GREMLIN Database
DUF817 - Protein of unknown function (DUF817)
PFAM: PF05675 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 237 (237)
Sequences: 1999 (1097)
Seq/√Len: 71.3
META: 0.714

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_W182_R4.3611.00
22_L45_A4.2271.00
43_L95_L4.1561.00
129_Y135_T3.8061.00
18_L49_I3.5111.00
152_I155_I3.2721.00
37_A94_L3.1851.00
175_R180_R3.1541.00
54_L64_A3.0071.00
144_V148_T2.8591.00
188_G192_V2.8571.00
52_A56_F2.7401.00
163_V234_I2.6361.00
62_D65_K2.6191.00
93_A96_K2.5471.00
61_W65_K2.4621.00
124_L172_V2.4401.00
160_F227_G2.4381.00
213_N219_S2.3771.00
51_A55_A2.3251.00
3_L6_G2.1961.00
134_A166_L2.1651.00
194_F198_L2.0481.00
2_F6_G2.0451.00
30_P33_A1.9681.00
128_R169_R1.9081.00
124_L192_V1.8691.00
9_Q114_Y1.8491.00
24_L206_T1.8241.00
22_L42_L1.8061.00
172_V192_V1.7811.00
125_R180_R1.7581.00
64_A68_L1.7491.00
131_P134_A1.7401.00
168_G171_W1.7391.00
172_V185_L1.7221.00
142_I235_I1.6971.00
41_F45_A1.6941.00
164_L186_L1.6921.00
45_A49_I1.6581.00
12_A121_L1.6500.99
183_M191_L1.6440.99
119_W124_L1.6290.99
57_R61_W1.6070.99
32_D35_P1.5540.99
127_T173_H1.5470.99
123_D175_R1.5160.99
155_I158_L1.5140.99
115_I188_G1.5000.99
203_G206_T1.4910.99
19_M23_L1.4650.99
37_A92_P1.4600.99
74_G109_A1.4540.99
189_F192_V1.4420.99
21_A25_L1.4330.99
53_M58_L1.4190.98
129_Y237_F1.4190.98
119_W126_F1.4060.98
79_L98_G1.4040.98
53_M109_A1.3850.98
224_G228_S1.3170.97
210_L215_L1.3120.97
148_T152_I1.3070.97
36_L41_F1.2990.97
44_L48_A1.2820.97
80_F149_H1.2720.97
157_W161_A1.2620.97
23_L208_A1.2520.97
160_F164_L1.2490.97
1_E8_K1.2460.96
190_V226_L1.2350.96
149_H152_I1.2350.96
19_M46_A1.2290.96
82_T96_K1.2190.96
118_A124_L1.2160.96
115_I118_A1.2120.96
173_H182_R1.2100.96
126_F237_F1.2060.96
84_I149_H1.1990.96
6_G10_A1.1830.95
167_F171_W1.1820.95
36_L44_L1.1750.95
165_L168_G1.1750.95
39_Y91_E1.1720.95
214_Q221_V1.1630.95
43_L47_L1.1550.95
72_V76_A1.1450.94
207_G210_L1.1210.94
189_F234_I1.1160.94
14_L18_L1.1150.94
135_T167_F1.1140.94
195_F198_L1.1010.93
202_I206_T1.0960.93
163_V230_F1.0900.93
1_E181_R1.0880.93
137_L141_A1.0800.92
189_F233_M1.0800.92
124_L185_L1.0750.92
115_I124_L1.0720.92
132_L136_V1.0690.92
26_T91_E1.0660.92
192_V233_M1.0640.92
164_L168_G1.0550.92
118_A122_F1.0500.91
115_I172_V1.0420.91
39_Y90_P1.0360.91
47_L51_A1.0270.90
194_F226_L1.0230.90
206_T210_L1.0180.90
153_P158_L1.0180.90
196_I236_S1.0060.89
191_L195_F0.9970.89
19_M110_A0.9960.89
153_P157_W0.9920.89
163_V189_F0.9870.89
93_A99_G0.9830.88
117_R121_L0.9670.88
66_V116_A0.9660.87
