T6SS_VipB - PFAM28P - GREMLIN Contacts

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T6SS_VipB - Type VI secretion system, ImpG, VasA, VC_A0110

PFAM:	PF05947	Sequences: LRYYERELAYLREMGAEFAEAYPKIAGRLGLEGDECEDPHVERLLEGFAFLAARVQLKLDDEFPEFTEALLELLYPHYLRPIPSMSIVQFEPDPGQGKLTEGFTIPRGTELRSRPVGEDGTACRFRTAYDVTLWPLEITEAEYSGAPLPPAVRLPAGRARAALRLRLRTTGGLPFSELGLDRLRFYLAGDDALAAALYELLLAHLVGVVVRPPGGGGARPVVLPASALRPVGFDDDEALLPYPPRSFPGYRLLQEYFAFPEKFLFFDLTGLDAALRRAGAGDEFELVFLLDRSDPPPLELRVDADNFRLGCTPAVNLFPKRAEPIRLDHRQTEYHVVPDRRRPLDYEVYSVDSVTGVGPGGGGEEREFRPFYSFRHGGGDERERGAYYTARRRPRLLSERQRRPGTEVFLSLVDLDFAPYRAPLRETLSVRLLCTNRDLPLRLPFGDGGGFTLEGGAPVARIRCLTGPTPPRRPPLGGDLLWRLISHLSLNYLSLVDGGAEALRELLRLYDFQDDAATRRQIEGIRSVSSRPVVRRLGRGPGAFVRGLEITLTLDEDAFAGSGLFLFGSVLERFFALYASINSFTQLVVRSTQRGEIKRWPPRAGQRPL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	609 (604)
Sequences:	4381 (3170)
Seq/√Len:	129.0
META:	0.65

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
86_S	314_A	5.764	1.00
352_D	433_L	5.374	1.00
322_A	432_L	4.732	1.00
205_L	288_F	4.593	1.00
184_R	267_D	4.402	1.00
167_L	284_F	4.161	1.00
137_E	168_R	3.564	1.00
531_R	549_E	3.563	1.00
3_Y	60_D	3.459	1.00
572_E	603_R	3.454	1.00
549_E	588_V	3.452	1.00
487_H	510_Y	3.438	1.00
138_I	165_L	3.374	1.00
89_Q	308_R	3.374	1.00
204_H	291_D	3.247	1.00
168_R	283_E	3.227	1.00
268_L	286_L	3.187	1.00
166_R	285_E	3.121	1.00
524_G	558_A	3.073	1.00
351_V	390_A	3.054	1.00
139_T	168_R	3.041	1.00
353_S	367_E	2.974	1.00
412_L	428_L	2.947	1.00
165_L	307_F	2.830	1.00
181_D	272_D	2.812	1.00
88_V	111_L	2.797	1.00
353_S	431_R	2.763	1.00
141_A	307_F	2.762	1.00
166_R	283_E	2.702	1.00
87_I	265_F	2.689	1.00
184_R	231_V	2.673	1.00
202_L	266_F	2.585	1.00
568_G	589_V	2.556	1.00
131_V	312_T	2.545	1.00
554_L	589_V	2.502	1.00
354_V	410_L	2.495	1.00
201_L	288_F	2.485	1.00
165_L	288_F	2.483	1.00
319_P	431_R	2.463	1.00
211_R	285_E	2.450	1.00
231_V	267_D	2.435	1.00
234_D	237_E	2.428	1.00
88_V	314_A	2.425	1.00
551_T	590_R	2.409	1.00
588_V	599_R	2.395	1.00
550_I	575_F	2.389	1.00
182_R	267_D	2.338	1.00
524_G	559_F	2.330	1.00
229_R	269_T	2.326	1.00
185_F	266_F	2.325	1.00
229_R	267_D	2.255	1.00
535_R	586_Q	2.233	1.00
163_L	290_L	2.229	1.00
129_Y	312_T	2.225	1.00
111_L	127_T	2.218	1.00
208_V	288_F	2.217	1.00
336_V	351_V	2.200	1.00
168_R	282_D	2.187	1.00
500_A	504_R	2.177	1.00
187_L	266_F	2.152	1.00
319_P	352_D	2.138	1.00
163_L	307_F	2.137	1.00
136_L	175_F	2.109	1.00
104_T	132_T	2.089	1.00
188_A	308_R	2.072	1.00
234_D	573_R	2.067	1.00
167_L	185_F	2.066	1.00
138_I	185_F	2.019	1.00
549_E	586_Q	1.984	1.00
175_F	284_F	1.973	1.00
110_E	124_R	1.965	1.00
104_T	130_D	1.955	1.00
571_L	575_F	1.940	1.00
356_G	368_F	1.933	1.00
224_P	227_A	1.928	1.00
550_I	585_T	1.912	1.00
141_A	165_L	1.911	1.00
195_A	264_L	1.898	1.00
