DUF808 - PFAM28P - GREMLIN Contacts

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DUF808 - Protein of unknown function (DUF808)

PFAM:	PF05661	Sequences: SGLLALLDDIAALAKLAAASLDDVAAMAKVAAKKTAGVLGDDLAVNAQYVTGVAADRELPVVWAIAKGSLRNKLLILLPAALLLSAFAPWAITPLLMLGGAYLCFEGAEKVAHKLLHSKEEDHAEHAELAAADLVALEKEKIKGAIRTDFILSAEIMVIALGTVADAPFLTQAAVLAVVALLITVGVYGLVALIVKMDDAGLHLARRSGAARALGRGLVRAMPKLMKALSVVGTAAMLLVGGGILVHGLPHAPHHALHHLAEAVAHAVPALGGVLGWLVPALLSAVVGLVAGAVVVAV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	298 (287)
Sequences:	5021 (3076)
Seq/√Len:	181.6
META:	0.69

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
228_A	232_V	5.571	1.00
70_L	181_L	3.568	1.00
101_A	295_V	3.522	1.00
63_W	67_K	3.374	1.00
245_L	291_A	3.244	1.00
97_M	248_G	2.869	1.00
169_F	173_A	2.839	1.00
207_R	211_A	2.783	1.00
208_S	211_A	2.638	1.00
170_L	174_A	2.553	1.00
259_H	262_E	2.529	1.00
108_A	293_A	2.408	1.00
112_A	116_L	2.394	1.00
250_P	254_H	2.365	1.00
250_P	255_H	2.331	1.00
75_L	177_A	2.288	1.00
255_H	258_H	2.264	1.00
255_H	259_H	2.198	1.00
71_R	75_L	2.185	1.00
217_G	221_A	2.122	1.00
164_V	175_V	2.111	1.00
67_K	71_R	2.111	1.00
168_P	171_T	2.043	1.00
182_L	186_G	2.034	1.00
203_H	207_R	1.985	1.00
282_L	286_V	1.978	1.00
90_W	94_P	1.930	1.00
64_A	139_K	1.919	1.00
213_A	216_R	1.897	1.00
224_K	228_A	1.894	1.00
197_M	218_L	1.861	1.00
262_E	266_H	1.859	1.00
59_L	63_W	1.858	1.00
208_S	212_R	1.830	1.00
220_R	224_K	1.827	1.00
209_G	212_R	1.819	1.00
133_D	136_A	1.814	1.00
101_A	291_A	1.813	1.00
243_G	247_H	1.780	1.00
71_R	143_K	1.728	1.00
246_V	287_V	1.726	1.00
252_A	256_A	1.719	1.00
70_L	75_L	1.683	1.00
111_V	115_L	1.673	1.00
1_S	5_A	1.669	1.00
93_T	248_G	1.662	1.00
197_M	225_L	1.637	1.00
105_F	109_E	1.619	1.00
214_L	217_G	1.616	1.00
134_L	137_L	1.612	1.00
254_H	258_H	1.566	1.00
280_P	284_S	1.563	1.00
178_V	182_L	1.557	1.00
171_T	174_A	1.532	1.00
78_L	180_A	1.527	1.00
197_M	200_A	1.522	1.00
70_L	185_V	1.475	1.00
239_L	285_A	1.456	1.00
94_P	97_M	1.452	1.00
200_A	204_L	1.433	1.00
126_H	130_A	1.431	1.00
86_A	172_Q	1.425	1.00
200_A	203_H	1.410	1.00
85_S	172_Q	1.400	1.00
193_L	200_A	1.398	1.00
171_T	175_V	1.394	1.00
135_V	139_K	1.380	1.00
53_V	141_K	1.375	1.00
253_P	261_A	1.373	1.00
200_A	218_L	1.359	1.00
224_K	227_K	1.357	1.00
112_A	296_V	1.355	1.00
260_L	263_A	1.355	1.00
231_V	234_T	1.349	1.00
281_A	284_S	1.341	1.00
64_A	142_I	1.338	1.00
167_A	171_T	1.337	1.00
210_A	213_A	1.337	1.00
83_L	87_F	1.336	1.00
173_A	177_A	1.335	1.00
216_R	220_R	1.333	1.00
210_A	214_L	1.326	1.00
179_V	183_I	1.322	1.00
257_L	261_A	1.321	1.00
243_G	284_S	1.320	1.00
78_L	82_L	1.291	1.00
177_A	181_L	1.291	1.00
84_L	91_A	1.286	1.00
212_R	216_R	1.283	1.00
205_A	216_R	1.281	1.00
118_S	121_E	1.271	1.00
