TelA - PFAM28P - GREMLIN Contacts

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TelA - Toxic anion resistance protein (TelA)

PFAM:	PF05816	Sequences: VDEFAAKIDITDSNSILQFGAEAQKKIADFSDRMLESVRTKDLGEVGDSLTDLVRTLKGFDPSELDEEKKLGFLGKLFGKAGNKLAKYFAKYESAQTQIDKIVDSLEKHQDELLKDNAMLDQLYEKNLEYFKELELYIAAGEKKLEELDEELLPALEAKAAASGDPEDAQALRDLREALDRLEKRVHDLKLTRQVSIQGAPQIRLIQNNNKELVEKIQSAIVNTIPLWKTQVVLALALARQKLALEAQRAVNDTTNELLKKNAEMLKQQTIEIAKEAERGIVDIETLKKANQNLIATIDEVLQIQEEGRAKRAEAEAELEKLEEELKQKLLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	332 (329)
Sequences:	4166 (2368)
Seq/√Len:	130.5
META:	0.72

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
146_E	150_E	4.759	1.00
267_K	296_A	3.823	1.00
158_A	162_A	3.768	1.00
142_E	190_K	3.731	1.00
288_K	318_E	3.634	1.00
303_Q	307_E	3.629	1.00
264_E	289_K	3.513	1.00
292_Q	296_A	3.497	1.00
263_A	293_N	3.447	1.00
147_E	151_E	3.378	1.00
260_K	289_K	3.270	1.00
148_L	175_L	3.244	1.00
272_E	275_K	2.895	1.00
157_E	161_A	2.831	1.00
289_K	293_N	2.812	1.00
9_D	12_D	2.779	1.00
310_A	314_E	2.689	1.00
242_K	246_E	2.636	1.00
141_G	186_V	2.512	1.00
158_A	161_A	2.463	1.00
155_A	158_A	2.350	1.00
264_E	293_N	2.347	1.00
267_K	271_I	2.300	1.00
267_K	293_N	2.275	1.00
321_K	325_E	2.270	1.00
314_E	317_A	2.208	1.00
307_E	311_K	2.142	1.00
256_N	286_T	2.123	1.00
249_R	253_D	2.097	1.00
311_K	314_E	2.085	1.00
318_E	321_K	2.064	1.00
72_G	75_G	2.045	1.00
3_E	7_K	2.017	1.00
94_S	97_T	2.012	1.00
151_E	155_A	2.010	1.00
155_A	159_K	1.996	1.00
149_D	179_L	1.990	1.00
25_K	29_D	1.967	1.00
253_D	257_E	1.960	1.00
306_E	310_A	1.937	1.00
157_E	176_R	1.921	1.00
285_E	288_K	1.900	1.00
149_D	183_E	1.867	1.00
170_Q	174_D	1.850	1.00
48_D	52_D	1.831	1.00
264_E	268_Q	1.822	1.00
126_K	129_E	1.806	1.00
160_A	173_R	1.798	1.00
154_P	158_A	1.793	1.00
300_E	303_Q	1.792	1.00
71_L	75_G	1.785	1.00
195_V	282_V	1.770	1.00
271_I	275_K	1.768	1.00
120_L	203_I	1.759	1.00
307_E	310_A	1.748	1.00
279_R	283_D	1.721	1.00
249_R	276_E	1.697	1.00
191_L	280_G	1.693	1.00
260_K	286_T	1.691	1.00
159_K	168_D	1.685	1.00
152_L	155_A	1.677	1.00
122_Q	125_E	1.673	1.00
288_K	292_Q	1.667	1.00
317_A	321_K	1.639	1.00
93_E	97_T	1.632	1.00
151_E	154_P	1.609	1.00
117_N	210_N	1.601	1.00
153_L	179_L	1.597	1.00
289_K	292_Q	1.568	1.00
261_K	264_E	1.561	1.00
268_Q	272_E	1.557	1.00
313_A	317_A	1.555	1.00
257_E	261_K	1.543	1.00
246_E	250_A	1.538	1.00
310_A	313_A	1.536	1.00
242_K	272_E	1.527	1.00
145_L	179_L	1.511	1.00
90_A	93_E	1.505	1.00
56_T	59_G	1.484	1.00
