GREMLIN Database
DUF808 - Protein of unknown function (DUF808)
PFAM: PF05661 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 298 (287)
Sequences: 5021 (3076)
Seq/√Len: 181.6
META: 0.69

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_A232_V5.5711.00
70_L181_L3.5681.00
101_A295_V3.5221.00
63_W67_K3.3741.00
245_L291_A3.2441.00
97_M248_G2.8691.00
169_F173_A2.8391.00
207_R211_A2.7831.00
208_S211_A2.6381.00
170_L174_A2.5531.00
259_H262_E2.5291.00
108_A293_A2.4081.00
112_A116_L2.3941.00
250_P254_H2.3651.00
250_P255_H2.3311.00
75_L177_A2.2881.00
255_H258_H2.2641.00
255_H259_H2.1981.00
71_R75_L2.1851.00
217_G221_A2.1221.00
164_V175_V2.1111.00
67_K71_R2.1111.00
168_P171_T2.0431.00
182_L186_G2.0341.00
203_H207_R1.9851.00
282_L286_V1.9781.00
90_W94_P1.9301.00
64_A139_K1.9191.00
213_A216_R1.8971.00
224_K228_A1.8941.00
197_M218_L1.8611.00
262_E266_H1.8591.00
59_L63_W1.8581.00
208_S212_R1.8301.00
220_R224_K1.8271.00
209_G212_R1.8191.00
133_D136_A1.8141.00
101_A291_A1.8131.00
243_G247_H1.7801.00
71_R143_K1.7281.00
246_V287_V1.7261.00
252_A256_A1.7191.00
70_L75_L1.6831.00
111_V115_L1.6731.00
1_S5_A1.6691.00
93_T248_G1.6621.00
197_M225_L1.6371.00
105_F109_E1.6191.00
214_L217_G1.6161.00
134_L137_L1.6121.00
254_H258_H1.5661.00
280_P284_S1.5631.00
178_V182_L1.5571.00
171_T174_A1.5321.00
78_L180_A1.5271.00
197_M200_A1.5221.00
70_L185_V1.4751.00
239_L285_A1.4561.00
94_P97_M1.4521.00
200_A204_L1.4331.00
126_H130_A1.4311.00
86_A172_Q1.4251.00
200_A203_H1.4101.00
85_S172_Q1.4001.00
193_L200_A1.3981.00
171_T175_V1.3941.00
135_V139_K1.3801.00
53_V141_K1.3751.00
253_P261_A1.3731.00
200_A218_L1.3591.00
224_K227_K1.3571.00
112_A296_V1.3551.00
260_L263_A1.3551.00
231_V234_T1.3491.00
281_A284_S1.3411.00
64_A142_I1.3381.00
167_A171_T1.3371.00
210_A213_A1.3371.00
83_L87_F1.3361.00
173_A177_A1.3351.00
216_R220_R1.3331.00
210_A214_L1.3261.00
179_V183_I1.3221.00
257_L261_A1.3211.00
243_G284_S1.3201.00
78_L82_L1.2911.00
177_A181_L1.2911.00
84_L91_A1.2861.00
212_R216_R1.2831.00
205_A216_R1.2811.00
118_S121_E1.2711.00
32_A182_L1.2541.00
164_V167_A1.2521.00
221_A225_L1.2491.00
290_V294_V1.2431.00
76_I150_F1.2401.00
160_A179_V1.2371.00
205_A219_V1.2311.00
254_H261_A1.2221.00
246_V257_L1.2211.00
228_A231_V1.2201.00
200_A214_L1.2141.00
25_A28_A1.2091.00
286_V290_V1.2041.00
279_V283_L1.2011.00
194_I229_L1.1991.00
274_V277_W1.1971.00
167_A172_Q1.1931.00
253_P257_L1.1901.00
246_V284_S1.1901.00
125_E128_E1.1891.00
102_Y109_E1.1841.00
82_L173_A1.1811.00
30_V33_K1.1751.00
256_A260_L1.1731.00
261_A265_A1.1711.00
71_R76_I1.1631.00
177_A180_A1.1631.00
268_V271_L1.1621.00
50_V53_V1.1591.00
139_K142_I1.1591.00
124_A128_E1.1581.00
277_W280_P1.1561.00
108_A289_L1.1541.00
268_V275_L1.1351.00
170_L173_A1.1331.00
66_A185_V1.1311.00
254_H257_L1.1251.00
108_A111_V1.1241.00
97_M101_A1.1101.00
250_P256_A1.1051.00
258_H262_E1.0991.00
63_W66_A1.0961.00
3_L7_L1.0921.00
160_A163_T1.0911.00
66_A70_L1.0821.00
275_L279_V1.0781.00
86_A169_F1.0761.00
111_V289_L1.0731.00
117_H120_E1.0701.00
197_M222_M1.0651.00
205_A212_R1.0611.00