32_A	182_L	1.254	1.00
164_V	167_A	1.252	1.00
221_A	225_L	1.249	1.00
290_V	294_V	1.243	1.00
76_I	150_F	1.240	1.00
160_A	179_V	1.237	1.00
205_A	219_V	1.231	1.00
254_H	261_A	1.222	1.00
246_V	257_L	1.221	1.00
228_A	231_V	1.220	1.00
200_A	214_L	1.214	1.00
25_A	28_A	1.209	1.00
286_V	290_V	1.204	1.00
279_V	283_L	1.201	1.00
194_I	229_L	1.199	1.00
274_V	277_W	1.197	1.00
167_A	172_Q	1.193	1.00
253_P	257_L	1.190	1.00
246_V	284_S	1.190	1.00
125_E	128_E	1.189	1.00
102_Y	109_E	1.184	1.00
82_L	173_A	1.181	1.00
30_V	33_K	1.175	1.00
256_A	260_L	1.173	1.00
261_A	265_A	1.171	1.00
71_R	76_I	1.163	1.00
177_A	180_A	1.163	1.00
268_V	271_L	1.162	1.00
50_V	53_V	1.159	1.00
139_K	142_I	1.159	1.00
124_A	128_E	1.158	1.00
277_W	280_P	1.156	1.00
108_A	289_L	1.154	1.00
268_V	275_L	1.135	1.00
170_L	173_A	1.133	1.00
66_A	185_V	1.131	1.00
254_H	257_L	1.125	1.00
108_A	111_V	1.124	1.00
97_M	101_A	1.110	1.00
250_P	256_A	1.105	1.00
258_H	262_E	1.099	1.00
63_W	66_A	1.096	1.00
3_L	7_L	1.092	1.00
160_A	163_T	1.091	1.00
66_A	70_L	1.082	1.00
275_L	279_V	1.078	1.00
86_A	169_F	1.076	1.00
111_V	289_L	1.073	1.00
117_H	120_E	1.070	1.00
197_M	222_M	1.065	1.00
205_A	212_R	1.061	1.00
28_A	178_V	1.057	1.00
239_L	281_A	1.055	1.00
95_L	150_F	1.054	1.00
125_E	129_L	1.053	1.00
235_A	285_A	1.052	1.00
88_A	91_A	1.051	1.00
262_E	265_A	1.048	1.00
186_G	190_L	1.045	1.00
76_I	80_A	1.044	1.00
59_L	200_A	1.043	1.00
111_V	231_V	1.041	1.00
45_V	49_Y	1.033	1.00
143_K	147_R	1.029	1.00
277_W	281_A	1.027	1.00
43_L	190_L	1.021	0.99
259_H	263_A	1.018	0.99
26_A	30_V	1.012	0.99
265_A	276_G	1.010	0.99
104_C	241_G	1.009	0.99
202_L	206_R	1.003	0.99
263_A	266_H	0.990	0.99
122_D	125_E	0.988	0.99
213_A	217_G	0.987	0.99
218_L	224_K	0.961	0.99
284_S	292_G	0.960	0.99
164_V	172_Q	0.959	0.99
28_A	32_A	0.956	0.99
123_H	127_A	0.955	0.99
249_L	252_A	0.942	0.99
35_T	39_L	0.940	0.99
260_L	264_V	0.939	0.99
283_L	287_V	0.933	0.99
261_A	276_G	0.927	0.99
249_L	253_P	0.924	0.99
253_P	258_H	0.922	0.99
112_A	293_A	0.921	0.99
214_L	221_A	0.912	0.99
253_P	256_A	0.909	0.99
252_A	258_H	0.909	0.99
262_E	276_G	0.908	0.99
231_V	235_A	0.907	0.99
257_L	283_L	0.902	0.99
249_L	256_A	0.901	0.99
45_V	48_Q	0.900	0.99
202_L	205_A	0.899	0.99
43_L	46_N	0.899	0.99
224_K	231_V	0.898	0.99
98_L	102_Y	0.893	0.99
113_H	116_L	0.886	0.99
120_E	124_A	0.883	0.99
114_K	231_V	0.883	0.99
2_G	13_L	0.873	0.98
202_L	219_V	0.872	0.98
139_K	143_K	0.868	0.98
5_A	13_L	0.866	0.98
62_V	66_A	0.865	0.98
174_A	177_A	0.864	0.98
108_A	112_A	0.862	0.98
36_A	186_G	0.861	0.98
209_G	213_A	0.859	0.98
293_A	297_A	0.856	0.98
174_A	178_V	0.853	0.98
3_L	10_I	0.851	0.98
26_A	29_K	0.848	0.98
203_H	206_R	0.846	0.98
126_H	129_L	0.845	0.98
272_G	276_G	0.842	0.98
221_A	224_K	0.839	0.98
250_P	258_H	0.837	0.98
