GREMLIN Database
CLPTM1 - Cleft lip and palate transmembrane protein 1 (CLPTM1)
PFAM: PF05602 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 426 (423)
Sequences: 623 (474)
Seq/√Len: 23.1
META: 0.164

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
330_F334_I10.7821.00
336_F354_G5.5371.00
89_V234_L4.8961.00
171_W236_L4.7231.00
417_I421_V4.2221.00
285_L288_L4.0991.00
355_I359_I4.0611.00
290_I294_I3.9021.00
295_L299_F3.7021.00
301_F355_I3.5581.00
114_P119_Y3.2041.00
336_F340_L3.1001.00
84_D237_T2.8820.99
290_I293_S2.8560.99
273_E276_R2.7860.99
222_S276_R2.7290.99
86_T233_E2.4770.98
413_Y420_A2.4690.98
392_E395_S2.3490.97
85_L236_L2.3340.97
328_N360_E2.3200.97
15_F19_F2.3000.97
49_T107_K2.2470.97
306_N320_L2.2160.96
369_D386_E2.1970.96
276_R280_E2.1690.96
145_N148_G2.1370.96
109_G114_P2.0450.94
369_D388_K2.0440.94
160_E291_V2.0340.94
351_I355_I2.0280.94
215_N275_K2.0260.94
95_N169_S2.0180.94
51_L179_L1.9790.93
317_L367_A1.9710.93
59_E90_P1.9190.92
178_N243_L1.9130.92
232_T417_I1.8990.92
406_K410_Y1.8850.91
339_L346_S1.8770.91
56_Y65_L1.8510.91
314_K320_L1.8040.89
51_L74_Y1.7960.89
339_L353_Q1.7950.89
180_V243_L1.7910.89
43_P74_Y1.7810.89
18_Y22_K1.7640.88
135_L334_I1.7550.88
296_H299_F1.7540.88
311_W366_K1.7500.88
396_K399_E1.7400.88
348_M352_S1.7400.88
8_I15_F1.7220.87
397_T401_D1.7170.87
94_Q169_S1.7150.87
299_F305_K1.6740.86
53_L105_V1.6740.86
112_P171_W1.6720.85
172_H405_F1.6620.85
156_E159_E1.6590.85
305_K309_S1.6540.85
339_L350_L1.6540.85
10_F14_F1.6430.84
17_K32_P1.6270.84
87_I145_N1.6260.84
95_N229_E1.6060.83
89_V93_V1.5950.83
418_G421_V1.5900.82
294_I298_V1.5850.82
6_F10_F1.5810.82
215_N251_Y1.5700.82
111_S116_D1.5650.81
88_K233_E1.5570.81
415_L420_A1.5420.80
2_I6_F1.5320.80
405_F416_L1.5310.80
172_H219_Q1.5190.79
5_A9_Y1.5190.79
288_L292_V1.5150.79
25_P28_P1.5020.79
8_I14_F1.4940.78
178_N275_K1.4790.77
243_L251_Y1.4700.77
15_F18_Y1.4650.77
105_V274_V1.4610.77
101_A175_L1.4540.76
150_E153_T1.4510.76
310_F320_L1.4480.76
308_I398_K1.4460.76
109_G112_P1.4440.76
294_I297_S1.4380.75
289_T293_S1.4380.75
213_F330_F1.4350.75
327_W331_S1.4290.75
407_Y411_V1.4140.74
90_P93_V1.4130.74
133_K216_D1.4040.74
342_N352_S1.4010.73
16_M20_F1.4000.73
369_D380_L1.3980.73
192_P249_Q1.3950.73
58_S102_H1.3900.73
146_L307_D1.3820.72
146_L338_Y1.3790.72
147_L424_L1.3670.72
217_F347_W1.3670.72
9_Y13_S1.3630.71
97_G132_T1.3590.71
300_E352_S1.3540.71
23_K33_S1.3520.71
