T6SS_VasE - PFAM28P - GREMLIN Contacts

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T6SS_VasE - Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE

PFAM:	PF05936	Sequences: HFQQQDRYLEALLEFRARALSPYPWGFSELEIDEEALANGKLALRRASGVFPDGTPFDIPGDDPLPPPLDLPEPPGARDLTVYLALPLRRPGGANVADEDAADSLARYRAEEREVRDENSTGADEAPVQVARLNLRLLLEGEDRDGYVTLPIARVVRDRDGQVVLDPDFIPPCLDISASPRLAGLLRELLGLLRARAEALARRLRGPSGAGFGAADVADFLLLQTLNRYEPLLRHLLEAPGLHPERLYRELLRLAGELATFSLESRRPPDLPAYDHDDLGACFAPLDALLRRLLSTVLEQRAVSIPLEERKYGIYVARLPDRRLLRSARFVLAVRADMPAEELRRRFPAQVKIGSVERIRELVNLALPGIPLRHLPVPPRQIPYRAGYQYFELDRSGPLWEQLLRSGGIALHVPGEFPGLELELWAI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	427 (426)
Sequences:	4523 (3168)
Seq/√Len:	153.5
META:	0.725

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
278_D	281_A	5.958	1.00
29_E	46_R	4.772	1.00
154_R	166_D	3.839	1.00
337_D	419_G	3.742	1.00
305_I	317_A	3.591	1.00
49_G	57_F	3.579	1.00
85_A	138_L	3.485	1.00
193_L	226_L	3.398	1.00
59_I	65_L	3.324	1.00
232_L	253_R	3.267	1.00
81_T	151_P	3.248	1.00
275_D	278_D	3.241	1.00
151_P	169_F	3.241	1.00
246_R	249_R	3.046	1.00
32_I	42_L	2.989	1.00
31_E	46_R	2.956	1.00
250_E	253_R	2.807	1.00
31_E	45_R	2.645	1.00
81_T	154_R	2.615	1.00
82_V	139_L	2.593	1.00
279_L	282_C	2.580	1.00
83_Y	149_T	2.553	1.00
347_F	351_V	2.553	1.00
81_T	140_E	2.484	1.00
228_R	257_E	2.429	1.00
27_F	47_A	2.385	1.00
334_V	347_F	2.370	1.00
29_E	48_S	2.357	1.00
233_L	251_L	2.335	1.00
235_H	245_E	2.311	1.00
58_D	61_G	2.295	1.00
333_A	388_Y	2.292	1.00
51_F	135_L	2.267	1.00
55_T	86_L	2.228	1.00
42_L	153_A	2.226	1.00
112_E	127_P	2.221	1.00
111_E	132_R	2.220	1.00
271_L	289_L	2.124	1.00
34_E	167_P	2.110	1.00
185_L	287_D	2.075	1.00
197_A	226_L	2.055	1.00
151_P	154_R	2.015	1.00
358_R	402_Q	2.003	1.00
193_L	254_L	2.000	1.00
30_L	44_L	1.993	1.00
355_S	399_L	1.985	1.00
231_P	256_G	1.980	1.00
156_V	166_D	1.979	1.00
69_L	142_E	1.972	1.00
319_L	325_L	1.913	1.00
338_M	343_L	1.906	1.00
114_E	125_E	1.902	1.00
409_I	424_L	1.894	1.00
5_Q	9_L	1.889	1.00
307_L	317_A	1.877	1.00
186_L	247_L	1.870	1.00
144_R	149_T	1.863	1.00
309_E	315_Y	1.844	1.00
47_A	57_F	1.841	1.00
80_L	141_G	1.835	1.00
42_L	137_L	1.831	1.00
153_A	165_L	1.819	1.00
342_E	346_R	1.791	1.00
33_D	45_R	1.776	1.00
331_V	375_L	1.766	1.00
