DUF817 - PFAM28P - GREMLIN Contacts

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DUF817 - Protein of unknown function (DUF817)

PFAM:	PF05675	Sequences: EFLRFGLKQAWACLFGGLMLALLLLTHLWPPDALPLARYDFLLLAALAIQAAMLAFRLETWDEAKVILLFHVVGTAMELFKTSIGSWSYPEPALLKIGGVPLFSGFMYAAVGSYIARAWRLFDLRFTRYPPLWATVLLAAAIYVNFFTHHYIPDIRWLLFAAVLLLFGRTWVHFRVWRRRRRMPLLLGFVLVAFFIWLAENIGTFTGAWLYPNQLDGWSLVSLGKLGSWFLLMIISF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	237 (237)
Sequences:	1999 (1097)
Seq/√Len:	71.3
META:	0.714

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
171_W	182_R	4.361	1.00
22_L	45_A	4.227	1.00
43_L	95_L	4.156	1.00
129_Y	135_T	3.806	1.00
18_L	49_I	3.511	1.00
152_I	155_I	3.272	1.00
37_A	94_L	3.185	1.00
175_R	180_R	3.154	1.00
54_L	64_A	3.007	1.00
144_V	148_T	2.859	1.00
188_G	192_V	2.857	1.00
52_A	56_F	2.740	1.00
163_V	234_I	2.636	1.00
62_D	65_K	2.619	1.00
93_A	96_K	2.547	1.00
61_W	65_K	2.462	1.00
124_L	172_V	2.440	1.00
160_F	227_G	2.438	1.00
213_N	219_S	2.377	1.00
51_A	55_A	2.325	1.00
3_L	6_G	2.196	1.00
134_A	166_L	2.165	1.00
194_F	198_L	2.048	1.00
2_F	6_G	2.045	1.00
30_P	33_A	1.968	1.00
128_R	169_R	1.908	1.00
124_L	192_V	1.869	1.00
9_Q	114_Y	1.849	1.00
24_L	206_T	1.824	1.00
22_L	42_L	1.806	1.00
172_V	192_V	1.781	1.00
125_R	180_R	1.758	1.00
64_A	68_L	1.749	1.00
131_P	134_A	1.740	1.00
168_G	171_W	1.739	1.00
172_V	185_L	1.722	1.00
142_I	235_I	1.697	1.00
41_F	45_A	1.694	1.00
164_L	186_L	1.692	1.00
45_A	49_I	1.658	1.00
12_A	121_L	1.650	0.99
183_M	191_L	1.644	0.99
119_W	124_L	1.629	0.99
57_R	61_W	1.607	0.99
32_D	35_P	1.554	0.99
127_T	173_H	1.547	0.99
123_D	175_R	1.516	0.99
155_I	158_L	1.514	0.99
115_I	188_G	1.500	0.99
203_G	206_T	1.491	0.99
19_M	23_L	1.465	0.99
37_A	92_P	1.460	0.99
74_G	109_A	1.454	0.99
189_F	192_V	1.442	0.99
21_A	25_L	1.433	0.99
53_M	58_L	1.419	0.98
129_Y	237_F	1.419	0.98
119_W	126_F	1.406	0.98
79_L	98_G	1.404	0.98
53_M	109_A	1.385	0.98
224_G	228_S	1.317	0.97
210_L	215_L	1.312	0.97
148_T	152_I	1.307	0.97
36_L	41_F	1.299	0.97
44_L	48_A	1.282	0.97
80_F	149_H	1.272	0.97
157_W	161_A	1.262	0.97
23_L	208_A	1.252	0.97
160_F	164_L	1.249	0.97
1_E	8_K	1.246	0.96
190_V	226_L	1.235	0.96
149_H	152_I	1.235	0.96
19_M	46_A	1.229	0.96
82_T	96_K	1.219	0.96
118_A	124_L	1.216	0.96
115_I	118_A	1.212	0.96
