GREMLIN Database
DUF788 - Protein of unknown function (DUF788)
PFAM: PF05620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 167 (166)
Sequences: 565 (447)
Seq/√Len: 34.7
META: 0.195

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_Y79_L6.0811.00
126_Y130_K3.3291.00
23_I103_W3.2601.00
134_L137_P3.1111.00
28_N58_Y2.7151.00
157_K161_K2.6341.00
3_N8_K2.4611.00
104_F119_L2.4051.00
16_T19_F2.3730.99
156_S161_K2.1660.99
49_L53_L2.1160.99
94_Y126_Y2.0440.98
45_S49_L2.0430.98
1_M7_K1.9520.98
35_R114_N1.9320.98
161_K165_R1.9240.98
62_Y66_E1.9160.98
113_S116_F1.9120.98
28_N51_Y1.9090.98
132_W137_P1.8820.97
64_Y68_M1.8020.96
103_W120_Y1.7710.96
90_G100_Y1.7680.96
155_T160_E1.7550.96
88_A92_T1.7400.96
18_K22_L1.6900.95
25_L29_A1.6750.95
145_G148_A1.6660.94
61_C65_L1.6570.94
128_A132_W1.6560.94
1_M8_K1.6540.94
36_F143_A1.6440.94
13_N85_D1.6380.94
102_T120_Y1.5610.92
144_G150_E1.5590.92
105_V120_Y1.5580.92
34_L38_F1.5370.92
108_L116_F1.5350.92
24_I62_Y1.5310.92
20_L100_Y1.4660.90
10_A69_A1.4620.90
6_A90_G1.4600.89
4_K8_K1.4240.88
156_S160_E1.4220.88
13_N17_L1.3720.86
94_Y115_K1.3640.86
156_S164_K1.3350.85
26_G30_L1.3280.84
102_T117_W1.3250.84
26_G139_L1.3170.84
146_A151_E1.3010.83
20_L96_F1.2740.82
160_E165_R1.2560.81
118_W121_L1.2420.80
28_N31_Y1.2410.80
58_Y69_A1.2310.80
21_H62_Y1.2180.79
69_A113_S1.2180.79
60_A146_A1.2150.79
6_A82_A1.1710.76
30_L34_L1.1590.75
10_A82_A1.1570.75
16_T96_F1.1520.75
102_T127_A1.1480.75
127_A131_L1.1450.74
17_L159_Q1.1410.74
151_E158_R1.1000.71
96_F100_Y1.0890.71
55_S59_L1.0870.70
26_G147_E1.0770.70
69_A81_D1.0720.69
27_V91_L1.0660.69
6_A161_K1.0610.68
19_F23_I1.0600.68
162_L165_R1.0490.68
154_A159_Q1.0390.67
149_A152_P1.0380.67
131_L134_L1.0370.67
65_L127_A1.0320.66
121_L125_A1.0240.66
141_G146_A1.0200.65
125_A129_Y1.0100.65
101_L104_F1.0070.64
20_L23_I1.0070.64
156_S165_R1.0000.64
6_A9_I0.9930.63
121_L148_A0.9930.63
32_L111_L0.9890.63
53_L57_P0.9850.63
92_T95_M0.9810.62
86_L92_T0.9700.61
103_W158_R0.9540.60
53_L120_Y0.9410.59
14_A53_L0.9400.59
50_L105_V0.9390.59
64_Y132_W0.9260.58
30_L81_D0.9190.57
156_S159_Q0.9180.57
106_Q109_S0.9130.57
100_Y156_S0.9080.56
8_K20_L0.9080.56
4_K120_Y0.8950.55
143_A148_A0.8840.54
69_A105_V0.8790.54
13_N90_G0.8700.53
5_G8_K0.8640.53
15_A107_V0.8590.52
65_L96_F0.8580.52
104_F136_G0.8570.52
74_D80_L0.8560.52
26_G150_E0.8420.51
12_E19_F0.8380.50
79_L120_Y0.8310.50
87_N96_F0.8310.50
83_G86_L0.8250.49
5_G9_I0.8220.49
69_A82_A0.8160.48
125_A152_P0.8100.48
22_L26_G0.8100.48
2_A7_K0.8040.47
74_D78_E0.7970.47
69_A112_F0.7950.47
30_L108_L0.7930.47
85_D117_W0.7900.46
15_A19_F0.7870.46
64_Y95_M0.7850.46
66_E70_R0.7830.46
9_I87_N0.7830.46
58_Y103_W0.7830.46
33_L73_Y0.7800.45
34_L112_F0.7800.45
45_S56_L0.7790.45
