GREMLIN Database
DUF883 - Bacterial protein of unknown function (DUF883)
PFAM: PF05957 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (90)
Sequences: 19556 (13466)
Seq/√Len: 1419.5
META: 0.893

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_N75_Q3.4621.00
55_R59_R2.1471.00
66_D70_R2.1411.00
65_T68_Y2.0371.00
54_A58_A2.0041.00
51_A55_R1.9171.00
66_D74_W1.8921.00
69_V76_A1.8721.00
53_A57_R1.7011.00
89_L92_R1.6521.00
57_R60_E1.6011.00
50_A53_A1.6001.00
79_I82_G1.5951.00
81_A85_L1.5841.00
50_A54_A1.5611.00
25_A29_A1.5121.00
61_A64_A1.5111.00
76_A79_I1.4921.00
58_A62_A1.4781.00
78_G81_A1.4771.00
46_R49_E1.4591.00
35_R39_A1.4371.00
47_L51_A1.4321.00
43_A47_L1.3941.00
39_A43_A1.3921.00
6_D9_A1.3891.00
80_A84_G1.3881.00
85_L89_L1.3681.00
82_G86_L1.3551.00
39_A42_D1.3431.00
62_A65_T1.3371.00
79_I83_V1.2681.00
42_D46_R1.2671.00
28_K31_E1.2171.00
64_A67_D1.2111.00
64_A68_Y1.2001.00
74_W78_G1.1931.00
81_A84_G1.1821.00
46_R50_A1.1691.00
28_K32_A1.1641.00
44_K48_A1.1491.00
33_R37_E1.1431.00
24_Q28_K1.1281.00
85_L88_G1.1131.00
62_A66_D1.0971.00
77_V81_A1.0921.00
21_T25_A1.0871.00
48_A51_A1.0731.00
16_E20_A1.0701.00
75_Q79_I1.0691.00
9_A13_D1.0541.00
35_R38_E1.0521.00
59_R62_A1.0461.00
69_V77_V1.0431.00
5_A8_K1.0141.00
37_E41_E1.0111.00
4_A8_K0.9971.00
55_R58_A0.9851.00
59_R63_K0.9821.00
75_Q78_G0.9791.00
78_G82_G0.9781.00
11_V15_E0.9741.00
63_K66_D0.9721.00
68_Y75_Q0.9521.00
32_A36_A0.9451.00
68_Y74_W0.9421.00
68_Y72_N0.8961.00
61_A65_T0.8591.00
24_Q27_E0.8521.00
31_E35_R0.8371.00
14_A18_L0.8111.00
42_D45_E0.8071.00
74_W77_V0.8031.00
41_E45_E0.7901.00
58_A61_A0.7891.00
15_E18_L0.7891.00
28_K36_A0.7881.00
6_D13_D0.7861.00
87_L91_L0.7821.00
60_E64_A0.7801.00
51_A54_A0.7761.00
20_A24_Q0.7761.00
10_L17_L0.7701.00
57_R61_A0.7591.00
56_E59_R0.7531.00
47_L50_A0.7501.00
13_D16_E0.7441.00
52_D56_E0.7311.00
48_A52_D0.7231.00
17_L24_Q0.7061.00
69_V74_W0.7011.00
11_V14_A0.6871.00
17_L20_A0.6831.00
54_A57_R0.6801.00
19_K22_A0.6701.00
81_A88_G0.6661.00
36_A39_A0.6591.00
26_G30_A0.6501.00
15_E19_K0.6501.00
76_A80_A0.6481.00
23_D26_G0.6461.00
65_T69_V0.6411.00
66_D69_V0.6341.00
12_A16_E0.6301.00
43_A46_R0.6281.00
86_L89_L0.6281.00
40_L44_K0.6231.00
41_E44_K0.6221.00
22_A26_G0.6071.00
11_V21_T0.6051.00
8_K12_A0.6041.00
45_E49_E0.6011.00
82_G85_L0.5881.00
5_A9_A0.5861.00
85_L91_L0.5851.00
70_R74_W0.5831.00
30_A34_E0.5811.00
8_K11_V0.5741.00
38_E42_D0.5691.00
29_A32_A0.5671.00
6_D10_L0.5661.00
12_A15_E0.5601.00
62_A74_W0.5571.00
77_V80_A0.5521.00
40_L43_A0.5481.00
4_A14_A0.5461.00
13_D17_L0.5391.00
80_A83_V0.5371.00
67_D71_E0.5371.00
52_D55_R0.5191.00
49_E53_A0.5161.00
63_K67_D0.5141.00
21_T26_G0.5031.00
21_T29_A0.5031.00
56_E60_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a01A 1 0.766 85.3 0.743 Contact Map
3r2pA 2 0.8191 79.1 0.76 Contact Map
1nfnA 1 0.6702 75.3 0.768 Contact Map
1gs9A 1 0.7979 74.4 0.769 Contact Map
2lemA 1 0.8191 70.1 0.777 Contact Map
2l7bA 1 0.8617 66.7 0.782 Contact Map
3s84A 2 0.5319 58.9 0.792 Contact Map
1rykA 1 0.734 46.8 0.807 Contact Map
1eq1A 1 0.766 31.6 0.824 Contact Map
2m8rA 1 0.9149 30.1 0.826 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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