336_V	430_V	1.893	1.00
333_E	391_R	1.884	1.00
138_I	167_L	1.870	1.00
205_L	228_L	1.864	1.00
164_R	285_E	1.845	1.00
167_L	175_F	1.838	1.00
553_T	590_R	1.822	1.00
174_P	177_E	1.820	1.00
128_A	239_L	1.817	1.00
333_E	393_R	1.782	1.00
238_A	251_R	1.768	1.00
549_E	599_R	1.744	1.00
90_F	105_I	1.744	1.00
102_G	134_W	1.713	1.00
308_R	311_C	1.710	1.00
148_L	154_L	1.699	1.00
149_P	152_V	1.699	1.00
554_L	564_L	1.694	1.00
86_S	466_T	1.692	1.00
90_F	312_T	1.682	1.00
554_L	567_F	1.679	1.00
107_R	130_D	1.677	1.00
574_F	578_Y	1.674	1.00
209_V	289_L	1.671	1.00
165_L	286_L	1.671	1.00
149_P	153_R	1.668	1.00
351_V	432_L	1.665	1.00
235_D	248_P	1.657	1.00
552_L	571_L	1.645	1.00
187_L	197_L	1.639	1.00
354_V	430_V	1.632	1.00
321_R	431_R	1.613	1.00
187_L	201_L	1.612	1.00
84_S	468_P	1.606	1.00
275_L	284_F	1.598	1.00
4_Y	8_L	1.592	1.00
77_H	246_S	1.588	1.00
347_E	437_R	1.586	1.00
227_A	270_G	1.585	1.00
338_P	348_V	1.584	1.00
238_A	248_P	1.581	1.00
322_A	430_V	1.577	1.00
265_F	311_C	1.573	1.00
211_R	287_V	1.573	1.00
527_S	553_T	1.568	1.00
206_V	291_D	1.568	1.00
91_E	461_R	1.564	1.00
207_G	222_V	1.557	1.00
163_L	302_V	1.556	1.00
556_E	591_S	1.542	1.00
328_D	331_Q	1.542	1.00
349_Y	435_T	1.539	1.00
87_I	311_C	1.533	1.00
11_L	15_G	1.531	1.00
89_Q	463_R	1.529	1.00
435_T	471_P	1.527	1.00
164_R	287_V	1.522	1.00
335_H	409_F	1.521	1.00
208_V	228_L	1.518	1.00
85_M	259_F	1.518	1.00
162_A	287_V	1.513	1.00
169_T	174_P	1.511	1.00
113_S	116_V	1.508	1.00
187_L	307_F	1.501	1.00
150_P	153_R	1.498	1.00
140_E	304_A	1.492	1.00
140_E	166_R	1.481	1.00
48_F	52_A	1.479	1.00
141_A	302_V	1.477	1.00
349_Y	352_D	1.476	1.00
556_E	593_Q	1.466	1.00
201_L	266_F	1.439	1.00
528_V	550_I	1.432	1.00
189_G	194_A	1.423	1.00
338_P	432_L	1.421	1.00
547_G	584_F	1.405	1.00
564_L	591_S	1.400	1.00
31_L	36_C	1.398	1.00
102_G	132_T	1.397	1.00
148_L	153_R	1.392	1.00
555_D	593_Q	1.391	1.00
141_A	304_A	1.389	1.00
210_V	286_L	1.388	1.00
127_T	312_T	1.380	1.00
142_E	164_R	1.377	1.00
198_Y	230_P	1.375	1.00
368_F	386_A	1.371	1.00
529_S	551_T	1.369	1.00
256_Y	521_Q	1.364	1.00
350_S	433_L	1.363	1.00
207_G	289_L	1.361	1.00
185_F	268_L	1.359	1.00
12_R	42_E	1.358	1.00
268_L	288_F	1.345	1.00
243_P	246_S	1.343	1.00
6_R	56_Q	1.340	1.00
500_A	528_V	1.330	1.00
319_P	433_L	1.329	1.00
567_F	571_L	1.326	1.00
451_F	464_C	1.325	1.00
526_R	555_D	1.324	1.00
10_Y	14_M	1.320	1.00
11_L	48_F	1.320	1.00
110_E	126_R	1.311	1.00
187_L	194_A	1.310	1.00
406_T	474_P	1.309	1.00
77_H	487_H	1.304	1.00
129_Y	262_K	1.302	1.00
533_V	549_E	1.301	1.00
80_R	349_Y	1.289	1.00
204_H	292_R	1.288	1.00
201_L	228_L	1.283	1.00
551_T	588_V	1.282	1.00
231_V	237_E	1.279	1.00
531_R	551_T	1.272	1.00
85_M	239_L	1.268	1.00
129_Y	231_V	1.265	1.00
148_L	151_A	1.264	1.00
586_Q	599_R	1.263	1.00
106_P	109_T	1.256	1.00
148_L	152_V	1.255	1.00
