GREMLIN Database
ExoD - Exopolysaccharide synthesis, ExoD
PFAM: PF06055 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 179 (177)
Sequences: 6831 (5113)
Seq/√Len: 384.3
META: 0.848

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_R81_R3.7001.00
20_G80_A3.6811.00
155_G164_V3.6621.00
16_R83_S3.1641.00
78_R82_R2.8531.00
36_L150_V2.5001.00
20_G81_R2.4521.00
138_I141_T2.3801.00
99_W102_R2.3441.00
111_L165_L2.2921.00
85_P88_R2.2741.00
91_R95_R2.2681.00
123_I164_V2.2161.00
151_L170_L2.1831.00
36_L153_A2.1461.00
60_L128_L2.1391.00
6_E97_L2.0991.00
102_R106_L1.9721.00
2_S104_E1.9331.00
98_P102_R1.9181.00
110_R162_L1.8951.00
20_G24_D1.7861.00
18_T21_E1.7711.00
6_E101_R1.7331.00
63_A128_L1.7101.00
130_L171_G1.7041.00
148_A170_L1.6671.00
111_L161_G1.6671.00
63_A124_G1.6641.00
117_R121_R1.6601.00
67_L125_L1.6351.00
162_L166_L1.6321.00
123_I168_L1.6011.00
116_G119_A1.5681.00
95_R98_P1.5541.00
39_A150_V1.5461.00
64_L68_L1.4901.00
152_L171_G1.4751.00
39_A59_L1.4651.00
174_A178_F1.4531.00
145_P148_A1.4221.00
86_R90_R1.3941.00
90_R94_R1.3931.00
35_L63_A1.3661.00
60_L132_L1.3591.00
118_P121_R1.3541.00
133_L137_P1.3431.00
59_L131_A1.3421.00
32_G153_A1.3411.00
75_L80_A1.3401.00
107_S158_E1.3371.00
44_L47_P1.3361.00
151_L163_L1.2941.00
67_L124_G1.2931.00
78_R81_R1.2871.00
111_L162_L1.2621.00
20_G77_R1.2321.00
63_A127_I1.2301.00
63_A131_A1.2221.00
134_L137_P1.2221.00
148_A174_A1.2081.00
88_R91_R1.2041.00
77_R80_A1.1901.00
95_R99_W1.1371.00
126_L168_L1.1341.00
67_L128_L1.1311.00
39_A146_A1.1301.00
60_L131_A1.1211.00
39_A153_A1.1181.00
18_T83_S1.1171.00
69_G121_R1.1161.00
148_A167_G1.1141.00
115_T118_P1.1111.00
4_L29_R1.0981.00
107_S163_L1.0981.00
137_P142_N1.0821.00
35_L149_I1.0821.00
11_E25_A1.0771.00
152_L167_G1.0751.00
173_A176_A1.0641.00
133_L136_L1.0611.00
31_F65_Q1.0601.00
119_A123_I1.0521.00
9_A97_L1.0341.00
70_R74_W1.0331.00
43_L147_L1.0201.00
97_L101_R1.0131.00
155_G167_G1.0111.00
46_L51_V1.0041.00
31_F73_P1.0011.00
40_L96_L1.0011.00
5_L93_L1.0001.00
171_G175_L0.9991.00
38_L59_L0.9951.00
151_L167_G0.9921.00
34_L62_L0.9871.00
173_A177_L0.9871.00
115_T164_V0.9781.00
65_Q70_R0.9581.00
64_L67_L0.9541.00
7_R11_E0.9531.00
54_V58_P0.9531.00
42_N49_P0.9511.00
66_L156_L0.9491.00
161_G165_L0.9351.00
6_E10_A0.9331.00
16_R85_P0.9271.00
127_I149_I0.9211.00
107_S154_L0.9001.00
126_L171_G0.8961.00
35_L153_A0.8921.00
153_A157_L0.8911.00
115_T159_R0.8881.00
98_P101_R0.8791.00
129_L175_L0.8751.00
87_A91_R0.8751.00
23_L34_L0.8711.00
131_A149_I0.8681.00
171_G174_A0.8511.00
42_N55_F0.8511.00
38_L55_F0.8361.00
117_R120_R0.8341.00
102_R105_R0.8251.00
131_A137_P0.8241.00
34_L73_P0.8231.00
123_I152_L0.8231.00
136_L142_N0.8211.00
172_L176_A0.8201.00
41_P92_L0.8191.00
9_A94_R0.8191.00
131_A134_L0.8171.00
155_G163_L0.8161.00
18_T81_R0.8121.00
96_L99_W0.8111.00
100_L104_E0.8051.00
69_G72_T0.7991.00
43_L48_I0.7981.00
165_L169_L0.7981.00
148_A171_G0.7951.00
