GREMLIN Database
PEX11 - Peroxisomal biogenesis factor 11 (PEX11)
PFAM: PF05648 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 223 (222)
Sequences: 1290 (972)
Seq/√Len: 65.2
META: 0.179

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_R215_S5.2461.00
55_A59_L4.6921.00
81_D142_Y3.5921.00
30_W205_G3.5611.00
151_E176_R3.2841.00
181_L217_I3.1661.00
95_Y132_G2.6981.00
19_R189_D2.6601.00
129_W133_L2.5721.00
61_L103_H2.5501.00
97_L128_F2.4571.00
57_K102_D2.4361.00
7_F219_L2.4341.00
2_D6_K2.3351.00
94_G135_L2.2421.00
20_L212_L2.1321.00
189_D193_P2.1311.00
188_C214_S2.1171.00
125_S132_G2.0991.00
159_K165_E2.0621.00
108_A115_L2.0321.00
189_D214_S2.0041.00
185_K189_D1.9801.00
23_Y211_G1.9311.00
20_L24_F1.8751.00
21_L52_L1.8051.00
43_A47_A1.8051.00
99_L103_H1.7961.00
64_F103_H1.7761.00
90_L135_L1.7711.00
57_K105_V1.7531.00
19_R214_S1.7060.99
100_F103_H1.6970.99
57_K63_K1.6970.99
124_W127_R1.6910.99
106_W110_A1.6810.99
195_H200_L1.6510.99
206_V210_A1.6470.99
48_L112_L1.6370.99
147_L172_L1.6310.99
133_L193_P1.6170.99
67_H99_L1.5940.99
103_H106_W1.5840.99
107_L113_L1.5790.99
57_K110_A1.5710.99
203_N206_V1.5510.99
163_G166_E1.5380.99
144_L176_R1.5210.99
144_L183_L1.4980.99
47_A51_Q1.4760.98
208_G211_G1.4700.98
66_E193_P1.4520.98
40_E44_R1.4520.98
4_L8_L1.4210.98
101_L124_W1.4000.98
23_Y57_K1.3780.97
16_K26_R1.3690.97
6_K10_T1.3660.97
84_L88_A1.3660.97
102_D110_A1.3620.97
64_F100_F1.3440.97
192_I196_W1.3260.97
214_S217_I1.3210.97
123_K127_R1.3140.97
105_V122_S1.3090.97
10_T13_G1.3050.97
204_P208_G1.2750.96
130_L197_L1.2610.96
212_L216_L1.2580.96
39_K43_A1.2530.96
140_D179_L1.2480.95
101_L121_W1.2120.95
40_E43_A1.1990.94
68_L112_L1.1940.94
102_D185_K1.1850.94
58_L106_W1.1750.94
160_E163_G1.1630.93
11_T14_R1.1380.93
133_L136_S1.1380.93
185_K214_S1.1330.93
166_E173_R1.1250.92
142_Y146_R1.1140.92
115_L119_K1.1130.92
160_E165_E1.1010.91
18_L58_L1.0940.91
147_L151_E1.0930.91
81_D85_R1.0900.91
130_L194_L1.0860.91
137_L183_L1.0770.90
40_E65_L1.0730.90
193_P197_L1.0640.90
63_K99_L1.0590.90
15_D106_W1.0580.90
137_L186_N1.0470.89
193_P196_W1.0460.89
151_E155_R1.0450.89
180_L184_V1.0410.89
69_Q73_S1.0350.89
129_W193_P1.0340.89
181_L220_Y1.0330.89
74_A88_A1.0320.88
161_G165_E1.0320.88
14_R102_D1.0290.88
51_Q58_L1.0230.88
98_Y101_L1.0210.88
7_F18_L1.0080.87
94_G132_G1.0070.87
97_L114_K1.0050.87
187_L191_L1.0030.87
102_D196_W1.0010.87
189_D195_H0.9820.86
