GREMLIN Database
TRP - Transient receptor potential (TRP) ion channel
PFAM: PF06011 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 426 (414)
Sequences: 816 (595)
Seq/√Len: 29.2
META: 0.126

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_A144_L6.9111.00
148_G214_L4.8941.00
52_G66_T4.4261.00
401_I405_F4.0971.00
312_S315_A3.5451.00
212_T303_G3.3851.00
81_M85_I3.3631.00
173_L178_W3.1501.00
359_L377_I3.0301.00
32_A35_S2.9591.00
208_F239_T2.7921.00
370_P373_V2.7611.00
164_L168_V2.7521.00
33_A37_S2.7451.00
383_V387_V2.6841.00
186_L189_R2.4350.99
100_L103_L2.3920.99
34_N37_S2.3310.99
300_F304_I2.2880.99
247_Y251_R2.2510.99
17_A23_G2.2150.98
219_F240_G2.2150.98
139_I147_T2.2020.98
190_N193_G2.1710.98
168_V172_L2.1620.98
315_A319_G2.1540.98
185_F189_R2.1040.98
161_V165_L2.0810.97
99_L102_S2.0570.97
291_F331_L1.9910.97
32_A37_S1.9570.96
356_N385_N1.9360.96
229_V233_V1.9290.96
98_T101_Y1.9220.96
185_F188_F1.8850.95
6_A10_G1.8690.95
190_N194_T1.8650.95
167_K171_E1.8540.95
232_V236_A1.8270.95
11_L15_A1.8140.94
171_E189_R1.8110.94
9_A13_L1.7970.94
25_S29_A1.7720.94
133_V139_I1.7700.94
247_Y253_A1.7460.93
225_W229_V1.7390.93
85_I89_R1.7380.93
222_G228_V1.7260.93
89_R94_G1.7250.93
8_I27_T1.7240.93
183_D188_F1.7210.93
189_R192_W1.7180.93
302_K328_L1.7120.92
143_N147_T1.6960.92
332_S337_F1.6950.92
144_L148_G1.6940.92
267_L281_Y1.6920.92
99_L103_L1.6750.92
321_L358_I1.6720.92
16_S322_I1.6610.91
84_S87_W1.6580.91
215_C307_G1.6530.91
124_T284_Y1.6480.91
192_W198_G1.6290.90
395_L399_N1.6280.90
193_G197_K1.6230.90
174_A177_G1.5940.89
305_F319_G1.5870.89
102_S105_T1.5660.89
248_K251_R1.5600.88
239_T243_G1.5580.88
398_V402_I1.5450.88
190_N197_K1.5360.88
89_R93_G1.5340.88
267_L274_L1.5270.87
31_V35_S1.5260.87
272_E320_L1.5220.87
230_L234_F1.5190.87
225_W228_V1.5190.87
94_G147_T1.5120.87
89_R92_T1.5090.87
411_R415_P1.4950.86
159_V168_V1.4750.85
306_I320_L1.4610.85
25_S28_A1.4540.85
31_V36_L1.4530.84
107_S110_V1.4520.84
24_H28_A1.4450.84
219_F232_V1.4410.84
251_R254_R1.4310.84
325_V329_I1.4170.83
250_I293_V1.4120.83
148_G152_F1.4110.83
278_G281_Y1.4100.83
30_H34_N1.4100.83
186_L190_N1.4040.82
331_L337_F1.4030.82
192_W196_L1.4000.82
120_G123_S1.3920.82
304_I308_A1.3910.82
211_I238_F1.3870.82
12_A20_S1.3860.82
4_A8_I1.3660.81
236_A240_G1.3660.81
202_R278_G1.3620.80
234_F243_G1.3610.80
49_A69_F1.3550.80
100_L104_S1.3520.80
21_G28_A1.3470.80
284_Y337_F1.3450.80
86_D89_R1.3450.80
406_S417_A1.3420.79
120_G124_T1.3400.79
111_K114_D1.3340.79
387_V391_V1.3330.79
150_L159_V1.3240.78
79_S83_D1.3210.78
340_K343_N1.3170.78
191_G195_V1.3120.78
