GREMLIN Database
TnpB_IS66 - IS66 Orf2 like protein
PFAM: PF05717 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (98)
Sequences: 32255 (15558)
Seq/√Len: 1571.6
META: 0.96

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_K18_G3.3591.00
40_R71_W2.5211.00
17_D63_R2.4351.00
51_Y60_W2.3591.00
83_T86_Q2.3511.00
46_R61_Y2.3311.00
14_K22_L2.3221.00
16_F61_Y2.2891.00
40_R44_R2.2601.00
21_A25_E2.1981.00
36_L49_I2.0301.00
84_A88_A1.9901.00
29_L79_V1.9331.00
51_Y58_W1.9211.00
64_L69_F1.8791.00
4_Y35_H1.6831.00
41_N45_D1.6811.00
10_T22_L1.5321.00
9_P42_R1.5141.00
23_V37_F1.4791.00
38_V49_I1.4721.00
48_K61_Y1.4531.00
70_R95_D1.4481.00
88_A92_E1.4331.00
55_D62_K1.4321.00
29_L35_H1.4021.00
43_R46_R1.3971.00
46_R63_R1.3901.00
56_G62_K1.3671.00
85_A92_E1.3631.00
12_M41_N1.3421.00
12_M46_R1.3221.00
22_L26_V1.2771.00
53_D62_K1.2611.00
10_T19_L1.2601.00
16_F57_F1.2531.00
58_W62_K1.2531.00
24_R30_D1.2521.00
85_A89_L1.2281.00
6_A10_T1.2251.00
20_A57_F1.1821.00
89_L94_I1.1571.00
50_L59_L1.1101.00
50_L57_F1.0861.00
74_D77_D1.0851.00
6_A27_L1.0831.00
24_R32_F1.0691.00
52_W65_E1.0651.00
31_P57_F1.0571.00
3_I36_L1.0481.00
23_V27_L1.0341.00
21_A24_R1.0321.00
20_A50_L1.0271.00
49_I60_W1.0041.00
2_R35_H1.0011.00
40_R47_I0.9561.00
20_A31_P0.9451.00
29_L33_S0.9321.00
52_W57_F0.9101.00
6_A22_L0.8981.00
3_I38_V0.8951.00
16_F59_L0.8931.00
12_M48_K0.8861.00
87_L91_L0.8861.00
30_D33_S0.8831.00
70_R97_R0.8671.00
23_V50_L0.8561.00
2_R29_L0.8501.00
8_G26_V0.8471.00
36_L51_Y0.8431.00
4_Y29_L0.8281.00
49_I87_L0.8281.00
95_D98_R0.8231.00
29_L37_F0.8141.00
23_V26_V0.8121.00
85_A88_A0.8051.00
2_R81_E0.7981.00
11_D14_K0.7841.00
15_G61_Y0.7801.00
44_R68_R0.7631.00
70_R96_L0.7541.00
95_D99_V0.7461.00
32_F57_F0.7451.00
20_A24_R0.7421.00
23_V39_F0.7271.00
38_V87_L0.7211.00
26_V35_H0.7161.00
9_P41_N0.7081.00
75_A78_G0.7061.00
53_D56_G0.7061.00
5_L40_R0.7051.00
52_W55_D0.7041.00
44_R71_W0.6981.00
7_T80_V0.6881.00
92_E99_V0.6851.00
15_G59_L0.6721.00
83_T88_A0.6651.00
44_R73_R0.6591.00
33_S37_F0.6551.00
27_L79_V0.6471.00
89_L92_E0.6421.00
6_A26_V0.6411.00
86_Q89_L0.6411.00
12_M15_G0.6351.00
40_R90_L0.6271.00
26_V29_L0.6251.00
5_L38_V0.6221.00
32_F52_W0.6201.00
17_D24_R0.6041.00
24_R31_P0.6031.00
8_G78_G0.6031.00
9_P44_R0.6021.00
23_V29_L0.6001.00
12_M59_L0.5981.00
10_T14_K0.5931.00
27_L31_P0.5831.00
47_I69_F0.5811.00
14_K21_A0.5751.00
14_K25_E0.5741.00
82_L90_L0.5731.00
58_W91_L0.5731.00
55_D58_W0.5721.00
18_G22_L0.5701.00
92_E96_L0.5651.00
16_F20_A0.5611.00
36_L60_W0.5611.00
74_D78_G0.5571.00
12_M61_Y0.5531.00
80_V97_R0.5491.00
62_K65_E0.5441.00
86_Q94_I0.5441.00
20_A23_V0.5421.00
17_D46_R0.5391.00
4_Y7_T0.5391.00
53_D58_W0.5331.00
70_R86_Q0.5301.00
15_G18_G0.5301.00
28_G78_G0.5261.00
80_V83_T0.5241.00
84_A92_E0.5201.00
5_L82_L0.5191.00
96_L99_V0.5181.00
80_V84_A0.5161.00
19_L48_K0.5061.00
43_R68_R0.5051.00
70_R98_R0.5011.00
54_G92_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wapA 2 0.63 34.8 0.883 Contact Map
3wamA 2 0.63 31.8 0.885 Contact Map
3vtwA 1 0.63 23.6 0.892 Contact Map
3vtvA 1 0.63 21.7 0.894 Contact Map
3h9dA 2 0.64 21 0.894 Contact Map
3w1yA 2 0.62 20.2 0.895 Contact Map
3ruiB 1 0.64 18.7 0.897 Contact Map
3m95A 1 0.63 17.1 0.899 Contact Map
2zjdA 1 0.66 13.9 0.903 Contact Map
2r2qA 1 0.66 12.6 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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