533_V	586_Q	1.254	1.00
58_K	61_D	1.252	1.00
193_L	306_N	1.246	1.00
77_H	254_Q	1.243	1.00
131_V	310_G	1.228	1.00
139_T	283_E	1.227	1.00
405_G	437_R	1.225	1.00
187_L	198_Y	1.225	1.00
169_T	175_F	1.220	1.00
507_L	522_I	1.218	0.99
556_E	594_R	1.208	0.99
314_A	464_C	1.203	0.99
410_L	430_V	1.202	0.99
348_V	408_V	1.195	0.99
242_Y	246_S	1.190	0.99
529_S	553_T	1.190	0.99
200_L	290_L	1.188	0.99
2_R	6_R	1.182	0.99
90_F	127_T	1.178	0.99
89_Q	311_C	1.178	0.99
186_Y	466_T	1.177	0.99
161_A	290_L	1.174	0.99
167_L	183_L	1.174	0.99
103_F	458_P	1.166	0.99
333_E	409_F	1.165	0.99
185_F	309_L	1.163	0.99
303_D	306_N	1.162	0.99
198_Y	233_F	1.157	0.99
553_T	592_T	1.157	0.99
138_I	309_L	1.152	0.99
209_V	287_V	1.151	0.99
87_I	466_T	1.146	0.99
393_R	409_F	1.144	0.99
77_H	510_Y	1.142	0.99
87_I	186_Y	1.140	0.99
357_V	429_S	1.137	0.99
105_I	312_T	1.134	0.99
8_L	12_R	1.132	0.99
17_E	20_E	1.127	0.99
591_S	594_R	1.125	0.99
565_F	598_K	1.120	0.99
554_L	591_S	1.119	0.99
191_D	261_E	1.116	0.99
366_R	426_E	1.113	0.99
390_A	408_V	1.112	0.99
137_E	170_T	1.109	0.99
144_S	148_L	1.108	0.99
441_L	471_P	1.103	0.99
86_S	464_C	1.099	0.99
24_K	28_R	1.093	0.99
586_Q	602_P	1.089	0.99
84_S	125_F	1.087	0.99
525_I	554_L	1.086	0.99
232_G	237_E	1.084	0.99
320_K	432_L	1.083	0.99
112_R	124_R	1.080	0.99
108_G	126_R	1.074	0.99
210_V	223_L	1.072	0.99
335_H	407_E	1.071	0.99
197_L	307_F	1.070	0.99
67_T	481_L	1.070	0.99
90_F	111_L	1.069	0.99
106_P	130_D	1.067	0.99
208_V	227_A	1.067	0.99
208_V	286_L	1.063	0.99
121_T	345_D	1.063	0.99
530_S	548_L	1.060	0.99
88_V	451_F	1.060	0.99
11_L	45_L	1.059	0.99
339_D	342_R	1.052	0.99
133_L	310_G	1.048	0.98
107_R	238_A	1.047	0.98
143_Y	161_A	1.045	0.98
554_L	559_F	1.043	0.98
93_D	96_Q	1.040	0.98
554_L	568_G	1.034	0.98
569_S	573_R	1.034	0.98
242_Y	251_R	1.030	0.98
149_P	154_L	1.029	0.98
351_V	388_Y	1.025	0.98
241_P	349_Y	1.023	0.98
302_V	306_N	1.023	0.98
483_R	505_E	1.022	0.98
317_L	349_Y	1.021	0.98
511_D	519_R	1.020	0.98
10_Y	15_G	1.017	0.98
197_L	302_V	1.015	0.98
525_I	575_F	1.012	0.98
520_R	558_A	1.012	0.98
251_R	255_E	1.010	0.98
182_R	269_T	1.010	0.98
511_D	518_T	1.005	0.98
533_V	588_V	1.001	0.98
82_I	85_M	1.000	0.98
151_A	155_P	0.998	0.98
145_G	150_P	0.998	0.98
134_W	183_L	0.997	0.98
134_W	310_G	0.997	0.98
504_R	523_E	0.996	0.98
58_K	65_E	0.995	0.98
25_I	28_R	0.993	0.98
167_L	286_L	0.991	0.98
52_A	55_V	0.991	0.98
322_A	351_V	0.989	0.98
205_L	290_L	0.989	0.98
52_A	56_Q	0.983	0.98
503_L	528_V	0.982	0.98
165_L	268_L	0.974	0.98
202_L	565_F	0.972	0.98
91_E	463_R	0.967	0.97
132_T	182_R	0.965	0.97
320_K	346_Y	0.964	0.97
202_L	228_L	0.964	0.97
96_Q	99_L	0.958	0.97
22_Y	560_A	0.958	0.97
343_P	346_Y	0.956	0.97
61_D	65_E	0.956	0.97
318_F	436_N	0.956	0.97
124_R	320_K	0.950	0.97
572_E	585_T	0.948	0.97
356_G	426_E	0.942	0.97
130_D	236_D	0.941	0.97
