GREMLIN Database
Glyco_transf_90 - Glycosyl transferase family 90
PFAM: PF05686 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 395 (333)
Sequences: 680 (451)
Seq/√Len: 24.7
META: 0.121

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_H286_E5.7001.00
213_C236_C3.8861.00
29_V324_F3.7911.00
46_K334_E3.3251.00
86_N110_S3.1861.00
39_R82_E3.1121.00
155_E288_Q2.8210.99
317_E320_K2.7980.99
159_P216_K2.7950.99
229_R233_L2.7070.99
16_L314_L2.5850.99
81_L315_L2.5240.99
157_K237_D2.4640.99
88_G224_V2.4290.98
44_N80_D2.3440.98
37_G88_G2.3280.98
90_W224_V2.2590.97
265_K272_D2.1770.97
241_L280_G2.1490.97
113_G248_Y2.1400.96
208_S211_D2.1010.96
43_V80_D2.0880.96
319_A322_L2.0760.96
147_E150_K2.0730.96
23_G323_K2.0680.96
175_D269_D2.0440.95
239_V287_A2.0410.95
144_S210_E2.0360.95
279_W283_H2.0070.95
231_K236_C1.9940.95
324_F331_G1.9440.94
239_V285_E1.9380.94
110_S119_D1.9070.93
280_G287_A1.8930.93
47_L71_L1.8830.93
6_P9_F1.8690.93
129_G132_E1.8580.92
7_D10_R1.8500.92
213_C222_E1.8410.92
141_L145_I1.8350.92
312_F316_N1.8350.92
162_F207_S1.8280.92
84_M108_L1.8270.92
91_P225_A1.8170.91
222_E242_K1.8000.91
46_K335_V1.7910.91
157_K239_V1.7890.91
237_D295_S1.7890.91
169_V249_E1.7880.91
161_A219_I1.7750.90
159_P281_N1.7740.90
233_L249_E1.7690.90
216_K284_D1.7650.90
158_E211_D1.7380.89
113_G117_T1.7290.89
40_Y47_L1.7090.89
88_G110_S1.7050.89
17_R335_V1.6820.88
285_E317_E1.6770.88
40_Y49_V1.6570.87
61_V68_L1.6530.87
80_D325_K1.6400.86
153_P156_D1.6320.86
114_D117_T1.6090.85
262_W280_G1.6070.85
121_V248_Y1.6050.85
5_C15_D1.5970.85
213_C231_K1.5910.85
46_K73_K1.5820.84
236_C250_F1.5460.83
329_P332_A1.5320.82
237_D292_K1.5320.82
259_Q293_A1.5260.82
227_S231_K1.5220.82
303_K306_Y1.5000.81
19_W23_G1.4910.81
289_A293_A1.4810.80
239_V302_L1.4280.78
234_L251_F1.4230.77
194_Q207_S1.4180.77
29_V293_A1.4160.77
5_C16_L1.4160.77
8_Y25_T1.4130.77
292_K296_D1.3900.76
173_R176_L1.3840.75
286_E289_A1.3730.75
43_V325_K1.3650.74
192_T215_Y1.3630.74
221_I243_V1.3470.73
94_P97_D1.3410.73
282_E285_E1.3390.73
11_W15_D1.3360.73
108_L289_A1.3350.73
256_K259_Q1.3320.72
128_W236_C1.3250.72
82_E309_C1.3240.72
297_F302_L1.3140.71
222_E236_C1.3100.71
86_N224_V1.3070.71
83_L160_Y1.3040.71
46_K271_S1.3030.71
145_I211_D1.2860.70
91_P110_S1.2770.69
296_D300_E1.2740.69
265_K271_S1.2720.69
242_K245_P1.2720.69
86_N91_P1.2640.68
211_D214_K1.2540.68
223_G227_S1.2470.67
186_L189_A1.2440.67
268_D271_S1.2380.67
121_V153_P1.2260.66
154_W284_D1.2260.66
112_C247_Y1.2230.66
256_K284_D1.2060.65
62_F70_L1.1980.64
110_S169_V1.1950.64
186_L192_T1.1860.63
21_E323_K1.1800.63
115_D285_E1.1790.63
131_P191_I1.1780.63
69_Q72_R1.1720.62
