GREMLIN Database
DUF922 - Bacterial protein of unknown function (DUF922)
PFAM: PF06037 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 158 (156)
Sequences: 2938 (2429)
Seq/√Len: 194.5
META: 0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_C120_C4.3851.00
99_I142_Q3.6671.00
69_W74_A3.5771.00
15_S19_R2.8611.00
95_G155_Q2.8511.00
64_I97_V2.7791.00
3_D68_R2.6501.00
95_G145_Y2.5971.00
31_D85_F2.3861.00
103_A138_Y2.3541.00
62_I97_V2.3341.00
144_A148_R2.2151.00
69_W82_W2.1361.00
90_R94_E2.1211.00
119_S122_A2.1191.00
8_T11_E2.0181.00
106_E137_E1.9961.00
140_A144_A1.8841.00
71_P83_D1.8811.00
150_N153_A1.8771.00
40_W131_A1.7211.00
92_H96_H1.7191.00
98_D102_E1.7161.00
4_V15_S1.6871.00
58_V104_A1.6291.00
13_R31_D1.6191.00
86_L90_R1.6101.00
64_I94_E1.6081.00
1_Y68_R1.5931.00
126_A129_A1.5881.00
100_A142_Q1.5691.00
145_Y149_T1.5631.00
130_L133_A1.5491.00
9_A78_L1.5401.00
110_A130_L1.5281.00
43_D55_S1.5111.00
32_A66_L1.4721.00
93_E96_H1.4621.00
111_L127_A1.4511.00
66_L90_R1.4301.00
108_E112_R1.4291.00
71_P79_R1.4151.00
102_E141_R1.4131.00
20_G29_R1.4111.00
66_L86_L1.3901.00
76_P80_A1.3701.00
117_A126_A1.3621.00
12_L78_L1.3571.00
36_W100_A1.3571.00
81_R84_R1.3381.00
60_L104_A1.3291.00
79_R83_D1.3041.00
97_V101_R1.3001.00
107_I111_L1.2941.00
150_N154_T1.2941.00
13_R17_N1.2681.00
94_E97_V1.2511.00
34_T62_I1.2341.00
95_G98_D1.1741.00
12_L69_W1.1731.00
137_E141_R1.1721.00
144_A147_R1.1691.00
6_G15_S1.1621.00
106_E134_I1.1541.00
149_T152_G1.1391.00
134_I138_Y1.1301.00
36_W85_F1.1171.00
70_P73_G1.0961.00
126_A130_L1.0921.00
74_A79_R1.0911.00
128_N132_R1.0901.00
96_H146_D1.0731.00
5_S15_S1.0601.00
100_A138_Y1.0591.00
45_E54_T1.0411.00
94_E98_D1.0321.00
6_G82_W1.0241.00
103_A134_I1.0231.00
130_L134_I1.0141.00
85_F89_L1.0081.00
99_I141_R1.0031.00
56_A111_L0.9961.00
92_H146_D0.9931.00
132_R136_A0.9820.99
105_R108_E0.9750.99
103_A141_R0.9690.99
106_E109_R0.9670.99
110_A114_L0.9660.99
78_L81_R0.9570.99
6_G11_E0.9550.99
70_P79_R0.9550.99
2_Y16_L0.9490.99
15_S18_R0.9280.99
134_I137_E0.9270.99
7_S11_E0.9110.99
17_N31_D0.9100.99
14_A18_R0.9090.99
75_S78_L0.8830.99
39_T59_T0.8800.99
124_E128_N0.8750.99
70_P74_A0.8710.99
47_S52_R0.8660.99
101_R105_R0.8580.99
98_D101_R0.8500.98
36_W142_Q0.8340.98
117_A122_A0.8330.98
32_A89_L0.8320.98
114_L127_A0.8250.98
9_A81_R0.8140.98
87_A91_R0.8120.98
137_E140_A0.8070.98
4_V12_L0.8030.98
110_A137_E0.7950.98
93_E146_D0.7830.97
151_H154_T0.7830.97
133_A137_E0.7810.97
44_Y124_E0.7730.97
138_Y142_Q0.7670.97
39_T61_D0.7650.97
87_A90_R0.7650.97
149_T156_G0.7620.97
38_L107_I0.7520.97
123_L127_A0.7370.96