209_V	222_V	0.936	0.97
261_E	466_T	0.932	0.97
407_E	437_R	0.932	0.97
348_V	432_L	0.929	0.97
146_A	153_R	0.928	0.97
181_D	269_T	0.926	0.97
208_V	223_L	0.926	0.97
84_S	469_T	0.919	0.96
358_G	364_E	0.919	0.96
208_V	224_P	0.919	0.96
479_D	483_R	0.915	0.96
159_A	289_L	0.915	0.96
146_A	149_P	0.914	0.96
278_A	281_G	0.913	0.96
552_L	589_V	0.910	0.96
89_Q	310_G	0.905	0.96
9_A	13_E	0.903	0.96
78_Y	510_Y	0.898	0.96
213_P	285_E	0.894	0.96
150_P	154_L	0.893	0.96
569_S	600_W	0.891	0.96
62_E	65_E	0.890	0.96
387_Y	413_V	0.889	0.96
223_L	227_A	0.886	0.96
536_R	544_F	0.885	0.96
336_V	348_V	0.885	0.96
525_I	552_L	0.882	0.96
107_R	128_A	0.881	0.96
58_K	62_E	0.881	0.96
325_I	430_V	0.880	0.96
84_S	440_P	0.879	0.95
14_M	17_E	0.879	0.95
508_R	523_E	0.875	0.95
522_I	525_I	0.873	0.95
138_I	304_A	0.873	0.95
90_F	462_I	0.871	0.95
526_R	553_T	0.870	0.95
392_R	408_V	0.870	0.95
526_R	592_T	0.869	0.95
185_F	286_L	0.868	0.95
152_V	155_P	0.867	0.95
72_E	392_R	0.865	0.95
347_E	473_R	0.865	0.95
532_P	546_R	0.865	0.95
15_G	50_F	0.865	0.95
216_G	219_R	0.864	0.95
148_L	155_P	0.862	0.95
250_Y	510_Y	0.858	0.95
126_R	317_L	0.857	0.95
31_L	34_D	0.854	0.95
6_R	9_A	0.851	0.95
134_W	180_L	0.850	0.95
15_G	46_E	0.849	0.95
356_G	428_L	0.848	0.95
82_I	254_Q	0.846	0.94
579_A	607_R	0.846	0.94
129_Y	237_E	0.845	0.94
533_V	584_F	0.845	0.94
159_A	206_V	0.844	0.94
250_Y	574_F	0.844	0.94
196_A	294_D	0.841	0.94
43_R	46_E	0.838	0.94
447_D	450_G	0.835	0.94
366_R	386_A	0.835	0.94
368_F	419_P	0.831	0.94
201_L	205_L	0.829	0.94
352_D	431_R	0.828	0.94
186_Y	264_L	0.826	0.94
552_L	575_F	0.825	0.94
10_Y	50_F	0.823	0.94
338_P	434_C	0.821	0.94
147_P	150_P	0.821	0.94
203_A	565_F	0.817	0.93
234_D	238_A	0.816	0.93
199_E	565_F	0.814	0.93
190_D	193_L	0.813	0.93
112_R	122_A	0.811	0.93
371_F	510_Y	0.811	0.93
508_R	519_R	0.811	0.93
490_L	494_S	0.809	0.93
200_L	204_H	0.809	0.93
189_G	306_N	0.808	0.93
169_T	178_L	0.808	0.93
149_P	155_P	0.806	0.93
537_L	545_V	0.805	0.93
438_D	471_P	0.805	0.93
110_E	319_P	0.804	0.93
64_P	67_T	0.802	0.93
525_I	587_L	0.801	0.93
526_R	529_S	0.800	0.93
74_L	492_Y	0.798	0.93
134_W	178_L	0.798	0.93
16_A	20_E	0.797	0.93
438_D	441_L	0.795	0.92
119_D	442_R	0.795	0.92
519_R	523_E	0.795	0.92
355_T	367_E	0.793	0.92
114_R	450_G	0.792	0.92
165_L	185_F	0.788	0.92
208_V	268_L	0.787	0.92
92_P	96_Q	0.785	0.92
250_Y	487_H	0.785	0.92
233_F	263_F	0.782	0.92
395_R	435_T	0.782	0.92
153_R	156_A	0.781	0.92
115_P	120_G	0.781	0.92
145_G	148_L	0.781	0.92
123_C	436_N	0.781	0.92
308_R	465_L	0.780	0.92
233_F	566_L	0.777	0.92
199_E	203_A	0.774	0.91
113_S	443_L	0.773	0.91
113_S	440_P	0.771	0.91
503_L	571_L	0.769	0.91
91_E	137_E	0.769	0.91
559_F	563_G	0.767	0.91
169_T	284_F	0.765	0.91
322_A	336_V	0.764	0.91
136_L	310_G	0.762	0.91
488_L	492_Y	0.760	0.91
36_C	42_E	0.759	0.91
