DUF922 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF922 - Bacterial protein of unknown function (DUF922)

PFAM:	PF06037	Sequences: YYDVSGSTAAELRASLNRRGPPVGGDGRRADAYTRWKLTWRYDYEPSGGGCRITSATVTLDITITLPRWPPAGASPALRARWDRFLAALRRHEEGHVDIAREAAREIERALRALPPAPSCAALEAAANALARAILAEYRARQRAYDRRTNHGATQGAI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	158 (156)
Sequences:	2938 (2429)
Seq/√Len:	194.5
META:	0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_C	120_C	4.385	1.00
99_I	142_Q	3.667	1.00
69_W	74_A	3.577	1.00
15_S	19_R	2.861	1.00
95_G	155_Q	2.851	1.00
64_I	97_V	2.779	1.00
3_D	68_R	2.650	1.00
95_G	145_Y	2.597	1.00
31_D	85_F	2.386	1.00
103_A	138_Y	2.354	1.00
62_I	97_V	2.334	1.00
144_A	148_R	2.215	1.00
69_W	82_W	2.136	1.00
90_R	94_E	2.121	1.00
119_S	122_A	2.119	1.00
8_T	11_E	2.018	1.00
106_E	137_E	1.996	1.00
140_A	144_A	1.884	1.00
71_P	83_D	1.881	1.00
150_N	153_A	1.877	1.00
40_W	131_A	1.721	1.00
92_H	96_H	1.719	1.00
98_D	102_E	1.716	1.00
4_V	15_S	1.687	1.00
58_V	104_A	1.629	1.00
13_R	31_D	1.619	1.00
86_L	90_R	1.610	1.00
64_I	94_E	1.608	1.00
1_Y	68_R	1.593	1.00
126_A	129_A	1.588	1.00
100_A	142_Q	1.569	1.00
145_Y	149_T	1.563	1.00
130_L	133_A	1.549	1.00
9_A	78_L	1.540	1.00
110_A	130_L	1.528	1.00
43_D	55_S	1.511	1.00
32_A	66_L	1.472	1.00
93_E	96_H	1.462	1.00
111_L	127_A	1.451	1.00
66_L	90_R	1.430	1.00
108_E	112_R	1.429	1.00
71_P	79_R	1.415	1.00
102_E	141_R	1.413	1.00
20_G	29_R	1.411	1.00
66_L	86_L	1.390	1.00
76_P	80_A	1.370	1.00
117_A	126_A	1.362	1.00
12_L	78_L	1.357	1.00
36_W	100_A	1.357	1.00
81_R	84_R	1.338	1.00
60_L	104_A	1.329	1.00
79_R	83_D	1.304	1.00
97_V	101_R	1.300	1.00
107_I	111_L	1.294	1.00
150_N	154_T	1.294	1.00
13_R	17_N	1.268	1.00
94_E	97_V	1.251	1.00
34_T	62_I	1.234	1.00
95_G	98_D	1.174	1.00
12_L	69_W	1.173	1.00
137_E	141_R	1.172	1.00
144_A	147_R	1.169	1.00
6_G	15_S	1.162	1.00
106_E	134_I	1.154	1.00
149_T	152_G	1.139	1.00
134_I	138_Y	1.130	1.00
36_W	85_F	1.117	1.00
70_P	73_G	1.096	1.00
126_A	130_L	1.092	1.00
74_A	79_R	1.091	1.00
128_N	132_R	1.090	1.00
96_H	146_D	1.073	1.00
5_S	15_S	1.060	1.00
100_A	138_Y	1.059	1.00
45_E	54_T	1.041	1.00
94_E	98_D	1.032	1.00
6_G	82_W	1.024	1.00
103_A	134_I	1.023	1.00
130_L	134_I	1.014	1.00
85_F	89_L	1.008	1.00
99_I	141_R	1.003	1.00
56_A	111_L	0.996	1.00
92_H	146_D	0.993	1.00
132_R	136_A	0.982	0.99
105_R	108_E	0.975	0.99
103_A	141_R	0.969	0.99
106_E	109_R	0.967	0.99
110_A	114_L	0.966	0.99
78_L	81_R	0.957	0.99
6_G	11_E	0.955	0.99
70_P	79_R	0.955	0.99
2_Y	16_L	0.949	0.99
15_S	18_R	0.928	0.99
134_I	137_E	0.927	0.99
7_S	11_E	0.911	0.99
17_N	31_D	0.910	0.99
14_A	18_R	0.909	0.99
75_S	78_L	0.883	0.99
39_T	59_T	0.880	0.99
124_E	128_N	0.875	0.99
70_P	74_A	0.871	0.99
47_S	52_R	0.866	0.99
101_R	105_R	0.858	0.99
98_D	101_R	0.850	0.98
36_W	142_Q	0.834	0.98
117_A	122_A	0.833	0.98
32_A	89_L	0.832	0.98
114_L	127_A	0.825	0.98
9_A	81_R	0.814	0.98
87_A	91_R	0.812	0.98
137_E	140_A	0.807	0.98
4_V	12_L	0.803	0.98
110_A	137_E	0.795	0.98
93_E	146_D	0.783	0.97
151_H	154_T	0.783	0.97
133_A	137_E	0.781	0.97
44_Y	124_E	0.773	0.97