98_Y208_G0.9810.86
18_L52_L0.9780.86
161_G164_K0.9770.86
164_K168_K0.9640.85
132_G135_L0.9610.85
71_A182_Q0.9600.85
213_V217_I0.9590.85
181_L221_Q0.9570.84
61_L68_L0.9550.84
67_H92_N0.9460.84
126_A196_W0.9420.83
86_L90_L0.9380.83
8_L214_S0.9300.83
139_R143_E0.9290.83
26_R49_E0.9270.82
19_R197_L0.9200.82
106_W210_A0.9180.82
160_E164_K0.9180.82
137_L141_L0.9170.82
87_L139_R0.9130.82
55_A104_I0.9110.81
186_N192_I0.9060.81
57_K211_G0.9010.81
182_Q186_N0.8980.80
93_L187_L0.8970.80
117_S131_L0.8970.80
136_S186_N0.8900.80
150_R175_E0.8830.79
19_R193_P0.8820.79
212_L219_L0.8740.79
62_G189_D0.8730.79
7_F20_L0.8710.78
27_L31_Y0.8690.78
136_S214_S0.8650.78
140_D186_N0.8640.78
82_P86_L0.8620.78
91_R95_Y0.8610.78
28_L45_L0.8600.77
155_R158_L0.8590.77
62_G214_S0.8540.77
148_R151_E0.8520.77
22_Q57_K0.8500.77
94_G202_L0.8480.76
71_A128_F0.8400.76
60_R98_Y0.8380.76
60_R129_W0.8310.75
188_C210_A0.8310.75
73_S104_I0.8300.75
143_E175_E0.8280.75
181_L185_K0.8270.75
150_R153_K0.8250.74
26_R189_D0.8210.74
20_L219_L0.8170.74
163_G184_V0.8160.74
61_L110_A0.8130.73
122_S125_S0.8120.73
64_F68_L0.8080.73
18_L59_L0.8040.73
150_R159_K0.8030.72
162_E165_E0.8020.72
47_A112_L0.7890.71
151_E154_L0.7830.71
20_L218_G0.7800.70
99_L102_D0.7790.70
211_G215_S0.7590.68
141_L155_R0.7590.68
64_F102_D0.7560.68
54_L110_A0.7550.68
116_K119_K0.7530.68
153_K168_K0.7490.67
163_G167_E0.7470.67
81_D84_L0.7430.67
64_F214_S0.7420.66
38_S41_L0.7410.66
162_E166_E0.7410.66
157_S170_R0.7410.66
145_R149_E0.7390.66
123_K213_V0.7370.66
151_E162_E0.7370.66
58_L117_S0.7320.65
83_V142_Y0.7320.65
71_A96_A0.7310.65
49_E57_K0.7300.65
101_L135_L0.7290.65
192_I207_V0.7290.65
190_L214_S0.7280.65
133_L186_N0.7260.65
95_Y129_W0.7260.65
192_I200_L0.7240.65
67_H70_A0.7240.65
102_D211_G0.7180.64
15_D26_R0.7170.64
96_A140_D0.7170.64
83_V138_V0.7150.64
55_A58_L0.7100.63
90_L184_V0.7070.63
21_L31_Y0.7060.63
121_W143_E0.6960.61
27_L209_L0.6960.61
67_H95_Y0.6950.61
21_L78_K0.6950.61
25_S45_L0.6940.61
141_L144_L0.6940.61
28_L37_A0.6930.61
175_E187_L0.6920.61
181_L188_C0.6900.61
9_A66_E0.6870.60
107_L112_L0.6870.60
33_L38_S0.6840.60
181_L214_S0.6780.59
11_T22_Q0.6720.59
186_N197_L0.6720.59
199_L211_G0.6720.59
2_D212_L0.6660.58
146_R150_R0.6620.58
122_S126_A0.6610.58
105_V109_K0.6610.58
68_L96_A0.6600.57
68_L93_L0.6600.57
16_K63_K0.6590.57
182_Q185_K0.6570.57
194_L207_V0.6550.57
92_N95_Y0.6510.56
168_K172_L0.6500.56