173_H	182_R	1.210	0.96
126_F	237_F	1.206	0.96
84_I	149_H	1.199	0.96
6_G	10_A	1.183	0.95
167_F	171_W	1.182	0.95
36_L	44_L	1.175	0.95
165_L	168_G	1.175	0.95
39_Y	91_E	1.172	0.95
214_Q	221_V	1.163	0.95
43_L	47_L	1.155	0.95
72_V	76_A	1.145	0.94
207_G	210_L	1.121	0.94
189_F	234_I	1.116	0.94
14_L	18_L	1.115	0.94
135_T	167_F	1.114	0.94
195_F	198_L	1.101	0.93
202_I	206_T	1.096	0.93
163_V	230_F	1.090	0.93
1_E	181_R	1.088	0.93
137_L	141_A	1.080	0.92
189_F	233_M	1.080	0.92
124_L	185_L	1.075	0.92
115_I	124_L	1.072	0.92
132_L	136_V	1.069	0.92
26_T	91_E	1.066	0.92
192_V	233_M	1.064	0.92
164_L	168_G	1.055	0.92
118_A	122_F	1.050	0.91
115_I	172_V	1.042	0.91
39_Y	90_P	1.036	0.91
47_L	51_A	1.027	0.90
194_F	226_L	1.023	0.90
206_T	210_L	1.018	0.90
153_P	158_L	1.018	0.90
196_I	236_S	1.006	0.89
191_L	195_F	0.997	0.89
19_M	110_A	0.996	0.89
153_P	157_W	0.992	0.89
163_V	189_F	0.987	0.89
93_A	99_G	0.983	0.88
117_R	121_L	0.967	0.88
66_V	116_A	0.966	0.87
170_T	185_L	0.965	0.87
74_G	104_S	0.965	0.87
69_L	73_V	0.963	0.87
54_L	68_L	0.960	0.87
1_E	6_G	0.960	0.87
53_M	56_F	0.958	0.87
218_W	221_V	0.957	0.87
185_L	188_G	0.947	0.86
70_F	111_V	0.937	0.86
212_P	218_W	0.935	0.86
29_W	33_A	0.932	0.86
157_W	228_S	0.932	0.86
84_I	110_A	0.926	0.85
16_G	19_M	0.924	0.85
142_I	234_I	0.920	0.85
141_A	155_I	0.920	0.85
43_L	93_A	0.898	0.83
203_G	208_A	0.897	0.83
18_L	52_A	0.897	0.83
67_I	112_G	0.897	0.83
173_H	180_R	0.894	0.83
114_Y	118_A	0.889	0.83
177_W	181_R	0.889	0.83
60_T	65_K	0.888	0.83
29_W	36_L	0.886	0.83
115_I	237_F	0.885	0.82
138_L	159_L	0.873	0.82
123_D	180_R	0.869	0.81
92_P	96_K	0.866	0.81
116_A	188_G	0.864	0.81
172_V	237_F	0.863	0.81
4_R	177_W	0.859	0.81
135_T	189_F	0.855	0.80
190_V	230_F	0.841	0.79
100_V	108_Y	0.836	0.79
112_G	116_A	0.830	0.78
157_W	227_G	0.828	0.78
198_L	210_L	0.827	0.78
103_F	208_A	0.826	0.78
149_H	228_S	0.823	0.78
25_L	28_L	0.823	0.78
79_L	99_G	0.822	0.78
4_R	7_L	0.816	0.77
138_L	163_V	0.816	0.77
118_A	192_V	0.813	0.77
223_L	226_L	0.812	0.77
30_P	35_P	0.811	0.77
48_A	52_A	0.810	0.76
214_Q	218_W	0.808	0.76
193_A	226_L	0.804	0.76
124_L	237_F	0.803	0.76
213_N	222_S	0.801	0.76
88_S	203_G	0.797	0.75
205_F	208_A	0.795	0.75
115_I	119_W	0.792	0.75
53_M	64_A	0.791	0.75
193_A	235_I	0.790	0.75
70_F	233_M	0.790	0.75
