GREMLIN Database
DUF846 - Eukaryotic protein of unknown function (DUF846)
PFAM: PF05832 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (138)
Sequences: 723 (504)
Seq/√Len: 42.9
META: 0.386

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_F11_F5.0161.00
18_L22_F3.7661.00
41_L125_A3.7491.00
66_D72_H3.3551.00
39_L43_A3.1081.00
5_A55_L2.9111.00
66_D70_E2.8011.00
11_F15_A2.5531.00
86_P90_R2.4651.00
63_N71_S2.2621.00
107_A119_L2.2551.00
9_H52_T2.2281.00
20_Y110_A2.1961.00
19_V23_G2.1791.00
62_W76_E2.1340.99
17_I102_L2.0150.99
6_L56_L1.9730.99
60_R76_E1.8580.99
5_A8_F1.7600.98
14_A21_L1.7410.98
47_T52_T1.7390.98
94_L98_V1.7120.98
88_D97_Y1.7100.98
19_V33_I1.7050.97
131_A135_G1.6670.97
112_L138_K1.6330.97
109_V113_S1.5030.95
34_F121_L1.4600.94
37_V121_L1.4320.93
54_R76_E1.4130.93
77_S88_D1.3700.92
54_R60_R1.3360.90
9_H95_A1.3140.90
41_L126_L1.3130.90
107_A122_V1.3120.90
105_V108_I1.2970.89
46_W51_V1.2810.88
12_F16_A1.2440.87
14_A19_V1.2330.86
23_G33_I1.2310.86
80_P85_N1.2260.86
45_F50_N1.2160.86
63_N73_W1.2100.85
131_A136_Y1.2020.85
6_L88_D1.2020.85
45_F49_K1.1760.84
65_V69_G1.1750.84
9_H13_K1.1740.84
42_A51_V1.1720.84
8_F11_F1.1640.83
77_S95_A1.1470.82
73_W76_E1.1320.81
134_Y137_T1.1260.81
54_R62_W1.0970.79
13_K48_V1.0960.79
106_L109_V1.0910.79
69_G73_W1.0780.78
12_F73_W1.0770.78
32_L36_I1.0730.78
97_Y137_T1.0600.77
118_W121_L1.0460.76
106_L122_V1.0450.76
38_I42_A1.0310.75
38_I116_F1.0270.75
25_L28_S1.0260.74
14_A18_L1.0140.74
107_A111_L1.0120.73
2_H5_A1.0120.73
104_V107_A0.9980.72
104_V126_L0.9860.71
49_K61_W0.9770.71
16_A52_T0.9750.71
89_S101_V0.9710.70
77_S127_V0.9660.70
48_V99_T0.9630.70
60_R63_N0.9600.69
28_S130_G0.9580.69
64_E72_H0.9410.68
20_Y58_G0.9340.67
7_F108_I0.9060.65
37_V59_L0.9020.65
3_P88_D0.8990.64
2_H39_L0.8970.64
78_R118_W0.8940.64
68_D72_H0.8880.63
7_F10_L0.8850.63
24_G136_Y0.8830.63
17_I70_E0.8640.61
38_I124_I0.8570.61
133_L137_T0.8490.60
36_I40_L0.8430.59
47_T55_L0.8430.59
7_F12_F0.8360.59
9_H16_A0.8330.58
24_G114_L0.8290.58
36_I86_P0.8240.57
85_N108_I0.8150.57
48_V61_W0.7940.55
15_A18_L0.7890.54
79_D104_V0.7840.54
90_R94_L0.7840.54
13_K78_R0.7820.54
59_L103_W0.7780.53
113_S137_T0.7690.52
13_K129_S0.7660.52
45_F132_N0.7650.52
107_A126_L0.7520.51
119_L122_V0.7510.51
69_G76_E0.7470.50
8_F12_F0.7460.50
30_F88_D0.7460.50
7_F52_T0.7450.50
6_L13_K0.7440.50
9_H64_E0.7340.49
79_D82_R0.7320.49
38_I85_N0.7280.48
83_R91_I0.7050.46
122_V125_A0.7040.46
56_L75_F0.7020.46
61_W93_W0.7000.46
110_A115_K0.6990.46
46_W55_L0.6980.46
117_K121_L0.6960.45
107_A110_A0.6930.45
96_L133_L0.6910.45
17_I34_F0.6910.45
10_L116_F0.6880.45
67_E98_V0.6840.44
33_I118_W0.6810.44
49_K62_W0.6700.43
38_I64_E0.6690.43
37_V41_L0.6630.42
23_G71_S0.6600.42
106_L118_W0.6560.42
21_L113_S0.6550.42
90_R104_V0.6530.41
62_W73_W0.6480.41
124_I137_T0.6460.41
97_Y100_P0.6370.40
58_G92_F0.6320.39
84_I89_S0.6320.39
26_F29_S0.6310.39
19_V27_S0.6300.39
104_V111_L0.6240.39
64_E124_I0.6240.39
106_L110_A0.6220.39
12_F48_V0.6150.38
98_V101_V0.6150.38
102_L106_L0.6100.37
18_L23_G0.6050.37
32_L117_K0.6030.37
3_P132_N0.6020.37
15_A94_L0.6000.37
42_A89_S0.5980.36
28_S94_L0.5970.36
120_L124_I0.5960.36
35_V77_S0.5940.36
2_H74_V0.5940.36
96_L101_V0.5940.36
24_G33_I0.5930.36
30_F118_W0.5910.36
36_I102_L0.5900.36
34_F124_I0.5850.35
29_S33_I0.5840.35
53_G60_R0.5840.35
18_L91_I0.5830.35
19_V24_G0.5820.35
33_I37_V0.5810.35
56_L124_I0.5810.35
8_F47_T0.5770.35
21_L108_I0.5760.35
64_E108_I0.5740.34
43_A68_D0.5730.34
86_P114_L0.5660.34
22_F36_I0.5650.34
130_G137_T0.5650.34
95_A126_L0.5640.33
23_G27_S0.5630.33
2_H55_L0.5620.33
10_L95_A0.5610.33
96_L100_P0.5560.33
56_L91_I0.5560.33
32_L120_L0.5530.33
105_V126_L0.5460.32
109_V115_K0.5410.32
67_E123_I0.5390.31
118_W138_K0.5370.31
43_A119_L0.5370.31
24_G42_A0.5350.31
90_R98_V0.5330.31
95_A129_S0.5270.30
39_L72_H0.5240.30
54_R103_W0.5240.30
78_R84_I0.5180.30
25_L38_I0.5160.30
73_W135_G0.5160.30
25_L110_A0.5160.30
38_I83_R0.5150.29
15_A40_L0.5140.29
50_N53_G0.5110.29
63_N76_E0.5110.29
29_S88_D0.5100.29
3_P6_L0.5050.29
48_V52_T0.5050.29
87_T112_L0.5040.29
121_L125_A0.5030.29
95_A104_V0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f1f4 1 0.0072 1.4 0.959 Contact Map
4px7A 1 0.5324 1.4 0.959 Contact Map
1u19A 2 0.4676 1.1 0.962 Contact Map
3c37A 1 0.295 0.9 0.964 Contact Map
2z73A 2 0.4892 0.9 0.964 Contact Map
1kf6D 2 0.4317 0.8 0.965 Contact Map
2kv5A 1 0.2374 0.8 0.965 Contact Map
3wo6A 1 0.4173 0.8 0.965 Contact Map
2jlnA 1 0.4892 0.8 0.965 Contact Map
4mqsA 1 0.2374 0.8 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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