191_G194_T1.3090.78
30_H33_A1.2940.77
231_A244_W1.2920.77
391_V394_I1.2880.76
278_G291_F1.2880.76
355_L359_L1.2780.76
57_N374_K1.2760.76
138_G153_L1.2690.75
71_W310_Q1.2670.75
71_W306_I1.2640.75
85_I150_L1.2630.75
196_L200_L1.2560.75
30_H36_L1.2490.74
188_F194_T1.2490.74
239_T294_P1.2480.74
89_R143_N1.2430.74
50_M317_A1.2420.74
394_I398_V1.2270.73
26_N29_A1.2210.72
145_F148_G1.2210.72
369_Q374_K1.2120.72
31_V34_N1.2100.72
230_L235_L1.2100.72
4_A411_R1.2100.72
50_M213_I1.2010.71
198_G202_R1.1980.71
170_L401_I1.1800.70
362_A377_I1.1720.69
195_V202_R1.1660.69
5_T71_W1.1630.69
10_G72_S1.1550.68
324_E357_V1.1530.68
128_R131_Q1.1500.68
99_L105_T1.1480.68
219_F222_G1.1470.68
1_V4_A1.1470.68
75_L144_L1.1440.67
58_Y62_Y1.1440.67
242_L245_A1.1430.67
372_I376_V1.1400.67
82_Q147_T1.1370.67
16_S24_H1.1370.67
232_V301_V1.1360.67
199_I246_A1.1350.67
16_S158_A1.1330.67
328_L351_V1.1330.67
61_I74_G1.1320.67
155_V164_L1.1310.66
411_R417_A1.1290.66
346_N349_I1.1280.66
406_S415_P1.1270.66
216_L308_A1.1260.66
197_K200_L1.1250.66
82_Q143_N1.1220.66
309_A319_G1.1160.65
412_R418_D1.1160.65
52_G59_P1.1120.65
199_I202_R1.1120.65
249_V254_R1.1080.65
194_T197_K1.1040.65
228_V232_V1.1000.64
256_S284_Y1.0970.64
192_W200_L1.0900.64
114_D119_T1.0890.63
176_F179_M1.0760.63
44_Y385_N1.0740.62
184_R187_D1.0740.62
343_N346_N1.0690.62
393_L412_R1.0680.62
40_D313_G1.0580.61
350_A377_I1.0580.61
274_L281_Y1.0570.61
49_A133_V1.0560.61
402_I406_S1.0560.61
136_L376_V1.0540.61
2_S5_T1.0530.61
26_N31_V1.0500.61
139_I301_V1.0490.61
11_L100_L1.0470.60
18_V23_G1.0470.60
100_L126_V1.0430.60
328_L347_I1.0430.60
36_L216_L1.0400.60
159_V164_L1.0390.60
228_V311_G1.0320.59
72_S218_Q1.0310.59
224_S267_L1.0250.59
332_S347_I1.0250.59
166_F169_I1.0200.58
284_Y295_L1.0180.58
406_S411_R1.0150.58
187_D190_N1.0120.58
91_A94_G1.0060.57
75_L148_G1.0060.57
10_G25_S1.0020.57
56_V364_V1.0010.57
32_A36_L1.0000.57
243_G291_F1.0000.57
55_S357_V0.9930.56
19_T27_T0.9900.56
99_L141_S0.9880.56
23_G26_N0.9830.55
184_R190_N0.9800.55
217_F297_L0.9790.55
206_I317_A0.9770.55
298_Y302_K0.9740.55
82_Q223_D0.9730.55
351_V355_L0.9690.54
106_T111_K0.9680.54
281_Y291_F0.9680.54
165_L168_V0.9670.54
63_Q320_L0.9670.54
16_S23_G0.9600.54
352_V384_I0.9560.53
380_V384_I0.9550.53
237_L306_I0.9530.53
411_R414_Q0.9510.53
157_A161_V0.9510.53
332_S351_V0.9510.53
21_G26_N0.9490.53
230_L245_A0.9450.53
17_A21_G0.9450.53
16_S192_W0.9440.52
200_L203_L0.9390.52
307_G310_Q0.9390.52
87_W91_A0.9380.52
144_L291_F0.9380.52
101_Y104_S0.9350.52
71_W343_N0.9330.52
111_K124_T0.9310.51
204_I276_K0.9310.51
12_A400_A0.9280.51
