GREMLIN Database
TraT - Enterobacterial TraT complement resistance protein
PFAM: PF05818 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 215 (214)
Sequences: 756 (582)
Seq/√Len: 39.8
META: 0.804

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_T55_V4.4591.00
57_D60_K4.3241.00
116_G120_G4.2421.00
85_L186_V3.4011.00
191_K198_E3.2531.00
124_G128_D3.0511.00
64_W178_W3.0181.00
122_L126_I2.8301.00
18_A59_D2.7411.00
145_S180_K2.6971.00
40_E44_K2.6911.00
187_S203_L2.5201.00
26_V44_K2.5141.00
120_G124_G2.3511.00
95_G120_G2.2391.00
3_D74_K2.2070.99
148_A152_V2.1860.99
24_V65_L2.1340.99
111_G115_G2.1250.99
174_E179_K2.0870.99
45_A48_A2.0330.99
18_A57_D2.0290.99
133_D190_N1.9990.99
122_L125_G1.9680.99
24_V215_F1.9530.99
156_T166_G1.9320.99
17_V21_K1.9260.99
154_Q170_Q1.9190.98
202_V205_E1.8710.98
112_G115_G1.8550.98
166_G182_R1.8100.98
98_A102_A1.8070.98
23_T60_K1.8040.98
21_K59_D1.7940.98
208_A212_A1.7280.97
65_L215_F1.6940.97
187_S206_K1.6900.97
10_D164_T1.6780.96
108_G112_G1.6750.96
63_Y146_E1.6730.96
18_A21_K1.6440.96
127_A130_L1.6430.96
84_A139_V1.5520.94
97_A103_G1.5460.94
148_A177_N1.5460.94
140_T187_S1.5340.94
71_Y137_T1.5240.94
17_V62_H1.5100.94
159_N169_T1.5020.93
31_T68_N1.4650.93
89_Y130_L1.4240.91
211_I214_I1.4170.91
42_A204_E1.4130.91
147_R178_W1.4070.91
206_K209_R1.3940.91
23_T53_R1.3710.90
118_L122_L1.3670.90
88_G184_R1.3580.89
158_A166_G1.3530.89
191_K194_L1.3470.89
22_R58_P1.3440.89
30_N33_D1.3390.89
55_V60_K1.3270.88
116_G119_A1.2770.86
196_F203_L1.2730.86
194_L199_A1.2630.86
71_Y128_D1.2610.86
21_K62_H1.2520.85
110_G113_A1.2450.85
133_D192_V1.2420.85
6_T210_S1.2280.84
19_P56_D1.2230.84
126_I191_K1.2090.83
85_L89_Y1.2080.83
112_G116_G1.2000.83
119_A123_A1.1960.82
47_L215_F1.1810.82
2_L5_Q1.1730.81
150_G172_S1.1630.81
22_R211_I1.1340.79
154_Q168_S1.1330.79
100_A117_G1.1300.79
125_G129_A1.1230.78
77_D80_A1.1160.78
78_P132_K1.1110.77
33_D206_K1.1110.77
71_Y139_V1.1060.77
95_G116_G1.1040.77
113_A116_G1.1040.77
159_N167_T1.1040.77
91_G102_A1.0860.76
44_K48_A1.0840.76
64_W180_K1.0700.75
49_A197_E1.0680.74
158_A168_S1.0680.74
97_A118_L1.0570.74
83_G136_Y1.0550.74
99_G116_G1.0530.73
64_W145_S1.0290.72
78_P190_N1.0160.71
74_K134_V1.0160.71
145_S178_W1.0110.70
97_A107_G1.0100.70
153_T171_T1.0080.70
84_A153_T0.9980.69
143_Q182_R0.9880.69
96_A100_A0.9860.68
114_A117_G0.9750.67
93_L97_A0.9730.67
92_A124_G0.9670.67
39_L185_I0.9640.67
28_V43_I0.9630.67
124_G138_M0.9620.66
34_K196_F0.9600.66
105_A109_S0.9560.66
97_A102_A0.9390.65
9_S85_L0.9390.65
28_V67_A0.9270.64
138_M187_S0.9150.63
124_G127_A0.9140.62
15_D180_K0.9130.62
72_V213_G0.9060.62
166_G170_Q0.8980.61
100_A113_A0.8970.61
134_V197_E0.8940.61
11_T56_D0.8820.60
153_T175_K0.8820.60
17_V63_Y0.8780.59
67_A140_T0.8770.59
142_V167_T0.8700.59
24_V205_E0.8650.58
37_F166_G0.8650.58
8_M70_L0.8610.58
37_F138_M0.8600.58
17_V57_D0.8600.58
82_E124_G0.8590.58
34_K187_S0.8480.57
29_R140_T0.8470.57
54_V110_G0.8470.57
64_W147_R0.8420.56
46_A205_E0.8380.56
15_D146_E0.8370.56
134_V192_V0.8350.55
164_T182_R0.8250.55
135_T188_T0.8210.54
45_A98_A0.8180.54
49_A98_A0.8180.54
80_A84_A0.8020.52
155_D166_G0.8010.52
98_A101_A0.8010.52
151_K175_K0.8000.52
138_M204_E0.7990.52
200_A204_E0.7990.52
12_I144_I0.7980.52
30_N68_N0.7960.52
10_D161_K0.7930.52
154_Q174_E0.7930.52
79_T82_E0.7920.52
143_Q160_L0.7910.51
142_V211_I0.7890.51
27_Q50_K0.7820.51
1_N4_V0.7760.50
143_Q181_Y0.7740.50
43_I67_A0.7650.49
72_V138_M0.7640.49
42_A208_A0.7640.49
27_Q43_I0.7630.49