324_E	328_Q	1.481	1.00
3_E	6_A	1.479	1.00
260_K	264_E	1.471	1.00
4_F	7_K	1.435	1.00
314_E	318_E	1.425	1.00
105_S	108_K	1.424	1.00
209_N	273_I	1.412	1.00
154_P	157_E	1.404	1.00
172_L	176_R	1.402	1.00
173_R	177_E	1.391	1.00
260_K	293_N	1.387	1.00
321_K	324_E	1.385	1.00
239_A	242_K	1.356	1.00
299_D	329_K	1.336	1.00
127_N	196_S	1.329	1.00
116_D	240_R	1.320	1.00
96_Q	100_D	1.313	1.00
165_D	168_D	1.309	1.00
239_A	243_L	1.302	1.00
325_E	328_Q	1.287	1.00
138_I	189_L	1.264	1.00
26_K	29_D	1.254	1.00
6_A	147_E	1.253	1.00
188_D	219_S	1.252	1.00
148_L	179_L	1.245	1.00
293_N	296_A	1.236	1.00
243_L	246_E	1.217	1.00
117_N	214_V	1.215	1.00
292_Q	325_E	1.215	1.00
296_A	300_E	1.213	1.00
32_D	229_K	1.197	0.99
144_K	147_E	1.195	0.99
146_E	149_D	1.190	0.99
271_I	300_E	1.175	0.99
156_L	159_K	1.169	0.99
147_E	152_L	1.166	0.99
33_R	36_E	1.157	0.99
245_L	269_Q	1.153	0.99
303_Q	306_E	1.150	0.99
77_L	81_A	1.133	0.99
110_Q	218_Q	1.120	0.99
317_A	320_E	1.119	0.99
131_F	135_E	1.119	0.99
14_N	18_Q	1.111	0.99
10_I	148_L	1.109	0.99
78_F	81_A	1.106	0.99
61_D	64_E	1.104	0.99
152_L	175_L	1.104	0.99
256_N	283_D	1.100	0.99
26_K	133_E	1.096	0.99
110_Q	114_L	1.084	0.99
13_S	121_D	1.083	0.99
73_F	77_L	1.081	0.99
177_E	208_N	1.074	0.99
267_K	300_E	1.066	0.99
249_R	272_E	1.066	0.99
131_F	197_I	1.057	0.99
129_E	133_E	1.050	0.99
196_S	199_G	1.047	0.99
53_L	220_A	1.040	0.98
139_A	143_K	1.039	0.98
204_R	207_Q	1.034	0.98
114_L	214_V	1.030	0.98
270_T	274_A	1.028	0.98
271_I	296_A	1.024	0.98
168_D	171_A	1.020	0.98
253_D	279_R	1.019	0.98
120_L	237_A	1.016	0.98
103_V	221_I	1.015	0.98
246_E	249_R	1.015	0.98
275_K	307_E	1.015	0.98
259_L	290_A	1.015	0.98
187_H	191_L	1.013	0.98
234_L	265_M	1.012	0.98
257_E	260_K	1.005	0.98
216_K	252_N	1.004	0.98
238_L	269_Q	1.000	0.98
217_I	244_A	0.989	0.98
50_L	298_I	0.985	0.98
181_R	215_E	0.983	0.98
22_E	25_K	0.983	0.98
52_D	56_T	0.978	0.98
224_T	255_T	0.976	0.98
52_D	55_R	0.973	0.98
80_K	83_N	0.969	0.98
202_Q	234_L	0.969	0.98
97_T	101_K	0.965	0.97
121_D	207_Q	0.965	0.97
156_L	175_L	0.964	0.97
184_K	277_A	0.962	0.97
280_G	283_D	0.959	0.97
148_L	152_L	0.956	0.97
45_E	48_D	0.947	0.97
296_A	299_D	0.947	0.97
301_V	305_Q	0.943	0.97
194_Q	197_I	0.938	0.97
252_N	276_E	0.937	0.97
121_D	125_E	0.932	0.97
283_D	286_T	0.928	0.97
145_L	186_V	0.928	0.97
55_R	87_K	0.924	0.97
300_E	304_I	0.923	0.97
286_T	289_K	0.922	0.97
106_L	217_I	0.918	0.97
113_L	244_A	0.917	0.97
320_E	324_E	0.911	0.96
177_E	180_D	0.907	0.96
278_E	308_G	0.903	0.96
299_D	303_Q	0.903	0.96
