GREMLIN Database
Prolamin_like - Prolamin-like
PFAM: PF05617 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (72)
Sequences: 632 (370)
Seq/√Len: 43.5
META: 0.127

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_I36_L3.1111.00
40_G70_W2.4221.00
34_K38_K2.1291.00
1_K4_S2.1080.99
15_E29_G1.9760.99
41_K45_P1.9440.99
8_E40_G1.8530.99
60_S67_D1.7360.98
20_I36_L1.6920.97
12_C32_C1.6560.97
41_K70_W1.6170.97
31_A34_K1.5770.96
6_L13_G1.5710.96
8_E26_T1.5340.95
48_F62_I1.4500.94
16_I40_G1.4280.93
53_F59_K1.3670.92
8_E14_L1.3090.90
39_I57_E1.3050.90
5_K40_G1.2780.89
19_S56_P1.2780.89
2_C12_C1.2590.88
53_F56_P1.2380.87
1_K70_W1.2330.87
21_F27_T1.2290.87
32_C43_C1.2290.87
7_T17_F1.2270.87
5_K70_W1.2220.86
43_C73_C1.2170.86
2_C43_C1.2080.86
2_C33_C1.1630.84
52_G55_P1.1570.83
8_E21_F1.1510.83
24_N42_D1.1480.83
65_K69_L1.1320.82
33_C73_C1.0940.80
55_P61_E1.0850.79
9_L40_G1.0700.78
58_L62_I1.0650.78
7_T35_A1.0240.75
15_E35_A1.0190.75
28_I47_M0.9950.73
64_E72_Y0.9950.73
13_G52_G0.9910.72
37_V67_D0.9880.72
40_G48_F0.9850.72
8_E44_H0.9840.72
16_I56_P0.9670.71
24_N41_K0.9590.70
38_K67_D0.9380.68
20_I44_H0.9270.67
9_L20_I0.9190.67
6_L46_A0.9160.66
36_L44_H0.9000.65
64_E67_D0.8980.65
8_E51_L0.8930.64
2_C32_C0.8900.64
60_S64_E0.8870.64
9_L13_G0.8870.64
6_L39_I0.8800.63
4_S49_K0.8780.63
8_E37_V0.8560.61
59_K62_I0.8090.57
40_G51_L0.7870.55
13_G37_V0.7860.55
36_L41_K0.7850.54
37_V40_G0.7830.54
16_I60_S0.7660.53
29_G71_N0.7490.51
13_G17_F0.7290.49
41_K72_Y0.7250.49
39_I42_D0.7170.48
24_N39_I0.7070.47
17_F21_F0.7030.47
36_L40_G0.6960.46
25_K67_D0.6770.44
61_E64_E0.6690.43
49_K70_W0.6680.43
9_L37_V0.6570.42
19_S52_G0.6520.42
11_G55_P0.6370.40
7_T14_L0.6290.40
13_G48_F0.6240.39
5_K31_A0.6160.38
47_M54_T0.6150.38
16_I72_Y0.6110.38
31_A50_S0.6010.37
13_G40_G0.6000.37
16_I55_P0.5940.36
10_P52_G0.5850.36
44_H51_L0.5840.36
55_P62_I0.5680.34
22_N34_K0.5670.34
35_A54_T0.5640.34
63_L66_S0.5630.34
27_T71_N0.5600.34
14_L36_L0.5580.33
29_G66_S0.5550.33
30_P71_N0.5500.33
15_E59_K0.5410.32
30_P62_I0.5390.32
11_G34_K0.5350.31
22_N29_G0.5350.31
11_G31_A0.5300.31
10_P13_G0.5150.30
51_L54_T0.5140.30
21_F26_T0.5060.29
56_P61_E0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rknA 1 0.9054 7.6 0.868 Contact Map
2malA 1 0.8514 4.3 0.882 Contact Map
1gxsB 1 0.5 4.2 0.883 Contact Map
1siyA 1 0.8514 3.7 0.886 Contact Map
1afhA 1 0.8649 3.6 0.887 Contact Map
1bwoA 1 0.8514 3.6 0.887 Contact Map
2algA 4 0.8514 2.8 0.893 Contact Map
2ln8A 1 0.3378 2.4 0.897 Contact Map
1t12A 1 0.8378 2.1 0.9 Contact Map
1whsB 1 0.473 2 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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