62_I100_A0.7260.96
139_R142_Q0.7200.96
56_A127_A0.7130.96
6_G20_G0.7130.96
107_I131_A0.7130.96
31_D89_L0.7120.96
20_G23_V0.7110.95
58_V111_L0.7040.95
110_A134_I0.7030.95
22_P25_G0.6990.95
2_Y65_T0.6950.95
69_W79_R0.6900.95
106_E141_R0.6860.95
12_L15_S0.6850.94
91_R155_Q0.6850.94
106_E110_A0.6840.94
122_A126_A0.6790.94
64_I90_R0.6770.94
47_S50_G0.6760.94
34_T97_V0.6760.94
66_L94_E0.6740.94
128_N131_A0.6720.94
125_A129_A0.6700.94
38_L100_A0.6700.94
22_P26_D0.6680.94
100_A103_A0.6680.94
152_G156_G0.6590.93
34_T93_E0.6590.93
135_L139_R0.6530.93
139_R143_R0.6480.93
60_L101_R0.6470.93
40_W128_N0.6430.92
104_A108_E0.6410.92
145_Y155_Q0.6380.92
60_L120_C0.6360.92
100_A104_A0.6350.92
138_Y141_R0.6300.92
53_I127_A0.6300.92
91_R95_G0.6270.91
106_E138_Y0.6260.91
107_I130_L0.6250.91
30_A151_H0.6240.91
135_L138_Y0.6220.91
88_A91_R0.6190.91
12_L16_L0.6180.91
91_R94_E0.6130.91
140_A143_R0.6130.91
146_D151_H0.6110.90
4_V19_R0.6070.90
20_G31_D0.6070.90
10_A14_A0.6020.90
131_A135_L0.6000.90
16_L31_D0.6000.90
133_A136_A0.5970.89
73_G76_P0.5940.89
4_V69_W0.5880.89
129_A133_A0.5860.88
83_D87_A0.5830.88
145_Y154_T0.5810.88
97_V103_A0.5710.87
32_A92_H0.5690.87
16_L85_F0.5670.87
47_S54_T0.5640.87
35_R63_T0.5630.86
95_G99_I0.5600.86
9_A13_R0.5590.86
56_A108_E0.5580.86
36_W40_W0.5570.86
41_R57_T0.5560.86
10_A41_R0.5560.86
15_S20_G0.5550.86
103_A106_E0.5540.86
32_A64_I0.5490.85
56_A131_A0.5480.85
4_V11_E0.5460.85
50_G116_P0.5450.85
38_L138_Y0.5450.85
114_L130_L0.5390.84
85_F103_A0.5370.84
43_D57_T0.5360.84
38_L60_L0.5350.84
41_R59_T0.5350.84
21_P24_G0.5350.84
152_G155_Q0.5340.83
42_Y127_A0.5330.83
42_Y128_N0.5300.83
22_P29_R0.5280.83
40_W135_L0.5280.83
74_A78_L0.5280.83
67_P152_G0.5270.83
44_Y54_T0.5250.82
89_L149_T0.5250.82
32_A88_A0.5240.82
34_T96_H0.5240.82
149_T154_T0.5230.82
81_R88_A0.5220.82
35_R65_T0.5210.82
115_P123_L0.5210.82
9_A32_A0.5200.82
37_K59_T0.5150.81
141_R144_A0.5150.81
80_A148_R0.5140.81
129_A132_R0.5100.81
107_I127_A0.5080.80
34_T92_H0.5080.80
92_H95_G0.5070.80
43_D54_T0.5050.80
81_R85_F0.5050.80
24_G28_R0.5050.80
32_A82_W0.5020.80
110_A127_A0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qhjA 2 0.6456 16.4 0.923 Contact Map
4p78A 2 0.3481 14.8 0.925 Contact Map
4jixA 2 0.6772 10.7 0.929 Contact Map
2p4fA 1 0 8.2 0.933 Contact Map
3wswA 4 0.5443 8 0.933 Contact Map
4rcjA 1 0.9494 5.4 0.938 Contact Map
2ksnA 1 0.5253 4.8 0.94 Contact Map
4za9A 2 0.5127 4.3 0.941 Contact Map
3pc6A 2 0.557 4.2 0.941 Contact Map
4jiuA 1 0.6456 4 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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