173_R189_A1.1650.62
82_E324_F1.1540.61
47_L335_V1.1520.61
333_V337_S1.1500.61
46_K150_K1.1480.61
56_F191_I1.1400.60
91_P119_D1.1390.60
4_T293_A1.1340.60
255_L273_L1.1290.59
141_L144_S1.1280.59
168_T224_V1.1190.59
17_R327_T1.1170.59
23_G127_F1.1160.58
246_E327_T1.1150.58
113_G302_L1.1110.58
227_S236_C1.1070.58
47_L198_T1.1050.58
56_F224_V1.1010.57
141_L273_L1.0810.56
30_E282_E1.0790.56
50_E331_G1.0730.55
110_S249_E1.0690.55
65_W69_Q1.0670.55
6_P12_I1.0670.55
257_P261_Y1.0570.54
17_R330_P1.0530.54
165_G173_R1.0470.54
180_N189_A1.0460.54
14_E17_R1.0440.53
64_L70_L1.0430.53
239_V280_G1.0400.53
80_D87_C1.0390.53
297_F301_N1.0380.53
12_I297_F1.0360.53
210_E272_D1.0290.52
32_A225_A1.0280.52
189_A273_L1.0260.52
41_V50_E1.0250.52
27_E31_R1.0010.50
89_D123_P0.9930.50
66_G69_Q0.9910.50
48_Y108_L0.9870.49
212_Q311_M0.9860.49
283_H288_Q0.9810.49
264_V276_A0.9800.49
77_R93_V0.9790.49
139_D204_F0.9780.49
183_D274_K0.9720.48
268_D272_D0.9700.48
95_K118_L0.9700.48
71_L75_P0.9600.47
207_S277_V0.9590.47
113_G245_P0.9570.47
176_L264_V0.9560.47
56_F193_K0.9560.47
115_D330_P0.9540.47
269_D272_D0.9520.47
82_E331_G0.9490.47
188_D191_I0.9470.46
42_I67_I0.9430.46
19_W22_T0.9420.46
41_V328_V0.9420.46
256_K267_D0.9400.46
235_A297_F0.9380.46
67_I319_A0.9370.46
244_K265_K0.9360.46
279_W286_E0.9310.45
240_V294_G0.9280.45
122_F314_L0.9260.45
224_V267_D0.9250.45
128_W213_C0.9240.45
179_C187_W0.9240.45
88_G221_I0.9220.45
222_E228_V0.9170.44
16_L109_F0.9130.44
12_I15_D0.9130.44
41_V109_F0.9040.43
265_K269_D0.9040.43
59_R71_L0.9010.43
197_D201_K0.8980.43
176_L189_A0.8980.43
232_Y236_C0.8940.43
177_L191_I0.8880.42
13_H317_E0.8870.42
131_P236_C0.8830.42
88_G114_D0.8810.42
132_E232_Y0.8810.42
186_L190_R0.8770.41
3_P328_V0.8740.41
260_H263_P0.8740.41
3_P267_D0.8720.41
29_V34_R0.8700.41
287_A291_A0.8670.41
15_D120_I0.8670.41
213_C250_F0.8650.41
151_R273_L0.8640.41
11_W14_E0.8630.40
229_R249_E0.8610.40
184_P187_W0.8590.40
18_P26_R0.8580.40
239_V268_D0.8580.40
220_Y226_W0.8560.40
110_S224_V0.8550.40
58_T61_V0.8550.40
33_K44_N0.8550.40
130_W221_I0.8530.40
166_N229_R0.8500.40
90_W113_G0.8500.40
122_F129_G0.8500.40
3_P21_E0.8470.39
270_C280_G0.8460.39
4_T7_D0.8430.39
124_D163_W0.8430.39
23_G26_R0.8430.39
31_R80_D0.8430.39
296_D330_P0.8410.39
194_Q225_A0.8400.39
4_T325_K0.8370.39
128_W231_K0.8360.39
124_D228_V0.8330.38
234_L294_G0.8320.38
33_K46_K0.8320.38
173_R180_N0.8260.38
10_R13_H0.8240.38
46_K155_E0.8240.38
39_R332_A0.8210.38
162_F218_K0.8200.37
166_N226_W0.8190.37
324_F327_T0.8180.37
9_F253_R0.8170.37
74_Y281_N0.8120.37
213_C247_Y0.8050.36
66_G129_G0.7980.36
236_C247_Y0.7950.36
93_V108_L0.7940.36
