GREMLIN Database
DUF802 - Domain of unknown function (DUF802)
PFAM: PF05650 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (53)
Sequences: 1747 (1239)
Seq/√Len: 170.2
META: 0.719

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_Q27_S2.7151.00
8_T12_V2.4371.00
38_L41_F2.1571.00
29_A33_D1.9901.00
14_D18_A1.9211.00
39_A43_A1.8641.00
5_F12_V1.8241.00
28_E32_A1.8021.00
43_A46_E1.7621.00
34_L41_F1.7371.00
25_R28_E1.7361.00
21_A24_Q1.7221.00
17_T22_R1.6821.00
35_R39_A1.6381.00
10_A14_D1.6021.00
22_R25_R1.5221.00
24_Q28_E1.4561.00
1_L5_F1.4351.00
9_A31_A1.3591.00
31_A35_R1.3371.00
14_D17_T1.3271.00
12_V15_T1.2341.00
28_E33_D1.1761.00
32_A36_Q1.1301.00
36_Q40_A1.0921.00
4_R10_A0.9850.99
33_D36_Q0.9820.99
34_L37_A0.9820.99
16_W19_A0.9690.99
3_A6_E0.9540.99
44_T48_R0.9350.99
19_A48_R0.8640.98
37_A41_F0.8440.98
46_E50_A0.8370.97
36_Q39_A0.8310.97
43_A47_Q0.8260.97
6_E9_A0.8220.97
22_R27_S0.8080.97
32_A35_R0.7920.96
20_L53_L0.7890.96
7_A11_T0.7810.96
31_A34_L0.7770.96
41_F48_R0.7690.96
18_A26_A0.7510.95
31_A51_A0.7470.95
29_A35_R0.7340.94
6_E10_A0.7310.94
11_T15_T0.7180.94
46_E49_S0.7120.94
44_T49_S0.7070.93
27_S30_L0.6950.93
9_A20_L0.6950.93
15_T27_S0.6920.93
35_R40_A0.6880.92
9_A53_L0.6770.92
44_T51_A0.6710.91
8_T15_T0.6700.91
1_L6_E0.6450.90
17_T24_Q0.6320.89
15_T34_L0.6190.88
9_A15_T0.6170.88
40_A51_A0.6080.87
3_A7_A0.6030.86
14_D21_A0.5860.85
1_L4_R0.5840.85
5_F8_T0.5800.84
18_A21_A0.5670.83
18_A22_R0.5650.83
20_L37_A0.5460.80
31_A50_A0.5440.80
25_R47_Q0.5420.80
1_L29_A0.5410.80
45_F48_R0.5350.79
28_E39_A0.5300.79
45_F49_S0.5260.78
20_L45_F0.5210.77
5_F21_A0.5070.75
12_V49_S0.5060.75
1_L8_T0.5020.75
5_F41_F0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s84A 2 1 4.4 0.813 Contact Map
3hl6A 2 0.3208 3.3 0.824 Contact Map
4n3yB 2 0.9811 2.3 0.838 Contact Map
1r6nA 1 0.5094 1.7 0.849 Contact Map
2lr8A 1 0.5472 1.4 0.856 Contact Map
3ci9A 5 0.566 1.3 0.859 Contact Map
3tu3B 1 0.2075 1.1 0.864 Contact Map
3osqA 1 0.3208 1.1 0.866 Contact Map
3nftA 2 1 1.1 0.868 Contact Map
4j42A 2 0.9434 1 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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