59_I	135_L	1.766	1.00
115_V	130_V	1.764	1.00
52_P	148_V	1.745	1.00
48_S	58_D	1.734	1.00
33_D	43_A	1.724	1.00
394_D	397_G	1.722	1.00
88_L	148_V	1.716	1.00
109_R	134_N	1.713	1.00
193_L	233_L	1.712	1.00
370_I	393_L	1.691	1.00
370_I	403_L	1.688	1.00
9_L	13_L	1.688	1.00
113_R	130_V	1.675	1.00
262_S	293_L	1.671	1.00
353_I	411_L	1.667	1.00
252_L	286_L	1.664	1.00
27_F	152_I	1.650	1.00
138_L	147_Y	1.638	1.00
170_I	179_S	1.608	1.00
169_F	172_P	1.605	1.00
85_A	149_T	1.581	1.00
115_V	128_V	1.571	1.00
198_E	267_R	1.564	1.00
47_A	59_I	1.563	1.00
6_D	9_L	1.535	1.00
170_I	279_L	1.522	1.00
289_L	292_R	1.522	1.00
154_R	280_G	1.521	1.00
317_A	409_I	1.517	1.00
335_R	421_E	1.515	1.00
229_Y	254_L	1.515	1.00
85_A	147_Y	1.498	1.00
329_R	392_E	1.494	1.00
280_G	284_A	1.478	1.00
47_A	84_L	1.477	1.00
36_A	43_A	1.470	1.00
192_L	291_R	1.466	1.00
41_K	70_D	1.463	1.00
114_E	127_P	1.455	1.00
138_L	144_R	1.455	1.00
176_I	186_L	1.436	1.00
229_Y	250_E	1.435	1.00
197_A	230_E	1.435	1.00
8_Y	12_L	1.426	1.00
97_A	106_A	1.424	1.00
371_P	397_G	1.418	1.00
194_R	230_E	1.417	1.00
255_A	271_L	1.416	1.00
397_G	401_E	1.411	1.00
361_E	365_L	1.403	1.00
353_I	393_L	1.398	1.00
14_E	18_R	1.394	1.00
236_L	250_E	1.392	1.00
284_A	288_A	1.390	1.00
53_D	148_V	1.388	1.00
31_E	34_E	1.384	1.00
232_L	250_E	1.359	1.00
168_D	284_A	1.358	1.00
83_Y	140_E	1.357	1.00
334_V	422_L	1.356	1.00
170_I	280_G	1.352	1.00
403_L	409_I	1.348	1.00
28_S	48_S	1.336	1.00
110_A	129_Q	1.314	1.00
401_E	404_L	1.312	1.00
335_R	388_Y	1.310	1.00
358_R	361_E	1.308	1.00
344_R	374_H	1.303	1.00
27_F	30_L	1.301	1.00
326_R	404_L	1.299	1.00
27_F	150_L	1.274	1.00
371_P	394_D	1.269	1.00
169_F	279_L	1.265	1.00
271_L	286_L	1.263	1.00
156_V	164_V	1.255	1.00
354_G	362_L	1.250	1.00
182_L	283_F	1.239	1.00
25_W	277_D	1.237	1.00
373_R	392_E	1.236	1.00
248_Y	282_C	1.236	1.00
42_L	82_V	1.234	1.00
21_S	246_R	1.227	1.00
352_K	367_L	1.226	1.00
356_V	408_G	1.218	1.00
289_L	293_L	1.215	1.00
74_P	77_A	1.198	1.00
353_I	372_L	1.196	1.00
310_R	316_V	1.189	1.00
170_I	182_L	1.177	1.00
245_E	249_R	1.173	1.00
248_Y	273_A	1.167	1.00
190_L	234_R	1.165	1.00
90_R	93_G	1.160	1.00
79_D	154_R	1.158	1.00
89_R	95_N	1.156	1.00
49_G	150_L	1.156	1.00
80_L	139_L	1.154	1.00
189_L	287_D	1.149	1.00
32_I	165_L	1.146	1.00
121_T	124_D	1.142	1.00