1_S	4_L	0.831	0.98
101_A	104_C	0.831	0.98
2_G	7_L	0.829	0.98
111_V	293_A	0.827	0.98
235_A	289_L	0.824	0.98
204_L	214_L	0.822	0.98
159_I	163_T	0.822	0.98
197_M	224_K	0.820	0.98
2_G	10_I	0.814	0.97
256_A	259_H	0.811	0.97
133_D	137_L	0.809	0.97
122_D	126_H	0.807	0.97
207_R	212_R	0.800	0.97
128_E	132_A	0.800	0.97
81_A	154_A	0.799	0.97
48_Q	234_T	0.797	0.97
165_A	172_Q	0.797	0.97
249_L	287_V	0.795	0.97
261_A	266_H	0.792	0.97
264_V	279_V	0.792	0.97
97_M	245_L	0.784	0.97
96_L	159_I	0.778	0.97
183_I	186_G	0.767	0.96
70_L	177_A	0.764	0.96
78_L	157_M	0.762	0.96
258_H	261_A	0.760	0.96
121_E	124_A	0.758	0.96
285_A	289_L	0.758	0.96
77_L	158_V	0.755	0.96
276_G	280_P	0.752	0.96
43_L	47_A	0.751	0.96
40_G	47_A	0.749	0.96
2_G	5_A	0.749	0.96
128_E	131_A	0.749	0.96
51_T	230_S	0.749	0.96
237_M	241_G	0.743	0.96
271_L	275_L	0.742	0.96
3_L	6_L	0.742	0.96
93_T	245_L	0.738	0.96
124_A	127_A	0.738	0.96
290_V	293_A	0.737	0.95
71_R	80_A	0.733	0.95
255_H	261_A	0.733	0.95
163_T	175_V	0.729	0.95
160_A	175_V	0.726	0.95
111_V	235_A	0.719	0.95
32_A	179_V	0.719	0.95
59_L	62_V	0.719	0.95
83_L	86_A	0.717	0.95
136_A	140_E	0.716	0.95
114_K	235_A	0.714	0.95
94_P	237_M	0.712	0.95
158_V	162_G	0.711	0.95
227_K	231_V	0.708	0.94
77_L	80_A	0.702	0.94
176_L	180_A	0.701	0.94
67_K	146_I	0.696	0.94
217_G	220_R	0.695	0.94
108_A	285_A	0.693	0.94
260_L	283_L	0.688	0.94
38_V	62_V	0.686	0.93
21_L	24_V	0.686	0.93
77_L	95_L	0.684	0.93
114_K	227_K	0.681	0.93
27_M	30_V	0.681	0.93
21_L	33_K	0.679	0.93
252_A	255_H	0.679	0.93
261_A	280_P	0.677	0.93
264_V	275_L	0.675	0.93
232_V	239_L	0.673	0.93
214_L	218_L	0.672	0.93
71_R	139_K	0.671	0.93
29_K	33_K	0.668	0.92
26_A	33_K	0.664	0.92
281_A	285_A	0.664	0.92
250_P	259_H	0.664	0.92
219_V	222_M	0.662	0.92
63_W	71_R	0.660	0.92
269_P	273_G	0.658	0.92
118_S	122_D	0.658	0.92
268_V	276_G	0.657	0.92
194_I	225_L	0.655	0.92
115_L	118_S	0.654	0.92
258_H	276_G	0.653	0.92
48_Q	51_T	0.652	0.92
266_H	269_P	0.652	0.92
11_A	26_A	0.650	0.91
256_A	261_A	0.648	0.91
271_L	279_V	0.646	0.91
33_K	40_G	0.645	0.91
93_T	97_M	0.644	0.91
46_N	49_Y	0.643	0.91
112_A	115_L	0.642	0.91
137_L	141_K	0.640	0.91
40_G	43_L	0.636	0.91
274_V	278_L	0.636	0.91
4_L	234_T	0.632	0.90
254_H	280_P	0.627	0.90
293_A	296_V	0.626	0.90
55_A	60_P	0.626	0.90
204_L	211_A	0.626	0.90
105_F	296_V	0.625	0.90
84_L	88_A	0.625	0.90
81_A	161_L	0.624	0.90
48_Q	53_V	0.622	0.90
119_K	122_D	0.622	0.90
193_L	197_M	0.621	0.90
211_A	214_L	0.619	0.89
96_L	248_G	0.619	0.89
124_A	131_A	0.614	0.89
94_P	98_L	0.614	0.89
36_A	40_G	0.611	0.89
26_A	32_A	0.610	0.89
120_E	123_H	0.607	0.88
243_G	246_V	0.607	0.88
243_G	281_A	0.605	0.88
183_I	232_V	0.605	0.88
261_A	284_S	0.604	0.88
124_A	132_A	0.604	0.88
10_I	13_L	0.604	0.88