253_L	506_L	0.757	0.90
32_E	35_E	0.755	0.90
82_I	258_A	0.754	0.90
255_E	262_K	0.753	0.90
129_Y	184_R	0.753	0.90
538_G	541_P	0.752	0.90
57_L	60_D	0.752	0.90
539_R	542_G	0.751	0.90
151_A	156_A	0.750	0.90
185_F	307_F	0.750	0.90
348_V	351_V	0.749	0.90
4_Y	19_A	0.749	0.90
505_E	508_R	0.747	0.90
453_L	462_I	0.747	0.90
373_S	485_I	0.745	0.90
322_A	338_P	0.744	0.90
521_Q	559_F	0.744	0.90
146_A	150_P	0.744	0.90
199_E	204_H	0.742	0.90
4_Y	7_E	0.742	0.90
87_I	465_L	0.742	0.90
31_L	40_H	0.742	0.90
31_L	37_E	0.741	0.90
591_S	597_I	0.736	0.89
534_V	546_R	0.735	0.89
202_L	231_V	0.734	0.89
215_G	219_R	0.733	0.89
115_P	122_A	0.732	0.89
172_G	282_D	0.732	0.89
344_L	401_Q	0.731	0.89
14_M	50_F	0.730	0.89
371_F	413_V	0.730	0.89
213_P	283_E	0.727	0.89
145_G	149_P	0.727	0.89
147_P	153_R	0.726	0.89
174_P	280_A	0.726	0.89
26_A	29_L	0.724	0.88
347_E	392_R	0.724	0.88
213_P	284_F	0.723	0.88
39_P	44_L	0.723	0.88
548_L	579_A	0.722	0.88
376_H	387_Y	0.720	0.88
559_F	567_F	0.720	0.88
576_A	603_R	0.719	0.88
179_G	272_D	0.718	0.88
503_L	575_F	0.718	0.88
437_R	471_P	0.716	0.88
56_Q	60_D	0.716	0.88
30_G	37_E	0.713	0.88
406_T	476_L	0.713	0.88
472_R	512_F	0.712	0.88
87_I	259_F	0.712	0.88
573_R	606_Q	0.711	0.88
78_Y	483_R	0.711	0.88
137_E	304_A	0.710	0.87
589_V	597_I	0.710	0.87
585_T	603_R	0.708	0.87
198_Y	202_L	0.708	0.87
213_P	216_G	0.707	0.87
32_E	36_C	0.707	0.87
324_P	357_V	0.706	0.87
146_A	152_V	0.702	0.87
85_M	128_A	0.700	0.87
494_S	578_Y	0.700	0.87
414_D	419_P	0.700	0.87
444_P	447_D	0.700	0.87
278_A	282_D	0.700	0.87
487_H	509_L	0.700	0.87
601_P	604_A	0.699	0.87
150_P	156_A	0.699	0.87
77_H	242_Y	0.698	0.87
521_Q	524_G	0.698	0.87
548_L	587_L	0.694	0.86
61_D	64_P	0.694	0.86
51_L	55_V	0.693	0.86
321_R	429_S	0.693	0.86
228_L	288_F	0.692	0.86
389_T	417_F	0.692	0.86
371_F	387_Y	0.690	0.86
188_A	194_A	0.689	0.86
188_A	306_N	0.688	0.86
86_S	468_P	0.688	0.86
516_A	519_R	0.688	0.86
198_Y	566_L	0.688	0.86
455_G	462_I	0.685	0.86
19_A	23_P	0.685	0.86
542_G	545_V	0.684	0.85
537_L	543_A	0.684	0.85
186_Y	265_F	0.681	0.85
109_T	453_L	0.680	0.85
212_P	281_G	0.680	0.85
85_M	258_A	0.680	0.85
501_E	504_R	0.677	0.85
465_L	468_P	0.676	0.85
88_V	464_C	0.675	0.85
68_E	72_E	0.674	0.85
11_L	51_L	0.673	0.85
522_I	567_F	0.673	0.85
576_A	606_Q	0.672	0.84
3_Y	53_A	0.669	0.84
402_R	407_E	0.669	0.84
144_S	149_P	0.668	0.84
359_P	424_L	0.668	0.84
579_A	585_T	0.667	0.84
150_P	155_P	0.665	0.84
503_L	552_L	0.665	0.84
80_R	432_L	0.664	0.84
210_V	274_A	0.663	0.84
373_S	376_H	0.663	0.84
42_E	46_E	0.663	0.84
199_E	563_G	0.662	0.84
546_R	580_S	0.662	0.84
371_F	487_H	0.661	0.83
77_H	250_Y	0.661	0.83
161_A	563_G	0.659	0.83
23_P	29_L	0.657	0.83
552_L	587_L	0.656	0.83
350_S	475_P	0.656	0.83
481_L	489_S	0.655	0.83
252_L	263_F	0.655	0.83
586_Q	603_R	0.652	0.83
445_F	465_L	0.652	0.83