69_L	139_L	1.136	1.00
227_N	260_T	1.133	1.00
247_L	251_L	1.131	1.00
243_H	274_Y	1.125	1.00
88_L	146_G	1.119	1.00
264_E	292_R	1.119	1.00
32_I	44_L	1.119	1.00
334_V	343_L	1.116	1.00
357_E	406_S	1.115	0.99
188_E	287_D	1.100	0.99
170_I	181_R	1.098	0.99
288_A	292_R	1.093	0.99
86_L	133_L	1.088	0.99
46_R	61_G	1.087	0.99
72_P	77_A	1.086	0.99
238_E	273_A	1.074	0.99
402_Q	405_R	1.073	0.99
42_L	165_L	1.070	0.99
230_E	267_R	1.070	0.99
281_A	285_P	1.065	0.99
86_L	135_L	1.061	0.99
399_L	402_Q	1.060	0.99
63_D	133_L	1.058	0.99
308_E	318_R	1.054	0.99
173_C	179_S	1.054	0.99
112_E	129_Q	1.054	0.99
255_A	286_L	1.035	0.99
49_G	84_L	1.034	0.99
189_L	233_L	1.033	0.99
82_V	137_L	1.028	0.99
27_F	49_G	1.028	0.99
336_A	343_L	1.026	0.99
252_L	271_L	1.026	0.99
85_A	136_R	1.025	0.99
70_D	73_E	1.024	0.99
324_L	328_A	1.024	0.99
141_G	144_R	1.021	0.99
223_L	227_N	1.016	0.99
413_V	422_L	1.010	0.99
374_H	389_Q	1.008	0.99
68_P	88_L	1.002	0.99
173_C	178_A	1.000	0.99
69_L	82_V	0.998	0.99
55_T	133_L	0.992	0.99
181_R	284_A	0.991	0.99
248_Y	252_L	0.990	0.99
143_D	149_T	0.990	0.99
351_V	372_L	0.987	0.99
356_V	359_I	0.984	0.99
60_P	63_D	0.979	0.99
385_R	388_Y	0.979	0.99
44_L	59_I	0.978	0.99
225_T	257_E	0.978	0.99
139_L	142_E	0.976	0.99
71_L	155_V	0.975	0.99
309_E	312_Y	0.975	0.99
411_L	424_L	0.970	0.99
285_P	288_A	0.966	0.99
339_P	342_E	0.964	0.99
353_I	409_I	0.961	0.98
57_F	135_L	0.959	0.98
239_A	242_L	0.957	0.98
96_V	110_A	0.956	0.98
360_R	364_N	0.947	0.98
230_E	234_R	0.943	0.98
358_R	399_L	0.933	0.98
69_L	137_L	0.932	0.98
155_V	165_L	0.932	0.98
334_V	420_L	0.932	0.98
83_Y	144_R	0.924	0.98
187_R	237_L	0.924	0.98
188_E	291_R	0.923	0.98
357_E	408_G	0.918	0.98
243_H	276_H	0.917	0.98
359_I	410_A	0.916	0.98
173_C	279_L	0.915	0.98
13_L	16_R	0.912	0.98
23_Y	239_A	0.911	0.98
32_I	153_A	0.910	0.98
287_D	291_R	0.902	0.98
354_G	358_R	0.899	0.98
331_V	427_I	0.897	0.98
7_R	118_E	0.893	0.98
395_R	400_W	0.890	0.98
19_A	28_S	0.884	0.97
275_D	281_A	0.884	0.97
27_F	173_C	0.883	0.97
172_P	279_L	0.881	0.97
96_V	119_N	0.878	0.97
194_R	234_R	0.877	0.97
38_A	162_Q	0.877	0.97
225_T	254_L	0.877	0.97
214_A	217_V	0.876	0.97
354_G	364_N	0.872	0.97
80_L	140_E	0.871	0.97
44_L	137_L	0.871	0.97
25_W	150_L	0.869	0.97
321_D	325_L	0.868	0.97
136_R	147_Y	0.868	0.97
