GREMLIN Database
DUF898 - Bacterial protein of unknown function (DUF898)
PFAM: PF05987 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 341 (333)
Sequences: 3195 (2710)
Seq/√Len: 148.5
META: 0.827

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_H115_S5.3441.00
292_T296_A4.6121.00
280_W284_S4.4381.00
68_L72_A3.7121.00
111_L164_T3.4761.00
274_R277_R3.0621.00
288_L296_A3.0281.00
30_I33_A2.9691.00
7_T48_R2.9311.00
124_D165_R2.8731.00
4_F49_L2.8631.00
252_A278_L2.8591.00
48_R53_P2.6531.00
22_L26_V2.5611.00
104_Y159_Y2.5241.00
32_S67_R2.4611.00
59_T62_E2.4481.00
252_A275_A2.4361.00
44_Y114_T2.4061.00
5_E48_R2.3651.00
49_L54_F2.3581.00
61_K65_K2.3471.00
289_I297_R2.1751.00
158_R162_N2.1731.00
199_G203_G2.1671.00
169_L265_G2.1401.00
289_I300_A2.1281.00
165_R170_R2.1001.00
13_Y39_R2.0911.00
161_V262_T2.0761.00
60_P64_L2.0641.00
284_S288_L2.0381.00
40_R110_R2.0261.00
277_R281_L2.0181.00
277_R311_H1.9801.00
272_T311_H1.9631.00
196_V200_A1.9621.00
267_H318_G1.9391.00
284_S287_L1.9331.00
249_Y253_R1.9211.00
122_G165_R1.9171.00
281_L307_Y1.8831.00
43_F302_V1.8051.00
41_R45_G1.8001.00
185_L189_L1.8001.00
150_P181_Y1.7891.00
112_R122_G1.7781.00
81_S88_G1.7781.00
89_L93_L1.7761.00
125_G159_Y1.7601.00
63_I67_R1.7441.00
20_N35_A1.7361.00
284_S303_R1.7311.00
177_A181_Y1.7301.00
132_L136_L1.7291.00
155_R158_R1.7091.00
236_A240_L1.7061.00
10_G288_L1.6801.00
141_T148_L1.6781.00
10_G296_A1.6641.00
137_W151_W1.6471.00
288_L291_L1.6321.00
43_F305_A1.6251.00
105_R108_R1.6101.00
24_T35_A1.6081.00
256_N271_S1.6011.00
127_A131_Y1.5831.00
175_G257_L1.5811.00
234_L238_L1.5771.00
129_G159_Y1.5591.00
23_L26_V1.5391.00
253_R275_A1.5391.00
79_L83_F1.5221.00
288_L292_T1.5181.00
129_G133_V1.5141.00
189_L193_L1.4951.00
33_A67_R1.4911.00
259_W269_F1.4881.00
104_Y127_A1.4811.00
283_L287_L1.4791.00
287_L291_L1.4641.00
154_A158_R1.4441.00
4_F314_L1.4321.00
74_L77_Y1.4281.00
41_R55_E1.4271.00
182_K186_L1.3821.00
200_A204_A1.3771.00
180_F258_V1.3711.00
154_A177_A1.3581.00
148_L151_W1.3551.00
327_A330_A1.3521.00
162_N173_F1.3521.00
70_A338_L1.3431.00
319_D322_E1.3371.00
193_L197_V1.3311.00
273_L307_Y1.3171.00
39_R301_K1.3161.00
10_G302_V1.3061.00
270_R315_L1.2981.00
62_E113_R1.2961.00
307_Y311_H1.2931.00
277_R280_W1.2921.00
187_A250_Y1.2911.00
7_T53_P1.2801.00
186_L189_L1.2781.00
230_A234_L1.2731.00
7_T46_N1.2711.00
93_L97_L1.2621.00
303_R307_Y1.2621.00
305_A309_A1.2561.00
278_L282_Y1.2331.00
97_L131_Y1.2321.00
75_V79_L1.2291.00
275_A279_L1.2291.00
84_S87_A1.2201.00
203_G207_G1.2111.00
183_R257_L1.2081.00
174_E263_R1.2051.00
186_L249_Y1.2001.00
255_R271_S1.1981.00
257_L261_G1.1981.00
101_W105_R1.1971.00
