GREMLIN Database
TelA - Toxic anion resistance protein (TelA)
PFAM: PF05816 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 332 (329)
Sequences: 4166 (2368)
Seq/√Len: 130.5
META: 0.72

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_E150_E4.7591.00
267_K296_A3.8231.00
158_A162_A3.7681.00
142_E190_K3.7311.00
288_K318_E3.6341.00
303_Q307_E3.6291.00
264_E289_K3.5131.00
292_Q296_A3.4971.00
263_A293_N3.4471.00
147_E151_E3.3781.00
260_K289_K3.2701.00
148_L175_L3.2441.00
272_E275_K2.8951.00
157_E161_A2.8311.00
289_K293_N2.8121.00
9_D12_D2.7791.00
310_A314_E2.6891.00
242_K246_E2.6361.00
141_G186_V2.5121.00
158_A161_A2.4631.00
155_A158_A2.3501.00
264_E293_N2.3471.00
267_K271_I2.3001.00
267_K293_N2.2751.00
321_K325_E2.2701.00
314_E317_A2.2081.00
307_E311_K2.1421.00
256_N286_T2.1231.00
249_R253_D2.0971.00
311_K314_E2.0851.00
318_E321_K2.0641.00
72_G75_G2.0451.00
3_E7_K2.0171.00
94_S97_T2.0121.00
151_E155_A2.0101.00
155_A159_K1.9961.00
149_D179_L1.9901.00
25_K29_D1.9671.00
253_D257_E1.9601.00
306_E310_A1.9371.00
157_E176_R1.9211.00
285_E288_K1.9001.00
149_D183_E1.8671.00
170_Q174_D1.8501.00
48_D52_D1.8311.00
264_E268_Q1.8221.00
126_K129_E1.8061.00
160_A173_R1.7981.00
154_P158_A1.7931.00
300_E303_Q1.7921.00
71_L75_G1.7851.00
195_V282_V1.7701.00
271_I275_K1.7681.00
120_L203_I1.7591.00
307_E310_A1.7481.00
279_R283_D1.7211.00
249_R276_E1.6971.00
191_L280_G1.6931.00
260_K286_T1.6911.00
159_K168_D1.6851.00
152_L155_A1.6771.00
122_Q125_E1.6731.00
288_K292_Q1.6671.00
317_A321_K1.6391.00
93_E97_T1.6321.00
151_E154_P1.6091.00
117_N210_N1.6011.00
153_L179_L1.5971.00
289_K292_Q1.5681.00
261_K264_E1.5611.00
268_Q272_E1.5571.00
313_A317_A1.5551.00
257_E261_K1.5431.00
246_E250_A1.5381.00
310_A313_A1.5361.00
242_K272_E1.5271.00
145_L179_L1.5111.00
90_A93_E1.5051.00
56_T59_G1.4841.00
324_E328_Q1.4811.00
3_E6_A1.4791.00
260_K264_E1.4711.00
4_F7_K1.4351.00
314_E318_E1.4251.00
105_S108_K1.4241.00
209_N273_I1.4121.00
154_P157_E1.4041.00
172_L176_R1.4021.00
173_R177_E1.3911.00
260_K293_N1.3871.00
321_K324_E1.3851.00
239_A242_K1.3561.00
299_D329_K1.3361.00
127_N196_S1.3291.00
116_D240_R1.3201.00
96_Q100_D1.3131.00
165_D168_D1.3091.00
239_A243_L1.3021.00
325_E328_Q1.2871.00
138_I189_L1.2641.00
26_K29_D1.2541.00
6_A147_E1.2531.00
188_D219_S1.2521.00
148_L179_L1.2451.00
293_N296_A1.2361.00
243_L246_E1.2171.00
117_N214_V1.2151.00
292_Q325_E1.2151.00
296_A300_E1.2131.00
32_D229_K1.1970.99
144_K147_E1.1950.99
146_E149_D1.1900.99
271_I300_E1.1750.99
156_L159_K1.1690.99
147_E152_L1.1660.99
33_R36_E1.1570.99
245_L269_Q1.1530.99
303_Q306_E1.1500.99
77_L81_A1.1330.99
110_Q218_Q1.1200.99