272_P	285_P	0.868	0.97
50_V	56_P	0.863	0.97
11_A	15_F	0.859	0.97
159_R	162_Q	0.854	0.97
60_P	66_P	0.853	0.97
302_A	383_P	0.853	0.97
316_V	356_V	0.852	0.97
121_T	125_E	0.851	0.97
362_L	369_G	0.851	0.97
356_V	410_A	0.849	0.97
82_V	155_V	0.848	0.97
352_K	366_A	0.843	0.97
359_I	363_V	0.841	0.97
42_L	71_L	0.841	0.97
137_L	152_I	0.841	0.97
96_V	131_A	0.837	0.96
341_E	345_R	0.830	0.96
53_D	107_R	0.830	0.96
356_V	360_R	0.829	0.96
83_Y	151_P	0.825	0.96
234_R	238_E	0.822	0.96
248_Y	271_L	0.821	0.96
99_E	102_A	0.820	0.96
373_R	394_D	0.820	0.96
6_D	10_E	0.818	0.96
81_T	169_F	0.815	0.96
16_R	50_V	0.815	0.96
64_P	132_R	0.814	0.96
358_R	365_L	0.814	0.96
173_C	176_I	0.814	0.96
244_P	274_Y	0.813	0.96
77_A	139_L	0.811	0.96
375_L	378_P	0.810	0.96
27_F	57_F	0.809	0.96
221_L	224_Q	0.801	0.95
197_A	267_R	0.800	0.95
224_Q	257_E	0.799	0.95
302_A	425_W	0.796	0.95
102_A	109_R	0.796	0.95
323_R	326_R	0.796	0.95
295_S	299_E	0.795	0.95
79_D	140_E	0.794	0.95
255_A	289_L	0.794	0.95
346_R	349_A	0.794	0.95
65_L	135_L	0.790	0.95
340_A	344_R	0.788	0.95
193_L	197_A	0.784	0.95
229_Y	253_R	0.784	0.95
338_M	417_F	0.783	0.95
111_E	130_V	0.783	0.95
30_L	152_I	0.782	0.95
183_A	237_L	0.779	0.95
316_V	408_G	0.777	0.95
44_L	65_L	0.775	0.95
12_L	56_P	0.775	0.95
197_A	227_N	0.774	0.94
387_G	392_E	0.773	0.94
282_C	285_P	0.773	0.94
49_G	135_L	0.770	0.94
388_Y	421_E	0.768	0.94
374_H	378_P	0.768	0.94
223_L	260_T	0.763	0.94
58_D	62_D	0.762	0.94
307_L	411_L	0.762	0.94
158_D	164_V	0.761	0.94
4_Q	7_R	0.760	0.94
357_E	364_N	0.759	0.94
285_P	289_L	0.756	0.94
329_R	381_Q	0.752	0.94
179_S	182_L	0.751	0.94
249_R	252_L	0.750	0.94
175_D	241_G	0.748	0.93
357_E	402_Q	0.745	0.93
192_L	196_R	0.745	0.93
232_L	249_R	0.744	0.93
23_Y	245_E	0.740	0.93
169_F	277_D	0.738	0.93
304_S	423_E	0.736	0.93
19_A	56_P	0.735	0.93
332_L	393_L	0.734	0.93
67_P	70_D	0.733	0.93
398_P	401_E	0.733	0.93
220_F	363_V	0.731	0.93
105_L	112_E	0.730	0.93
28_S	174_L	0.729	0.93
83_Y	143_D	0.727	0.92
415_G	418_P	0.725	0.92
255_A	259_A	0.725	0.92
281_A	284_A	0.724	0.92
51_F	57_F	0.718	0.92
379_P	390_Y	0.717	0.92
413_V	417_F	0.716	0.92
18_R	21_S	0.716	0.92
177_S	241_G	0.710	0.92
377_V	380_R	0.708	0.91
35_E	45_R	0.707	0.91
238_E	275_D	0.706	0.91
172_P	179_S	0.704	0.91
94_A	119_N	0.702	0.91