135_T	139_A	0.788	0.74
22_L	49_I	0.787	0.74
16_G	110_A	0.785	0.74
4_R	121_L	0.783	0.74
21_A	24_L	0.782	0.74
103_F	112_G	0.780	0.74
129_Y	167_F	0.779	0.74
112_G	137_L	0.778	0.74
9_Q	174_F	0.776	0.73
75_T	79_L	0.769	0.73
158_L	162_A	0.767	0.72
163_V	170_T	0.765	0.72
192_V	196_I	0.764	0.72
122_F	192_V	0.763	0.72
51_A	54_L	0.762	0.72
183_M	195_F	0.761	0.72
128_R	168_G	0.757	0.71
83_S	151_Y	0.756	0.71
183_M	188_G	0.756	0.71
76_A	79_L	0.756	0.71
196_I	234_I	0.751	0.71
17_G	20_L	0.745	0.70
117_R	233_M	0.744	0.70
163_V	186_L	0.740	0.70
219_S	223_L	0.740	0.70
176_V	181_R	0.739	0.70
50_Q	54_L	0.739	0.70
130_P	169_R	0.738	0.70
18_L	22_L	0.737	0.69
208_A	233_M	0.737	0.69
10_A	13_C	0.735	0.69
26_T	38_R	0.733	0.69
45_A	53_M	0.730	0.69
119_W	181_R	0.728	0.69
73_V	235_I	0.726	0.68
3_L	7_L	0.725	0.68
208_A	217_G	0.721	0.68
174_F	183_M	0.720	0.68
140_A	144_V	0.711	0.67
91_E	96_K	0.706	0.66
4_R	176_V	0.703	0.66
94_L	98_G	0.702	0.66
144_V	152_I	0.695	0.65
176_V	180_R	0.692	0.65
187_L	230_F	0.691	0.64
20_L	23_L	0.690	0.64
134_A	137_L	0.690	0.64
188_G	191_L	0.690	0.64
172_V	188_G	0.689	0.64
82_T	99_G	0.686	0.64
42_L	112_G	0.685	0.64
7_L	17_G	0.680	0.63
231_L	235_I	0.679	0.63
164_L	230_F	0.678	0.63
11_W	14_L	0.677	0.63
4_R	237_F	0.676	0.63
80_F	150_H	0.668	0.62
68_L	112_G	0.668	0.62
198_L	202_I	0.664	0.61
111_V	135_T	0.664	0.61
210_L	213_N	0.664	0.61
111_V	206_T	0.663	0.61
172_V	189_F	0.663	0.61
157_W	160_F	0.662	0.61
14_L	53_M	0.654	0.60
128_R	171_W	0.648	0.60
159_L	166_L	0.648	0.60
8_K	11_W	0.645	0.59
133_W	137_L	0.644	0.59
3_L	178_R	0.638	0.58
8_K	12_A	0.636	0.58
26_T	41_F	0.636	0.58
11_W	16_G	0.635	0.58
158_L	165_L	0.635	0.58
161_A	165_L	0.632	0.58
42_L	68_L	0.630	0.57
82_T	98_G	0.629	0.57
11_W	77_M	0.629	0.57
55_A	61_W	0.627	0.57
11_W	121_L	0.626	0.57
109_A	204_T	0.625	0.57
77_M	117_R	0.625	0.57
229_W	232_L	0.625	0.57
23_L	103_F	0.623	0.57
165_L	187_L	0.622	0.56
4_R	8_K	0.622	0.56
26_T	39_Y	0.617	0.56
17_G	183_M	0.617	0.56
6_G	17_G	0.616	0.56
3_L	179_R	0.615	0.56
10_A	17_G	0.608	0.55
111_V	196_I	0.608	0.55
206_T	233_M	0.607	0.55
160_F	230_F	0.607	0.55
66_V	98_G	0.605	0.54
197_W	220_L	0.605	0.54
19_M	49_I	0.604	0.54
163_V	235_I	0.601	0.54
93_A	104_S	0.600	0.54
79_L	93_A	0.597	0.53
104_S	109_A	0.594	0.53