45_L97_L0.6480.56
22_Q102_D0.6470.56
82_P149_E0.6460.56
209_L213_V0.6420.55
212_L215_S0.6390.55
80_P156_K0.6380.55
51_Q64_F0.6370.55
96_A215_S0.6350.55
45_L209_L0.6330.54
45_L61_L0.6320.54
54_L62_G0.6320.54
141_L152_K0.6320.54
7_F16_K0.6310.54
103_H130_L0.6270.54
151_E172_L0.6220.53
16_K218_G0.6210.53
65_L150_R0.6140.52
58_L91_R0.6130.52
71_A92_N0.6130.52
95_Y210_A0.6100.52
45_L210_A0.6080.51
89_V94_G0.6060.51
52_L55_A0.6050.51
208_G213_V0.6030.51
21_L51_Q0.6020.51
63_K100_F0.6010.51
160_E167_E0.6000.50
63_K67_H0.5990.50
159_K164_K0.5980.50
37_A42_A0.5970.50
159_K162_E0.5960.50
54_L188_C0.5930.50
65_L210_A0.5930.50
15_D20_L0.5930.50
92_N99_L0.5920.49
57_K126_A0.5900.49
152_K164_K0.5900.49
84_L143_E0.5880.49
126_A132_G0.5870.49
149_E160_E0.5850.49
98_Y103_H0.5830.48
46_K50_S0.5810.48
71_A127_R0.5790.48
174_K178_A0.5760.48
132_G189_D0.5720.47
191_L210_A0.5710.47
191_L212_L0.5690.47
160_E168_K0.5680.47
88_A91_R0.5640.46
64_F67_H0.5630.46
40_E174_K0.5610.46
20_L23_Y0.5560.45
14_R19_R0.5530.45
24_F27_L0.5510.45
219_L222_L0.5510.45
94_G186_N0.5500.45
28_L31_Y0.5470.44
78_K168_K0.5400.43
12_D19_R0.5380.43
70_A100_F0.5370.43
130_L193_P0.5360.43
28_L38_S0.5350.43
199_L212_L0.5350.43
102_D194_L0.5340.43
26_R102_D0.5340.43
22_Q56_R0.5320.43
14_R215_S0.5300.42
50_S53_S0.5290.42
198_G207_V0.5290.42
108_A215_S0.5290.42
76_D79_P0.5280.42
154_L209_L0.5280.42
152_K157_S0.5270.42
14_R23_Y0.5270.42
98_Y114_K0.5260.42
54_L214_S0.5260.42
144_L180_L0.5260.42
29_A33_L0.5250.42
51_Q62_G0.5240.42
88_A218_G0.5240.42
120_K125_S0.5240.42
100_F109_K0.5230.41
99_L106_W0.5210.41
61_L106_W0.5190.41
106_W121_W0.5180.41
186_N198_G0.5160.41
156_K159_K0.5150.41
98_Y192_I0.5140.40
101_L130_L0.5120.40
87_L152_K0.5110.40
128_F220_Y0.5110.40
88_A139_R0.5080.40
157_S160_E0.5060.40
159_K202_L0.5040.39
59_L129_W0.5040.39
115_L118_A0.5030.39
76_D102_D0.5010.39
13_G23_Y0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a9hA 4 0.3543 7.3 0.945 Contact Map
3g43E 2 0.278 4 0.951 Contact Map
4opcA 1 0.3408 3.6 0.952 Contact Map
4i77Z 1 0.2646 2.6 0.956 Contact Map
2kmfA 1 0.2825 2.5 0.956 Contact Map
3lk5A 2 0.2422 2.3 0.957 Contact Map
1xkpA 1 0.2332 2.1 0.958 Contact Map
2bgcA 2 0.4843 1.9 0.958 Contact Map
1wmwA 2 0.2825 1.9 0.959 Contact Map
3mk4A 1 0.3812 1.8 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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