112_Q2.4620.99
56_E69_D2.3980.99
91_E94_M2.2730.99
65_S78_N2.2380.99
97_Y101_S2.2060.99
13_V29_N2.1120.98
35_D38_K2.0360.98
26_R64_Y1.9560.97
61_G110_F1.7830.95
106_G109_D1.7070.94
73_V110_F1.6780.93
49_L68_L1.6730.93
23_A64_Y1.5310.89
60_V65_S1.5110.89
18_S25_G1.5020.88
19_M100_E1.5010.88
36_L121_I1.4540.87
72_E104_F1.4170.85
3_Y17_F1.4030.85
2_E7_R1.3940.84
74_M117_W1.3760.83
74_M104_F1.3510.82
2_E10_T1.3510.82
46_I114_L1.3290.81
42_L57_W1.3080.80
39_L118_R1.3080.80
105_C109_D1.3020.80
32_V114_L1.2810.79
69_D73_V1.2710.78
40_D118_R1.2670.78
19_M97_Y1.2660.78
17_F114_L1.2550.77
3_Y15_A1.2290.76
15_A114_L1.2170.75
15_A29_N1.2100.75
19_M22_E1.2050.74
35_D41_E1.1880.73
18_S22_E1.1770.72
66_L73_V1.1680.72
19_M101_S1.1610.71
18_S103_A1.1290.69
20_G100_E1.1280.69
68_L80_L1.1240.69
28_L113_L1.1210.69
36_L118_R1.1160.68
6_I16_R1.1150.68
112_Q115_E1.1130.68
70_G116_S1.0980.67
111_L115_E1.0610.64
31_E63_E1.0570.64
80_L103_A1.0510.64
10_T78_N1.0480.63
94_M97_Y1.0340.62
69_D93_D1.0290.62
45_A49_L1.0050.60
13_V117_W1.0020.60
49_L54_E1.0000.60
83_E104_F0.9360.55
17_F25_G0.9280.54
108_E112_Q0.9180.53
7_R15_A0.9050.52
23_A76_R0.9010.52
3_Y116_S0.9000.52
85_D108_E0.8980.52
2_E6_I0.8900.51
6_I10_T0.8830.50
30_E33_G0.8720.49
55_R76_R0.8600.48
73_V78_N0.8550.48
8_D14_K0.8540.48
43_L111_L0.8530.48
37_A42_L0.8510.48
25_G33_G0.8460.47
17_F24_I0.8450.47
91_E95_S0.8430.47
11_G17_F0.8420.47
39_L43_L0.8410.47
26_R30_E0.8340.46
44_A48_Q0.8300.46
31_E61_G0.8250.46
23_A77_A0.8230.45
21_H25_G0.8140.45
26_R63_E0.8100.44
63_E99_E0.8090.44
11_G15_A0.7870.43
104_F117_W0.7820.42
61_G75_V0.7800.42
81_D87_E0.7510.40
15_A113_L0.7500.40
107_L119_E0.7480.39
18_S61_G0.7440.39
59_L107_L0.7360.39
82_F92_E0.7350.38
4_E10_T0.7240.38
63_E72_E0.7230.38
63_E78_N0.7220.37
108_E111_L0.7020.36
48_Q51_G0.6980.36
12_Q37_A0.6980.36
52_S70_G0.6970.36
115_E119_E0.6970.36
64_Y77_A0.6950.35
107_L121_I0.6940.35
81_D90_L0.6830.35
2_E49_L0.6830.35
10_T14_K0.6690.34
1_M5_F0.6650.33
115_E118_R0.6640.33
72_E120_F0.6620.33
40_D51_G0.6610.33
8_D64_Y0.6560.33
8_D12_Q0.6550.33
103_A116_S0.6530.32
37_A48_Q0.6480.32
80_L98_D0.6420.32
52_S66_L0.6400.31
23_A110_F0.6390.31
20_G119_E0.6380.31
47_E98_D0.6350.31
3_Y22_E0.6340.31
25_G30_E0.6270.31
8_D59_L0.6270.31
9_L14_K0.6190.30
24_I52_S0.6170.30
84_G90_L0.6110.29
79_A98_D0.6110.29
44_A89_E0.6070.29
88_E93_D0.6040.29
36_L40_D0.5990.29
87_E115_E0.5960.28
30_E64_Y0.5940.28
28_L116_S0.5920.28
77_A94_M0.5910.28
87_E91_E0.5880.28
73_V107_L0.5870.28
77_A101_S0.5850.28
43_L115_E0.5840.28
45_A57_W0.5830.28
11_G64_Y0.5800.27
87_E90_L0.5790.27
3_Y34_G0.5780.27
42_L114_L0.5750.27
49_L111_L0.5700.27
5_F28_L0.5690.27
48_Q119_E0.5690.27
38_K59_L0.5670.27
92_E95_S0.5670.27
68_L107_L0.5640.26
2_E121_I0.5620.26
10_T25_G0.5600.26
77_A99_E0.5560.26
12_Q20_G0.5540.26
41_E59_L0.5530.26
13_V77_A0.5480.25
10_T16_R0.5460.25
49_L53_Q0.5450.25
61_G78_N0.5440.25
24_I53_Q0.5440.25
15_A25_G0.5420.25
83_E89_E0.5380.25
88_E102_L0.5330.25
22_E97_Y0.5330.25
46_I110_F0.5290.24
65_S75_V0.5290.24
4_E9_L0.5280.24
16_R40_D0.5270.24
23_A97_Y0.5260.24
62_H71_E0.5210.24
16_R39_L0.5200.24
52_S55_R0.5190.24
23_A101_S0.5170.24
21_H31_E0.5170.24
5_F72_E0.5120.23
67_L74_M0.5110.23
27_W77_A0.5030.23
42_L49_L0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q67A 2 0.4132 13.5 0.928 Contact Map
4kmdA 2 0.5785 12.1 0.93 Contact Map
2lydA 1 0.3636 7.1 0.937 Contact Map
1dvoA 1 0.3884 6.8 0.937 Contact Map
1nnvA 1 0.4711 6.2 0.938 Contact Map
3bidA 2 0.4876 6 0.939 Contact Map
4b6hA 1 0.3636 5.7 0.94 Contact Map
2qklA 1 0.3554 3.8 0.945 Contact Map
2k7iA 2 0.4959 2.8 0.948 Contact Map
3zk4A 5 0.3388 2.5 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0134 seconds.