GREMLIN Database
Tcp11 - T-complex protein 11
PFAM: PF05794 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 396 (387)
Sequences: 918 (647)
Seq/√Len: 32.9
META: 0.118

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_L333_R4.3801.00
109_R149_D4.1671.00
78_L81_Q4.0851.00
105_C110_D3.8781.00
28_K32_D3.3811.00
301_E304_R3.3461.00
105_C146_M3.3341.00
301_E305_E3.1881.00
4_E11_F3.1431.00
314_Q318_V3.0731.00
4_E8_D2.7211.00
29_A32_D2.6731.00
105_C113_V2.5271.00
4_E7_F2.4841.00
283_K369_E2.4791.00
309_A313_G2.4511.00
295_V301_E2.4491.00
314_Q317_K2.4190.99
315_L318_V2.3320.99
186_T234_E2.2600.99
3_H170_E2.2470.99
4_E13_F2.2170.99
294_A298_I2.1930.99
265_S269_S2.1870.99
2_A11_F2.1860.99
52_I140_F2.1720.99
297_S301_E2.1710.99
24_E28_K2.1700.99
106_A149_D2.1500.99
315_L319_L2.1270.99
155_I217_L2.1020.98
326_V329_L2.0990.98
7_F11_F2.0670.98
110_D146_M2.0660.98
102_K114_K2.0440.98
314_Q323_S2.0340.98
2_A13_F2.0290.98
300_L303_V2.0110.98
299_A305_E1.9910.98
23_K27_H1.9870.98
106_A110_D1.9400.97
75_D81_Q1.8820.97
106_A160_P1.8660.97
250_L373_L1.8620.97
183_L261_L1.8390.96
152_N239_D1.8210.96
293_E301_E1.8190.96
89_D133_V1.8030.96
105_C149_D1.8000.96
3_H16_N1.7820.96
5_I155_I1.7610.95
105_C142_V1.7580.95
271_L286_L1.7500.95
48_L51_E1.7480.95
308_K312_K1.7400.95
354_K357_P1.7310.95
317_K320_Q1.7180.95
215_K220_G1.7120.94
160_P183_L1.6960.94
22_V28_K1.6880.94
56_L134_D1.6740.94
388_F392_Y1.6630.94
28_K247_R1.6590.94
22_V29_A1.6550.93
73_V96_F1.6510.93
56_L183_L1.6460.93
18_L22_V1.6450.93
109_R146_M1.6340.93
112_E145_L1.6230.93
295_V299_A1.6130.93
8_D11_F1.5990.92
170_E333_R1.5770.92
353_Q356_A1.5710.91
76_L155_I1.5540.91
298_I304_R1.5490.91
300_L305_E1.5470.91
105_C116_L1.5360.91
246_L249_Q1.5350.90
169_Y173_K1.5200.90
17_S20_G1.5140.90
59_L63_P1.5090.90
2_A7_F1.5070.90
297_S302_I1.5020.90
314_Q320_Q1.5020.90
223_D335_R1.5000.89
299_A303_V1.4960.89
336_L339_L1.4780.89
388_F391_W1.4730.89
155_I248_A1.4640.88
96_F143_L1.4570.88
381_V385_W1.4540.88
5_I159_R1.4410.87
333_R363_L1.4280.87
299_A304_R1.4230.87
371_E375_E1.4230.87
40_P45_A1.4200.87
108_V146_M1.4120.86
384_N388_F1.4090.86
174_F183_L1.4030.86
142_V146_M1.4010.86
310_S319_L1.3750.85
183_L234_E1.3710.85
311_L318_V1.3680.85
88_L388_F1.3650.84
308_K311_L1.3610.84
355_S359_L1.3590.84
31_W147_K1.3580.84
7_F13_F1.3580.84
110_D113_V1.3550.84
311_L314_Q1.3510.84
148_L152_N1.3450.84
293_E298_I1.3440.83