281_L304_L1.1841.00
129_G132_L1.1771.00
40_R44_Y1.1711.00
151_W177_A1.1651.00
139_L143_L1.1641.00
151_W154_A1.1501.00
128_W132_L1.1451.00
248_A252_A1.1240.99
263_R268_R1.1230.99
141_T152_A1.1200.99
219_G222_A1.1060.99
56_Y63_I1.0990.99
107_L160_Q1.0970.99
184_Y250_Y1.0940.99
264_L269_F1.0930.99
207_G210_A1.0930.99
40_R56_Y1.0830.99
229_L233_G1.0830.99
171_F264_L1.0830.99
176_S179_D1.0820.99
136_L140_L1.0810.99
281_L284_S1.0780.99
131_Y135_L1.0740.99
157_K180_F1.0730.99
62_E65_K1.0610.99
5_E310_E1.0580.99
9_S12_E1.0560.99
80_A84_S1.0480.99
276_R280_W1.0460.99
153_H184_Y1.0440.99
253_R276_R1.0430.99
193_L200_A1.0410.99
296_A299_W1.0380.99
8_G46_N1.0380.99
232_L236_A1.0370.99
285_N303_R1.0340.99
200_A203_G1.0340.99
168_D324_V1.0220.99
296_A300_A1.0140.99
58_G62_E1.0010.99
126_S129_G0.9990.99
137_W152_A0.9930.99
141_T144_T0.9910.99
88_G92_L0.9900.99
6_F13_Y0.9850.99
124_D170_R0.9830.99
48_R51_G0.9820.99
19_V38_R0.9750.98
147_L185_L0.9700.98
316_G319_D0.9680.98
320_L323_F0.9660.98
144_T148_L0.9490.98
335_G338_L0.9470.98
128_W131_Y0.9460.98
268_R315_L0.9440.98
71_V75_V0.9390.98
195_L199_G0.9340.98
8_G12_E0.9240.98
40_R111_L0.9210.98
73_L338_L0.9200.98
15_R19_V0.9180.98
45_G55_E0.9100.98
33_A63_I0.9070.98
141_T146_G0.9040.98
272_T313_T0.9010.97
97_L100_P0.8990.97
12_E42_Y0.8960.97
110_R118_G0.8940.97
86_L90_L0.8930.97
309_A312_L0.8930.97
217_G220_A0.8920.97
182_K185_L0.8920.97
153_H250_Y0.8920.97
123_F159_Y0.8900.97
16_I19_V0.8890.97
68_L75_V0.8870.97
4_F312_L0.8850.97
14_F19_V0.8850.97
277_R307_Y0.8840.97
292_T295_L0.8840.97
72_A76_A0.8830.97
169_L323_F0.8820.97
301_K305_A0.8810.97
306_R310_E0.8780.97
11_G15_R0.8760.97
270_R313_T0.8750.97
179_D182_K0.8730.97
55_E115_S0.8720.97
183_R186_L0.8710.97
52_D117_R0.8680.97
267_H316_G0.8680.97
201_L205_L0.8670.97
157_K258_V0.8650.97
316_G320_L0.8640.97
57_H120_R0.8610.97
70_A337_E0.8570.97
12_E16_I0.8570.97
288_L299_W0.8550.97
107_L164_T0.8480.96
199_G202_A0.8440.96
229_L237_L0.8420.96
59_T113_R0.8420.96
217_G221_G0.8420.96
6_F302_V0.8390.96
218_A221_G0.8380.96
49_L314_L0.8360.96
162_N172_S0.8350.96
335_G339_A0.8330.96
281_L285_N0.8320.96
49_L116_W0.8270.96
130_A156_L0.8250.96
67_R337_E0.8230.96
100_P103_I0.8220.96
271_S311_H0.8210.96
233_G238_L0.8190.96
189_L196_V0.8130.95
267_H317_A0.8110.95
97_L101_W0.8090.95
249_Y276_R0.8080.95
72_A79_L0.8070.95
255_R259_W0.8060.95
285_N300_A0.8030.95
291_L296_A0.8000.95
80_A88_G0.7990.95
140_L143_L0.7980.95
142_L145_L0.7960.95
133_V136_L0.7950.95
77_Y88_G0.7920.95
253_R256_N0.7920.95
15_R22_L0.7900.95
62_E109_F0.7890.95
137_W155_R0.7860.94
38_R42_Y0.7840.94
99_L103_I0.7810.94
99_L102_L0.7810.94