26_K	126_K	0.899	0.96
118_A	122_Q	0.898	0.96
309_R	313_A	0.897	0.96
104_D	108_K	0.896	0.96
250_A	253_D	0.890	0.96
86_A	90_A	0.887	0.96
107_E	221_I	0.886	0.96
143_K	147_E	0.885	0.96
103_V	225_I	0.883	0.96
84_K	87_K	0.879	0.96
220_A	248_Q	0.878	0.96
127_N	200_A	0.877	0.96
56_T	98_Q	0.873	0.95
59_G	86_A	0.871	0.95
51_T	90_A	0.871	0.95
152_L	156_L	0.867	0.95
5_A	143_K	0.867	0.95
163_S	168_D	0.865	0.95
79_G	82_G	0.865	0.95
149_D	180_D	0.860	0.95
220_A	251_V	0.859	0.95
51_T	55_R	0.859	0.95
208_N	212_E	0.856	0.95
308_G	312_R	0.856	0.95
153_L	157_E	0.855	0.95
190_K	316_E	0.851	0.95
164_G	168_D	0.843	0.95
268_Q	275_K	0.839	0.94
4_F	136_L	0.839	0.94
176_R	180_D	0.838	0.94
73_F	76_K	0.836	0.94
150_E	154_P	0.833	0.94
26_K	129_E	0.832	0.94
206_I	237_A	0.832	0.94
143_K	146_E	0.831	0.94
101_K	104_D	0.830	0.94
242_K	245_L	0.827	0.94
124_Y	204_R	0.826	0.94
55_R	90_A	0.824	0.94
324_E	327_K	0.823	0.94
209_N	270_T	0.821	0.94
111_D	114_L	0.819	0.94
187_H	280_G	0.817	0.94
111_D	115_K	0.812	0.93
135_E	193_R	0.810	0.93
209_N	224_T	0.805	0.93
56_T	102_I	0.804	0.93
12_D	15_S	0.800	0.93
109_H	247_A	0.797	0.93
124_Y	200_A	0.794	0.93
86_A	93_E	0.789	0.92
58_K	86_A	0.781	0.92
212_E	277_A	0.778	0.92
198_Q	262_N	0.776	0.92
187_H	194_Q	0.775	0.92
130_Y	196_S	0.774	0.92
71_L	74_L	0.773	0.92
93_E	101_K	0.773	0.92
113_L	210_N	0.771	0.91
238_L	245_L	0.769	0.91
269_Q	273_I	0.764	0.91
238_L	241_Q	0.764	0.91
5_A	147_E	0.761	0.91
133_E	136_L	0.760	0.91
195_V	259_L	0.759	0.91
316_E	320_E	0.757	0.91
186_V	190_K	0.756	0.91
18_Q	21_A	0.755	0.91
275_K	300_E	0.752	0.90
144_K	152_L	0.751	0.90
114_L	118_A	0.749	0.90
100_D	103_V	0.749	0.90
71_L	76_K	0.748	0.90
150_E	162_A	0.747	0.90
286_T	290_A	0.746	0.90
261_K	265_M	0.744	0.90
148_L	151_E	0.743	0.90
49_S	52_D	0.743	0.90
245_L	276_E	0.741	0.90
153_L	156_L	0.741	0.90
318_E	322_L	0.739	0.90
14_N	118_A	0.737	0.90
328_Q	331_L	0.729	0.89
5_A	139_A	0.727	0.89
59_G	91_K	0.727	0.89
122_Q	126_K	0.727	0.89
72_G	78_F	0.726	0.89
50_L	213_L	0.724	0.89
125_E	129_E	0.721	0.89
325_E	329_K	0.720	0.88
146_E	162_A	0.719	0.88
142_E	186_V	0.718	0.88
78_F	82_G	0.713	0.88
220_A	269_Q	0.712	0.88
194_Q	322_L	0.711	0.88
55_R	58_K	0.709	0.88
174_D	204_R	0.708	0.88
159_K	162_A	0.700	0.87
19_F	182_L	0.700	0.87
160_A	172_L	0.700	0.87
274_A	278_E	0.697	0.87
60_F	88_Y	0.696	0.87
10_I	16_I	0.696	0.87
182_L	186_V	0.695	0.87
254_T	265_M	0.694	0.87
306_E	309_R	0.691	0.86
262_N	266_L	0.687	0.86
298_I	301_V	0.687	0.86
223_N	227_L	0.686	0.86