317_A320_E1.1190.99
131_F135_E1.1190.99
14_N18_Q1.1110.99
10_I148_L1.1090.99
78_F81_A1.1060.99
61_D64_E1.1040.99
152_L175_L1.1040.99
256_N283_D1.1000.99
26_K133_E1.0960.99
110_Q114_L1.0840.99
13_S121_D1.0830.99
73_F77_L1.0810.99
177_E208_N1.0740.99
267_K300_E1.0660.99
249_R272_E1.0660.99
131_F197_I1.0570.99
129_E133_E1.0500.99
196_S199_G1.0470.99
53_L220_A1.0400.98
139_A143_K1.0390.98
204_R207_Q1.0340.98
114_L214_V1.0300.98
270_T274_A1.0280.98
271_I296_A1.0240.98
168_D171_A1.0200.98
253_D279_R1.0190.98
120_L237_A1.0160.98
103_V221_I1.0150.98
246_E249_R1.0150.98
275_K307_E1.0150.98
259_L290_A1.0150.98
187_H191_L1.0130.98
234_L265_M1.0120.98
257_E260_K1.0050.98
216_K252_N1.0040.98
238_L269_Q1.0000.98
217_I244_A0.9890.98
50_L298_I0.9850.98
181_R215_E0.9830.98
22_E25_K0.9830.98
52_D56_T0.9780.98
224_T255_T0.9760.98
52_D55_R0.9730.98
80_K83_N0.9690.98
202_Q234_L0.9690.98
97_T101_K0.9650.97
121_D207_Q0.9650.97
156_L175_L0.9640.97
184_K277_A0.9620.97
280_G283_D0.9590.97
148_L152_L0.9560.97
45_E48_D0.9470.97
296_A299_D0.9470.97
301_V305_Q0.9430.97
194_Q197_I0.9380.97
252_N276_E0.9370.97
121_D125_E0.9320.97
283_D286_T0.9280.97
145_L186_V0.9280.97
55_R87_K0.9240.97
300_E304_I0.9230.97
286_T289_K0.9220.97
106_L217_I0.9180.97
113_L244_A0.9170.97
320_E324_E0.9110.96
177_E180_D0.9070.96
278_E308_G0.9030.96
299_D303_Q0.9030.96
26_K126_K0.8990.96
118_A122_Q0.8980.96
309_R313_A0.8970.96
104_D108_K0.8960.96
250_A253_D0.8900.96
86_A90_A0.8870.96
107_E221_I0.8860.96
143_K147_E0.8850.96
103_V225_I0.8830.96
84_K87_K0.8790.96
220_A248_Q0.8780.96
127_N200_A0.8770.96
56_T98_Q0.8730.95
59_G86_A0.8710.95
51_T90_A0.8710.95
152_L156_L0.8670.95
5_A143_K0.8670.95
163_S168_D0.8650.95
79_G82_G0.8650.95
149_D180_D0.8600.95
220_A251_V0.8590.95
51_T55_R0.8590.95
208_N212_E0.8560.95
308_G312_R0.8560.95
153_L157_E0.8550.95
190_K316_E0.8510.95
164_G168_D0.8430.95
268_Q275_K0.8390.94
4_F136_L0.8390.94
176_R180_D0.8380.94
73_F76_K0.8360.94
150_E154_P0.8330.94
26_K129_E0.8320.94
206_I237_A0.8320.94
143_K146_E0.8310.94
101_K104_D0.8300.94
242_K245_L0.8270.94
124_Y204_R0.8260.94
55_R90_A0.8240.94
324_E327_K0.8230.94
209_N270_T0.8210.94
111_D114_L0.8190.94
187_H280_G0.8170.94
111_D115_K0.8120.93
135_E193_R0.8100.93
209_N224_T0.8050.93
56_T102_I0.8040.93
12_D15_S0.8000.93
109_H247_A0.7970.93
124_Y200_A0.7940.93
86_A93_E0.7890.92
58_K86_A0.7810.92
212_E277_A0.7780.92
198_Q262_N0.7760.92
187_H194_Q0.7750.92
130_Y196_S0.7740.92
71_L74_L0.7730.92
93_E101_K0.7730.92
113_L210_N0.7710.91
238_L245_L0.7690.91
269_Q273_I0.7640.91
238_L241_Q0.7640.91
5_A147_E0.7610.91
133_E136_L0.7600.91
