GREMLIN Database
DUF908 - Domain of Unknown Function (DUF908)
PFAM: PF06012 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 313 (297)
Sequences: 515 (387)
Seq/√Len: 22.4
META: 0.217

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_S43_L6.6061.00
12_T25_Y6.4161.00
31_L46_T4.7281.00
11_F15_L3.2271.00
41_D219_Q3.1741.00
130_Y189_Y2.9771.00
185_L191_V2.9260.99
7_A10_R2.8710.99
140_S159_S2.6400.99
217_R221_L2.5590.98
177_S180_E2.4650.98
225_L258_L2.3940.98
275_L288_S2.3550.97
178_D203_I2.2890.97
257_E308_R2.2230.96
112_L209_F2.1660.96
150_L154_S2.1640.96
6_L42_V2.1470.95
178_D207_K2.1430.95
25_Y56_R2.1400.95
42_V185_L2.1020.95
113_A218_Q2.0820.94
2_R39_D2.0420.94
120_P123_W2.0220.94
16_L49_L2.0080.93
149_P152_R1.9950.93
6_L41_D1.9880.93
2_R6_L1.9640.92
134_S138_S1.8810.91
301_G308_R1.8520.90
266_P311_V1.8430.90
130_Y191_V1.8330.90
227_A230_N1.8240.89
33_D182_L1.8210.89
127_H167_H1.8190.89
259_L297_G1.8190.89
43_L281_A1.8150.89
131_Y162_G1.7940.89
147_P151_R1.7920.88
217_R224_R1.7910.88
146_T151_R1.7810.88
228_I251_L1.7780.88
168_I236_S1.7460.87
292_S306_L1.7420.87
250_E290_V1.7310.87
300_H308_R1.6650.84
290_V301_G1.6610.84
225_L233_Y1.6570.84
12_T20_T1.6280.83
25_Y228_I1.6200.83
49_L241_Q1.6070.82
85_L98_G1.6030.82
135_S160_S1.5970.82
14_L17_E1.5870.81
123_W259_L1.5750.81
168_I194_E1.5740.81
47_L303_L1.5560.80
258_L265_V1.5530.80
108_D113_A1.5250.79
278_E304_L1.5140.78
219_Q223_I1.4920.77
19_C54_A1.4890.77
113_A221_L1.4810.77
136_S141_S1.4700.76
295_N302_I1.4400.74
15_L22_R1.4160.73
13_R28_S1.3880.72
22_R56_R1.3860.72
299_N305_S1.3790.71
134_S140_S1.3740.71
126_V206_A1.3740.71
6_L45_A1.3680.71
11_F14_L1.3670.70
88_L256_A1.3580.70
12_T27_S1.3390.69
53_L294_L1.3380.69
182_L200_L1.3250.68
16_L46_T1.3250.68
154_S159_S1.3110.67
27_S31_L1.2950.66
278_E295_N1.2860.66
291_L296_A1.2830.65
93_G99_L1.2620.64
98_G112_L1.2590.64
88_L274_L1.2560.64
294_L307_L1.2530.64
166_I199_L1.2490.63
136_S142_S1.2490.63
297_G300_H1.2470.63
166_I173_L1.2470.63
115_S154_S1.2430.63
300_H307_L1.2390.63
144_P148_T1.2380.63
28_S53_L1.2290.62
27_S301_G1.2270.62
59_A62_R1.2250.62
116_D269_I1.2210.62
295_N298_V1.2090.61
16_L225_L1.2050.60
15_L56_R1.2020.60
138_S141_S1.2010.60
295_N304_L1.1970.60
57_Y226_L1.1960.60
42_V249_P1.1950.60
2_R37_S1.1910.60
182_L306_L1.1780.59
26_N45_A1.1760.59
230_N233_Y1.1760.59
158_S166_I1.1730.58