138_Y	142_Q	0.767	0.97
39_T	61_D	0.765	0.97
87_A	90_R	0.765	0.97
149_T	156_G	0.762	0.97
38_L	107_I	0.752	0.97
123_L	127_A	0.737	0.96
62_I	100_A	0.726	0.96
139_R	142_Q	0.720	0.96
56_A	127_A	0.713	0.96
6_G	20_G	0.713	0.96
107_I	131_A	0.713	0.96
31_D	89_L	0.712	0.96
20_G	23_V	0.711	0.95
58_V	111_L	0.704	0.95
110_A	134_I	0.703	0.95
22_P	25_G	0.699	0.95
2_Y	65_T	0.695	0.95
69_W	79_R	0.690	0.95
106_E	141_R	0.686	0.95
12_L	15_S	0.685	0.94
91_R	155_Q	0.685	0.94
106_E	110_A	0.684	0.94
122_A	126_A	0.679	0.94
64_I	90_R	0.677	0.94
47_S	50_G	0.676	0.94
34_T	97_V	0.676	0.94
66_L	94_E	0.674	0.94
128_N	131_A	0.672	0.94
125_A	129_A	0.670	0.94
38_L	100_A	0.670	0.94
22_P	26_D	0.668	0.94
100_A	103_A	0.668	0.94
152_G	156_G	0.659	0.93
34_T	93_E	0.659	0.93
135_L	139_R	0.653	0.93
139_R	143_R	0.648	0.93
60_L	101_R	0.647	0.93
40_W	128_N	0.643	0.92
104_A	108_E	0.641	0.92
145_Y	155_Q	0.638	0.92
60_L	120_C	0.636	0.92
100_A	104_A	0.635	0.92
138_Y	141_R	0.630	0.92
53_I	127_A	0.630	0.92
91_R	95_G	0.627	0.91
106_E	138_Y	0.626	0.91
107_I	130_L	0.625	0.91
30_A	151_H	0.624	0.91
135_L	138_Y	0.622	0.91
88_A	91_R	0.619	0.91
12_L	16_L	0.618	0.91
91_R	94_E	0.613	0.91
140_A	143_R	0.613	0.91
146_D	151_H	0.611	0.90
4_V	19_R	0.607	0.90
20_G	31_D	0.607	0.90
10_A	14_A	0.602	0.90
131_A	135_L	0.600	0.90
16_L	31_D	0.600	0.90
133_A	136_A	0.597	0.89
73_G	76_P	0.594	0.89
4_V	69_W	0.588	0.89
129_A	133_A	0.586	0.88
83_D	87_A	0.583	0.88
145_Y	154_T	0.581	0.88
97_V	103_A	0.571	0.87
32_A	92_H	0.569	0.87
16_L	85_F	0.567	0.87
47_S	54_T	0.564	0.87
35_R	63_T	0.563	0.86
95_G	99_I	0.560	0.86
9_A	13_R	0.559	0.86
56_A	108_E	0.558	0.86
36_W	40_W	0.557	0.86
41_R	57_T	0.556	0.86
10_A	41_R	0.556	0.86
15_S	20_G	0.555	0.86
103_A	106_E	0.554	0.86
32_A	64_I	0.549	0.85
56_A	131_A	0.548	0.85
4_V	11_E	0.546	0.85
50_G	116_P	0.545	0.85
38_L	138_Y	0.545	0.85
114_L	130_L	0.539	0.84
85_F	103_A	0.537	0.84
43_D	57_T	0.536	0.84
38_L	60_L	0.535	0.84
41_R	59_T	0.535	0.84
21_P	24_G	0.535	0.84
152_G	155_Q	0.534	0.83
42_Y	127_A	0.533	0.83
42_Y	128_N	0.530	0.83
22_P	29_R	0.528	0.83
40_W	135_L	0.528	0.83
74_A	78_L	0.528	0.83
67_P	152_G	0.527	0.83
44_Y	54_T	0.525	0.82
89_L	149_T	0.525	0.82
32_A	88_A	0.524	0.82
34_T	96_H	0.524	0.82
149_T	154_T	0.523	0.82
81_R	88_A	0.522	0.82
35_R	65_T	0.521	0.82
115_P	123_L	0.521	0.82
9_A	32_A	0.520	0.82
37_K	59_T	0.515	0.81
141_R	144_A	0.515	0.81
80_A	148_R	0.514	0.81
129_A	132_R	0.510	0.81
107_I	127_A	0.508	0.80
34_T	92_H	0.508	0.80
92_H	95_G	0.507	0.80
43_D	54_T	0.505	0.80
81_R	85_F	0.505	0.80
24_G	28_R	0.505	0.80
32_A	82_W	0.502	0.80
110_A	127_A	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qhjA	2	0.6456	16.4	0.923	Contact Map
4p78A	2	0.3481	14.8	0.925	Contact Map
4jixA	2	0.6772	10.7	0.929	Contact Map
2p4fA	1	0	8.2	0.933	Contact Map
3wswA	4	0.5443	8	0.933	Contact Map
4rcjA	1	0.9494	5.4	0.938	Contact Map
2ksnA	1	0.5253	4.8	0.94	Contact Map
4za9A	2	0.5127	4.3	0.941	Contact Map
3pc6A	2	0.557	4.2	0.941	Contact Map
4jiuA	1	0.6456	4	0.942	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0067 seconds.