195_V259_L0.7590.91
316_E320_E0.7570.91
186_V190_K0.7560.91
18_Q21_A0.7550.91
275_K300_E0.7520.90
144_K152_L0.7510.90
114_L118_A0.7490.90
100_D103_V0.7490.90
71_L76_K0.7480.90
150_E162_A0.7470.90
286_T290_A0.7460.90
261_K265_M0.7440.90
148_L151_E0.7430.90
49_S52_D0.7430.90
245_L276_E0.7410.90
153_L156_L0.7410.90
318_E322_L0.7390.90
14_N118_A0.7370.90
328_Q331_L0.7290.89
5_A139_A0.7270.89
59_G91_K0.7270.89
122_Q126_K0.7270.89
72_G78_F0.7260.89
50_L213_L0.7240.89
125_E129_E0.7210.89
325_E329_K0.7200.88
146_E162_A0.7190.88
142_E186_V0.7180.88
78_F82_G0.7130.88
220_A269_Q0.7120.88
194_Q322_L0.7110.88
55_R58_K0.7090.88
174_D204_R0.7080.88
159_K162_A0.7000.87
19_F182_L0.7000.87
160_A172_L0.7000.87
274_A278_E0.6970.87
60_F88_Y0.6960.87
10_I16_I0.6960.87
182_L186_V0.6950.87
254_T265_M0.6940.87
306_E309_R0.6910.86
262_N266_L0.6870.86
298_I301_V0.6870.86
223_N227_L0.6860.86
72_G76_K0.6860.86
75_G78_F0.6830.86
33_R122_Q0.6830.86
188_D216_K0.6800.85
321_K328_Q0.6790.85
107_E110_Q0.6770.85
173_R176_R0.6740.85
70_K73_F0.6740.85
209_N241_Q0.6730.85
238_L254_T0.6720.85
271_I303_Q0.6700.85
160_A163_S0.6690.85
313_A316_E0.6670.84
275_K303_Q0.6660.84
157_E172_L0.6660.84
242_K265_M0.6650.84
11_T171_A0.6630.84
128_L171_A0.6630.84
101_K105_S0.6620.84
21_A25_K0.6620.84
312_R315_A0.6610.84
8_I140_A0.6610.84
193_R323_E0.6600.84
156_L160_A0.6560.83
39_R94_S0.6560.83
142_E316_E0.6520.83
44_G47_G0.6520.83
228_W231_Q0.6520.83
285_E311_K0.6500.83
275_K279_R0.6480.83
282_V286_T0.6470.83
241_Q254_T0.6460.82
19_F137_Y0.6430.82
27_I199_G0.6420.82
172_L177_E0.6420.82
27_I31_S0.6420.82
320_E328_Q0.6410.82
39_R42_D0.6400.82
101_K108_K0.6390.82
5_A8_I0.6360.81
143_K185_R0.6360.81
187_H190_K0.6350.81
159_K171_A0.6340.81
319_L323_E0.6330.81
53_L99_I0.6320.81
236_L239_A0.6240.80
181_R208_N0.6220.80
156_L171_A0.6210.80
292_Q314_E0.6200.80
241_Q269_Q0.6190.80
128_L197_I0.6170.79
19_F140_A0.6160.79
240_R243_L0.6160.79
227_L258_L0.6130.79
153_L172_L0.6100.79
238_L265_M0.6100.79
172_L179_L0.6090.79
8_I19_F0.6090.79
192_T223_N0.6080.78
151_E179_L0.6070.78
100_D104_D0.6070.78
193_R197_I0.6060.78
270_T301_V0.6060.78
303_Q310_A0.6060.78
212_E245_L0.6020.78
228_W291_N0.6020.78
15_S19_F0.6010.78
77_L80_K0.6000.78
57_L105_S0.5990.77
277_A308_G0.5990.77
123_L126_K0.5980.77
298_I302_L0.5980.77
304_I308_G0.5980.77
226_P312_R0.5970.77
117_N238_L0.5970.77
131_F200_A0.5950.77
70_K76_K0.5940.77
41_K45_E0.5930.77
124_Y128_L0.5910.76
175_L179_L0.5890.76
51_T54_V0.5880.76
36_E96_Q0.5880.76
136_L139_A0.5870.76
145_L183_E0.5850.76
92_Y235_A0.5840.76
287_L322_L0.5830.76
95_A98_Q0.5830.76
81_A84_K0.5820.75
86_A89_F0.5810.75