72_G	76_K	0.686	0.86
75_G	78_F	0.683	0.86
33_R	122_Q	0.683	0.86
188_D	216_K	0.680	0.85
321_K	328_Q	0.679	0.85
107_E	110_Q	0.677	0.85
173_R	176_R	0.674	0.85
70_K	73_F	0.674	0.85
209_N	241_Q	0.673	0.85
238_L	254_T	0.672	0.85
271_I	303_Q	0.670	0.85
160_A	163_S	0.669	0.85
313_A	316_E	0.667	0.84
275_K	303_Q	0.666	0.84
157_E	172_L	0.666	0.84
242_K	265_M	0.665	0.84
11_T	171_A	0.663	0.84
128_L	171_A	0.663	0.84
101_K	105_S	0.662	0.84
21_A	25_K	0.662	0.84
312_R	315_A	0.661	0.84
8_I	140_A	0.661	0.84
193_R	323_E	0.660	0.84
156_L	160_A	0.656	0.83
39_R	94_S	0.656	0.83
142_E	316_E	0.652	0.83
44_G	47_G	0.652	0.83
228_W	231_Q	0.652	0.83
285_E	311_K	0.650	0.83
275_K	279_R	0.648	0.83
282_V	286_T	0.647	0.83
241_Q	254_T	0.646	0.82
19_F	137_Y	0.643	0.82
27_I	199_G	0.642	0.82
172_L	177_E	0.642	0.82
27_I	31_S	0.642	0.82
320_E	328_Q	0.641	0.82
39_R	42_D	0.640	0.82
101_K	108_K	0.639	0.82
5_A	8_I	0.636	0.81
143_K	185_R	0.636	0.81
187_H	190_K	0.635	0.81
159_K	171_A	0.634	0.81
319_L	323_E	0.633	0.81
53_L	99_I	0.632	0.81
236_L	239_A	0.624	0.80
181_R	208_N	0.622	0.80
156_L	171_A	0.621	0.80
292_Q	314_E	0.620	0.80
241_Q	269_Q	0.619	0.80
128_L	197_I	0.617	0.79
19_F	140_A	0.616	0.79
240_R	243_L	0.616	0.79
227_L	258_L	0.613	0.79
153_L	172_L	0.610	0.79
238_L	265_M	0.610	0.79
172_L	179_L	0.609	0.79
8_I	19_F	0.609	0.79
192_T	223_N	0.608	0.78
151_E	179_L	0.607	0.78
100_D	104_D	0.607	0.78
193_R	197_I	0.606	0.78
270_T	301_V	0.606	0.78
303_Q	310_A	0.606	0.78
212_E	245_L	0.602	0.78
228_W	291_N	0.602	0.78
15_S	19_F	0.601	0.78
77_L	80_K	0.600	0.78
57_L	105_S	0.599	0.77
277_A	308_G	0.599	0.77
123_L	126_K	0.598	0.77
298_I	302_L	0.598	0.77
304_I	308_G	0.598	0.77
226_P	312_R	0.597	0.77
117_N	238_L	0.597	0.77
131_F	200_A	0.595	0.77
70_K	76_K	0.594	0.77
41_K	45_E	0.593	0.77
124_Y	128_L	0.591	0.76
175_L	179_L	0.589	0.76
51_T	54_V	0.588	0.76
36_E	96_Q	0.588	0.76
136_L	139_A	0.587	0.76
145_L	183_E	0.585	0.76
92_Y	235_A	0.584	0.76
287_L	322_L	0.583	0.76
95_A	98_Q	0.583	0.76
81_A	84_K	0.582	0.75
86_A	89_F	0.581	0.75
324_E	330_L	0.581	0.75
138_I	193_R	0.577	0.75
42_D	45_E	0.575	0.75
245_L	273_I	0.574	0.74
69_K	75_G	0.574	0.74
62_P	83_N	0.574	0.74
323_E	327_K	0.574	0.74
131_F	196_S	0.573	0.74
211_K	214_V	0.571	0.74
248_Q	252_N	0.570	0.74
246_E	272_E	0.568	0.74
185_R	194_Q	0.567	0.74
4_F	8_I	0.566	0.73
263_A	283_D	0.566	0.73
109_H	241_Q	0.565	0.73
231_Q	262_N	0.565	0.73
201_P	226_P	0.563	0.73
28_A	32_D	0.562	0.73
202_Q	248_Q	0.561	0.73
180_D	278_E	0.559	0.72
82_G	86_A	0.559	0.72