165_V182_L1.1630.58
12_T55_Q1.1600.58
203_I272_L1.1550.57
95_K99_L1.1520.57
44_L219_Q1.1470.57
157_E212_G1.1450.56
171_S174_S1.1410.56
295_N301_G1.1390.56
130_Y266_P1.1280.55
265_V271_T1.1230.55
142_S184_K1.1220.55
25_Y94_G1.1220.55
84_R200_L1.1190.55
244_L251_L1.1180.55
112_L254_E1.1170.55
222_A228_I1.1120.54
281_A291_L1.1090.54
258_L294_L1.1080.54
250_E266_P1.0950.53
2_R213_S1.0920.53
62_R245_F1.0910.53
142_S158_S1.0900.53
141_S155_S1.0790.52
230_N234_V1.0760.52
256_A304_L1.0700.51
252_I293_A1.0640.51
82_L249_P1.0620.51
295_N299_N1.0550.50
171_S175_S1.0510.50
145_S148_T1.0460.50
22_R49_L1.0400.49
10_R18_N1.0370.49
42_V203_I1.0350.49
28_S92_W1.0330.49
219_Q234_V1.0310.49
137_S228_I1.0300.49
223_I226_L1.0280.48
148_T152_R1.0240.48
150_L155_S1.0170.48
225_L231_L1.0120.47
2_R199_L1.0060.47
60_S63_R1.0000.47
5_V162_G0.9980.46
199_L204_R0.9970.46
166_I185_L0.9930.46
191_V216_S0.9820.45
138_S158_S0.9820.45
110_V302_I0.9810.45
282_R296_A0.9780.45
220_L236_S0.9780.45
250_E275_L0.9740.45
26_N302_I0.9730.45
90_Q93_G0.9610.44
143_V158_S0.9570.44
218_Q226_L0.9570.44
204_R224_R0.9500.43
294_L301_G0.9440.43
147_P153_S0.9380.42
44_L48_R0.9370.42
5_V311_V0.9360.42
8_I273_A0.9270.42
148_T151_R0.9220.41
114_P136_S0.9210.41
29_E33_D0.9200.41
256_A295_N0.9200.41
44_L223_I0.9180.41
58_S245_F0.9180.41
10_R45_A0.9130.41
19_C226_L0.9120.41
14_L22_R0.9080.40
5_V142_S0.9080.40
150_L153_S0.9050.40
13_R290_V0.9030.40
217_R236_S0.8920.39
252_I286_R0.8900.39
88_L307_L0.8860.39
265_V269_I0.8830.39
278_E298_V0.8780.38
222_A272_L0.8700.38
34_L84_R0.8690.38
30_H306_L0.8640.37
137_S140_S0.8630.37
135_S138_S0.8610.37
251_L298_V0.8590.37
225_L234_V0.8570.37
295_N306_L0.8560.37
220_L229_A0.8560.37
26_N159_S0.8540.37
265_V292_S0.8530.37
245_F249_P0.8490.37
138_S150_L0.8490.37
31_L35_L0.8470.36
18_N88_L0.8450.36
222_A269_I0.8440.36
131_Y257_E0.8440.36
45_A238_S0.8410.36
200_L280_L0.8410.36
288_S296_A0.8410.36
259_L289_D0.8400.36
274_L290_V0.8390.36
50_L244_L0.8340.36
253_N259_L0.8300.35
241_Q307_L0.8280.35
89_A274_L0.8250.35
206_A209_F0.8230.35
265_V293_A0.8220.35
183_A265_V0.8210.35
237_E240_F0.8200.35
284_R307_L0.8180.35
296_A304_L0.8170.35
146_T227_A0.8160.34
146_T150_L0.8100.34
143_V146_T0.8080.34
7_A140_S0.8080.34
116_D119_L0.8070.34
24_L127_H0.8050.34
46_T200_L0.8040.34
277_L286_R0.8000.33
142_S180_E0.7980.33
89_A206_A0.7970.33
23_S56_R0.7970.33