146_M149_L0.9270.51
89_R327_Y0.9160.50
311_G350_A0.9150.50
65_W69_F0.9140.50
140_E385_N0.9120.50
5_T9_A0.9110.50
13_L17_A0.9100.50
167_K298_Y0.9040.49
274_L278_G0.9020.49
410_D413_Y0.9020.49
16_S28_A0.9000.49
14_L384_I0.8970.49
309_A315_A0.8960.49
98_T103_L0.8960.49
355_L384_I0.8940.49
14_L27_T0.8940.49
168_V171_E0.8890.48
13_L16_S0.8880.48
11_L293_V0.8880.48
305_F323_I0.8870.48
145_F152_F0.8860.48
172_L176_F0.8860.48
376_V379_V0.8830.48
113_L119_T0.8800.47
361_L367_F0.8800.47
164_L170_L0.8740.47
145_F150_L0.8720.47
144_L149_L0.8690.47
7_V368_G0.8690.47
52_G228_V0.8690.47
26_N242_L0.8650.46
87_W93_G0.8630.46
169_I178_W0.8630.46
55_S311_G0.8600.46
253_A267_L0.8590.46
242_L252_I0.8590.46
238_F248_K0.8570.46
177_G181_K0.8570.46
21_G27_T0.8540.45
103_L108_V0.8530.45
17_A22_L0.8520.45
19_T406_S0.8510.45
89_R227_A0.8490.45
209_P310_Q0.8450.45
98_T104_S0.8420.44
19_T28_A0.8410.44
10_G16_S0.8400.44
13_L22_L0.8310.44
14_L337_F0.8300.44
152_F212_T0.8300.44
280_L324_E0.8290.43
210_Q214_L0.8250.43
13_L23_G0.8250.43
25_S170_L0.8210.43
35_S233_V0.8200.43
158_A161_V0.8180.43
243_G247_Y0.8180.43
161_V168_V0.8160.42
23_G28_A0.8140.42
407_K410_D0.8140.42
318_I361_L0.8120.42
230_L233_V0.8110.42
205_L217_F0.8080.42
131_Q397_L0.8080.42
20_S23_G0.8060.42
19_T24_H0.8060.42
401_I406_S0.8050.42
285_R288_A0.8050.42
156_I159_V0.8020.41
236_A401_I0.8010.41
10_G210_Q0.8000.41
189_R205_L0.7970.41
16_S22_L0.7970.41
28_A31_V0.7960.41
113_L325_V0.7920.41
223_D331_L0.7910.41
19_T22_L0.7900.40
15_A371_Q0.7870.40
372_I375_G0.7860.40
87_W94_G0.7820.40
404_L417_A0.7820.40
96_P102_S0.7820.40
128_R268_Y0.7810.40
167_K170_L0.7800.40
64_A74_G0.7800.40
290_W374_K0.7800.40
224_S227_A0.7770.40
288_A375_G0.7770.40
330_A333_V0.7760.39
14_L18_V0.7750.39
344_V347_I0.7750.39
324_E345_F0.7720.39
77_N238_F0.7710.39
28_A235_L0.7710.39
412_R417_A0.7700.39
142_T351_V0.7690.39
104_S200_L0.7660.39
290_W309_A0.7660.39
88_Y94_G0.7640.39
149_L157_A0.7640.39
48_I57_N0.7620.38
229_V326_L0.7600.38
300_F396_I0.7580.38
390_L394_I0.7580.38
72_S76_I0.7560.38
13_L26_N0.7560.38
192_W197_K0.7560.38
21_G24_H0.7550.38
219_F239_T0.7540.38
145_F149_L0.7530.38
27_T30_H0.7520.38
88_Y93_G0.7520.38
22_L29_A0.7520.38
54_L58_Y0.7510.38
224_S296_L0.7500.38
197_K204_I0.7500.38
202_R206_I0.7450.37
98_T102_S0.7420.37
190_N200_L0.7390.37
233_V243_G0.7310.36
190_N195_V0.7290.36
302_K365_P0.7280.36
327_Y352_V0.7270.36
25_S36_L0.7260.36
49_A66_T0.7260.36
181_K184_R0.7260.36
195_V201_L0.7250.36
86_D90_R0.7230.36
230_L244_W0.7220.35
41_L45_F0.7220.35
218_Q353_R0.7210.35
73_M301_V0.7200.35
62_Y364_V0.7190.35
