GREMLIN Database
PhnJ - Phosphonate metabolism protein PhnJ
PFAM: PF06007 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 274 (272)
Sequences: 1406 (418)
Seq/√Len: 25.3
META: 0.73

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_D180_D4.7571.00
179_M212_V4.1681.00
194_M217_K4.0701.00
175_G217_K3.7691.00
189_N220_S3.6971.00
24_V198_L3.6511.00
119_Y199_Q3.5741.00
51_V55_I3.4551.00
193_H217_K3.4341.00
20_I209_I3.0611.00
102_T199_Q2.8701.00
113_E215_Y2.8571.00
99_I118_V2.8241.00
240_L273_R2.7760.99
109_T271_K2.7400.99
171_V179_M2.7210.99
102_T201_F2.6960.99
20_I51_V2.6500.99
192_L199_Q2.5890.99
163_I169_Y2.5020.99
93_D271_K2.4940.99
263_C269_C2.4710.99
5_F87_G2.4610.99
56_I62_L2.4310.99
119_Y192_L2.4230.99
79_R90_T2.3410.98
102_T119_Y2.3360.98
113_E196_P2.2840.98
56_I86_A2.2510.98
172_M178_V2.1860.97
196_P215_Y2.1810.97
241_C269_C2.1150.96
192_L195_S2.1130.96
134_E137_T2.0160.95
162_H229_E2.0130.95
241_C263_C2.0120.95
55_I99_I2.0060.95
237_P244_T2.0020.95
128_R134_E1.9980.95
195_S199_Q1.9710.95
40_M49_L1.9180.94
95_A109_T1.9080.94
53_A82_F1.8810.93
253_T256_A1.8800.93
243_A246_S1.8090.92
240_L270_E1.7960.91
193_H219_E1.7860.91
24_V116_I1.7830.91
81_F85_T1.7780.91
4_N10_E1.7260.90
123_I129_F1.7260.90
83_A90_T1.6910.89
243_A272_R1.6710.88
20_I24_V1.6590.88
157_I226_H1.6520.88
71_D270_E1.6460.87
136_E139_K1.6350.87
61_V89_A1.6220.87
56_I99_I1.6170.86
219_E222_D1.5660.85
138_R208_R1.5360.83
34_A49_L1.5310.83
125_E137_T1.5040.82
52_T62_L1.5000.82
134_E138_R1.4720.81
117_L199_Q1.4690.80
93_D96_E1.4670.80
62_L82_F1.4430.79
111_L197_A1.4130.78
149_M169_Y1.3910.77
117_L195_S1.3900.77
71_D77_S1.3780.76
94_T267_D1.3740.76
130_L148_L1.3630.75
119_Y201_F1.3570.75
178_V221_L1.3560.75
254_D258_G1.3510.74
19_A209_I1.3410.74
270_E273_R1.3390.74
123_I168_D1.3200.73
187_F191_K1.3090.72
78_I85_T1.3040.72
144_A176_R1.2920.71
117_L192_L1.2910.71
267_D271_K1.2900.71
230_V233_F1.2790.70
193_H196_P1.2630.69
246_S268_Y1.2600.69
140_M169_Y1.2460.68
49_L78_I1.2340.67
20_I55_I1.2330.67
123_I180_D1.2300.67
5_F88_V1.2100.66
129_F180_D1.1880.64
93_D267_D1.1690.63
149_M178_V1.1670.63
270_E274_A1.1670.63
245_D248_L1.1610.63
10_E13_K1.1610.63
109_T196_P1.1550.62
110_P196_P1.1430.61
133_R137_T1.1040.59
128_R137_T1.1000.58
123_I128_R1.1000.58
89_A96_E1.0980.58
173_V218_V1.0880.58
51_V200_L1.0850.57
165_T168_D1.0780.57
136_E151_V1.0710.56
81_F249_D1.0610.56
53_A72_T1.0600.55
247_Y266_T1.0540.55
92_T270_E1.0490.55
166_S231_E1.0330.54
73_T77_S1.0290.53
95_A271_K1.0260.53
186_K230_V1.0200.53
61_V98_T1.0160.52
35_S42_Y1.0140.52
131_E207_K1.0090.52
222_D227_P1.0090.52
180_D210_Y1.0080.52
156_D163_I1.0050.52
129_F168_D1.0050.52
33_F44_W1.0010.51
6_A86_A0.9750.49
29_Y134_E0.9630.48
165_T169_Y0.9620.48
196_P199_Q0.9600.48
229_E232_R0.9460.47
21_L25_A0.9400.47
93_D109_T0.9290.46
81_F147_G0.9280.46
174_N217_K0.9230.46
49_L82_F0.9210.45
193_H231_E0.9200.45