30_H37_S0.7940.33
272_L275_L0.7930.33
51_L282_R0.7890.33
15_L258_L0.7880.33
22_R232_A0.7850.33
19_C56_R0.7760.32
15_L19_C0.7750.32
92_W248_E0.7750.32
47_L226_L0.7750.32
25_Y197_F0.7740.32
130_Y185_L0.7730.32
5_V157_E0.7730.32
266_P281_A0.7720.32
284_R287_L0.7690.32
258_L267_L0.7690.32
143_V154_S0.7680.32
10_R13_R0.7620.31
217_R258_L0.7600.31
168_I174_S0.7600.31
265_V273_A0.7550.31
145_S158_S0.7520.31
43_L55_Q0.7500.30
217_R301_G0.7500.30
144_P149_P0.7480.30
86_L173_L0.7440.30
222_A255_L0.7440.30
278_E306_L0.7430.30
182_L203_I0.7430.30
111_S133_S0.7410.30
19_C29_E0.7410.30
143_V155_S0.7400.30
47_L204_R0.7400.30
170_D174_S0.7380.30
97_E201_T0.7320.29
138_S157_E0.7320.29
299_N307_L0.7310.29
141_S221_L0.7290.29
203_I307_L0.7290.29
59_A63_R0.7270.29
182_L192_P0.7270.29
56_R299_N0.7260.29
192_P280_L0.7240.29
281_A292_S0.7240.29
116_D183_A0.7220.29
133_S184_K0.7190.29
223_I230_N0.7190.29
283_Y299_N0.7110.28
86_L266_P0.7100.28
256_A306_L0.7080.28
135_S141_S0.7070.28
128_F191_V0.7070.28
299_N302_I0.7070.28
118_S223_I0.6990.28
233_Y279_A0.6990.28
41_D284_R0.6990.28
34_L223_I0.6990.28
23_S28_S0.6960.27
261_P298_V0.6960.27
155_S158_S0.6950.27
281_A304_L0.6920.27
200_L250_E0.6920.27
137_S157_E0.6920.27
204_R225_L0.6910.27
274_L286_R0.6900.27
18_N52_R0.6880.27
33_D142_S0.6880.27
50_L254_E0.6870.27
45_A98_G0.6860.27
27_S126_V0.6850.27
141_S159_S0.6830.27
291_L307_L0.6810.27
53_L60_S0.6750.26
109_L209_F0.6730.26
298_V308_R0.6730.26
302_I310_A0.6720.26
144_P151_R0.6690.26
218_Q227_A0.6670.26
88_L249_P0.6660.26
202_R225_L0.6590.25
155_S238_S0.6580.25
9_L34_L0.6560.25
298_V304_L0.6560.25
143_V147_P0.6540.25
93_G98_G0.6530.25
252_I269_I0.6530.25
6_L39_D0.6520.25
43_L182_L0.6510.25
137_S160_S0.6500.25
236_S273_A0.6500.25
245_F248_E0.6490.25
15_L251_L0.6480.25
42_V132_P0.6470.25
28_S294_L0.6430.25
84_R229_A0.6430.25
169_P243_K0.6380.24
155_S161_S0.6380.24
11_F283_Y0.6380.24
201_T209_F0.6370.24
128_F133_S0.6370.24
223_I235_H0.6350.24
30_H47_L0.6350.24
292_S296_A0.6350.24
42_V276_A0.6350.24
145_S291_L0.6330.24
271_T281_A0.6320.24
19_C30_H0.6310.24
19_C310_A0.6310.24
115_S215_E0.6270.24
145_S155_S0.6270.24
290_V296_A0.6220.24
148_T153_S0.6210.24
299_N304_L0.6200.23
40_L220_L0.6190.23
141_S158_S0.6170.23
79_N258_L0.6170.23
220_L227_A0.6160.23
186_V191_V0.6150.23
180_E202_R0.6140.23
191_V195_L0.6130.23
17_E204_R0.6110.23
140_S150_L0.6100.23