28_A178_V1.0571.00
239_L281_A1.0551.00
95_L150_F1.0541.00
125_E129_L1.0531.00
235_A285_A1.0521.00
88_A91_A1.0511.00
262_E265_A1.0481.00
186_G190_L1.0451.00
76_I80_A1.0441.00
59_L200_A1.0431.00
111_V231_V1.0411.00
45_V49_Y1.0331.00
143_K147_R1.0291.00
277_W281_A1.0271.00
43_L190_L1.0210.99
259_H263_A1.0180.99
26_A30_V1.0120.99
265_A276_G1.0100.99
104_C241_G1.0090.99
202_L206_R1.0030.99
263_A266_H0.9900.99
122_D125_E0.9880.99
213_A217_G0.9870.99
218_L224_K0.9610.99
284_S292_G0.9600.99
164_V172_Q0.9590.99
28_A32_A0.9560.99
123_H127_A0.9550.99
249_L252_A0.9420.99
35_T39_L0.9400.99
260_L264_V0.9390.99
283_L287_V0.9330.99
261_A276_G0.9270.99
249_L253_P0.9240.99
253_P258_H0.9220.99
112_A293_A0.9210.99
214_L221_A0.9120.99
253_P256_A0.9090.99
252_A258_H0.9090.99
262_E276_G0.9080.99
231_V235_A0.9070.99
257_L283_L0.9020.99
249_L256_A0.9010.99
45_V48_Q0.9000.99
202_L205_A0.8990.99
43_L46_N0.8990.99
224_K231_V0.8980.99
98_L102_Y0.8930.99
113_H116_L0.8860.99
120_E124_A0.8830.99
114_K231_V0.8830.99
2_G13_L0.8730.98
202_L219_V0.8720.98
139_K143_K0.8680.98
5_A13_L0.8660.98
62_V66_A0.8650.98
174_A177_A0.8640.98
108_A112_A0.8620.98
36_A186_G0.8610.98
209_G213_A0.8590.98
293_A297_A0.8560.98
174_A178_V0.8530.98
3_L10_I0.8510.98
26_A29_K0.8480.98
203_H206_R0.8460.98
126_H129_L0.8450.98
272_G276_G0.8420.98
221_A224_K0.8390.98
250_P258_H0.8370.98
1_S4_L0.8310.98
101_A104_C0.8310.98
2_G7_L0.8290.98
111_V293_A0.8270.98
235_A289_L0.8240.98
204_L214_L0.8220.98
159_I163_T0.8220.98
197_M224_K0.8200.98
2_G10_I0.8140.97
256_A259_H0.8110.97
133_D137_L0.8090.97
122_D126_H0.8070.97
207_R212_R0.8000.97
128_E132_A0.8000.97
81_A154_A0.7990.97
48_Q234_T0.7970.97
165_A172_Q0.7970.97
249_L287_V0.7950.97
261_A266_H0.7920.97
264_V279_V0.7920.97
97_M245_L0.7840.97
96_L159_I0.7780.97
183_I186_G0.7670.96
70_L177_A0.7640.96
78_L157_M0.7620.96
258_H261_A0.7600.96
121_E124_A0.7580.96
285_A289_L0.7580.96
77_L158_V0.7550.96
276_G280_P0.7520.96
43_L47_A0.7510.96
40_G47_A0.7490.96
2_G5_A0.7490.96
128_E131_A0.7490.96
51_T230_S0.7490.96
237_M241_G0.7430.96
271_L275_L0.7420.96
3_L6_L0.7420.96
93_T245_L0.7380.96
124_A127_A0.7380.96
290_V293_A0.7370.95
71_R80_A0.7330.95
255_H261_A0.7330.95
163_T175_V0.7290.95
160_A175_V0.7260.95
111_V235_A0.7190.95
32_A179_V0.7190.95
59_L62_V0.7190.95
83_L86_A0.7170.95
136_A140_E0.7160.95
114_K235_A0.7140.95
94_P237_M0.7120.95
158_V162_G0.7110.95
227_K231_V0.7080.94
77_L80_A0.7020.94
176_L180_A0.7010.94
67_K146_I0.6960.94
217_G220_R0.6950.94
108_A285_A0.6930.94
260_L283_L0.6880.94
38_V62_V0.6860.93
21_L24_V0.6860.93
77_L95_L0.6840.93
114_K227_K0.6810.93
27_M30_V0.6810.93
21_L33_K0.6790.93
252_A255_H0.6790.93
261_A280_P0.6770.93
264_V275_L0.6750.93
232_V239_L0.6730.93
214_L218_L0.6720.93
71_R139_K0.6710.93
29_K33_K0.6680.92
26_A33_K0.6640.92
281_A285_A0.6640.92
250_P259_H0.6640.92
219_V222_M0.6620.92
63_W71_R0.6600.92
269_P273_G0.6580.92
118_S122_D0.6580.92
268_V276_G0.6570.92
194_I225_L0.6550.92
115_L118_S0.6540.92
258_H276_G0.6530.92
48_Q51_T0.6520.92
266_H269_P0.6520.92
11_A26_A0.6500.91
256_A261_A0.6480.91