95_A217_K0.9170.45
52_T56_I0.9160.45
92_T267_D0.9070.44
56_I85_T0.9030.44
126_P180_D0.8960.44
175_G194_M0.8950.44
59_D83_A0.8880.43
42_Y53_A0.8860.43
175_G219_E0.8840.43
14_R138_R0.8820.43
5_F59_D0.8740.42
6_A85_T0.8710.42
57_G168_D0.8680.42
106_I192_L0.8580.41
98_T114_G0.8560.41
207_K212_V0.8560.41
15_M72_T0.8550.41
208_R262_V0.8530.41
152_K165_T0.8510.40
49_L53_A0.8450.40
150_H224_E0.8440.40
194_M215_Y0.8400.40
133_R136_E0.8380.39
33_F81_F0.8350.39
16_I209_I0.8300.39
245_D272_R0.8280.39
55_I118_V0.8260.39
81_F161_G0.8220.38
132_P180_D0.8200.38
56_I88_V0.8180.38
53_A151_V0.8160.38
269_C272_R0.8150.38
106_I177_Y0.8110.38
114_G195_S0.8090.37
124_P153_L0.8080.37
203_A206_E0.8060.37
140_M148_L0.8040.37
145_E220_S0.8030.37
151_V186_K0.7970.37
42_Y150_H0.7970.37
253_T258_G0.7950.37
98_T200_L0.7930.36
54_S59_D0.7930.36
34_A40_M0.7920.36
175_G193_H0.7860.36
162_H166_S0.7860.36
144_A172_M0.7820.36
61_V79_R0.7760.35
94_T109_T0.7700.35
186_K231_E0.7660.35
16_I157_I0.7630.34
154_Y264_S0.7610.34
44_W218_V0.7580.34
264_S269_C0.7570.34
117_L256_A0.7570.34
20_I26_I0.7490.33
25_A147_G0.7450.33
15_M19_A0.7440.33
123_I149_M0.7440.33
156_D166_S0.7410.33
37_E181_P0.7340.32
262_V267_D0.7320.32
83_A86_A0.7320.32
173_V179_M0.7310.32
42_Y72_T0.7300.32
138_R247_Y0.7240.32
16_I33_F0.7190.32
61_V247_Y0.7170.31
154_Y169_Y0.7170.31
201_F212_V0.7160.31
212_V231_E0.7140.31
38_M165_T0.7130.31
22_K46_T0.7100.31
78_I88_V0.7100.31
84_R208_R0.7090.31
86_A99_I0.7040.31
77_S261_F0.7040.31
172_M176_R0.7020.30
184_I192_L0.6980.30
36_R50_Q0.6980.30
42_Y49_L0.6960.30
193_H215_Y0.6950.30
125_E128_R0.6950.30
156_D169_Y0.6930.30
8_L169_Y0.6920.30
119_Y195_S0.6910.30
174_N247_Y0.6830.29
114_G215_Y0.6820.29
61_V96_E0.6810.29
72_T82_F0.6790.29
128_R218_V0.6770.29
177_Y268_Y0.6770.29
249_D261_F0.6760.29
145_E189_N0.6730.29
197_A249_D0.6720.29
139_K186_K0.6710.29
12_T85_T0.6680.28
192_L231_E0.6680.28
15_M42_Y0.6680.28
133_R267_D0.6680.28
171_V218_V0.6670.28
254_D259_R0.6660.28
123_I247_Y0.6640.28
40_M73_T0.6630.28
187_F220_S0.6610.28
80_R123_I0.6590.28
87_G212_V0.6590.28
44_W173_V0.6580.28
76_V131_E0.6570.28
131_E200_L0.6560.28
51_V202_G0.6550.28
40_M46_T0.6530.28
3_Y7_Y0.6460.27
24_V230_V0.6440.27
79_R151_V0.6400.27
44_W125_E0.6390.27
80_R151_V0.6360.27
148_L151_V0.6350.26
243_A269_C0.6320.26
44_W128_R0.6300.26
7_Y86_A0.6300.26
56_I240_L0.6290.26
130_L212_V0.6280.26
102_T208_R0.6280.26
55_I207_K0.6260.26
102_T156_D0.6230.26
4_N12_T0.6230.26
89_A251_V0.6220.26
77_S148_L0.6210.26
51_V79_R0.6190.26
99_I111_L0.6190.26
97_A115_Q0.6170.25
212_V250_E0.6160.25
233_F246_S0.6130.25
41_P208_R0.6130.25
55_I59_D0.6110.25
187_F190_P0.6110.25
179_M207_K0.6090.25
241_C246_S0.6080.25
123_I132_P0.6070.25
222_D226_H0.6060.25
44_W179_M0.6060.25
44_W171_V0.6050.25
255_D258_G0.6040.25
145_E160_H0.6030.25
118_V273_R0.6030.25
41_P49_L0.5980.24
186_K229_E0.5940.24
132_P191_K0.5940.24
81_F149_M0.5940.24