5_V114_P0.6090.23
23_S231_L0.6070.23
138_S264_G0.6050.23
221_L224_R0.6050.23
92_W98_G0.6050.23
154_S157_E0.6030.23
124_G175_S0.6030.23
134_S143_V0.6020.23
174_S180_E0.6010.23
30_H51_L0.5980.22
118_S126_V0.5980.22
38_T200_L0.5950.22
199_L297_G0.5950.22
22_R55_Q0.5940.22
217_R270_Q0.5930.22
63_R168_I0.5920.22
163_L245_F0.5910.22
199_L280_L0.5900.22
181_L309_K0.5870.22
18_N186_V0.5860.22
155_S159_S0.5860.22
36_N266_P0.5830.22
92_W112_L0.5800.22
136_S263_D0.5780.21
37_S200_L0.5740.21
94_G261_P0.5740.21
239_D306_L0.5730.21
113_A311_V0.5720.21
115_S266_P0.5700.21
8_I215_E0.5670.21
140_S158_S0.5670.21
38_T173_L0.5660.21
304_L310_A0.5650.21
222_A234_V0.5650.21
42_V160_S0.5630.21
163_L259_L0.5620.21
42_V238_S0.5580.21
89_A273_A0.5580.21
3_E173_L0.5530.20
144_P152_R0.5520.20
142_S167_H0.5510.20
43_L46_T0.5500.20
304_L308_R0.5490.20
187_E236_S0.5490.20
11_F303_L0.5490.20
5_V166_I0.5490.20
258_L261_P0.5480.20
137_S190_D0.5460.20
111_S120_P0.5450.20
3_E288_S0.5440.20
114_P117_D0.5430.20
2_R203_I0.5430.20
37_S237_E0.5410.20
146_T155_S0.5410.20
162_G251_L0.5400.20
35_L232_A0.5400.20
49_L300_H0.5400.20
81_L107_N0.5390.20
71_A74_L0.5370.20
138_S156_D0.5360.20
220_L284_R0.5350.20
139_E177_S0.5310.19
125_T181_L0.5310.19
134_S196_R0.5300.19
137_S141_S0.5300.19
38_T254_E0.5280.19
128_F138_S0.5270.19
93_G304_L0.5270.19
29_E125_T0.5260.19
78_Y83_D0.5260.19
248_E262_E0.5250.19
127_H232_A0.5250.19
110_V258_L0.5210.19
278_E308_R0.5180.19
56_R60_S0.5160.19
206_A303_L0.5160.19
24_L27_S0.5140.19
7_A186_V0.5140.19
15_L257_E0.5120.19
124_G220_L0.5120.19
56_R231_L0.5120.19
213_S221_L0.5110.19
128_F134_S0.5100.18
73_L168_I0.5100.18
79_N230_N0.5090.18
176_E184_K0.5090.18
5_V9_L0.5030.18
60_S230_N0.5030.18
8_I21_N0.5020.18
12_T19_C0.5020.18
140_S145_S0.5020.18
3_E210_S0.5020.18
47_L271_T0.5000.18
7_A221_L0.5000.18
220_L226_L0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i2zA 1 0.8562 50.4 0.951 Contact Map
2z6hA 3 0.8658 42 0.954 Contact Map
4uafB 1 0.4601 34.3 0.956 Contact Map
4db6A 1 0.4313 31.6 0.957 Contact Map
2z6gA 1 0.8243 31.2 0.957 Contact Map
4ev8A 1 0.1693 25.9 0.958 Contact Map
4plqA 1 0.4441 25.6 0.958 Contact Map
4r0zA 1 0.3706 23.2 0.959 Contact Map
3ldzA 1 0.2588 22.9 0.96 Contact Map
1xm9A 1 0.2013 21.4 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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