5_G11_E0.7610.44
9_I96_F0.7600.44
162_L166_G0.7590.44
1_M5_G0.7580.44
17_L73_Y0.7550.43
141_G147_E0.7430.42
122_V147_E0.7420.42
142_F146_A0.7390.42
138_W149_A0.7370.42
141_G152_P0.7370.42
30_L82_A0.7370.42
146_A150_E0.7350.42
100_Y104_F0.7350.42
98_V123_I0.7340.42
101_L108_L0.7340.42
49_L122_V0.7340.42
23_I100_Y0.7290.41
34_L39_R0.7240.41
38_F44_T0.7210.40
17_L21_H0.7190.40
140_G143_A0.7190.40
93_E96_F0.7170.40
16_T20_L0.7090.40
38_F101_L0.7080.39
13_N100_Y0.7020.39
4_K12_E0.7000.39
5_G48_L0.6970.39
74_D89_E0.6970.39
123_I130_K0.6960.38
78_E81_D0.6880.38
23_I129_Y0.6870.38
145_G152_P0.6840.37
152_P156_S0.6820.37
28_N106_Q0.6820.37
125_A134_L0.6800.37
47_S51_Y0.6780.37
31_Y109_S0.6770.37
141_G150_E0.6740.37
108_L122_V0.6720.37
86_L159_Q0.6690.36
42_S114_N0.6680.36
114_N125_A0.6640.36
107_V111_L0.6600.36
55_S77_G0.6550.35
130_K134_L0.6520.35
33_L49_L0.6470.35
14_A18_K0.6380.34
161_K164_K0.6350.34
24_I104_F0.6320.33
158_R162_L0.6320.33
163_E166_G0.6310.33
9_I13_N0.6310.33
29_A33_L0.6250.33
48_L57_P0.6220.33
121_L150_E0.6210.33
46_R50_L0.6210.33
133_G136_G0.6110.32
156_S162_L0.6070.32
65_L103_W0.6070.32
144_G152_P0.6020.31
104_F129_Y0.5990.31
18_K127_A0.5990.31
144_G147_E0.5990.31
69_A72_K0.5990.31
12_E87_N0.5990.31
9_I92_T0.5940.31
92_T96_F0.5930.31
91_L94_Y0.5870.30
63_Y158_R0.5860.30
154_A158_R0.5830.30
14_A52_L0.5780.29
74_D77_G0.5780.29
51_Y92_T0.5770.29
131_L153_E0.5720.29
25_L45_S0.5710.29
158_R166_G0.5690.29
76_D89_E0.5660.29
45_S105_V0.5610.28
109_S131_L0.5600.28
136_G143_A0.5590.28
112_F116_F0.5590.28
28_N55_S0.5580.28
159_Q162_L0.5540.28
115_K118_W0.5480.27
13_N20_L0.5480.27
142_F148_A0.5470.27
39_R45_S0.5450.27
9_I19_F0.5440.27
65_L100_Y0.5410.27
75_E139_L0.5400.27
94_Y124_P0.5370.27
80_L98_V0.5360.27
51_Y58_Y0.5330.26
30_L151_E0.5330.26
19_F87_N0.5290.26
28_N71_P0.5290.26
160_E164_K0.5280.26
111_L146_A0.5250.26
60_A122_V0.5230.26
99_I123_I0.5220.26
36_F45_S0.5220.26
157_K160_E0.5200.26
18_K30_L0.5200.26
72_K125_A0.5160.25
80_L83_G0.5150.25
57_P113_S0.5150.25
119_L152_P0.5130.25
142_F158_R0.5100.25
38_F112_F0.5100.25
110_S144_G0.5080.25
77_G123_I0.5080.25
71_P112_F0.5070.25
56_L60_A0.5060.25
56_L98_V0.5050.25
15_A54_L0.5040.24
132_W136_G0.5000.24
16_T108_L0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sjdD 1 0.0898 14 0.942 Contact Map
3mk7C 2 0.6587 11.6 0.944 Contact Map
3zs9C 1 0.0958 11 0.945 Contact Map
1qfqB 1 0.0958 8.8 0.947 Contact Map
1jzpA 1 0.1198 6.1 0.951 Contact Map
4cylA 1 0.1856 5.2 0.953 Contact Map
3ukxC 1 0.0479 4.7 0.953 Contact Map
4ltoA 3 0.7006 4.7 0.953 Contact Map
3tx3A 2 0.9222 4.3 0.954 Contact Map
3qapA 1 0.4371 4 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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