170_T185_L0.9650.87
74_G104_S0.9650.87
69_L73_V0.9630.87
54_L68_L0.9600.87
1_E6_G0.9600.87
53_M56_F0.9580.87
218_W221_V0.9570.87
185_L188_G0.9470.86
70_F111_V0.9370.86
212_P218_W0.9350.86
29_W33_A0.9320.86
157_W228_S0.9320.86
84_I110_A0.9260.85
16_G19_M0.9240.85
142_I234_I0.9200.85
141_A155_I0.9200.85
43_L93_A0.8980.83
203_G208_A0.8970.83
18_L52_A0.8970.83
67_I112_G0.8970.83
173_H180_R0.8940.83
114_Y118_A0.8890.83
177_W181_R0.8890.83
60_T65_K0.8880.83
29_W36_L0.8860.83
115_I237_F0.8850.82
138_L159_L0.8730.82
123_D180_R0.8690.81
92_P96_K0.8660.81
116_A188_G0.8640.81
172_V237_F0.8630.81
4_R177_W0.8590.81
135_T189_F0.8550.80
190_V230_F0.8410.79
100_V108_Y0.8360.79
112_G116_A0.8300.78
157_W227_G0.8280.78
198_L210_L0.8270.78
103_F208_A0.8260.78
149_H228_S0.8230.78
25_L28_L0.8230.78
79_L99_G0.8220.78
4_R7_L0.8160.77
138_L163_V0.8160.77
118_A192_V0.8130.77
223_L226_L0.8120.77
30_P35_P0.8110.77
48_A52_A0.8100.76
214_Q218_W0.8080.76
193_A226_L0.8040.76
124_L237_F0.8030.76
213_N222_S0.8010.76
88_S203_G0.7970.75
205_F208_A0.7950.75
115_I119_W0.7920.75
53_M64_A0.7910.75
193_A235_I0.7900.75
70_F233_M0.7900.75
135_T139_A0.7880.74
22_L49_I0.7870.74
16_G110_A0.7850.74
4_R121_L0.7830.74
21_A24_L0.7820.74
103_F112_G0.7800.74
129_Y167_F0.7790.74
112_G137_L0.7780.74
9_Q174_F0.7760.73
75_T79_L0.7690.73
158_L162_A0.7670.72
163_V170_T0.7650.72
192_V196_I0.7640.72
122_F192_V0.7630.72
51_A54_L0.7620.72
183_M195_F0.7610.72
128_R168_G0.7570.71
83_S151_Y0.7560.71
183_M188_G0.7560.71
76_A79_L0.7560.71
196_I234_I0.7510.71
17_G20_L0.7450.70
117_R233_M0.7440.70
163_V186_L0.7400.70
219_S223_L0.7400.70
176_V181_R0.7390.70
50_Q54_L0.7390.70
130_P169_R0.7380.70
18_L22_L0.7370.69
208_A233_M0.7370.69
10_A13_C0.7350.69
26_T38_R0.7330.69
45_A53_M0.7300.69
119_W181_R0.7280.69
73_V235_I0.7260.68
3_L7_L0.7250.68
208_A217_G0.7210.68
174_F183_M0.7200.68
140_A144_V0.7110.67
91_E96_K0.7060.66
4_R176_V0.7030.66
94_L98_G0.7020.66
144_V152_I0.6950.65
176_V180_R0.6920.65
187_L230_F0.6910.64
20_L23_L0.6900.64
134_A137_L0.6900.64
188_G191_L0.6900.64
172_V188_G0.6890.64
82_T99_G0.6860.64
42_L112_G0.6850.64
7_L17_G0.6800.63
231_L235_I0.6790.63
164_L230_F0.6780.63
11_W14_L0.6770.63
4_R237_F0.6760.63
80_F150_H0.6680.62
68_L112_G0.6680.62
198_L202_I0.6640.61
111_V135_T0.6640.61
210_L213_N0.6640.61
111_V206_T0.6630.61
172_V189_F0.6630.61
157_W160_F0.6620.61
14_L53_M0.6540.60
128_R171_W0.6480.60
159_L166_L0.6480.60
8_K11_W0.6450.59
133_W137_L0.6440.59
3_L178_R0.6380.58
8_K12_A0.6360.58
26_T41_F0.6360.58
11_W16_G0.6350.58
158_L165_L0.6350.58