106_P	127_T	0.651	0.83
202_L	230_P	0.651	0.83
169_T	173_L	0.650	0.82
376_H	473_R	0.650	0.82
568_G	572_E	0.649	0.82
49_A	53_A	0.649	0.82
85_M	240_L	0.649	0.82
13_E	30_G	0.648	0.82
40_H	43_R	0.647	0.82
229_R	234_D	0.646	0.82
24_K	27_G	0.646	0.82
536_R	542_G	0.643	0.82
100_T	173_L	0.641	0.82
114_R	452_T	0.640	0.81
116_V	122_A	0.638	0.81
210_V	268_L	0.638	0.81
272_D	275_L	0.638	0.81
36_C	47_G	0.637	0.81
143_Y	290_L	0.636	0.81
36_C	147_P	0.635	0.81
82_I	255_E	0.635	0.81
52_A	59_L	0.635	0.81
336_V	390_A	0.634	0.81
327_L	421_R	0.634	0.81
311_C	577_L	0.633	0.81
508_R	511_D	0.632	0.81
557_D	593_Q	0.632	0.81
151_A	154_L	0.632	0.81
555_D	558_A	0.632	0.81
181_D	271_L	0.631	0.81
149_P	156_A	0.631	0.81
89_Q	307_F	0.631	0.81
398_S	405_G	0.629	0.80
559_F	571_L	0.629	0.80
575_F	585_T	0.627	0.80
437_R	473_R	0.625	0.80
81_P	471_P	0.624	0.80
569_S	572_E	0.624	0.80
75_Y	510_Y	0.623	0.80
72_E	79_L	0.622	0.80
491_N	506_L	0.622	0.80
232_G	263_F	0.621	0.79
440_P	443_L	0.621	0.79
232_G	255_E	0.621	0.79
486_S	490_L	0.620	0.79
78_Y	250_Y	0.619	0.79
210_V	221_V	0.619	0.79
242_Y	254_Q	0.619	0.79
223_L	226_S	0.619	0.79
267_D	271_L	0.618	0.79
233_F	262_K	0.618	0.79
573_R	603_R	0.618	0.79
302_V	307_F	0.617	0.79
184_R	310_G	0.616	0.79
512_F	518_T	0.615	0.79
541_P	545_V	0.615	0.79
113_S	121_T	0.614	0.79
491_N	495_L	0.614	0.79
121_T	439_L	0.613	0.79
406_T	437_R	0.612	0.78
138_I	310_G	0.612	0.78
586_Q	601_P	0.612	0.78
68_E	79_L	0.612	0.78
75_Y	78_Y	0.611	0.78
324_P	427_T	0.611	0.78
489_S	493_L	0.611	0.78
323_E	340_R	0.611	0.78
491_N	494_S	0.611	0.78
386_A	420_Y	0.611	0.78
494_S	580_S	0.610	0.78
75_Y	247_F	0.610	0.78
389_T	563_G	0.610	0.78
116_V	120_G	0.609	0.78
155_P	158_R	0.608	0.78
198_Y	565_F	0.608	0.78
145_G	152_V	0.607	0.78
79_L	131_V	0.607	0.78
242_Y	512_F	0.606	0.78
235_D	251_R	0.606	0.78
384_R	416_D	0.606	0.78
453_L	457_A	0.604	0.78
237_E	262_K	0.604	0.78
528_V	552_L	0.603	0.77
490_L	578_Y	0.602	0.77
443_L	450_G	0.602	0.77
48_F	312_T	0.601	0.77
67_T	485_I	0.601	0.77
136_L	180_L	0.600	0.77
169_T	282_D	0.598	0.77
356_G	386_A	0.598	0.77
249_G	252_L	0.597	0.77
342_R	346_Y	0.597	0.77
335_H	343_P	0.596	0.77
15_G	51_L	0.595	0.77
572_E	576_A	0.595	0.77
228_L	254_Q	0.595	0.77
213_P	219_R	0.594	0.76
163_L	212_P	0.594	0.76
36_C	45_L	0.593	0.76
101_E	179_G	0.592	0.76
591_S	595_G	0.591	0.76
457_A	462_I	0.591	0.76
572_E	587_L	0.591	0.76
194_A	306_N	0.590	0.76
572_E	600_W	0.590	0.76
252_L	570_V	0.590	0.76
387_Y	414_D	0.589	0.76
538_G	542_G	0.589	0.76
18_F	22_Y	0.588	0.76
113_S	123_C	0.588	0.76
21_A	27_G	0.587	0.76
198_Y	264_L	0.587	0.76
400_R	407_E	0.586	0.75
63_F	481_L	0.586	0.75
88_V	375_R	0.586	0.75
94_P	460_A	0.586	0.75
111_L	314_A	0.585	0.75
63_F	66_F	0.583	0.75
58_K	349_Y	0.583	0.75
152_V	158_R	0.581	0.75
589_V	608_P	0.581	0.75