294_A297_S1.3440.83
189_W235_T1.3430.83
56_L106_A1.3300.83
113_V116_L1.3300.83
111_E257_A1.3220.82
186_T189_W1.3190.82
293_E297_S1.3170.82
106_A166_A1.3100.82
319_L327_R1.2950.81
31_W48_L1.2910.81
140_F162_L1.2900.81
75_D86_G1.2880.81
104_L153_F1.2800.80
196_E254_I1.2800.80
133_V246_L1.2760.80
72_E84_E1.2730.80
251_Q255_I1.2710.80
65_R166_A1.2670.80
281_K284_R1.2660.80
40_P51_E1.2640.79
30_F37_E1.2530.79
37_E49_L1.2510.79
174_F234_E1.2460.78
8_D13_F1.2410.78
307_T315_L1.2400.78
113_V142_V1.2390.78
210_P380_L1.2290.77
189_W220_G1.2260.77
83_A88_L1.2250.77
331_E339_L1.2170.77
4_E14_P1.1870.75
246_L373_L1.1750.74
42_Y52_I1.1640.73
151_A155_I1.1490.73
20_G24_E1.1460.72
14_P17_S1.1430.72
34_L38_L1.1420.72
308_K315_L1.1410.72
313_G317_K1.1390.72
239_D242_R1.1280.71
105_C109_R1.1280.71
179_E328_K1.1240.71
195_A199_A1.1040.69
48_L59_L1.1030.69
225_L250_L1.1010.69
314_Q321_P1.0970.69
297_S303_V1.0970.69
152_N159_R1.0880.68
6_A10_D1.0860.68
313_G318_V1.0800.68
31_W38_L1.0790.68
16_N252_Q1.0790.68
170_E239_D1.0780.68
299_A302_I1.0760.67
294_A301_E1.0720.67
389_G393_E1.0700.67
116_L146_M1.0690.67
247_R251_Q1.0660.67
312_K324_P1.0660.67
223_D342_L1.0630.66
297_S305_E1.0620.66
173_K178_L1.0620.66
179_E373_L1.0590.66
205_S209_G1.0580.66
6_A9_P1.0520.66
78_L82_Q1.0510.66
30_F289_L1.0430.65
81_Q89_D1.0390.65
174_F235_T1.0390.65
31_W137_R1.0380.65
59_L146_M1.0370.65
88_L261_L1.0360.64
286_L302_I1.0300.64
31_W51_E1.0250.64
95_E99_S1.0250.64
170_E326_V1.0220.63
314_Q319_L1.0210.63
3_H7_F1.0190.63
345_R348_G1.0190.63
302_I305_E1.0160.63
78_L85_H1.0150.63
77_D95_E1.0080.62
343_S347_L1.0050.62
316_L319_L1.0050.62
148_L151_A1.0040.62
39_P42_Y1.0030.62
192_E223_D0.9960.61
173_K176_E0.9930.61
139_I150_M0.9930.61
53_K57_L0.9910.61
318_V323_S0.9860.61
6_A166_A0.9850.60
105_C153_F0.9780.60
109_R152_N0.9770.60
5_I78_L0.9770.60
93_L390_P0.9760.60
383_V388_F0.9740.60
146_M159_R0.9730.60
167_V387_V0.9730.60
40_P46_I0.9690.59
338_L356_A0.9680.59
149_D152_N0.9660.59
28_K137_R0.9630.59
105_C170_E0.9620.59
338_L343_S0.9620.59
116_L384_N0.9590.58
116_L153_F0.9570.58
33_A44_R0.9530.58
19_E24_E0.9490.58
6_A330_L0.9480.57
75_D88_L0.9440.57
104_L154_Q0.9410.57
293_E318_V0.9400.57
186_T190_L0.9350.56
148_L163_I0.9340.56
106_A133_V0.9290.56
253_L334_I0.9270.56
114_K282_L0.9260.56
317_K380_L0.9220.55
209_G232_F0.9210.55
101_L113_V0.9200.55
24_E30_F0.9200.55
97_I144_E0.9200.55
329_L335_R0.9170.55