109_R	132_R	0.701	0.91
408_G	411_L	0.700	0.91
170_I	173_C	0.698	0.91
357_E	361_E	0.698	0.91
380_R	384_Y	0.696	0.91
372_L	413_V	0.695	0.91
259_A	293_L	0.693	0.91
158_D	161_G	0.693	0.91
236_L	242_L	0.693	0.91
67_P	71_L	0.692	0.90
190_L	233_L	0.686	0.90
222_L	297_V	0.683	0.90
331_V	382_I	0.682	0.90
344_R	348_P	0.676	0.89
60_P	65_L	0.675	0.89
216_D	220_F	0.675	0.89
173_C	182_L	0.675	0.89
272_P	282_C	0.675	0.89
9_L	12_L	0.672	0.89
71_L	163_V	0.672	0.89
140_E	151_P	0.670	0.89
174_L	279_L	0.667	0.89
138_L	142_E	0.667	0.89
393_L	424_L	0.665	0.89
361_E	364_N	0.664	0.89
275_D	282_C	0.663	0.89
176_I	183_A	0.662	0.88
49_G	59_I	0.662	0.88
183_A	187_R	0.661	0.88
342_E	345_R	0.661	0.88
223_L	324_L	0.659	0.88
322_R	326_R	0.657	0.88
35_E	39_N	0.656	0.88
244_P	276_H	0.653	0.88
202_R	212_F	0.652	0.88
217_V	221_L	0.651	0.88
338_M	342_E	0.648	0.87
47_A	152_I	0.648	0.87
16_R	56_P	0.648	0.87
155_V	163_V	0.648	0.87
231_P	250_E	0.648	0.87
341_E	344_R	0.647	0.87
4_Q	115_V	0.646	0.87
179_S	183_A	0.646	0.87
399_L	403_L	0.644	0.87
43_A	68_P	0.644	0.87
252_L	282_C	0.643	0.87
398_P	402_Q	0.643	0.87
175_D	236_L	0.641	0.87
5_Q	8_Y	0.641	0.87
377_V	384_Y	0.639	0.87
44_L	47_A	0.637	0.86
255_A	290_L	0.637	0.86
31_E	152_I	0.637	0.86
176_I	247_L	0.636	0.86
215_A	225_T	0.635	0.86
136_R	142_E	0.635	0.86
207_P	214_A	0.633	0.86
418_P	422_L	0.631	0.86
37_L	163_V	0.629	0.86
177_S	238_E	0.628	0.86
51_F	148_V	0.628	0.86
403_L	408_G	0.627	0.86
87_P	138_L	0.627	0.86
143_D	147_Y	0.627	0.86
120_S	125_E	0.626	0.86
153_A	258_L	0.625	0.85
218_A	296_T	0.624	0.85
189_L	251_L	0.624	0.85
204_L	211_G	0.623	0.85
3_Q	6_D	0.620	0.85
120_S	123_A	0.619	0.85
84_L	135_L	0.619	0.85
246_R	250_E	0.618	0.85
346_R	350_Q	0.618	0.85
354_G	399_L	0.618	0.85
321_D	324_L	0.617	0.85
160_D	184_G	0.617	0.85
324_L	426_A	0.617	0.85
95_N	118_E	0.615	0.85
407_G	414_P	0.614	0.84
196_R	301_R	0.614	0.84
79_D	157_R	0.614	0.84
345_R	349_A	0.613	0.84
79_D	156_V	0.613	0.84
57_F	133_L	0.613	0.84
86_L	148_V	0.611	0.84
222_L	366_A	0.611	0.84
186_L	190_L	0.610	0.84
401_E	405_R	0.610	0.84
138_L	149_T	0.608	0.84
269_P	289_L	0.608	0.84
137_L	165_L	0.608	0.84
400_W	403_L	0.607	0.84
228_R	253_R	0.607	0.84
227_N	261_F	0.605	0.84
17_A	20_L	0.604	0.83
229_Y	270_D	0.604	0.83
352_K	359_I	0.604	0.83