271_L279_V0.6460.91
33_K40_G0.6450.91
93_T97_M0.6440.91
46_N49_Y0.6430.91
112_A115_L0.6420.91
137_L141_K0.6400.91
40_G43_L0.6360.91
274_V278_L0.6360.91
4_L234_T0.6320.90
254_H280_P0.6270.90
293_A296_V0.6260.90
55_A60_P0.6260.90
204_L211_A0.6260.90
105_F296_V0.6250.90
84_L88_A0.6250.90
81_A161_L0.6240.90
48_Q53_V0.6220.90
119_K122_D0.6220.90
193_L197_M0.6210.90
211_A214_L0.6190.89
96_L248_G0.6190.89
124_A131_A0.6140.89
94_P98_L0.6140.89
36_A40_G0.6110.89
26_A32_A0.6100.89
120_E123_H0.6070.88
243_G246_V0.6070.88
243_G281_A0.6050.88
183_I232_V0.6050.88
261_A284_S0.6040.88
124_A132_A0.6040.88
10_I13_L0.6040.88
261_A264_V0.6030.88
137_L140_E0.6020.88
77_L154_A0.6010.88
272_G280_P0.6010.88
53_V137_L0.6000.88
85_S161_L0.5990.88
222_M225_L0.5980.88
83_L169_F0.5930.87
83_L173_A0.5930.87
109_E113_H0.5920.87
29_K40_G0.5920.87
63_W70_L0.5900.87
80_A84_L0.5890.87
243_G280_P0.5890.87
150_F180_A0.5880.87
160_A176_L0.5880.87
119_K123_H0.5860.87
32_A232_V0.5850.87
273_G276_G0.5850.87
272_G275_L0.5830.86
57_R138_E0.5820.86
88_A94_P0.5800.86
70_L180_A0.5800.86
230_S234_T0.5780.86
29_K46_N0.5760.86
166_D172_Q0.5750.86
29_K43_L0.5750.86
61_V146_I0.5720.85
278_L284_S0.5720.85
250_P253_P0.5720.85
260_L279_V0.5710.85
38_V159_I0.5700.85
192_A200_A0.5690.85
130_A135_V0.5690.85
56_D59_L0.5690.85
194_I226_M0.5680.85
190_L194_I0.5650.85
175_V178_V0.5640.85
277_W285_A0.5630.84
7_L13_L0.5610.84
254_H259_H0.5610.84
235_A238_L0.5570.84
126_H132_A0.5550.84
8_D11_A0.5510.83
4_L13_L0.5500.83
284_S287_V0.5480.83
48_Q237_M0.5480.83
114_K230_S0.5470.83
124_A130_A0.5460.83
160_A164_V0.5440.82
53_V56_D0.5440.82
142_I146_I0.5420.82
25_A30_V0.5420.82
62_V197_M0.5420.82
33_K39_L0.5420.82
11_A227_K0.5420.82
95_L154_A0.5380.82
27_M36_A0.5370.82
129_L132_A0.5340.81
27_M171_T0.5320.81
261_A269_P0.5290.81
254_H262_E0.5280.80
140_E143_K0.5280.80
108_A295_V0.5270.80
54_A134_L0.5260.80
4_L21_L0.5260.80
85_S175_V0.5250.80
35_T183_I0.5250.80
75_L79_P0.5240.80
32_A186_G0.5240.80
27_M175_V0.5240.80
245_L248_G0.5230.80
129_L134_L0.5220.80
33_K36_A0.5190.79
77_L150_F0.5160.79
29_K35_T0.5150.79
77_L141_K0.5140.79
163_T182_L0.5130.79
53_V229_L0.5130.79
265_A274_V0.5120.78
77_L281_A0.5100.78
107_G238_L0.5100.78
160_A183_I0.5090.78
272_G279_V0.5070.78
13_L137_L0.5070.78
270_A275_L0.5070.78
294_V297_A0.5060.78
123_H126_H0.5060.78
40_G46_N0.5060.78
125_E130_A0.5060.78
181_L185_V0.5060.78
147_R150_F0.5060.78
81_A162_G0.5050.78
289_L293_A0.5030.77
183_I226_M0.5020.77
132_A137_L0.5020.77
95_L105_F0.5010.77
98_L295_V0.5000.77
5_A10_I0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kpqA 1 0.1779 5.2 0.981 Contact Map
2nq5A 1 0.198 5.2 0.981 Contact Map
2kluA 1 0.0839 3.9 0.982 Contact Map
2v3cC 1 0.2416 3.8 0.982 Contact Map
1fryA 1 0.0973 3.4 0.983 Contact Map
3bz1X 1 0.0738 3.2 0.983 Contact Map
1ldfA 3 0.349 3 0.983 Contact Map
3orgA 2 0.2181 2.8 0.983 Contact Map
3wu2X 1 0.0738 2.6 0.984 Contact Map
4nn3A 1 0.2685 2.5 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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