220_L275_K1.3390.70
169_S227_I1.3190.69
99_L411_V1.3170.69
23_K27_C1.3150.69
178_N406_K1.3140.69
248_F320_L1.3100.68
326_L364_I1.2860.67
86_T199_I1.2800.66
182_D299_F1.2780.66
55_V238_I1.2710.66
180_V211_I1.2650.65
132_T169_S1.2640.65
14_F18_Y1.2590.65
395_S398_K1.2580.65
172_H224_L1.2390.64
87_I336_F1.2360.64
13_S17_K1.2340.64
375_D382_R1.2340.64
404_A419_Y1.2300.63
273_E277_I1.2300.63
111_S114_P1.2270.63
74_Y182_D1.2230.63
320_L352_S1.2220.63
29_T212_L1.2200.63
9_Y12_S1.2110.62
258_F261_Q1.2040.62
332_Q339_L1.2000.61
52_D56_Y1.1990.61
192_P410_Y1.1910.61
370_V385_F1.1910.61
341_D366_K1.1860.60
405_F412_L1.1840.60
265_G280_E1.1810.60
304_F359_I1.1810.60
305_K308_I1.1790.60
8_I12_S1.1760.60
311_W321_S1.1730.59
305_K311_W1.1720.59
310_F318_V1.1660.59
37_S40_P1.1640.59
177_L213_F1.1640.59
324_S367_A1.1560.58
274_V277_I1.1550.58
43_P314_K1.1540.58
31_D56_Y1.1540.58
335_I350_L1.1540.58
269_S293_S1.1510.58
131_L236_L1.1380.57
144_K276_R1.1380.57
151_E155_E1.1330.57
106_T112_P1.1290.57
266_F352_S1.1280.56
4_R11_I1.1190.56
215_N218_W1.1150.56
299_F306_N1.1140.55
70_K152_E1.1100.55
96_N134_Y1.1070.55
236_L372_I1.0990.54
87_I105_V1.0950.54
246_W249_Q1.0850.53
412_L420_A1.0830.53
320_L366_K1.0820.53
310_F395_S1.0820.53
371_R386_E1.0770.53
355_I391_S1.0770.53
292_V323_R1.0720.53
75_G180_V1.0710.53
35_Y38_Y1.0690.52
255_D336_F1.0630.52
30_S417_I1.0620.52
171_W234_L1.0570.52
24_P27_C1.0530.51
320_L412_L1.0510.51
113_D116_D1.0500.51
6_F34_C1.0500.51
228_N235_P1.0460.51
46_P49_T1.0420.50
409_S413_Y1.0380.50
372_I381_P1.0360.50
228_N234_L1.0350.50
219_Q224_L1.0340.50
18_Y26_P1.0300.50
152_E199_I1.0300.50
16_M19_F1.0280.50
11_I34_C1.0280.50
82_E237_T1.0270.49
175_L384_V1.0270.49
305_K408_L1.0250.49
12_S15_F1.0200.49
3_L402_E1.0200.49
19_F23_K1.0080.48
23_K28_P1.0030.48
82_E239_T0.9990.47
198_Y248_F0.9940.47
205_N335_I0.9920.47
185_V378_G0.9890.47
212_L229_E0.9890.47
28_P34_C0.9890.47
300_E322_V0.9870.47
146_L341_D0.9810.46
31_D421_V0.9800.46
310_F390_L0.9780.46
212_L377_P0.9770.46
180_V245_L0.9760.46
31_D34_C0.9710.46
150_E250_L0.9670.45
23_K26_P0.9660.45
414_P422_Y0.9640.45
292_V299_F0.9630.45
6_F12_S0.9600.45
327_W353_Q0.9570.45
30_S33_S0.9570.45
296_H310_F0.9530.44
10_F13_S0.9490.44
8_I17_K0.9480.44
135_L221_R0.9460.44
197_Q256_E0.9460.44
411_V425_L0.9440.44
303_A307_D0.9430.44
119_Y190_Q0.9410.43
303_A321_S0.9390.43
218_W404_A0.9360.43
180_V294_I0.9340.43