145_L	149_D	0.558	0.72
110_Q	113_L	0.558	0.72
120_L	210_N	0.557	0.72
137_Y	189_L	0.557	0.72
309_R	312_R	0.555	0.72
3_E	26_K	0.555	0.72
175_L	178_A	0.555	0.72
257_E	286_T	0.554	0.72
123_L	230_T	0.553	0.72
74_L	77_L	0.553	0.72
306_E	313_A	0.553	0.72
304_I	312_R	0.552	0.72
4_F	9_D	0.550	0.71
40_T	98_Q	0.550	0.71
18_Q	22_E	0.548	0.71
264_E	267_K	0.548	0.71
88_Y	92_Y	0.548	0.71
223_N	241_Q	0.546	0.71
52_D	87_K	0.545	0.71
291_N	322_L	0.545	0.71
40_T	51_T	0.543	0.70
270_T	297_T	0.542	0.70
234_L	262_N	0.541	0.70
88_Y	232_V	0.540	0.70
166_P	172_L	0.539	0.70
27_I	196_S	0.539	0.70
274_A	301_V	0.538	0.70
24_Q	185_R	0.538	0.70
72_G	79_G	0.538	0.70
195_V	224_T	0.538	0.70
109_H	244_A	0.538	0.70
284_I	288_K	0.537	0.69
157_E	160_A	0.537	0.69
199_G	269_Q	0.535	0.69
6_A	9_D	0.534	0.69
106_L	198_Q	0.533	0.69
57_L	254_T	0.532	0.69
65_L	68_E	0.531	0.69
268_Q	273_I	0.531	0.69
311_K	315_A	0.530	0.68
216_K	304_I	0.530	0.68
302_L	306_E	0.530	0.68
123_L	233_V	0.529	0.68
46_V	49_S	0.527	0.68
187_H	315_A	0.527	0.68
32_D	36_E	0.527	0.68
295_I	325_E	0.526	0.68
108_K	150_E	0.525	0.68
48_D	51_T	0.525	0.68
280_G	284_I	0.524	0.68
180_D	183_E	0.524	0.68
67_E	70_K	0.522	0.67
6_A	22_E	0.522	0.67
144_K	148_L	0.520	0.67
191_L	319_L	0.520	0.67
294_L	297_T	0.519	0.67
256_N	260_K	0.519	0.67
12_D	18_Q	0.517	0.67
57_L	247_A	0.517	0.67
160_A	167_E	0.516	0.66
186_V	189_L	0.515	0.66
63_S	66_D	0.515	0.66
69_K	77_L	0.514	0.66
190_K	193_R	0.513	0.66
124_Y	207_Q	0.512	0.66
268_Q	271_I	0.512	0.66
23_A	137_Y	0.512	0.66
147_E	175_L	0.511	0.66
53_L	103_V	0.511	0.66
191_L	223_N	0.511	0.66
121_D	124_Y	0.509	0.65
303_Q	314_E	0.508	0.65
246_E	253_D	0.508	0.65
184_K	305_Q	0.508	0.65
141_G	182_L	0.507	0.65
245_L	249_R	0.507	0.65
123_L	214_V	0.507	0.65
278_E	304_I	0.506	0.65
227_L	231_Q	0.505	0.65
149_D	313_A	0.505	0.65
31_S	36_E	0.505	0.65
10_I	13_S	0.505	0.65
319_L	322_L	0.504	0.65
30_F	126_K	0.504	0.65
327_K	330_L	0.502	0.64
5_A	21_A	0.500	0.64
36_E	40_T	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3vkgA	2	0.75	81.1	0.919	Contact Map
4uxvA	1	0.9157	64.3	0.929	Contact Map
1i84S	2	0.3193	48.3	0.936	Contact Map
4uy3A	1	0.5331	42	0.938	Contact Map
4rh7A	1	0.8735	30.2	0.943	Contact Map
2ic6A	1	0.2289	26.7	0.944	Contact Map
3g67A	2	0.5331	22.5	0.946	Contact Map
2ch7A	2	0.747	21.8	0.946	Contact Map
4k1pA	1	0.7651	21.3	0.947	Contact Map
1c1gA	2	0.8253	18.6	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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