355_S	358_R	0.604	0.83
238_E	252_L	0.603	0.83
297_V	300_Q	0.603	0.83
381_Q	427_I	0.602	0.83
262_S	296_T	0.600	0.83
21_S	162_Q	0.599	0.83
84_L	87_P	0.599	0.83
411_L	420_L	0.599	0.83
370_I	395_R	0.599	0.83
7_R	53_D	0.598	0.83
69_L	73_E	0.598	0.83
335_R	387_G	0.598	0.83
78_R	195_A	0.598	0.83
110_A	259_A	0.596	0.83
44_L	152_I	0.593	0.82
119_N	122_G	0.592	0.82
313_G	363_V	0.591	0.82
177_S	183_A	0.590	0.82
185_L	189_L	0.590	0.82
175_D	240_P	0.589	0.82
314_I	359_I	0.589	0.82
30_L	47_A	0.588	0.82
64_P	67_P	0.585	0.81
2_F	119_N	0.585	0.81
113_R	241_G	0.585	0.81
322_R	407_G	0.585	0.81
39_N	191_G	0.583	0.81
190_L	230_E	0.583	0.81
257_E	260_T	0.583	0.81
150_L	172_P	0.582	0.81
360_R	363_V	0.580	0.81
393_L	403_L	0.580	0.81
313_G	360_R	0.579	0.81
55_T	107_R	0.579	0.81
21_S	24_P	0.578	0.81
278_D	282_C	0.577	0.81
77_A	80_L	0.575	0.80
186_L	292_R	0.575	0.80
101_A	104_S	0.575	0.80
363_V	366_A	0.574	0.80
312_Y	315_Y	0.574	0.80
139_L	153_A	0.573	0.80
151_P	277_D	0.571	0.80
63_D	66_P	0.570	0.80
211_G	215_A	0.569	0.80
236_L	240_P	0.568	0.80
120_S	124_D	0.568	0.80
199_A	300_Q	0.566	0.79
51_F	150_L	0.566	0.79
67_P	73_E	0.566	0.79
325_L	330_F	0.566	0.79
15_F	58_D	0.565	0.79
316_V	410_A	0.565	0.79
13_L	17_A	0.565	0.79
42_L	51_F	0.564	0.79
382_I	425_W	0.564	0.79
279_L	284_A	0.564	0.79
197_A	313_G	0.563	0.79
156_V	168_D	0.562	0.79
308_E	316_V	0.562	0.79
145_D	215_A	0.562	0.79
201_A	227_N	0.562	0.79
338_M	346_R	0.561	0.79
176_I	242_L	0.561	0.79
84_L	152_I	0.561	0.79
207_P	213_G	0.560	0.79
213_G	216_D	0.558	0.78
15_F	56_P	0.558	0.78
312_Y	364_N	0.557	0.78
206_G	220_F	0.557	0.78
27_F	169_F	0.557	0.78
46_R	167_P	0.556	0.78
138_L	304_S	0.554	0.78
73_E	77_A	0.553	0.78
355_S	403_L	0.553	0.78
381_Q	384_Y	0.552	0.78
310_R	318_R	0.552	0.78
125_E	233_L	0.551	0.77
203_R	215_A	0.549	0.77
344_R	354_G	0.549	0.77
412_H	420_L	0.547	0.77
171_P	279_L	0.546	0.77
171_P	178_A	0.545	0.77
204_L	207_P	0.545	0.77
220_F	245_E	0.545	0.77
224_Q	261_F	0.543	0.76
222_L	226_L	0.543	0.76
84_L	150_L	0.542	0.76
127_P	337_D	0.541	0.76
231_P	268_P	0.539	0.76
210_A	214_A	0.538	0.76
175_D	239_A	0.538	0.76
139_L	155_V	0.538	0.76
151_P	172_P	0.537	0.76
57_F	84_L	0.537	0.76
128_V	361_E	0.536	0.76
105_L	155_V	0.536	0.76
314_I	364_N	0.535	0.75
405_R	409_I	0.535	0.75
