GREMLIN Database
Ebp2 - Eukaryotic rRNA processing protein EBP2
PFAM: PF05890 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 268 (266)
Sequences: 543 (407)
Seq/√Len: 24.9
META: 0.136

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_G268_R3.6451.00
5_E8_D3.6171.00
263_P268_R2.9951.00
145_G156_R2.9531.00
132_S136_R2.9531.00
251_G254_G2.9161.00
262_R268_R2.8120.99
265_K268_R2.7100.99
201_K205_G2.6920.99
138_Q141_L2.5450.99
155_E159_E2.5400.99
261_K267_R2.3620.98
91_L96_V2.2940.98
148_V156_R2.2690.98
203_K206_G2.2130.97
50_W54_L2.1900.97
262_R265_K2.1630.97
70_L125_E2.1480.97
6_L11_D2.0580.96
139_R149_Q2.0260.95
231_G234_S2.0160.95
27_K95_G1.9840.95
7_S10_E1.9690.94
39_K42_R1.9500.94
228_K231_G1.9440.94
4_I8_D1.9340.94
132_S139_R1.8770.93
141_L145_G1.8430.92
235_N238_E1.8350.92
2_E5_E1.8130.91
157_Q161_K1.7540.90
163_T167_I1.7530.90
6_L9_L1.7330.90
254_G259_K1.7160.89
135_A141_L1.7080.89
256_K259_K1.6970.88
158_K162_E1.6780.88
166_K173_K1.6600.87
237_A241_N1.6500.87
136_R140_E1.6280.86
135_A138_Q1.6010.85
256_K260_K1.5790.85
69_D76_F1.5650.84
85_L89_P1.5370.83
126_A130_K1.5360.83
157_Q160_K1.5300.83
90_L94_L1.5280.82
242_D246_F1.5190.82
224_G227_G1.5140.82
69_D104_Y1.5100.82
185_D232_S1.5070.82
152_K156_R1.4510.79
199_K202_K1.4500.79
56_V123_L1.4480.79
14_L18_E1.4460.79
186_D190_V1.4430.79
15_E18_E1.4430.79
213_N220_D1.4330.78
226_G229_K1.4300.78
69_D72_R1.4210.78
198_K201_K1.4120.77
4_I7_S1.3920.76
84_V117_K1.3810.75
86_E90_L1.3780.75
257_K260_K1.3660.75
153_L156_R1.3640.75
88_R98_F1.3600.74
128_A132_S1.3580.74
23_H28_L1.3540.74
35_A43_I1.3480.74
201_K206_G1.3440.73
202_K259_K1.3430.73
132_S135_A1.3400.73
43_I267_R1.3350.73
148_V151_E1.3340.73
54_L96_V1.3330.73
57_T95_G1.3320.73
202_K205_G1.3250.72
201_K204_G1.3170.72
111_S225_F1.3120.72
10_E13_E1.3020.71
50_W131_A1.2970.71
65_D77_Y1.2920.70
246_F256_K1.2860.70
12_G15_E1.2840.70
110_K114_H1.2820.70
91_L94_L1.2770.69
131_A135_A1.2760.69
150_V154_Q1.2720.69
185_D247_S1.2630.69
165_E168_K1.2500.68
48_L56_V1.2500.68
152_K155_E1.2370.67
8_D12_G1.2350.67
135_A139_R1.2350.67
2_E266_S1.2270.66
56_V86_E1.2200.66
124_D127_A1.2090.65
199_K203_K1.2010.65
41_E44_K1.1950.64
218_A221_A1.1800.63
252_G255_G1.1780.63
207_G210_G1.1780.63
52_E112_D1.1740.63
84_V188_F1.1540.61
212_P220_D1.1520.61
165_E263_P1.1420.61
216_R220_D1.1400.60
137_K142_K1.1340.60
121_K141_L1.1300.60
249_K267_R1.1220.59
32_N137_K1.1190.59
114_H128_A1.1110.58
136_R174_R1.1100.58
118_I194_D1.1060.58
93_K111_S1.0960.57
12_G17_G1.0940.57
253_G256_K1.0880.57
90_L143_K1.0870.57
19_D22_P1.0820.56
65_D68_D1.0810.56
9_L12_G1.0800.56
156_R173_K1.0700.56
122_L161_K1.0640.55
33_K80_A1.0590.55
194_D256_K1.0530.54
104_Y139_R1.0520.54
263_P266_S1.0470.54
87_A173_K1.0450.54
230_R239_S1.0430.54
51_I133_E1.0420.54
68_D71_K1.0400.53
81_L155_E1.0390.53