161_A264_V0.7910.36
49_V110_S0.7900.35
49_V171_E0.7850.35
198_T244_K0.7830.35
105_P326_P0.7810.35
176_L219_I0.7810.35
111_Y130_W0.7790.35
297_F331_G0.7770.35
184_P192_T0.7740.34
283_H323_K0.7730.34
24_I296_D0.7730.34
153_P157_K0.7720.34
86_N119_D0.7700.34
213_C227_S0.7680.34
25_T292_K0.7680.34
126_S231_K0.7680.34
3_P330_P0.7640.34
145_I208_S0.7600.34
320_K323_K0.7580.33
125_W228_V0.7530.33
244_K267_D0.7520.33
211_D278_D0.7520.33
28_M78_L0.7520.33
107_P119_D0.7510.33
222_E226_W0.7500.33
231_K249_E0.7490.33
243_V291_A0.7460.33
4_T331_G0.7450.33
47_L305_D0.7440.33
128_W311_M0.7440.33
4_T14_E0.7410.32
98_Y106_P0.7400.32
38_F87_C0.7390.32
4_T116_D0.7390.32
222_E232_Y0.7350.32
86_N90_W0.7340.32
130_W232_Y0.7300.32
82_E90_W0.7300.32
327_T331_G0.7280.32
42_I114_D0.7270.31
11_W19_W0.7230.31
140_L145_I0.7220.31
164_R223_G0.7210.31
213_C226_W0.7190.31
118_L323_K0.7180.31
288_Q315_L0.7180.31
164_R188_D0.7170.31
56_F168_T0.7170.31
7_D268_D0.7140.31
59_R213_C0.7140.31
234_L242_K0.7130.31
85_F308_Y0.7120.31
4_T78_L0.7110.30
275_E330_P0.7090.30
155_E285_E0.7090.30
270_C273_L0.7080.30
167_P249_E0.7070.30
77_R316_N0.7060.30
65_W70_L0.7060.30
205_K215_Y0.7050.30
136_G181_R0.7050.30
267_D271_S0.7040.30
126_S225_A0.7020.30
239_V262_W0.7000.30
37_G53_G0.7000.30
110_S172_T0.6990.30
41_V82_E0.6990.30
68_L219_I0.6980.30
163_W229_R0.6970.30
131_P142_L0.6960.30
188_D298_I0.6960.30
90_W225_A0.6960.30
43_V328_V0.6960.30
90_W121_V0.6950.29
67_I295_S0.6920.29
179_C321_L0.6900.29
17_R255_L0.6890.29
277_V280_G0.6880.29
122_F127_F0.6870.29
86_N294_G0.6860.29
37_G224_V0.6860.29
242_K252_Y0.6850.29
73_K284_D0.6830.29
56_F88_G0.6820.29
143_K147_E0.6820.29
234_L255_L0.6770.28
58_T70_L0.6760.28
145_I254_G0.6750.28
44_N48_Y0.6740.28
226_W231_K0.6710.28
64_L69_Q0.6700.28
27_E331_G0.6680.28
293_A327_T0.6680.28
168_T193_K0.6670.28
44_N278_D0.6660.28
322_L326_P0.6660.28
3_P211_D0.6650.28
213_C249_E0.6650.28
319_A324_F0.6640.28
225_A236_C0.6630.28
77_R335_V0.6620.28
103_A268_D0.6610.27
109_F219_I0.6600.27
125_W307_V0.6600.27
111_Y124_D0.6600.27
252_Y255_L0.6600.27
5_C8_Y0.6590.27
64_L72_R0.6570.27
108_L314_L0.6560.27
115_D292_K0.6560.27
129_G133_I0.6550.27
46_K274_K0.6550.27
160_Y188_D0.6540.27
219_I233_L0.6520.27
177_L275_E0.6520.27
16_L235_A0.6510.27
268_D292_K0.6510.27
26_R325_K0.6510.27
239_V259_Q0.6480.27
192_T252_Y0.6480.27
107_P318_Y0.6480.27
94_P335_V0.6470.27
14_E288_Q0.6460.27
180_N184_P0.6440.27
68_L112_C0.6420.26
6_P10_R0.6370.26
154_W279_W0.6370.26
21_E268_D0.6360.26
16_L270_C0.6350.26
161_A216_K0.6340.26
59_R159_P0.6320.26
81_L322_L0.6310.26
104_A335_V0.6280.26
62_F69_Q0.6270.26
226_W249_E0.6250.25