89_Q	137_E	0.580	0.75
199_E	536_R	0.579	0.75
520_R	523_E	0.579	0.75
176_S	280_A	0.578	0.74
207_G	266_F	0.578	0.74
509_L	522_I	0.577	0.74
64_P	482_W	0.577	0.74
356_G	458_P	0.576	0.74
198_Y	569_S	0.576	0.74
314_A	468_P	0.576	0.74
48_F	387_Y	0.575	0.74
63_F	67_T	0.575	0.74
347_E	471_P	0.575	0.74
228_L	268_L	0.575	0.74
338_P	430_V	0.574	0.74
250_Y	578_Y	0.574	0.74
71_L	75_Y	0.573	0.74
254_Q	512_F	0.573	0.74
495_L	578_Y	0.573	0.74
37_E	42_E	0.573	0.74
205_L	208_V	0.573	0.74
9_A	190_D	0.573	0.74
143_Y	163_L	0.572	0.74
105_I	529_S	0.570	0.73
184_R	237_E	0.569	0.73
250_Y	490_L	0.569	0.73
481_L	485_I	0.568	0.73
53_A	420_Y	0.568	0.73
517_A	521_Q	0.568	0.73
206_V	422_A	0.568	0.73
565_F	569_S	0.566	0.73
116_V	119_D	0.565	0.73
162_A	290_L	0.565	0.73
15_G	31_L	0.564	0.73
85_M	315_V	0.564	0.73
131_V	184_R	0.562	0.72
210_V	284_F	0.562	0.72
568_G	600_W	0.562	0.72
8_L	26_A	0.562	0.72
12_R	36_C	0.562	0.72
445_F	464_C	0.561	0.72
475_P	512_F	0.561	0.72
198_Y	563_G	0.560	0.72
166_R	213_P	0.559	0.72
125_F	310_G	0.559	0.72
39_P	43_R	0.559	0.72
72_E	80_R	0.558	0.72
174_P	282_D	0.558	0.72
428_L	466_T	0.558	0.72
144_S	153_R	0.557	0.72
227_A	269_T	0.557	0.72
181_D	270_G	0.557	0.72
573_R	576_A	0.556	0.72
16_A	170_T	0.556	0.72
162_A	289_L	0.556	0.72
371_F	435_T	0.556	0.72
201_L	290_L	0.556	0.72
152_V	156_A	0.555	0.71
271_L	286_L	0.554	0.71
258_A	262_K	0.554	0.71
320_K	340_R	0.554	0.71
368_F	426_E	0.553	0.71
141_A	306_N	0.553	0.71
499_G	536_R	0.553	0.71
115_P	519_R	0.553	0.71
65_E	477_G	0.552	0.71
318_F	434_C	0.552	0.71
368_F	425_R	0.552	0.71
25_I	48_F	0.552	0.71
98_K	101_E	0.552	0.71
11_L	47_G	0.552	0.71
108_G	130_D	0.551	0.71
348_V	494_S	0.551	0.71
511_D	522_I	0.551	0.71
520_R	591_S	0.550	0.71
320_K	339_D	0.550	0.71
15_G	24_K	0.550	0.71
324_P	429_S	0.549	0.71
550_I	576_A	0.549	0.71
69_A	72_E	0.549	0.71
132_T	525_I	0.549	0.71
511_D	514_D	0.549	0.71
126_R	543_A	0.548	0.71
121_T	346_Y	0.548	0.71
58_K	63_F	0.548	0.71
202_L	205_L	0.546	0.70
189_G	465_L	0.545	0.70
180_L	185_F	0.545	0.70
554_L	587_L	0.545	0.70
395_R	403_R	0.544	0.70
173_L	177_E	0.543	0.70
3_Y	6_R	0.543	0.70
66_F	206_V	0.543	0.70
165_L	205_L	0.542	0.70
97_G	103_F	0.542	0.70
125_F	589_V	0.542	0.70
564_L	589_V	0.542	0.70
86_S	465_L	0.541	0.70
327_L	334_Y	0.540	0.69
210_V	217_G	0.540	0.69
23_P	26_A	0.539	0.69
130_D	257_F	0.539	0.69
136_L	309_L	0.539	0.69
322_A	388_Y	0.539	0.69
320_K	434_C	0.539	0.69
11_L	49_A	0.539	0.69
191_D	194_A	0.538	0.69
353_S	460_A	0.537	0.69
436_N	439_L	0.537	0.69
139_T	166_R	0.536	0.69
138_I	307_F	0.536	0.69
47_G	56_Q	0.536	0.69
138_I	188_A	0.535	0.69
154_L	157_G	0.535	0.69
460_A	465_L	0.534	0.69
197_L	306_N	0.534	0.69
97_G	100_T	0.534	0.69
441_L	470_P	0.534	0.69
44_L	241_P	0.533	0.68
182_R	272_D	0.533	0.68
369_R	385_G	0.532	0.68
248_P	315_V	0.532	0.68