261_A	264_V	0.603	0.88
137_L	140_E	0.602	0.88
77_L	154_A	0.601	0.88
272_G	280_P	0.601	0.88
53_V	137_L	0.600	0.88
85_S	161_L	0.599	0.88
222_M	225_L	0.598	0.88
83_L	169_F	0.593	0.87
83_L	173_A	0.593	0.87
109_E	113_H	0.592	0.87
29_K	40_G	0.592	0.87
63_W	70_L	0.590	0.87
80_A	84_L	0.589	0.87
243_G	280_P	0.589	0.87
150_F	180_A	0.588	0.87
160_A	176_L	0.588	0.87
119_K	123_H	0.586	0.87
32_A	232_V	0.585	0.87
273_G	276_G	0.585	0.87
272_G	275_L	0.583	0.86
57_R	138_E	0.582	0.86
88_A	94_P	0.580	0.86
70_L	180_A	0.580	0.86
230_S	234_T	0.578	0.86
29_K	46_N	0.576	0.86
166_D	172_Q	0.575	0.86
29_K	43_L	0.575	0.86
61_V	146_I	0.572	0.85
278_L	284_S	0.572	0.85
250_P	253_P	0.572	0.85
260_L	279_V	0.571	0.85
38_V	159_I	0.570	0.85
192_A	200_A	0.569	0.85
130_A	135_V	0.569	0.85
56_D	59_L	0.569	0.85
194_I	226_M	0.568	0.85
190_L	194_I	0.565	0.85
175_V	178_V	0.564	0.85
277_W	285_A	0.563	0.84
7_L	13_L	0.561	0.84
254_H	259_H	0.561	0.84
235_A	238_L	0.557	0.84
126_H	132_A	0.555	0.84
8_D	11_A	0.551	0.83
4_L	13_L	0.550	0.83
284_S	287_V	0.548	0.83
48_Q	237_M	0.548	0.83
114_K	230_S	0.547	0.83
124_A	130_A	0.546	0.83
160_A	164_V	0.544	0.82
53_V	56_D	0.544	0.82
142_I	146_I	0.542	0.82
25_A	30_V	0.542	0.82
62_V	197_M	0.542	0.82
33_K	39_L	0.542	0.82
11_A	227_K	0.542	0.82
95_L	154_A	0.538	0.82
27_M	36_A	0.537	0.82
129_L	132_A	0.534	0.81
27_M	171_T	0.532	0.81
261_A	269_P	0.529	0.81
254_H	262_E	0.528	0.80
140_E	143_K	0.528	0.80
108_A	295_V	0.527	0.80
54_A	134_L	0.526	0.80
4_L	21_L	0.526	0.80
85_S	175_V	0.525	0.80
35_T	183_I	0.525	0.80
75_L	79_P	0.524	0.80
32_A	186_G	0.524	0.80
27_M	175_V	0.524	0.80
245_L	248_G	0.523	0.80
129_L	134_L	0.522	0.80
33_K	36_A	0.519	0.79
77_L	150_F	0.516	0.79
29_K	35_T	0.515	0.79
77_L	141_K	0.514	0.79
163_T	182_L	0.513	0.79
53_V	229_L	0.513	0.79
265_A	274_V	0.512	0.78
77_L	281_A	0.510	0.78
107_G	238_L	0.510	0.78
160_A	183_I	0.509	0.78
272_G	279_V	0.507	0.78
13_L	137_L	0.507	0.78
270_A	275_L	0.507	0.78
294_V	297_A	0.506	0.78
123_H	126_H	0.506	0.78
40_G	46_N	0.506	0.78
125_E	130_A	0.506	0.78
181_L	185_V	0.506	0.78
147_R	150_F	0.506	0.78
81_A	162_G	0.505	0.78
289_L	293_A	0.503	0.77
183_I	226_M	0.502	0.77
132_A	137_L	0.502	0.77
95_L	105_F	0.501	0.77
98_L	295_V	0.500	0.77
5_A	10_I	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2kpqA	1	0.1779	5.2	0.981	Contact Map
2nq5A	1	0.198	5.2	0.981	Contact Map
2kluA	1	0.0839	3.9	0.982	Contact Map
2v3cC	1	0.2416	3.8	0.982	Contact Map
1fryA	1	0.0973	3.4	0.983	Contact Map
3bz1X	1	0.0738	3.2	0.983	Contact Map
1ldfA	3	0.349	3	0.983	Contact Map
3orgA	2	0.2181	2.8	0.983	Contact Map
3wu2X	1	0.0738	2.6	0.984	Contact Map
4nn3A	1	0.2685	2.5	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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