37_E44_R0.9170.55
77_D334_I0.9100.54
72_E100_L0.9070.54
22_V27_H0.9050.54
35_R131_D0.9050.54
26_M29_A0.9000.54
101_L142_V0.8930.53
376_R380_L0.8930.53
312_K318_V0.8870.52
231_E240_R0.8860.52
350_V356_A0.8790.52
111_E289_L0.8780.52
55_I144_E0.8780.52
110_D149_D0.8750.51
36_E162_L0.8710.51
332_Q336_L0.8680.51
144_E153_F0.8670.51
306_E309_A0.8630.50
156_R243_L0.8630.50
2_A8_D0.8600.50
5_I11_F0.8590.50
53_K114_K0.8590.50
311_L322_D0.8590.50
146_M154_Q0.8590.50
307_T314_Q0.8580.50
59_L156_R0.8580.50
217_L221_L0.8510.49
63_P66_L0.8490.49
316_L320_Q0.8480.49
232_F240_R0.8450.49
261_L362_G0.8400.49
295_V298_I0.8400.49
105_C163_I0.8360.48
252_Q255_I0.8360.48
169_Y176_E0.8320.48
74_L109_R0.8280.48
159_R189_W0.8280.48
327_R333_R0.8250.47
107_P110_D0.8230.47
307_T310_S0.8220.47
13_F144_E0.8200.47
140_F303_V0.8190.47
57_L67_R0.8180.47
67_R89_D0.8170.47
136_L191_R0.8170.47
337_F388_F0.8160.47
285_R301_E0.8120.46
238_L331_E0.8090.46
338_L347_L0.8050.46
292_D313_G0.8030.45
67_R139_I0.8010.45
104_L162_L0.8010.45
65_R93_L0.7990.45
196_E223_D0.7990.45
94_A246_L0.7970.45
234_E257_A0.7940.45
363_L366_L0.7940.45
9_P13_F0.7920.45
114_K144_E0.7920.45
61_L388_F0.7900.44
26_M30_F0.7890.44
296_E300_L0.7890.44
155_I160_P0.7890.44
19_E30_F0.7880.44
105_C138_G0.7880.44
192_E253_L0.7870.44
21_R30_F0.7870.44
53_K134_D0.7860.44
248_A259_V0.7840.44
314_Q322_D0.7830.44
5_I9_P0.7820.44
165_H384_N0.7810.44
146_M153_F0.7810.44
13_F20_G0.7790.44
27_H30_F0.7790.44
86_G136_L0.7750.43
8_D353_Q0.7750.43
71_E132_L0.7750.43
241_A291_E0.7690.43
298_I311_L0.7670.43
355_S358_E0.7660.42
162_L250_L0.7570.42
11_F20_G0.7570.42
85_H134_D0.7550.42
270_D273_G0.7520.41
192_E231_E0.7500.41
103_K236_L0.7490.41
308_K314_Q0.7490.41
331_E335_R0.7470.41
174_F186_T0.7440.41
220_G274_S0.7440.41
234_E238_L0.7380.40
312_K315_L0.7370.40
4_E144_E0.7360.40
375_E380_L0.7360.40
103_K157_S0.7350.40
350_V353_Q0.7340.40
37_E75_D0.7330.40
18_L286_L0.7320.40
81_Q133_V0.7320.40
327_R331_E0.7310.40
8_D14_P0.7300.40
96_F156_R0.7260.39
313_G319_L0.7240.39
56_L101_L0.7210.39
196_E282_L0.7210.39
188_K276_P0.7180.39
106_A162_L0.7180.39
234_E362_G0.7160.38
307_T317_K0.7120.38
42_Y48_L0.7110.38
118_E126_N0.7100.38
356_A359_L0.7100.38
138_G141_E0.7090.38
317_K321_P0.7090.38
195_A198_L0.7090.38
174_F242_R0.7070.38
4_E23_K0.7050.38
319_L329_L0.7050.38
59_L304_R0.7050.38
315_L322_D0.7050.38
59_L150_M0.7040.38
209_G364_A0.7030.37
336_L340_A0.7000.37