347_F	413_V	0.534	0.75
372_L	393_L	0.534	0.75
2_F	5_Q	0.533	0.75
259_A	267_R	0.533	0.75
122_G	125_E	0.532	0.75
117_D	124_D	0.532	0.75
16_R	19_A	0.532	0.75
4_Q	128_V	0.532	0.75
1_H	26_G	0.531	0.75
242_L	246_R	0.530	0.75
305_I	409_I	0.530	0.75
186_L	239_A	0.528	0.74
328_A	426_A	0.528	0.74
191_G	195_A	0.528	0.74
311_K	408_G	0.526	0.74
159_R	164_V	0.525	0.74
167_P	184_G	0.525	0.74
146_G	275_D	0.524	0.74
220_F	227_N	0.523	0.74
262_S	298_L	0.523	0.74
115_V	127_P	0.523	0.74
386_A	389_Q	0.523	0.74
10_E	133_L	0.523	0.74
14_E	146_G	0.522	0.74
393_L	396_S	0.522	0.74
362_L	375_L	0.522	0.74
36_A	41_K	0.521	0.74
220_F	261_F	0.521	0.74
230_E	400_W	0.521	0.74
374_H	391_F	0.521	0.74
216_D	222_L	0.520	0.73
123_A	147_Y	0.520	0.73
185_L	233_L	0.520	0.73
324_L	330_F	0.520	0.73
395_R	404_L	0.517	0.73
220_F	225_T	0.517	0.73
214_A	218_A	0.517	0.73
59_I	382_I	0.517	0.73
205_R	216_D	0.517	0.73
49_G	131_A	0.517	0.73
194_R	198_E	0.516	0.73
419_G	425_W	0.516	0.73
109_R	168_D	0.516	0.73
354_G	359_I	0.516	0.73
278_D	284_A	0.516	0.73
413_V	420_L	0.515	0.73
71_L	139_L	0.515	0.73
353_I	403_L	0.513	0.72
343_L	347_F	0.512	0.72
407_G	420_L	0.512	0.72
271_L	282_C	0.512	0.72
8_Y	11_A	0.511	0.72
29_E	45_R	0.511	0.72
2_F	148_V	0.510	0.72
261_F	351_V	0.509	0.72
1_H	6_D	0.509	0.72
58_D	411_L	0.508	0.72
10_E	20_L	0.508	0.72
28_S	175_D	0.508	0.72
117_D	379_P	0.507	0.72
224_Q	260_T	0.507	0.72
91_P	162_Q	0.506	0.71
259_A	289_L	0.506	0.71
383_P	390_Y	0.506	0.71
6_D	13_L	0.506	0.71
252_L	416_E	0.505	0.71
14_E	56_P	0.505	0.71
388_Y	423_E	0.504	0.71
370_I	399_L	0.504	0.71
153_A	169_F	0.504	0.71
118_E	131_A	0.502	0.71
344_R	389_Q	0.502	0.71
211_G	214_A	0.502	0.71
352_K	365_L	0.501	0.71
89_R	118_E	0.501	0.71
380_R	427_I	0.500	0.70
370_I	397_G	0.500	0.70
74_P	80_L	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lpeA	1	0.1944	12.3	0.974	Contact Map
2l3lA	1	0.26	7.6	0.976	Contact Map
2re7A	2	0.1944	4.3	0.979	Contact Map
1o9aB	1	0.0562	4.2	0.979	Contact Map
3dmbA	5	0.1967	4.1	0.979	Contact Map
3ec6A	2	0.1827	3.9	0.979	Contact Map
2nr4A	2	0.1733	3.5	0.979	Contact Map
2i02A	2	0.1874	3.5	0.979	Contact Map
2ol5A	2	0.185	3.4	0.98	Contact Map
2fhqA	2	0.192	3.4	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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