231_A234_L0.7800.94
116_W166_F0.7780.94
58_G112_R0.7750.94
296_A303_R0.7740.94
81_S91_L0.7720.94
35_A38_R0.7710.94
290_V293_L0.7670.94
255_R312_L0.7670.94
14_F18_I0.7650.94
183_R249_Y0.7640.94
275_A278_L0.7620.93
183_R253_R0.7610.93
254_L258_V0.7610.93
297_R301_K0.7540.93
168_D323_F0.7540.93
157_K160_Q0.7540.93
64_L67_R0.7520.93
6_F47_T0.7510.93
233_G237_L0.7490.93
178_G182_K0.7430.93
132_L137_W0.7420.93
134_F156_L0.7410.92
317_A320_L0.7390.92
240_L244_L0.7390.92
204_A207_G0.7370.92
24_T32_S0.7350.92
122_G326_A0.7340.92
289_I296_A0.7340.92
104_Y130_A0.7340.92
337_E340_D0.7340.92
81_S84_S0.7330.92
175_G261_G0.7320.92
213_A216_A0.7280.92
141_T149_Y0.7270.92
149_Y153_H0.7270.92
252_A273_L0.7240.92
292_T298_P0.7230.92
106_A110_R0.7220.92
137_W140_L0.7220.92
326_A329_A0.7220.92
33_A44_Y0.7150.91
194_G242_A0.7120.91
334_L338_L0.7100.91
79_L82_Q0.7050.91
125_G131_Y0.7010.90
13_Y17_W0.7010.90
285_N304_L0.6980.90
42_Y302_V0.6970.90
208_A212_G0.6960.90
285_N298_P0.6960.90
209_L214_A0.6950.90
204_A208_A0.6910.90
244_L248_A0.6870.89
35_A43_F0.6850.89
87_A91_L0.6810.89
107_L138_P0.6810.89
173_F262_T0.6810.89
173_F261_G0.6810.89
164_T171_F0.6800.89
109_F112_R0.6790.89
72_A75_V0.6780.89
22_L293_L0.6770.89
32_S63_I0.6760.89
283_L286_L0.6760.89
130_A267_H0.6760.89
259_W312_L0.6760.89
243_Y247_Y0.6680.88
274_R307_Y0.6650.88
212_G215_A0.6620.88
36_K66_G0.6610.88
10_G14_F0.6590.87
284_S296_A0.6580.87
39_R297_R0.6550.87
299_W302_V0.6500.87
32_S337_E0.6500.87
301_K304_L0.6490.87
300_A307_Y0.6480.86
135_L139_L0.6430.86
207_G211_A0.6430.86
17_W38_R0.6420.86
154_A175_G0.6420.86
179_D257_L0.6410.86
47_T309_A0.6400.86
248_A282_Y0.6390.86
161_V164_T0.6390.86
216_A220_A0.6380.86
216_A219_G0.6370.86
80_A87_A0.6360.85
21_L39_R0.6360.85
191_A195_L0.6360.85
154_A257_L0.6340.85
52_D116_W0.6330.85
110_R164_T0.6330.85
169_L266_G0.6320.85
187_A249_Y0.6300.85
33_A37_V0.6300.85
206_A210_A0.6290.85
214_A217_G0.6290.85
40_R67_R0.6280.85
231_A235_L0.6260.85
314_L321_D0.6260.85
50_D116_W0.6240.84
240_L243_Y0.6240.84
41_R46_N0.6220.84
158_R173_F0.6220.84
89_L92_L0.6220.84
196_V203_G0.6220.84
142_L148_L0.6180.84
23_L27_T0.6170.84
190_L246_L0.6170.84
298_P335_G0.6170.84
137_W141_T0.6160.84
133_V137_W0.6150.83
37_V63_I0.6130.83
111_L114_T0.6120.83
153_H157_K0.6120.83
190_L194_G0.6110.83
189_L202_A0.6090.83
104_Y131_Y0.6090.83
47_T305_A0.6080.83
304_L308_R0.6070.83
156_L161_V0.6060.83
32_S36_K0.6050.83
248_A278_L0.6040.82
175_G179_D0.6030.82
121_F166_F0.6030.82
140_L148_L0.6010.82
211_A215_A0.6010.82
211_A216_A0.6000.82
213_A232_L0.5990.82
161_V338_L0.5980.82
152_A156_L0.5970.82
204_A211_A0.5950.81
43_F47_T0.5950.81