135_T190_N0.7600.49
192_V196_F0.7600.49
134_V194_L0.7530.48
110_G114_A0.7490.48
24_V47_L0.7480.48
203_L213_G0.7380.47
68_N181_Y0.7370.47
33_D198_E0.7360.46
123_A126_I0.7330.46
40_E56_D0.7320.46
1_N143_Q0.7310.46
52_Y99_G0.7260.46
55_V99_G0.7240.45
153_T164_T0.7230.45
23_T88_G0.7190.45
191_K199_A0.7180.45
196_F206_K0.7160.45
76_A81_A0.7110.44
190_N193_N0.7110.44
91_G119_A0.7070.44
111_G114_A0.7040.44
204_E214_I0.6990.43
131_V192_V0.6970.43
196_F200_A0.6900.42
105_A156_T0.6850.42
93_L123_A0.6770.41
11_T68_N0.6750.41
97_A100_A0.6750.41
43_I76_A0.6730.41
43_I211_I0.6730.41
10_D39_L0.6720.41
152_V180_K0.6720.41
160_L163_G0.6700.40
33_D66_Q0.6700.40
32_S104_A0.6680.40
183_T189_A0.6660.40
140_T190_N0.6590.40
44_K56_D0.6550.39
15_D36_E0.6540.39
14_L33_D0.6520.39
144_I214_I0.6500.39
111_G117_G0.6480.39
127_A192_V0.6450.38
57_D86_A0.6410.38
45_A49_A0.6410.38
25_Y141_D0.6410.38
27_Q55_V0.6410.38
30_N120_G0.6380.38
185_I210_S0.6370.38
17_V29_R0.6350.37
154_Q179_K0.6350.37
53_R87_G0.6310.37
66_Q143_Q0.6290.37
106_N110_G0.6290.37
90_G102_A0.6260.37
137_T186_V0.6230.36
125_G130_L0.6220.36
47_L144_I0.6220.36
119_A159_N0.6190.36
65_L142_V0.6180.36
157_Q169_T0.6150.36
141_D184_R0.6140.36
34_K138_M0.6100.35
26_V48_A0.6090.35
121_G191_K0.6080.35
187_S196_F0.6060.35
150_G175_K0.6040.35
13_F58_P0.6030.35
12_I31_T0.6020.35
22_R100_A0.6010.35
153_T156_T0.6010.35
113_A170_Q0.5990.34
13_F64_W0.5970.34
158_A165_S0.5970.34
89_Y212_A0.5930.34
61_A199_A0.5930.34
154_Q160_L0.5920.34
72_V196_F0.5890.34
194_L201_P0.5890.34
125_G132_K0.5870.33
202_V212_A0.5850.33
90_G184_R0.5840.33
138_M203_L0.5840.33
103_G111_G0.5840.33
93_L155_D0.5830.33
74_K138_M0.5830.33
102_A119_A0.5810.33
37_F208_A0.5800.33
146_E181_Y0.5800.33
42_A46_A0.5790.33
58_P146_E0.5770.33
109_S144_I0.5750.32
179_K206_K0.5720.32
120_G209_R0.5690.32
6_T9_S0.5680.32
154_Q176_S0.5680.32
25_Y61_A0.5650.32
30_N144_I0.5640.32
40_E142_V0.5630.32
22_R56_D0.5630.32
27_Q182_R0.5600.31
42_A205_E0.5590.31
94_A102_A0.5580.31
197_E200_A0.5570.31
123_A127_A0.5570.31
113_A121_G0.5570.31
73_G206_K0.5550.31
96_A152_V0.5540.31
185_I208_A0.5520.31
39_L208_A0.5520.31
11_T14_L0.5520.31
15_D21_K0.5510.31
106_N112_G0.5500.30
48_A175_K0.5500.30
87_G90_G0.5480.30
105_A114_A0.5450.30
103_G115_G0.5450.30
65_L84_A0.5430.30
127_A131_V0.5420.30
41_S48_A0.5410.30
138_M200_A0.5410.30
136_Y152_V0.5400.30
142_V164_T0.5380.30
34_K72_V0.5370.29
152_V174_E0.5360.29
26_V41_S0.5350.29
3_D16_P0.5300.29
137_T175_K0.5290.29
57_D98_A0.5270.29
76_A135_T0.5270.29
53_R205_E0.5270.29
188_T211_I0.5250.29
96_A123_A0.5230.28
83_G100_A0.5220.28
54_V170_Q0.5210.28
162_Q181_Y0.5200.28
59_D122_L0.5180.28
70_L183_T0.5180.28
137_T188_T0.5170.28
6_T187_S0.5110.28
36_E200_A0.5110.28
129_A183_T0.5110.28
63_Y125_G0.5100.27
72_V187_S0.5090.27
81_A128_D0.5070.27
142_V183_T0.5060.27
140_T207_L0.5060.27
18_A46_A0.5050.27
109_S112_G0.5040.27
114_A120_G0.5030.27
118_L147_R0.5020.27
210_S214_I0.5020.27
148_A151_K0.5020.27
171_T176_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n4rB 1 0.6512 32.7 0.948 Contact Map
2r76A 2 0.5907 22.9 0.952 Contact Map
2lbgA 1 0.1256 21.8 0.952 Contact Map
2jxpA 1 0.6651 20.9 0.953 Contact Map
3bf2A 2 0.5721 15.1 0.956 Contact Map
2m5yA 1 0.507 12.2 0.957 Contact Map
2b0hA 1 0.2372 10 0.959 Contact Map
3ldtA 2 0.4047 7.9 0.961 Contact Map
2kvpA 1 0.3674 7.4 0.961 Contact Map
1h3lA 1 0.2465 6.1 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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