161_A	164_L	0.591	0.53
224_G	227_G	0.591	0.53
96_K	99_G	0.591	0.53
230_F	237_F	0.589	0.52
172_V	183_M	0.589	0.52
132_L	135_T	0.586	0.52
47_L	95_L	0.582	0.52
7_L	69_L	0.581	0.51
127_T	171_W	0.580	0.51
142_I	163_V	0.578	0.51
174_F	181_R	0.578	0.51
205_F	220_L	0.576	0.51
225_K	232_L	0.576	0.51
167_F	237_F	0.576	0.51
8_K	122_F	0.574	0.51
37_A	43_L	0.573	0.50
197_W	204_T	0.572	0.50
46_A	49_I	0.570	0.50
134_A	163_V	0.567	0.50
52_A	55_A	0.566	0.50
93_A	207_G	0.564	0.49
37_A	96_K	0.562	0.49
79_L	82_T	0.561	0.49
30_P	34_L	0.559	0.49
49_I	96_K	0.558	0.49
13_C	195_F	0.557	0.49
148_T	165_L	0.556	0.48
1_E	4_R	0.554	0.48
187_L	190_V	0.554	0.48
18_L	45_A	0.553	0.48
118_A	172_V	0.553	0.48
187_L	191_L	0.552	0.48
80_F	186_L	0.550	0.48
186_L	196_I	0.549	0.48
232_L	236_S	0.545	0.47
70_F	110_A	0.545	0.47
60_T	115_I	0.542	0.47
114_Y	122_F	0.539	0.46
28_L	66_V	0.538	0.46
163_V	167_F	0.537	0.46
90_P	93_A	0.535	0.46
124_L	180_R	0.535	0.46
185_L	189_F	0.535	0.46
19_M	203_G	0.534	0.46
130_P	167_F	0.532	0.45
4_R	27_H	0.531	0.45
2_F	8_K	0.530	0.45
72_V	158_L	0.529	0.45
84_I	99_G	0.528	0.45
56_F	166_L	0.528	0.45
44_L	95_L	0.526	0.45
186_L	190_V	0.525	0.45
54_L	130_P	0.522	0.44
88_S	96_K	0.522	0.44
29_W	41_F	0.522	0.44
17_G	82_T	0.520	0.44
37_A	44_L	0.520	0.44
66_V	86_S	0.518	0.44
114_Y	192_V	0.518	0.44
188_G	196_I	0.517	0.44
125_R	175_R	0.514	0.43
133_W	166_L	0.514	0.43
61_W	64_A	0.512	0.43
197_W	209_W	0.512	0.43
133_W	165_L	0.512	0.43
148_T	157_W	0.511	0.43
84_I	148_T	0.509	0.43
42_L	93_A	0.509	0.43
75_T	80_F	0.507	0.42
193_A	230_F	0.505	0.42
121_L	129_Y	0.505	0.42
69_L	151_Y	0.505	0.42
29_W	43_L	0.504	0.42
1_E	75_T	0.504	0.42
74_G	84_I	0.504	0.42
198_L	226_L	0.502	0.42
210_L	219_S	0.501	0.42
222_S	234_I	0.500	0.42
82_T	93_A	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2m7gA	1	0.2574	14.8	0.974	Contact Map
3rceA	1	0.7848	3.2	0.981	Contact Map
3synE	1	0.0675	2.5	0.982	Contact Map
4uvjA	2	0.173	2.3	0.982	Contact Map
3tx3A	2	0.27	2.1	0.983	Contact Map
2hacA	2	0.135	1.8	0.983	Contact Map
1m56D	1	0.1435	1.6	0.984	Contact Map
1hznA	1	0.1055	1.5	0.984	Contact Map
4bjsA	3	0.0633	1.2	0.985	Contact Map
1qleD	1	0.1519	1.1	0.985	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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