161_A165_L0.6320.58
42_L68_L0.6300.57
82_T98_G0.6290.57
11_W77_M0.6290.57
55_A61_W0.6270.57
11_W121_L0.6260.57
109_A204_T0.6250.57
77_M117_R0.6250.57
229_W232_L0.6250.57
23_L103_F0.6230.57
165_L187_L0.6220.56
4_R8_K0.6220.56
26_T39_Y0.6170.56
17_G183_M0.6170.56
6_G17_G0.6160.56
3_L179_R0.6150.56
10_A17_G0.6080.55
111_V196_I0.6080.55
206_T233_M0.6070.55
160_F230_F0.6070.55
66_V98_G0.6050.54
197_W220_L0.6050.54
19_M49_I0.6040.54
163_V235_I0.6010.54
93_A104_S0.6000.54
79_L93_A0.5970.53
104_S109_A0.5940.53
161_A164_L0.5910.53
224_G227_G0.5910.53
96_K99_G0.5910.53
230_F237_F0.5890.52
172_V183_M0.5890.52
132_L135_T0.5860.52
47_L95_L0.5820.52
7_L69_L0.5810.51
127_T171_W0.5800.51
142_I163_V0.5780.51
174_F181_R0.5780.51
205_F220_L0.5760.51
225_K232_L0.5760.51
167_F237_F0.5760.51
8_K122_F0.5740.51
37_A43_L0.5730.50
197_W204_T0.5720.50
46_A49_I0.5700.50
134_A163_V0.5670.50
52_A55_A0.5660.50
93_A207_G0.5640.49
37_A96_K0.5620.49
79_L82_T0.5610.49
30_P34_L0.5590.49
49_I96_K0.5580.49
13_C195_F0.5570.49
148_T165_L0.5560.48
1_E4_R0.5540.48
187_L190_V0.5540.48
18_L45_A0.5530.48
118_A172_V0.5530.48
187_L191_L0.5520.48
80_F186_L0.5500.48
186_L196_I0.5490.48
232_L236_S0.5450.47
70_F110_A0.5450.47
60_T115_I0.5420.47
114_Y122_F0.5390.46
28_L66_V0.5380.46
163_V167_F0.5370.46
90_P93_A0.5350.46
124_L180_R0.5350.46
185_L189_F0.5350.46
19_M203_G0.5340.46
130_P167_F0.5320.45
4_R27_H0.5310.45
2_F8_K0.5300.45
72_V158_L0.5290.45
84_I99_G0.5280.45
56_F166_L0.5280.45
44_L95_L0.5260.45
186_L190_V0.5250.45
54_L130_P0.5220.44
88_S96_K0.5220.44
29_W41_F0.5220.44
17_G82_T0.5200.44
37_A44_L0.5200.44
66_V86_S0.5180.44
114_Y192_V0.5180.44
188_G196_I0.5170.44
125_R175_R0.5140.43
133_W166_L0.5140.43
61_W64_A0.5120.43
197_W209_W0.5120.43
133_W165_L0.5120.43
148_T157_W0.5110.43
84_I148_T0.5090.43
42_L93_A0.5090.43
75_T80_F0.5070.42
193_A230_F0.5050.42
121_L129_Y0.5050.42
69_L151_Y0.5050.42
29_W43_L0.5040.42
1_E75_T0.5040.42
74_G84_I0.5040.42
198_L226_L0.5020.42
210_L219_S0.5010.42
222_S234_I0.5000.42
82_T93_A0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m7gA 1 0.2574 14.8 0.974 Contact Map
3rceA 1 0.7848 3.2 0.981 Contact Map
3synE 1 0.0675 2.5 0.982 Contact Map
4uvjA 2 0.173 2.3 0.982 Contact Map
3tx3A 2 0.27 2.1 0.983 Contact Map
2hacA 2 0.135 1.8 0.983 Contact Map
1m56D 1 0.1435 1.6 0.984 Contact Map
1hznA 1 0.1055 1.5 0.984 Contact Map
4bjsA 3 0.0633 1.2 0.985 Contact Map
1qleD 1 0.1519 1.1 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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