3_H239_D0.6990.37
297_S300_L0.6980.37
224_L236_L0.6970.37
356_A361_G0.6950.37
56_L128_D0.6950.37
32_D77_D0.6940.37
351_G357_P0.6930.37
102_K117_V0.6920.37
350_V359_L0.6920.37
2_A14_P0.6900.36
70_I103_K0.6900.36
7_F153_F0.6890.36
157_S244_Q0.6880.36
3_H392_Y0.6860.36
132_L156_R0.6850.36
3_H113_V0.6810.36
160_P261_L0.6800.36
15_P18_L0.6760.35
156_R182_S0.6750.35
37_E146_M0.6730.35
18_L29_A0.6720.35
243_L380_L0.6720.35
60_L79_I0.6710.35
247_R312_K0.6710.35
105_C144_E0.6710.35
74_L311_L0.6690.35
162_L309_A0.6670.35
5_I65_R0.6650.35
166_A232_F0.6630.34
110_D152_N0.6630.34
16_N55_I0.6630.34
81_Q86_G0.6630.34
294_A299_A0.6600.34
99_S111_E0.6590.34
105_C159_R0.6580.34
366_L377_L0.6580.34
143_L235_T0.6570.34
276_P336_L0.6560.34
338_L379_R0.6560.34
46_I80_R0.6560.34
366_L370_L0.6550.34
116_L154_Q0.6540.34
318_V322_D0.6520.34
188_K192_E0.6510.33
133_V139_I0.6510.33
138_G142_V0.6500.33
253_L329_L0.6500.33
85_H133_V0.6490.33
113_V170_E0.6490.33
309_A316_L0.6490.33
140_F294_A0.6480.33
116_L144_E0.6480.33
20_G151_A0.6460.33
133_V242_R0.6450.33
143_L159_R0.6450.33
313_G316_L0.6450.33
80_R84_E0.6430.33
162_L282_L0.6410.33
286_L298_I0.6400.33
137_R147_K0.6400.33
199_A205_S0.6380.33
247_R290_L0.6380.33
201_S211_S0.6380.33
253_L317_K0.6380.33
200_E344_A0.6370.32
186_T392_Y0.6360.32
76_L84_E0.6360.32
73_V158_L0.6340.32
249_Q376_R0.6340.32
246_L376_R0.6340.32
81_Q242_R0.6320.32
11_F14_P0.6300.32
105_C147_K0.6300.32
319_L323_S0.6280.32
309_A319_L0.6270.32
197_L380_L0.6260.32
338_L373_L0.6250.32
192_E377_L0.6250.32
38_L349_R0.6250.32
306_E359_L0.6240.32
343_S348_G0.6240.32
379_R386_Q0.6210.31
309_A314_Q0.6200.31
116_L135_G0.6200.31
72_E92_K0.6190.31
329_L332_Q0.6180.31
268_G273_G0.6170.31
3_H9_P0.6170.31
42_Y51_E0.6140.31
144_E154_Q0.6140.31
27_H38_L0.6130.31
350_V358_E0.6090.30
4_E17_S0.6080.30
8_D135_G0.6080.30
199_A211_S0.6080.30
257_A266_L0.6070.30
172_K176_E0.6070.30
358_E365_P0.6060.30
266_L286_L0.6040.30
140_F180_K0.6020.30
170_E363_L0.6020.30
95_E103_K0.6000.30
153_F263_T0.6000.30
7_F12_Q0.5970.30
155_I252_Q0.5960.30
290_L334_I0.5950.29
30_F52_I0.5950.29
174_F239_D0.5930.29
166_A177_R0.5920.29
339_L348_G0.5920.29
210_P296_E0.5920.29
102_K153_F0.5900.29
333_R370_L0.5890.29
74_L149_D0.5880.29
361_G390_P0.5880.29
156_R241_A0.5880.29
162_L204_S0.5870.29
29_A39_P0.5860.29
5_I14_P0.5860.29
112_E141_E0.5860.29
97_I143_L0.5850.29
15_P158_L0.5840.29
2_A104_L0.5830.29