147_Q151_E1.0330.53
39_K171_K1.0250.52
81_L85_L1.0250.52
206_G209_K1.0200.52
78_K85_L1.0190.52
7_S12_G1.0160.52
166_K170_L1.0140.52
135_A171_K1.0060.51
33_K36_L1.0050.51
85_L154_Q1.0040.51
56_V83_A1.0030.51
50_W80_A0.9990.50
177_L180_L0.9980.50
45_L87_A0.9920.50
145_G149_Q0.9880.50
67_N120_Q0.9870.50
210_G213_N0.9800.49
184_D187_E0.9780.49
36_L111_S0.9760.49
182_D207_G0.9740.49
81_L98_F0.9730.49
118_I175_K0.9730.49
10_E17_G0.9690.48
114_H123_L0.9680.48
32_N170_L0.9680.48
88_R136_R0.9670.48
132_S145_G0.9500.47
74_L77_Y0.9480.47
168_K171_K0.9480.47
42_R50_W0.9460.47
242_D245_G0.9450.47
70_L98_F0.9440.46
93_K120_Q0.9410.46
227_G239_S0.9400.46
63_I66_V0.9350.46
210_G261_K0.9310.46
144_F148_V0.9300.45
198_K203_K0.9290.45
112_D122_L0.9290.45
162_E237_A0.9290.45
6_L20_V0.9280.45
79_Q168_K0.9240.45
77_Y87_A0.9210.45
65_D81_L0.9150.44
75_A170_L0.9140.44
172_K176_G0.9080.44
215_K219_K0.9010.43
88_R131_A0.8990.43
104_Y149_Q0.8990.43
57_T167_I0.8900.43
245_G248_A0.8870.42
203_K207_G0.8870.42
32_N35_A0.8850.42
251_G257_K0.8800.42
118_I191_A0.8780.42
79_Q235_N0.8780.42
114_H161_K0.8750.42
7_S19_D0.8740.41
46_K80_A0.8730.41
77_Y110_K0.8720.41
118_I127_A0.8660.41
5_E9_L0.8610.41
60_P191_A0.8570.40
81_L125_E0.8550.40
243_F247_S0.8520.40
56_V65_D0.8520.40
123_L127_A0.8450.39
64_D251_G0.8370.39
199_K205_G0.8350.39
66_V79_Q0.8350.39
243_F246_F0.8330.39
81_L159_E0.8320.39
129_I135_A0.8250.38
216_R226_G0.8200.38
119_K145_G0.8190.38
22_P27_K0.8160.37
51_I94_L0.8150.37
200_K206_G0.8130.37
139_R145_G0.8100.37
213_N216_R0.8090.37
10_E16_P0.8080.37
39_K54_L0.8060.37
29_T50_W0.8020.37
225_F229_K0.8010.36
124_D219_K0.7980.36
230_R242_D0.7970.36
255_G260_K0.7940.36
50_W53_H0.7940.36
216_R219_K0.7930.36
200_K203_K0.7910.36
144_F151_E0.7870.36
214_K217_Q0.7850.35
111_S184_D0.7850.35
160_K227_G0.7840.35
133_E236_T0.7820.35
70_L152_K0.7810.35
13_E16_P0.7730.35
187_E225_F0.7650.34
130_K144_F0.7640.34
213_N219_K0.7640.34
52_E101_P0.7600.34
237_A240_S0.7580.34
236_T239_S0.7570.34
30_I236_T0.7550.33
135_A147_Q0.7500.33
246_F250_K0.7480.33
57_T148_V0.7480.33
79_Q155_E0.7480.33
152_K234_S0.7480.33
130_K166_K0.7470.33
213_N246_F0.7470.33
84_V89_P0.7460.33
117_K160_K0.7440.33
98_F139_R0.7400.32
34_A161_K0.7340.32
162_E245_G0.7340.32
36_L155_E0.7330.32
154_Q167_I0.7330.32
253_G259_K0.7310.32
44_K237_A0.7300.32
264_G267_R0.7250.32
22_P25_P0.7210.31
105_F145_G0.7180.31
56_V213_N0.7160.31
78_K98_F0.7160.31
95_G221_A0.7150.31
64_D87_A0.7150.31
81_L134_E0.7130.31
117_K243_F0.7120.31
116_E119_K0.7090.31
54_L80_A0.7080.30
136_R194_D0.7060.30
130_K134_E0.7030.30
6_L12_G0.6980.30
222_K225_F0.6950.30
50_W126_A0.6940.30
192_V195_A0.6920.29
121_K143_K0.6870.29
161_K240_S0.6860.29
215_K224_G0.6860.29
135_A170_L0.6830.29
139_R170_L0.6810.29
40_L95_G0.6800.29
140_E242_D0.6800.29
98_F156_R0.6770.29
8_D11_D0.6740.28
