GREMLIN Database
DUF814 - Domain of unknown function (DUF814)
PFAM: PF05670 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 90 (86)
Sequences: 20839 (12893)
Seq/√Len: 1390.3
META: 0.898

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_S60_E2.6451.00
44_V65_A2.4651.00
39_I72_A2.1721.00
59_E63_Q2.0901.00
33_W43_H2.0721.00
8_F57_T2.0701.00
6_D57_T1.9841.00
83_T87_Y1.9651.00
11_L47_R1.8951.00
21_E26_L1.8891.00
12_V64_L1.7621.00
15_N18_Q1.6881.00
41_G65_A1.6731.00
36_A39_I1.6661.00
31_D47_R1.6611.00
27_A85_R1.6441.00
11_L26_L1.5691.00
60_E63_Q1.5441.00
37_K81_D1.5381.00
9_L47_R1.5011.00
30_N84_Q1.4821.00
66_A78_V1.4731.00
34_L46_L1.4181.00
32_L84_Q1.4121.00
34_L62_A1.4121.00
21_E25_K1.4051.00
12_V44_V1.4031.00
4_S57_T1.3591.00
27_A45_I1.3261.00
10_I44_V1.3041.00
10_I61_A1.3041.00
13_G19_N1.3011.00
37_K79_P1.2991.00
84_Q87_Y1.2851.00
40_P70_K1.2471.00
44_V64_L1.2251.00
63_Q67_Y1.2211.00
46_L57_T1.2161.00
12_V68_Y1.1771.00
32_L58_L1.1311.00
23_T85_R1.0571.00
17_K21_E1.0431.00
11_L22_L1.0391.00
53_E56_P1.0341.00
45_I85_R1.0171.00
14_R18_Q1.0121.00
46_L61_A1.0091.00
4_S60_E1.0051.00
34_L82_Y0.9811.00
4_S8_F0.9751.00
34_L58_L0.9611.00
23_T88_V0.9601.00
72_A75_S0.9581.00
23_T43_H0.9541.00
6_D54_P0.9321.00
29_P85_R0.9311.00
16_A35_H0.9231.00
32_L82_Y0.9201.00
72_A78_V0.9151.00
67_Y73_R0.9021.00
12_V42_S0.9021.00
34_L61_A0.8931.00
83_T88_V0.8911.00
4_S10_I0.8801.00
26_L47_R0.8421.00
39_I70_K0.8381.00
48_T53_E0.8141.00
27_A33_W0.8141.00
28_R47_R0.8141.00
44_V61_A0.7961.00
35_H43_H0.7901.00
24_F85_R0.7881.00
4_S7_G0.7861.00
16_A20_D0.7831.00
32_L48_T0.7681.00
48_T84_Q0.7621.00
5_S57_T0.7551.00
36_A72_A0.7531.00
24_F88_V0.7491.00
48_T51_G0.7471.00
60_E67_Y0.7461.00
54_P57_T0.7431.00
57_T60_E0.7331.00
36_A69_S0.7301.00
52_E55_P0.7241.00
9_L49_P0.7061.00
58_L82_Y0.7051.00
18_Q21_E0.7031.00
66_A80_V0.6881.00
20_D24_F0.6841.00
48_T54_P0.6691.00
23_T27_A0.6561.00
27_A43_H0.6461.00
30_N86_K0.6451.00
42_S69_S0.6381.00
36_A80_V0.6331.00
49_P52_E0.6301.00
20_D90_K0.6271.00
22_L26_L0.6181.00
30_N48_T0.5961.00
20_D25_K0.5961.00
75_S78_V0.5931.00
66_A79_P0.5901.00
59_E77_K0.5831.00
83_T86_K0.5791.00
23_T33_W0.5771.00
10_I64_L0.5751.00
36_A65_A0.5731.00
10_I60_E0.5701.00
51_G54_P0.5671.00
8_F49_P0.5571.00
56_P59_E0.5521.00
6_D56_P0.5511.00
5_S10_I0.5491.00
51_G55_P0.5471.00
48_T52_E0.5421.00
38_G79_P0.5381.00
11_L18_Q0.5361.00
50_G53_E0.5351.00
34_L80_V0.5321.00
87_Y90_K0.5301.00
23_T26_L0.5271.00
28_R49_P0.5251.00
8_F48_T0.5211.00
39_I75_S0.5141.00
62_A80_V0.5121.00
36_A41_G0.5111.00
36_A70_K0.5101.00
29_P86_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vxtI 1 0.3333 7.8 0.901 Contact Map
3vp6A 2 0.9667 6.7 0.904 Contact Map
1js3A 2 0.9778 6.4 0.905 Contact Map
3abzA 3 0.3889 5.5 0.908 Contact Map
4e1oA 2 0.9778 5.3 0.908 Contact Map
4d0jA 4 0.3222 5.3 0.909 Contact Map
2hmaA 2 0.8889 5 0.91 Contact Map
3k40A 2 0.9556 4.6 0.911 Contact Map
4g1gA 2 0.9889 4.3 0.912 Contact Map
2qmaA 2 0.9667 4.3 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.005 seconds.