107_P147_K0.5820.29
387_V391_W0.5810.29
246_L380_L0.5810.29
1_L151_A0.5800.28
41_D44_R0.5800.28
84_E213_S0.5790.28
291_E321_P0.5760.28
315_L387_V0.5760.28
136_L279_V0.5750.28
23_K70_I0.5750.28
105_C154_Q0.5740.28
74_L106_A0.5720.28
105_C133_V0.5700.28
137_R181_G0.5690.28
111_E288_A0.5690.28
174_F261_L0.5670.28
221_L381_V0.5660.28
211_S350_V0.5650.27
183_L186_T0.5640.27
132_L135_G0.5630.27
298_I302_I0.5620.27
265_S268_G0.5620.27
281_K285_R0.5610.27
251_Q293_E0.5610.27
101_L131_D0.5610.27
106_A109_R0.5600.27
97_I109_R0.5590.27
309_A317_K0.5580.27
337_F384_N0.5580.27
296_E304_R0.5560.27
232_F380_L0.5560.27
116_L138_G0.5550.27
70_I376_R0.5540.27
30_F237_L0.5530.27
45_A67_R0.5520.27
178_L234_E0.5510.27
116_L142_V0.5490.26
98_L139_I0.5480.26
323_S389_G0.5480.26
60_L253_L0.5480.26
317_K334_I0.5460.26
100_L115_K0.5460.26
155_I162_L0.5440.26
195_A298_I0.5440.26
212_P380_L0.5440.26
107_P289_L0.5430.26
353_Q358_E0.5430.26
45_A145_L0.5420.26
102_K144_E0.5420.26
295_V303_V0.5410.26
196_E250_L0.5400.26
21_R215_K0.5380.26
193_A377_L0.5380.26
315_L327_R0.5360.26
105_C166_A0.5350.25
1_L4_E0.5320.25
111_E209_G0.5300.25
218_N381_V0.5300.25
80_R247_R0.5290.25
23_K269_S0.5290.25
93_L264_R0.5290.25
332_Q339_L0.5280.25
79_I189_W0.5280.25
38_L253_L0.5260.25
311_L319_L0.5250.25
251_Q317_K0.5250.25
112_E247_R0.5240.25
248_A316_L0.5240.25
317_K323_S0.5230.25
36_E138_G0.5230.25
39_P45_A0.5230.25
50_K76_L0.5220.25
362_G366_L0.5210.25
192_E347_L0.5210.25
188_K220_G0.5210.25
67_R70_I0.5200.25
152_N170_E0.5190.25
158_L182_S0.5180.24
96_F146_M0.5180.24
35_R134_D0.5180.24
11_F30_F0.5170.24
59_L155_I0.5150.24
30_F173_K0.5150.24
276_P373_L0.5110.24
342_L386_Q0.5110.24
24_E303_V0.5100.24
351_G356_A0.5100.24
34_L337_F0.5090.24
254_I383_V0.5080.24
38_L142_V0.5070.24
45_A227_W0.5060.24
146_M170_E0.5060.24
302_I388_F0.5040.24
224_L231_E0.5030.24
82_Q148_L0.5020.23
186_T224_L0.5020.23
113_V146_M0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jiuA 1 0.1212 14.3 0.969 Contact Map
3dfzA 2 0.2399 12.5 0.97 Contact Map
1wteA 2 0.2298 8.9 0.972 Contact Map
4qhjA 2 0.1061 6.4 0.974 Contact Map
3h4sE 1 0.2374 5.8 0.974 Contact Map
3fmeA 1 0.2197 5.7 0.974 Contact Map
1gs9A 1 0.3409 5 0.975 Contact Map
3bpjA 2 0.1919 4.9 0.975 Contact Map
4wlrB 1 0.2374 4.4 0.976 Contact Map
4jixA 2 0.1111 4.3 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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