GREMLIN Database
DUF805 - Protein of unknown function (DUF805)
PFAM: PF05656 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (104)
Sequences: 34214 (28757)
Seq/√Len: 2819.9
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_S15_W3.3491.00
60_V73_L3.0291.00
8_A12_E2.6931.00
85_V89_L2.5341.00
4_F57_A2.3461.00
72_W75_L2.2971.00
64_H70_G2.2361.00
98_P103_P2.0671.00
93_P96_P2.0411.00
84_I88_V1.9871.00
88_V92_L1.9841.00
9_S12_E1.9281.00
14_W90_L1.8791.00
66_T92_L1.8681.00
59_T73_L1.8371.00
60_V70_G1.8091.00
47_F51_L1.7771.00
67_G100_R1.7311.00
53_I57_A1.6831.00
8_A58_V1.6721.00
20_N47_F1.6671.00
57_A61_R1.6341.00
8_A61_R1.6151.00
97_G104_D1.5601.00
67_G95_T1.5351.00
9_S104_D1.5041.00
20_N24_S1.4831.00
3_S6_G1.4421.00
59_T90_L1.4381.00
66_T88_V1.3841.00
71_W74_L1.3411.00
68_R88_V1.3041.00
27_L31_D1.2501.00
60_V64_H1.2061.00
50_A54_P1.1951.00
16_F58_V1.1881.00
20_N51_L1.1691.00
7_R65_D1.1661.00
13_Y59_T1.1591.00
31_D39_G1.1281.00
13_Y90_L1.0991.00
20_N55_S1.0971.00
15_W19_F1.0751.00
3_S8_A1.0681.00
2_F53_I1.0561.00
9_S93_P1.0551.00
31_D44_S1.0541.00
73_L76_G1.0381.00
96_P104_D1.0301.00
16_F20_N1.0211.00
93_P104_D1.0101.00
94_G104_D1.0091.00
59_T63_L0.9941.00
87_L91_F0.9771.00
63_L73_L0.9691.00
75_L78_I0.9691.00
29_I33_A0.9671.00
24_S28_G0.9621.00
16_F19_F0.9511.00
66_T89_L0.9501.00
89_L92_L0.9321.00
41_G45_L0.9261.00
25_I29_I0.9211.00
17_V20_N0.9161.00
44_S48_S0.8901.00
76_G83_L0.8821.00
86_L90_L0.8631.00
57_A60_V0.8491.00
17_V21_L0.8461.00
17_V55_S0.8331.00
42_I46_L0.8261.00
59_T76_G0.8251.00
69_S72_W0.8141.00
68_R72_W0.8141.00
87_L90_L0.8061.00
45_L49_L0.7951.00
63_L68_R0.7891.00
99_N102_G0.7861.00
31_D41_G0.7841.00
23_V47_F0.7831.00
68_R92_L0.7821.00
63_L85_V0.7731.00
66_T94_G0.7691.00
54_P57_A0.7681.00
46_L50_A0.7651.00
24_S44_S0.7611.00
76_G86_L0.7551.00
31_D34_L0.7471.00
4_F56_L0.7431.00
4_F60_V0.7411.00
82_G85_V0.7391.00
10_R93_P0.7391.00
98_P104_D0.7261.00
27_L47_F0.7161.00
95_T104_D0.7091.00
24_S48_S0.7031.00
54_P58_V0.7001.00
17_V24_S0.6991.00
27_L44_S0.6951.00
19_F23_V0.6931.00
78_I82_G0.6931.00
28_G32_G0.6911.00
42_I45_L0.6911.00
75_L82_G0.6891.00
21_L25_I0.6861.00
11_S14_W0.6831.00
31_D35_G0.6831.00
22_I26_V0.6781.00
56_L60_V0.6761.00
79_P82_G0.6681.00
63_L72_W0.6661.00
6_G61_R0.6651.00
39_G42_I0.6641.00
63_L66_T0.6641.00
53_I61_R0.6611.00
56_L73_L0.6581.00
60_V69_S0.6531.00
66_T90_L0.6471.00
63_L89_L0.6431.00
28_G44_S0.6421.00
70_G73_L0.6411.00
94_G101_Y0.6391.00
95_T101_Y0.6281.00
8_A16_F0.6271.00
31_D36_G0.6251.00
15_W18_L0.6231.00
33_A36_G0.6191.00
14_W66_T0.6121.00
98_P102_G0.6111.00
2_F54_P0.6111.00
94_G99_N0.6061.00
19_F22_I0.6011.00
48_S51_L0.5981.00
81_I84_I0.5961.00
60_V71_W0.5951.00
88_V91_F0.5941.00
32_G36_G0.5811.00
26_V29_I0.5781.00
92_L95_T0.5641.00
41_G44_S0.5601.00
52_L55_S0.5581.00
74_L77_L0.5561.00
7_R64_H0.5491.00
38_G42_I0.5441.00
18_L22_I0.5371.00
31_D42_I0.5351.00
82_G86_L0.5341.00
20_N23_V0.5181.00
23_V26_V0.5151.00
76_G82_G0.5141.00
38_G41_G0.5131.00
96_P100_R0.5121.00
10_R14_W0.5121.00
86_L89_L0.5111.00
26_V30_L0.5091.00
4_F53_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mkcC 1 0.1524 5.6 0.9 Contact Map
4wd8A 3 0.9048 4.6 0.904 Contact Map
3ux4A 3 0.981 3.1 0.912 Contact Map
2kogA 1 0.381 3.1 0.912 Contact Map
4rdqA 5 0.7714 3.1 0.912 Contact Map
2a65A 2 0.9619 2.6 0.914 Contact Map
1fftA 1 0.7714 2.4 0.916 Contact Map
4pgrA 1 0.9143 2.2 0.918 Contact Map
1rypF 1 0.8571 2.2 0.918 Contact Map
3mk7A 1 0.781 2.1 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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