200_K205_G0.6710.28
40_L68_D0.6700.28
38_A42_R0.6700.28
11_D49_P0.6670.28
93_K254_G0.6670.28
41_E92_K0.6650.28
67_N77_Y0.6650.28
68_D75_A0.6640.28
118_I224_G0.6640.28
155_E216_R0.6630.28
174_R230_R0.6630.28
209_K243_F0.6550.27
2_E111_S0.6500.27
75_A119_K0.6500.27
149_Q224_G0.6500.27
74_L121_K0.6470.27
94_L234_S0.6440.27
39_K53_H0.6420.27
126_A166_K0.6420.27
2_E258_G0.6420.27
199_K210_G0.6380.26
94_L155_E0.6370.26
32_N129_I0.6370.26
80_A87_A0.6330.26
244_S250_K0.6320.26
100_R107_E0.6310.26
250_K253_G0.6300.26
120_Q124_D0.6280.26
7_S151_E0.6250.26
233_K236_T0.6230.26
254_G257_K0.6190.25
26_Q35_A0.6180.25
199_K206_G0.6180.25
37_K94_L0.6170.25
68_D248_A0.6160.25
86_E94_L0.6100.25
99_S102_D0.6060.25
135_A166_K0.6060.25
203_K248_A0.6050.25
147_Q170_L0.6050.25
222_K226_G0.6050.25
74_L144_F0.6040.24
137_K156_R0.6030.24
60_P118_I0.6020.24
253_G260_K0.6010.24
54_L123_L0.6010.24
151_E163_T0.5990.24
10_E102_D0.5970.24
202_K207_G0.5960.24
161_K256_K0.5940.24
134_E180_L0.5920.24
252_G259_K0.5920.24
120_Q261_K0.5920.24
124_D128_A0.5910.24
137_K140_E0.5900.24
75_A81_L0.5890.24
225_F228_K0.5880.24
68_D192_V0.5860.24
99_S105_F0.5860.24
105_F174_R0.5840.23
2_E9_L0.5840.23
197_K202_K0.5830.23
180_L237_A0.5820.23
70_L155_E0.5820.23
56_V96_V0.5810.23
136_R147_Q0.5800.23
254_G260_K0.5800.23
93_K242_D0.5800.23
50_W236_T0.5790.23
84_V263_P0.5780.23
14_L111_S0.5770.23
67_N71_K0.5740.23
121_K158_K0.5720.23
53_H84_V0.5710.23
33_K257_K0.5700.23
12_G18_E0.5650.22
59_D66_V0.5620.22
6_L14_L0.5610.22
95_G171_K0.5590.22
98_F121_K0.5590.22
43_I249_K0.5580.22
159_E172_K0.5530.22
136_R149_Q0.5470.22
182_D210_G0.5470.22
100_R112_D0.5470.22
207_G256_K0.5460.22
43_I165_E0.5450.21
236_T240_S0.5440.21
153_L157_Q0.5430.21
19_D234_S0.5430.21
150_V158_K0.5420.21
77_Y114_H0.5410.21
40_L57_T0.5410.21
215_K267_R0.5360.21
73_E106_A0.5350.21
58_S82_A0.5350.21
196_K202_K0.5340.21
252_G257_K0.5340.21
97_P208_K0.5310.21
90_L123_L0.5280.21
31_N135_A0.5270.21
256_K266_S0.5240.20
190_V218_A0.5230.20
143_K160_K0.5230.20
70_L140_E0.5220.20
57_T138_Q0.5210.20
214_K223_F0.5200.20
118_I211_K0.5180.20
166_K174_R0.5160.20
246_F249_K0.5130.20
119_K128_A0.5110.20
222_K227_G0.5100.20
59_D148_V0.5090.20
105_F211_K0.5070.20
153_L211_K0.5050.20
3_D159_E0.5050.20
145_G151_E0.5030.19
23_H263_P0.5020.19
27_K246_F0.5000.19
149_Q219_K0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l3oA 1 0.3545 29.9 0.962 Contact Map
2r6aC 1 0.4776 8.7 0.97 Contact Map
2ffsA 2 0.347 6.4 0.972 Contact Map
1jliA 1 0.3134 6.2 0.972 Contact Map
1lv4A 1 0.0784 4.8 0.973 Contact Map
2xz3A 3 0.3694 4.3 0.974 Contact Map
1jg7A 1 0.2873 3.8 0.975 Contact Map
3j20B 1 0.3657 3.3 0.975 Contact Map
4kblA 2 0.0037 3.1 0.976 Contact Map
4uabA 2 0.3172 3 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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