33_A36_L0.7190.35
304_I315_A0.7180.35
321_L325_V0.7180.35
208_F300_F0.7150.35
215_C349_I0.7140.35
192_W392_L0.7110.35
16_S75_L0.7100.35
329_I390_L0.7090.35
408_N412_R0.7080.34
300_F308_A0.7080.34
54_L306_I0.7070.34
10_G155_V0.7070.34
185_F190_N0.7060.34
65_W223_D0.7060.34
149_L165_L0.7050.34
130_I151_F0.7040.34
396_I399_N0.7030.34
276_K286_A0.7030.34
15_A23_G0.7020.34
222_G232_V0.7020.34
357_V390_L0.7000.34
19_T31_V0.7000.34
224_S284_Y0.6990.34
292_F375_G0.6990.34
382_I386_A0.6980.34
162_L234_F0.6980.34
18_V22_L0.6980.34
113_L176_F0.6940.33
42_F305_F0.6920.33
196_L202_R0.6900.33
18_V21_G0.6900.33
51_T302_K0.6890.33
165_L174_A0.6890.33
101_Y144_L0.6880.33
253_A344_V0.6860.33
166_F241_L0.6850.33
101_Y108_V0.6830.33
105_T109_Q0.6830.33
309_A396_I0.6820.33
127_V379_V0.6820.33
134_A404_L0.6790.32
40_D353_R0.6790.32
64_A269_D0.6780.32
323_I326_L0.6770.32
252_I255_R0.6760.32
259_M263_P0.6750.32
403_A417_A0.6740.32
160_V297_L0.6740.32
79_S113_L0.6730.32
397_L400_A0.6720.32
154_I172_L0.6710.32
390_L393_L0.6700.32
53_M73_M0.6690.32
40_D71_W0.6680.32
27_T166_F0.6680.32
247_Y314_L0.6680.32
184_R240_G0.6660.32
68_N74_G0.6650.32
119_T236_A0.6650.32
171_E175_R0.6650.32
234_F238_F0.6620.31
159_V368_G0.6600.31
12_A17_A0.6590.31
6_A9_A0.6590.31
301_V306_I0.6580.31
147_T223_D0.6570.31
328_L335_R0.6540.31
17_A20_S0.6530.31
240_G348_L0.6530.31
369_Q415_P0.6520.31
310_Q343_N0.6520.31
198_G201_L0.6510.31
285_R334_L0.6500.30
301_V304_I0.6470.30
106_T121_S0.6470.30
167_K189_R0.6470.30
339_D380_V0.6460.30
153_L350_A0.6460.30
197_K203_L0.6430.30
202_R274_L0.6430.30
193_G196_L0.6420.30
92_T223_D0.6390.30
190_N205_L0.6380.30
140_E356_N0.6360.30
303_G349_I0.6340.29
413_Y418_D0.6340.29
305_F309_A0.6320.29
239_T323_I0.6320.29
296_L334_L0.6320.29
7_V386_A0.6320.29
4_A18_V0.6310.29
268_Y300_F0.6310.29
45_F69_F0.6310.29
345_F354_V0.6300.29
8_I29_A0.6300.29
201_L288_A0.6290.29
49_A73_M0.6280.29
121_S384_I0.6270.29
53_M72_S0.6270.29
403_A415_P0.6270.29
119_T123_S0.6260.29
190_N411_R0.6260.29
83_D397_L0.6260.29
148_G173_L0.6260.29
88_Y140_E0.6250.29
127_V325_V0.6240.29
42_F317_A0.6230.29
266_I287_S0.6230.29
130_I192_W0.6230.29
318_I366_E0.6220.29
64_A136_L0.6220.29
152_F207_G0.6200.29
148_G210_Q0.6190.28
3_W10_G0.6190.28
9_A25_S0.6190.28
157_A325_V0.6170.28
15_A320_L0.6160.28
102_S122_S0.6160.28
97_T105_T0.6140.28
98_T105_T0.6130.28
152_F168_V0.6120.28
81_M236_A0.6120.28
131_Q134_A0.6080.28
22_L28_A0.6080.28
26_N30_H0.6080.28
311_G315_A0.6070.28
143_N146_M0.6050.28
155_V295_L0.6040.28
151_F154_I0.6040.28
157_A284_Y0.6020.27
360_L364_V0.6010.27