7_Y125_E0.5930.24
100_I111_L0.5910.24
262_V266_T0.5910.24
163_I226_H0.5900.24
12_T15_M0.5900.24
174_N266_T0.5890.24
94_T112_R0.5870.24
69_A182_S0.5870.24
20_I200_L0.5840.24
51_V209_I0.5830.24
41_P143_L0.5830.24
155_E190_P0.5820.24
71_D240_L0.5820.24
73_T247_Y0.5810.24
138_R181_P0.5790.23
158_A186_K0.5790.23
168_D178_V0.5780.23
34_A145_E0.5770.23
99_I261_F0.5730.23
132_P168_D0.5710.23
81_F160_H0.5700.23
78_I220_S0.5700.23
80_R176_R0.5690.23
15_M53_A0.5680.23
263_C272_R0.5680.23
251_V260_M0.5670.23
16_I112_R0.5660.23
106_I191_K0.5650.23
139_K145_E0.5640.23
39_P43_G0.5630.23
154_Y220_S0.5630.23
59_D247_Y0.5630.23
167_Y181_P0.5620.23
239_A258_G0.5620.23
85_T202_G0.5620.23
235_G253_T0.5610.23
54_S233_F0.5610.23
158_A246_S0.5600.22
232_R235_G0.5600.22
129_F132_P0.5600.22
149_M208_R0.5590.22
199_Q212_V0.5570.22
184_I212_V0.5570.22
125_E139_K0.5560.22
49_L180_D0.5560.22
102_T262_V0.5560.22
152_K156_D0.5540.22
35_S150_H0.5530.22
129_F148_L0.5520.22
137_T171_V0.5510.22
54_S89_A0.5510.22
133_R157_I0.5500.22
78_I82_F0.5500.22
49_L201_F0.5480.22
38_M235_G0.5460.22
124_P134_E0.5440.22
172_M180_D0.5430.22
11_Q151_V0.5430.22
34_A136_E0.5430.22
87_G190_P0.5420.22
69_A77_S0.5410.22
158_A194_M0.5400.21
150_H186_K0.5390.21
245_D268_Y0.5390.21
22_K26_I0.5390.21
70_D203_A0.5380.21
238_C241_C0.5360.21
77_S80_R0.5340.21
143_L167_Y0.5330.21
100_I171_V0.5320.21
77_S209_I0.5320.21
69_A78_I0.5300.21
33_F266_T0.5300.21
144_A229_E0.5300.21
115_Q257_G0.5280.21
243_A248_L0.5280.21
57_G124_P0.5280.21
243_A274_A0.5270.21
62_L90_T0.5270.21
239_A262_V0.5240.21
6_A160_H0.5240.21
2_G96_E0.5230.21
9_D17_R0.5220.21
44_W137_T0.5220.21
174_N177_Y0.5220.21
79_R154_Y0.5220.21
160_H164_A0.5220.21
140_M154_Y0.5210.21
169_Y230_V0.5200.20
143_L266_T0.5200.20
140_M207_K0.5190.20
178_V219_E0.5170.20
85_T94_T0.5170.20
250_E261_F0.5170.20
136_E149_M0.5160.20
149_M154_Y0.5160.20
95_A112_R0.5160.20
51_V118_V0.5150.20
91_T115_Q0.5150.20
111_L119_Y0.5130.20
148_L220_S0.5130.20
126_P168_D0.5120.20
152_K180_D0.5110.20
128_R167_Y0.5110.20
136_E264_S0.5100.20
163_I227_P0.5090.20
7_Y22_K0.5080.20
95_A110_P0.5080.20
118_V234_D0.5080.20
19_A23_A0.5070.20
45_G48_G0.5060.20
230_V235_G0.5060.20
89_A255_D0.5050.20
162_H165_T0.5050.20
71_D126_P0.5050.20
33_F171_V0.5040.20
148_L169_Y0.5040.20
9_D36_R0.5040.20
20_I166_S0.5040.20
33_F36_R0.5020.20
49_L143_L0.5010.20
5_F234_D0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3efoB 1 0.3102 69.6 0.973 Contact Map
3eh2A 1 0.3942 54.5 0.975 Contact Map
2fsuA 2 0.562 37.5 0.978 Contact Map
2fqhA 1 0.1642 27 0.979 Contact Map
3eh1A 1 0.354 20.4 0.98 Contact Map
1vd4A 1 0.1825 19.1 0.981 Contact Map
2yrcA 1 0.1533 12.1 0.982 Contact Map
2epxA 1 0.1569 12.1 0.982 Contact Map
3n2bA 2 0.4015 11.3 0.983 Contact Map
1m2oA 2 0.3029 11.1 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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