56_G131_A0.7891.00
79_L82_R0.7881.00
61_L64_L0.7861.00
62_L73_P0.7851.00
9_A12_A0.7741.00
87_A90_R0.7741.00
168_L172_L0.7741.00
52_S56_G0.7721.00
42_N56_G0.7711.00
166_L170_L0.7701.00
59_L134_L0.7701.00
12_A86_R0.7641.00
134_L142_N0.7621.00
30_S73_P0.7591.00
11_E14_G0.7541.00
39_A149_I0.7531.00
131_A135_A0.7521.00
114_L165_L0.7441.00
42_N146_A0.7431.00
152_L168_L0.7431.00
132_L136_L0.7411.00
23_L80_A0.7371.00
19_L79_L0.7361.00
35_L62_L0.7301.00
144_L174_A0.7281.00
66_L124_G0.7231.00
110_R161_G0.7201.00
24_D80_A0.7191.00
36_L154_L0.7181.00
28_E120_R0.7131.00
40_L150_V0.7101.00
19_L38_L0.7091.00
133_L178_F0.7041.00
59_L63_A0.7011.00
112_T115_T0.6991.00
91_R94_R0.6991.00
3_D7_R0.6970.99
45_P49_P0.6960.99
144_L177_L0.6960.99
143_T147_L0.6940.99
41_P142_N0.6940.99
29_R32_G0.6910.99
110_R160_D0.6890.99
53_T135_A0.6880.99
8_L25_A0.6750.99
32_G157_L0.6740.99
15_E85_P0.6730.99
8_L12_A0.6720.99
35_L127_I0.6670.99
7_R10_A0.6660.99
61_L79_L0.6570.99
49_P52_S0.6560.99
109_P112_T0.6560.99
61_L74_W0.6530.99
36_L40_L0.6490.99
60_L64_L0.6460.99
64_L128_L0.6440.99
89_L92_L0.6430.99
106_L109_P0.6400.99
93_L96_L0.6350.99
153_A156_L0.6290.99
42_N51_V0.6260.99
84_L89_L0.6250.99
136_L141_T0.6240.99
24_D72_T0.6180.99
42_N52_S0.6130.99
53_T142_N0.6090.99
44_L48_I0.6090.99
55_F58_P0.6060.99
162_L165_L0.6040.99
58_P62_L0.6020.99
138_I142_N0.5980.98
161_G164_V0.5980.98
130_L149_I0.5970.98
56_G135_A0.5950.98
36_L39_A0.5950.98
28_E71_R0.5950.98
115_T119_A0.5950.98
159_R165_L0.5940.98
47_P143_T0.5930.98
93_L135_A0.5930.98
63_A67_L0.5930.98
43_L149_I0.5840.98
21_E24_D0.5820.98
145_P174_A0.5820.98
42_N48_I0.5820.98
123_I156_L0.5810.98
127_I152_L0.5810.98
42_N46_L0.5750.98
70_R73_P0.5750.98
168_L171_G0.5710.98
148_A152_L0.5680.98
8_L15_E0.5670.98
94_R98_P0.5670.98
65_Q74_W0.5620.98
3_D6_E0.5600.98
15_E86_R0.5580.98
35_L59_L0.5540.97
63_A152_L0.5530.97
155_G165_L0.5520.97
51_V54_V0.5460.97
24_D27_G0.5430.97
44_L95_R0.5420.97
121_R124_G0.5420.97
63_A130_L0.5420.97
170_L174_A0.5400.97
52_S142_N0.5390.97
42_N143_T0.5390.97
125_L129_L0.5390.97
57_L61_L0.5370.97
29_R159_R0.5360.97
38_L62_L0.5330.97
152_L164_V0.5310.97
9_A90_R0.5310.97
58_P127_I0.5260.97
15_E21_E0.5240.96
42_N134_L0.5240.96
6_E94_R0.5230.96
8_L22_L0.5220.96
80_A83_S0.5210.96
18_T23_L0.5200.96
53_T137_P0.5170.96
65_Q73_P0.5110.96
75_L79_L0.5100.96
129_L133_L0.5090.96
35_L66_L0.5000.95
14_G21_E0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eqcA 2 0.2682 11.7 0.94 Contact Map
3comA 1 0.2626 10.8 0.941 Contact Map
4wv4B 1 0.2737 5.3 0.949 Contact Map
4wv4A 1 0.1788 4.6 0.95 Contact Map
3bpqA 2 0.1341 4.6 0.95 Contact Map
1ciiA 1 0.4022 4.2 0.951 Contact Map
3w9iA 3 0.9609 4 0.952 Contact Map
2yfwB 2 0.2123 3.7 0.952 Contact Map
4dx5A 3 0.9609 3.7 0.952 Contact Map
4a0dA 1 0.3073 3.5 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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