324_E330_L0.5810.75
138_I193_R0.5770.75
42_D45_E0.5750.75
245_L273_I0.5740.74
69_K75_G0.5740.74
62_P83_N0.5740.74
323_E327_K0.5740.74
131_F196_S0.5730.74
211_K214_V0.5710.74
248_Q252_N0.5700.74
246_E272_E0.5680.74
185_R194_Q0.5670.74
4_F8_I0.5660.73
263_A283_D0.5660.73
109_H241_Q0.5650.73
231_Q262_N0.5650.73
201_P226_P0.5630.73
28_A32_D0.5620.73
202_Q248_Q0.5610.73
180_D278_E0.5590.72
82_G86_A0.5590.72
145_L149_D0.5580.72
110_Q113_L0.5580.72
120_L210_N0.5570.72
137_Y189_L0.5570.72
309_R312_R0.5550.72
3_E26_K0.5550.72
175_L178_A0.5550.72
257_E286_T0.5540.72
123_L230_T0.5530.72
74_L77_L0.5530.72
306_E313_A0.5530.72
304_I312_R0.5520.72
4_F9_D0.5500.71
40_T98_Q0.5500.71
18_Q22_E0.5480.71
264_E267_K0.5480.71
88_Y92_Y0.5480.71
223_N241_Q0.5460.71
52_D87_K0.5450.71
291_N322_L0.5450.71
40_T51_T0.5430.70
270_T297_T0.5420.70
234_L262_N0.5410.70
88_Y232_V0.5400.70
166_P172_L0.5390.70
27_I196_S0.5390.70
274_A301_V0.5380.70
24_Q185_R0.5380.70
72_G79_G0.5380.70
195_V224_T0.5380.70
109_H244_A0.5380.70
284_I288_K0.5370.69
157_E160_A0.5370.69
199_G269_Q0.5350.69
6_A9_D0.5340.69
106_L198_Q0.5330.69
57_L254_T0.5320.69
65_L68_E0.5310.69
268_Q273_I0.5310.69
311_K315_A0.5300.68
216_K304_I0.5300.68
302_L306_E0.5300.68
123_L233_V0.5290.68
46_V49_S0.5270.68
187_H315_A0.5270.68
32_D36_E0.5270.68
295_I325_E0.5260.68
108_K150_E0.5250.68
48_D51_T0.5250.68
280_G284_I0.5240.68
180_D183_E0.5240.68
67_E70_K0.5220.67
6_A22_E0.5220.67
144_K148_L0.5200.67
191_L319_L0.5200.67
294_L297_T0.5190.67
256_N260_K0.5190.67
12_D18_Q0.5170.67
57_L247_A0.5170.67
160_A167_E0.5160.66
186_V189_L0.5150.66
63_S66_D0.5150.66
69_K77_L0.5140.66
190_K193_R0.5130.66
124_Y207_Q0.5120.66
268_Q271_I0.5120.66
23_A137_Y0.5120.66
147_E175_L0.5110.66
53_L103_V0.5110.66
191_L223_N0.5110.66
121_D124_Y0.5090.65
303_Q314_E0.5080.65
246_E253_D0.5080.65
184_K305_Q0.5080.65
141_G182_L0.5070.65
245_L249_R0.5070.65
123_L214_V0.5070.65
278_E304_I0.5060.65
227_L231_Q0.5050.65
149_D313_A0.5050.65
31_S36_E0.5050.65
10_I13_S0.5050.65
319_L322_L0.5040.65
30_F126_K0.5040.65
327_K330_L0.5020.64
5_A21_A0.5000.64
36_E40_T0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vkgA 2 0.75 81.1 0.919 Contact Map
4uxvA 1 0.9157 64.3 0.929 Contact Map
1i84S 2 0.3193 48.3 0.936 Contact Map
4uy3A 1 0.5331 42 0.938 Contact Map
4rh7A 1 0.8735 30.2 0.943 Contact Map
2ic6A 1 0.2289 26.7 0.944 Contact Map
3g67A 2 0.5331 22.5 0.946 Contact Map
2ch7A 2 0.747 21.8 0.946 Contact Map
4k1pA 1 0.7651 21.3 0.947 Contact Map
1c1gA 2 0.8253 18.6 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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