GREMLIN Database
CFEM - CFEM domain
PFAM: PF05730 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (64)
Sequences: 2318 (2022)
Seq/√Len: 252.8
META: 0.138

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_C44_C4.9221.00
23_C30_C3.7441.00
50_T53_D2.6621.00
59_N63_A2.1301.00
51_A55_L2.0861.00
7_A10_L2.0511.00
9_A57_A1.9611.00
34_N37_F1.9141.00
31_L37_F1.7851.00
8_C49_C1.7751.00
55_L59_N1.6751.00
5_L9_A1.6501.00
17_L20_S1.5251.00
35_A39_S1.4311.00
53_D56_A1.4311.00
11_T15_S1.4241.00
16_A40_A1.3531.00
36_A40_A1.3361.00
10_L14_T1.2961.00
42_T46_A1.2451.00
58_L62_Q1.2321.00
63_A66_A1.1991.00
36_A39_S1.1631.00
59_N62_Q1.1331.00
6_P9_A1.1051.00
9_A61_A1.0801.00
17_L31_L1.0751.00
19_A40_A1.0611.00
28_V64_L1.0581.00
4_D64_L1.0241.00
50_T55_L0.9641.00
29_A33_T0.9621.00
32_C65_C0.9431.00
13_L37_F0.9351.00
5_L60_A0.9281.00
16_A43_D0.9221.00
62_Q66_A0.9021.00
26_T31_L0.8681.00
39_S42_T0.8580.99
13_L41_V0.8500.99
22_G34_N0.8260.99
38_Q42_T0.8200.99
13_L31_L0.8180.99
55_L58_L0.8080.99
55_L61_A0.7830.99
7_A11_T0.7740.99
31_L41_V0.7650.99
9_A60_A0.7630.99
43_D47_S0.7550.99
6_P11_T0.7420.98
11_T14_T0.7390.98
50_T57_A0.7340.98
17_L28_V0.7260.98
11_T48_A0.7230.98
45_V57_A0.7170.98
6_P53_D0.7060.98
56_A59_N0.6920.98
58_L66_A0.6900.98
9_A48_A0.6890.98
51_A54_A0.6820.97
54_A61_A0.6790.97
14_T25_L0.6700.97
19_A22_G0.6690.97
21_S34_N0.6490.96
14_T18_A0.6450.96
38_Q62_Q0.6410.96
5_L42_T0.6400.96
16_A41_V0.6350.96
4_D28_V0.6350.96
13_L45_V0.6330.96
15_S48_A0.6250.96
39_S43_D0.6250.96
33_T36_A0.6240.96
3_S10_L0.6210.95
13_L16_A0.6200.95
4_D60_A0.6200.95
14_T43_D0.6080.95
52_A55_L0.6050.95
34_N38_Q0.6010.95
52_A56_A0.5900.94
35_A51_A0.5900.94
4_D63_A0.5890.94
37_F41_V0.5890.94
17_L37_F0.5740.93
9_A49_C0.5740.93
24_S52_A0.5710.93
55_L66_A0.5680.93
59_N64_L0.5470.91
60_A64_L0.5450.91
18_A21_S0.5390.91
45_V58_L0.5200.89
54_A58_L0.5190.89
26_T62_Q0.5150.89
35_A42_T0.5090.88
28_V41_V0.5030.88
3_S35_A0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ln4A 1 0.4697 3.3 0.84 Contact Map
2fqaA 1 0.4091 1.6 0.864 Contact Map
4ttnB 1 0.3939 1.5 0.866 Contact Map
2lamA 1 0.4394 1.5 0.867 Contact Map
2e3eA 1 0.5 1.2 0.873 Contact Map
2lr5A 1 0.5 1.2 0.875 Contact Map
1i2uA 1 0.5 1.1 0.877 Contact Map
2kozA 1 0.5 1.1 0.878 Contact Map
1kalA 1 0.3636 1 0.879 Contact Map
2e3gA 1 0.4848 1 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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