252_I348_L0.6010.27
174_A179_M0.6000.27
170_L241_L0.5990.27
82_Q94_G0.5960.27
68_N147_T0.5940.27
169_I348_L0.5940.27
254_R258_K0.5920.27
256_S262_N0.5910.27
85_I92_T0.5900.27
144_L302_K0.5890.27
196_L209_P0.5890.27
144_L152_F0.5890.27
162_L241_L0.5870.26
73_M207_G0.5870.26
13_L27_T0.5850.26
169_I190_N0.5840.26
51_T57_N0.5830.26
56_V163_V0.5830.26
137_A165_L0.5800.26
328_L354_V0.5800.26
107_S111_K0.5790.26
318_I398_V0.5790.26
224_S242_L0.5780.26
304_I322_I0.5760.26
375_G382_I0.5740.26
112_R315_A0.5730.26
71_W274_L0.5720.26
6_A21_G0.5690.25
25_S53_M0.5670.25
106_T240_G0.5670.25
347_I359_L0.5650.25
102_S351_V0.5640.25
212_T238_F0.5640.25
75_L223_D0.5640.25
10_G303_G0.5630.25
360_L371_Q0.5630.25
121_S161_V0.5600.25
62_Y66_T0.5590.25
45_F389_T0.5580.25
275_L329_I0.5580.25
320_L324_E0.5550.25
268_Y282_N0.5540.25
257_K262_N0.5530.24
55_S146_M0.5530.24
226_A284_Y0.5520.24
121_S130_I0.5520.24
407_K411_R0.5490.24
285_R331_L0.5460.24
165_L297_L0.5460.24
184_R194_T0.5450.24
164_L284_Y0.5440.24
85_I88_Y0.5440.24
212_T296_L0.5440.24
243_G311_G0.5430.24
170_L179_M0.5430.24
163_V167_K0.5420.24
192_W195_V0.5410.24
298_Y324_E0.5390.24
211_I284_Y0.5380.24
211_I296_L0.5380.24
363_F378_G0.5380.24
173_L179_M0.5370.24
61_I376_V0.5360.23
280_L351_V0.5350.23
350_A365_P0.5340.23
189_R214_L0.5340.23
114_D329_I0.5340.23
390_L398_V0.5340.23
401_I404_L0.5320.23
28_A326_L0.5310.23
97_T364_V0.5280.23
2_S237_L0.5270.23
325_V332_S0.5260.23
104_S172_L0.5250.23
36_L107_S0.5240.23
95_N323_I0.5240.23
18_V165_L0.5230.23
73_M214_L0.5230.23
200_L365_P0.5230.23
339_D383_V0.5220.23
162_L309_A0.5220.23
106_T114_D0.5220.23
69_F145_F0.5170.22
121_S359_L0.5160.22
184_R188_F0.5160.22
96_P215_C0.5160.22
239_T250_I0.5150.22
105_T119_T0.5150.22
219_F308_A0.5150.22
158_A176_F0.5130.22
149_L154_I0.5130.22
139_I148_G0.5120.22
213_I344_V0.5120.22
183_D189_R0.5100.22
355_L369_Q0.5090.22
166_F348_L0.5090.22
15_A270_D0.5080.22
114_D391_V0.5070.22
151_F305_F0.5070.22
301_V311_G0.5060.22
17_A29_A0.5060.22
341_S402_I0.5040.22
361_L391_V0.5020.22
1_V111_K0.5020.22
285_R327_Y0.5020.22
121_S348_L0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kncB 1 0.1385 34 0.965 Contact Map
2m20A 2 0.1033 8.1 0.973 Contact Map
2kncA 1 0.1268 7.2 0.974 Contact Map
2l8sA 1 0.108 4.3 0.977 Contact Map
1scfA 4 0 4.1 0.977 Contact Map
2kluA 1 0.1221 3 0.978 Contact Map
2k1eA 3 0.2418 2.8 0.979 Contact Map
2micA 2 0.0939 2.7 0.979 Contact Map
3hd6A 3 0.1033 2.6 0.979 Contact Map
2l9uA 2 0.0869 2.5 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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