126_R	311_C	0.532	0.68
22_Y	31_L	0.532	0.68
326_R	425_R	0.531	0.68
77_H	323_E	0.531	0.68
113_S	122_A	0.530	0.68
322_A	429_S	0.530	0.68
513_Q	518_T	0.530	0.68
89_Q	304_A	0.529	0.68
336_V	408_V	0.528	0.68
355_T	431_R	0.528	0.68
366_R	421_R	0.528	0.68
486_S	493_L	0.527	0.68
194_A	264_L	0.527	0.68
215_G	218_A	0.527	0.68
143_Y	200_L	0.526	0.67
445_F	450_G	0.526	0.67
128_A	131_V	0.526	0.67
107_R	236_D	0.526	0.67
114_R	504_R	0.526	0.67
184_R	268_L	0.525	0.67
61_D	486_S	0.525	0.67
437_R	441_L	0.525	0.67
250_Y	494_S	0.524	0.67
564_L	567_F	0.524	0.67
290_L	402_R	0.524	0.67
589_V	598_K	0.523	0.67
243_P	475_P	0.523	0.67
170_T	173_L	0.523	0.67
156_A	506_L	0.523	0.67
590_R	596_E	0.523	0.67
38_D	43_R	0.523	0.67
229_R	352_D	0.523	0.67
85_M	88_V	0.522	0.67
210_V	271_L	0.522	0.67
266_F	288_F	0.520	0.67
512_F	567_F	0.520	0.67
255_E	439_L	0.519	0.66
371_F	486_S	0.519	0.66
115_P	121_T	0.519	0.66
3_Y	49_A	0.518	0.66
596_E	599_R	0.518	0.66
343_P	437_R	0.518	0.66
263_F	314_A	0.517	0.66
92_P	98_K	0.517	0.66
206_V	289_L	0.517	0.66
62_E	79_L	0.517	0.66
78_Y	512_F	0.516	0.66
346_Y	435_T	0.516	0.66
138_I	305_D	0.516	0.66
588_V	592_T	0.515	0.66
211_R	393_R	0.515	0.66
203_A	598_K	0.515	0.66
540_G	543_A	0.515	0.66
212_P	215_G	0.515	0.66
128_A	262_K	0.514	0.66
131_V	199_E	0.514	0.66
398_S	401_Q	0.514	0.66
195_A	369_R	0.514	0.66
554_L	592_T	0.513	0.66
202_L	320_K	0.513	0.66
46_E	50_F	0.513	0.66
63_F	85_M	0.512	0.65
207_G	224_P	0.512	0.65
132_T	181_D	0.511	0.65
40_H	324_P	0.510	0.65
346_Y	437_R	0.510	0.65
68_E	480_L	0.510	0.65
100_T	177_E	0.510	0.65
34_D	40_H	0.510	0.65
10_Y	387_Y	0.510	0.65
29_L	39_P	0.509	0.65
496_V	530_S	0.508	0.65
193_L	210_V	0.508	0.65
598_K	602_P	0.508	0.65
165_L	304_A	0.507	0.65
579_A	605_G	0.507	0.65
15_G	30_G	0.506	0.64
209_V	220_P	0.506	0.64
28_R	31_L	0.506	0.64
350_S	390_A	0.506	0.64
185_F	269_T	0.505	0.64
15_G	19_A	0.505	0.64
438_D	473_R	0.505	0.64
125_F	194_A	0.505	0.64
179_G	182_R	0.505	0.64
140_E	210_V	0.504	0.64
208_V	226_S	0.504	0.64
572_E	586_Q	0.504	0.64
371_F	417_F	0.504	0.64
10_Y	22_Y	0.504	0.64
484_L	488_L	0.503	0.64
47_G	51_L	0.503	0.64
8_L	39_P	0.503	0.64
415_L	418_A	0.502	0.64
105_I	551_T	0.502	0.64
332_T	416_D	0.502	0.64
200_L	300_L	0.501	0.64
258_A	472_R	0.500	0.64
550_I	571_L	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4me7E	2	0.064	13.9	0.982	Contact Map
1h0hA	1	0.1527	10.9	0.983	Contact Map
3bmbA	1	0.1905	7.7	0.984	Contact Map
2cw1A	1	0.0985	6.9	0.984	Contact Map
2w9yA	1	0.1084	6.7	0.984	Contact Map
4bxhA	3	0.0673	6.5	0.984	Contact Map
3he5A	1	0.0263	5.8	0.985	Contact Map
1z21A	1	0.1527	5.7	0.985	Contact Map
1kqfA	3	0.179	5.7	0.985	Contact Map
3ibpA	2	0.0837	5	0.985	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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