GREMLIN Database
CreA - CreA protein
PFAM: PF05981 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 131 (127)
Sequences: 2691 (818)
Seq/√Len: 72.6
META: 0.809

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_K78_E4.0361.00
28_P66_T3.4031.00
23_D102_R3.2581.00
33_H125_T3.0991.00
13_P45_A3.0211.00
5_S14_N2.8921.00
7_V15_D2.8351.00
21_A31_T2.7951.00
85_R92_L2.6281.00
31_T62_T2.6191.00
30_V126_V2.4301.00
9_K15_D2.3661.00
95_V110_Y2.2671.00
28_P68_K2.1371.00
3_S18_V2.0721.00
44_G49_A2.0591.00
12_G42_I2.0511.00
13_P16_K2.0121.00
4_V108_L1.9261.00
42_I46_L1.9241.00
54_D120_K1.8971.00
21_A102_R1.8791.00
77_G97_I1.8001.00
19_V97_I1.7621.00
5_S8_F1.6901.00
79_E93_R1.6801.00
28_P67_F1.6481.00
7_V116_E1.5950.99
93_R112_D1.5860.99
42_I45_A1.5700.99
5_S15_D1.4480.99
56_S60_R1.4460.99
100_A103_N1.4200.99
61_Q65_I1.4050.98
5_S16_K1.3720.98
72_P77_G1.3380.98
39_T51_D1.3210.98
76_D100_A1.3200.98
87_L113_K1.2740.97
21_A33_H1.2630.97
36_R85_R1.2430.97
27_V105_L1.2370.97
58_A104_T1.1750.95
31_T102_R1.1720.95
88_L92_L1.1260.94
7_V10_L1.1240.94
41_G44_G1.1010.93
82_S93_R1.0980.93
92_L109_A1.0940.93
106_V123_I1.0730.93
94_V97_I1.0360.91
22_F34_V1.0270.91
82_S91_K1.0180.90
23_D31_T1.0140.90
9_K12_G0.9900.89
29_G61_Q0.9700.88
39_T49_A0.9430.87
15_D39_T0.9400.87
46_L116_E0.9320.86
103_N128_I0.9310.86
88_L114_L0.9160.85
37_A51_D0.9150.85
32_C59_C0.9110.85
51_D85_R0.8920.84
104_T125_T0.8830.83
125_T129_M0.8800.83
36_R92_L0.8700.82
3_S7_V0.8690.82
113_K116_E0.8510.81
43_K49_A0.8460.80
83_E93_R0.8420.80
37_A52_P0.8330.79
20_E36_R0.8260.79
10_L13_P0.8250.78
34_V94_V0.8250.78
48_L87_L0.8240.78
52_P55_A0.8170.78
70_K98_Y0.8060.77
1_I5_S0.8010.76
8_F13_P0.8000.76
66_T69_G0.7970.76
27_V30_V0.7950.76
110_Y120_K0.7940.76
71_L98_Y0.7900.75
18_V38_K0.7880.75
39_T43_K0.7770.74
98_Y103_N0.7770.74
36_R55_A0.7750.74
5_S13_P0.7750.74
37_A85_R0.7740.74
26_K80_V0.7700.74
112_D120_K0.7610.73
22_F94_V0.7500.72
31_T101_K0.7480.71
28_P69_G0.7440.71
38_K85_R0.7430.71
14_N45_A0.7430.71
60_R124_S0.7430.71
11_L15_D0.7410.71
15_D42_I0.7390.70
26_K69_G0.7390.70
87_L114_L0.7370.70
37_A55_A0.7230.69
7_V12_G0.7220.69
118_S124_S0.7200.68
57_I109_A0.7130.68
55_A120_K0.7130.68
33_H123_I0.7070.67
101_K104_T0.7060.67
37_A119_P0.7020.66
39_T48_L0.7010.66
61_Q128_I0.6980.66
70_K101_K0.6840.64
84_R91_K0.6790.64
30_V105_L0.6740.63
83_E92_L0.6740.63
69_G98_Y0.6730.63
79_E91_K0.6710.63
7_V14_N0.6690.63
53_S90_K0.6680.63
9_K39_T0.6640.62
26_K71_L0.6620.62
33_H62_T0.6570.61
27_V67_F0.6560.61
23_D101_K0.6540.61
82_S108_L0.6530.61
43_K46_L0.6400.59
7_V114_L0.6320.58
29_G63_G0.6270.58
36_R110_Y0.6270.58
62_T104_T0.6240.57
55_A88_L0.6210.57
46_L87_L0.6170.57
21_A34_V0.6110.56
6_T16_K0.6110.56
68_K71_L0.6110.56
96_R99_D0.6080.55
54_D118_S0.6080.55
15_D48_L0.6060.55
82_S111_S0.6020.55
52_P120_K0.5960.54
41_G60_R0.5950.54
81_F94_V0.5910.53
72_P76_D0.5900.53
8_F12_G0.5890.53
13_P40_G0.5830.52
43_K87_L0.5820.52
112_D118_S0.5770.52
82_S98_Y0.5760.52
20_E67_F0.5740.51
29_G65_I0.5730.51
40_G119_P0.5730.51
11_L14_N0.5720.51
115_I119_P0.5700.51
79_E84_R0.5640.50
106_V125_T0.5630.50
76_D98_Y0.5620.50
57_I92_L0.5620.50
52_P84_R0.5600.50
91_K112_D0.5590.49
86_S113_K0.5580.49
66_T101_K0.5580.49
17_I38_K0.5530.49
21_A62_T0.5520.49
36_R83_E0.5480.48
55_A92_L0.5480.48
35_S55_A0.5440.48
27_V66_T0.5440.48
91_K110_Y0.5400.47
8_F15_D0.5380.47
4_V17_I0.5320.46
67_F103_N0.5310.46
10_L15_D0.5280.46
26_K66_T0.5270.46
95_V108_L0.5250.45
16_K38_K0.5220.45
98_Y128_I0.5210.45
15_D37_A0.5170.44
70_K100_A0.5160.44
68_K72_P0.5150.44
6_T13_P0.5130.44
26_K72_P0.5120.44
85_R126_V0.5090.43
25_P46_L0.5060.43
35_S111_S0.5060.43
2_G17_I0.5050.43
122_S125_T0.5040.43
45_A48_L0.5030.43
39_T46_L0.5010.42
14_N17_I0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c75H 2 0.7863 10 0.95 Contact Map
3cnkA 2 0.5802 4.7 0.957 Contact Map
1v18B 1 0.1985 3.9 0.959 Contact Map
3kmhA 2 0.3053 3.7 0.959 Contact Map
2ljuA 1 0.3511 2.3 0.963 Contact Map
3bdkA 2 0.9084 2.3 0.963 Contact Map
2dlgA 1 0.7252 2.3 0.963 Contact Map
2dgyA 1 0.4733 2 0.964 Contact Map
2if6A 1 0.4198 2 0.965 Contact Map
2bopA 2 0.313 1.9 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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