98_L102_L0.5930.81
24_T33_A0.5910.81
190_L193_L0.5890.81
54_F121_F0.5890.81
14_F17_W0.5870.81
214_A218_A0.5870.81
183_R187_A0.5860.80
194_G239_L0.5850.80
259_W262_T0.5820.80
168_D326_A0.5820.80
108_R125_G0.5810.80
263_R266_G0.5810.80
60_P63_I0.5790.80
36_K40_R0.5770.79
84_S91_L0.5760.79
324_V335_G0.5760.79
40_R164_T0.5760.79
209_L212_G0.5730.79
166_F323_F0.5720.79
151_W155_R0.5710.79
32_S37_V0.5710.79
249_Y257_L0.5690.79
206_A209_L0.5680.78
39_R43_F0.5670.78
119_I325_A0.5640.78
133_V152_A0.5620.78
20_N38_R0.5610.78
32_S70_A0.5610.78
153_H254_L0.5610.78
280_W287_L0.5570.77
12_E46_N0.5560.77
8_G42_Y0.5550.77
119_I122_G0.5550.77
57_H113_R0.5540.77
168_D327_A0.5530.77
319_D324_V0.5530.77
106_A339_A0.5510.76
61_K64_L0.5490.76
3_P313_T0.5480.76
153_H156_L0.5470.76
133_V159_Y0.5440.75
249_Y275_A0.5430.75
198_A217_G0.5420.75
161_V258_V0.5400.75
201_L236_A0.5400.75
197_V200_A0.5400.75
304_L307_Y0.5390.75
28_L90_L0.5380.75
235_L239_L0.5380.75
4_F309_A0.5380.75
43_F301_K0.5380.75
248_A279_L0.5380.75
107_L111_L0.5370.74
9_S302_V0.5370.74
208_A211_A0.5370.74
90_L94_L0.5350.74
53_P116_W0.5350.74
255_R273_L0.5350.74
16_I46_N0.5350.74
194_G198_A0.5350.74
10_G299_W0.5330.74
144_T147_L0.5320.74
73_L91_L0.5310.74
51_G117_R0.5310.74
88_G95_L0.5310.74
138_P142_L0.5310.74
140_L144_T0.5300.74
277_R310_E0.5300.74
5_E51_G0.5290.73
78_Y82_Q0.5270.73
149_Y152_A0.5250.73
192_L212_G0.5240.73
210_A213_A0.5240.73
143_L148_L0.5230.73
32_S64_L0.5230.73
211_A217_G0.5220.72
245_L279_L0.5220.72
94_L97_L0.5210.72
324_V327_A0.5200.72
39_R109_F0.5200.72
197_V201_L0.5200.72
32_S44_Y0.5190.72
208_A218_A0.5180.72
271_S312_L0.5180.72
101_W131_Y0.5170.72
123_F130_A0.5160.72
170_R264_L0.5140.71
126_S159_Y0.5130.71
216_A221_G0.5120.71
63_I335_G0.5100.71
156_L160_Q0.5100.71
195_L205_L0.5090.71
215_A230_A0.5090.71
207_G237_L0.5090.71
70_A336_E0.5090.71
174_E202_A0.5090.71
233_G240_L0.5080.70
138_P141_T0.5070.70
26_V33_A0.5070.70
16_I42_Y0.5060.70
228_L231_A0.5050.70
185_L188_W0.5050.70
295_L298_P0.5040.70
300_A304_L0.5030.70
233_G236_A0.5020.69
273_L308_R0.5020.69
236_A239_L0.5020.69
273_L278_L0.5010.69
186_L193_L0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2duyA 1 0.0938 9.9 0.971 Contact Map
4iajA 5 0.0762 3.7 0.977 Contact Map
1wazA 1 0.1349 2.6 0.978 Contact Map
2yxhA 2 0.1672 2.1 0.979 Contact Map
2hi2A 1 0.176 2 0.98 Contact Map
2ca5A 1 0.0557 1.7 0.98 Contact Map
2k8oA 1 0.1173 1.7 0.98 Contact Map
2k1aA 1 0.1232 1.6 0.981 Contact Map
4pj0U 1 0.1085 1.5 0.981 Contact Map
1q16C 2 0.2845 1.5 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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