229_R309_C0.6220.25
109_F162_F0.6220.25
42_I244_K0.6200.25
163_W222_E0.6180.25
329_P334_E0.6160.25
47_L115_D0.6160.25
241_L263_P0.6130.25
268_D293_A0.6080.25
69_Q74_Y0.6080.25
93_V251_F0.6070.25
162_F252_Y0.6050.24
29_V334_E0.6050.24
130_W213_C0.6050.24
135_I209_L0.6040.24
27_E272_D0.6030.24
294_G299_R0.6030.24
174_L224_V0.6020.24
214_K296_D0.6020.24
98_Y251_F0.5990.24
26_R155_E0.5980.24
115_D248_Y0.5950.24
109_F322_L0.5940.24
195_D264_V0.5940.24
193_K197_D0.5930.24
168_T294_G0.5920.24
172_T252_Y0.5900.24
20_K289_A0.5890.24
69_Q212_Q0.5890.24
273_L282_E0.5880.24
82_E319_A0.5860.23
6_P13_H0.5860.23
21_E104_A0.5830.23
7_D273_L0.5830.23
218_K229_R0.5820.23
262_W287_A0.5810.23
251_F310_Y0.5810.23
20_K26_R0.5800.23
131_P168_T0.5800.23
302_L337_S0.5790.23
151_R211_D0.5760.23
297_F322_L0.5760.23
143_K267_D0.5760.23
180_N188_D0.5730.23
71_L297_F0.5730.23
107_P302_L0.5710.23
51_K78_L0.5680.22
10_R273_L0.5680.22
94_P114_D0.5660.22
66_G70_L0.5650.22
127_F232_Y0.5650.22
181_R190_R0.5640.22
239_V245_P0.5640.22
27_E188_D0.5600.22
127_F231_K0.5600.22
139_D225_A0.5590.22
205_K239_V0.5590.22
207_S287_A0.5580.22
115_D267_D0.5580.22
59_R69_Q0.5580.22
124_D236_C0.5560.22
220_Y240_V0.5560.22
131_P213_C0.5550.22
42_I81_L0.5500.22
242_K337_S0.5490.22
124_D249_E0.5480.21
226_W229_R0.5460.21
244_K263_P0.5440.21
114_D246_E0.5440.21
23_G321_L0.5430.21
262_W308_Y0.5420.21
7_D17_R0.5410.21
163_W249_E0.5410.21
157_K214_K0.5400.21
111_Y132_E0.5400.21
296_D319_A0.5400.21
236_C243_V0.5390.21
109_F314_L0.5380.21
23_G28_M0.5380.21
161_A270_C0.5350.21
7_D259_Q0.5330.21
172_T335_V0.5320.21
178_K193_K0.5300.21
153_P267_D0.5290.21
11_W245_P0.5270.20
141_L237_D0.5270.20
213_C228_V0.5250.20
213_C233_L0.5250.20
224_V268_D0.5240.20
130_W236_C0.5220.20
109_F321_L0.5180.20
31_R47_L0.5170.20
9_F15_D0.5160.20
13_H20_K0.5150.20
23_G315_L0.5140.20
15_D19_W0.5130.20
32_A106_P0.5130.20
266_R335_V0.5120.20
150_K319_A0.5110.20
35_T51_K0.5110.20
46_K149_N0.5090.20
113_G242_K0.5090.20
174_L244_K0.5070.20
122_F249_E0.5070.20
163_W234_L0.5060.20
56_F61_V0.5060.20
46_K319_A0.5050.19
125_W128_W0.5020.19
63_T85_F0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x7rA 1 0.5595 30.9 0.976 Contact Map
3qhpA 1 0.3949 29.7 0.976 Contact Map
2x6qA 1 0.6405 29.3 0.976 Contact Map
4bfcA 3 0.443 23 0.978 Contact Map
4dgwB 1 0.2127 22.8 0.978 Contact Map
3c48A 2 0.7696 12.4 0.98 Contact Map
5c8hA 1 0.2481 12.1 0.98 Contact Map
2g8lA 2 0.3342 11.7 0.98 Contact Map
3oy2A 2 0.7165 11.6 0.98 Contact Map
1p4wA 1 0.0608 10.8 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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