141_R278_L0.9330.43
94_Q232_T0.9310.43
76_D79_D0.9290.43
177_L214_V0.9290.43
368_V385_F0.9270.43
172_H186_Y0.9230.42
7_V11_I0.9200.42
400_Y403_L0.9100.41
199_I250_L0.9100.41
373_R383_I0.9100.41
365_T370_V0.9090.41
327_W402_E0.9070.41
266_F347_W0.9050.41
274_V425_L0.9030.41
310_F331_S0.9020.41
269_S300_E0.9020.41
227_I231_V0.8990.41
49_T274_V0.8920.40
231_V308_I0.8910.40
346_S350_L0.8900.40
174_N237_T0.8870.40
183_F211_I0.8870.40
17_K20_F0.8860.40
171_W235_P0.8860.40
78_S250_L0.8830.40
5_A12_S0.8810.39
199_I300_E0.8800.39
228_N304_F0.8760.39
182_D186_Y0.8710.39
116_D119_Y0.8700.39
14_F22_K0.8680.39
146_L363_K0.8680.39
270_E278_L0.8660.38
101_A335_I0.8650.38
23_K30_S0.8630.38
181_P209_Y0.8620.38
129_K133_K0.8590.38
307_D363_K0.8580.38
208_Y213_F0.8580.38
406_K421_V0.8580.38
314_K350_L0.8560.38
244_S423_S0.8530.38
54_Y106_T0.8500.37
153_T157_E0.8490.37
195_L292_V0.8490.37
217_F328_N0.8470.37
303_A311_W0.8460.37
300_E405_F0.8450.37
132_T394_E0.8430.37
398_K402_E0.8430.37
320_L408_L0.8420.37
295_L367_A0.8410.37
351_I359_I0.8400.37
106_T109_G0.8400.37
378_G381_P0.8390.37
372_I383_I0.8360.36
229_E232_T0.8350.36
299_F366_K0.8340.36
338_Y407_Y0.8310.36
296_H321_S0.8300.36
139_K142_K0.8240.36
9_Y192_P0.8230.36
285_L289_T0.8230.36
274_V376_P0.8230.36
87_I234_L0.8210.36
176_T341_D0.8210.36
45_W49_T0.8210.36
285_L293_S0.8200.35
145_N182_D0.8200.35
277_I280_E0.8190.35
231_V336_F0.8190.35
125_V220_L0.8180.35
9_Y24_P0.8180.35
401_D414_P0.8180.35
9_Y255_D0.8170.35
21_G26_P0.8140.35
232_T425_L0.8080.35
315_K425_L0.8050.35
154_E227_I0.8050.35
417_I420_A0.8010.34
383_I386_E0.8010.34
106_T111_S0.8010.34
209_Y285_L0.7990.34
234_L404_A0.7970.34
131_L275_K0.7960.34
356_G360_E0.7950.34
283_P352_S0.7900.34
170_H276_R0.7880.33
394_E400_Y0.7870.33
406_K409_S0.7870.33
201_L327_W0.7860.33
218_W279_L0.7860.33
194_P249_Q0.7850.33
43_P312_R0.7850.33
2_I32_P0.7840.33
176_T284_Y0.7830.33
281_T299_F0.7820.33
295_L298_V0.7810.33
152_E162_E0.7810.33
273_E408_L0.7800.33
53_L212_L0.7790.33
23_K37_S0.7790.33
213_F216_D0.7780.33
292_V306_N0.7750.33
235_P424_L0.7740.33
15_F20_F0.7730.33
9_Y16_M0.7700.32
28_P160_E0.7700.32
90_P99_L0.7690.32
19_F22_K0.7690.32
108_S225_I0.7670.32
323_R397_T0.7660.32
275_K345_T0.7650.32
273_E410_Y0.7640.32
392_E396_K0.7640.32
99_L161_E0.7630.32
65_L104_F0.7610.32
127_F200_R0.7600.32
146_L424_L0.7600.32
217_F267_S0.7570.32
52_D70_K0.7540.31
168_V226_P0.7530.31
215_N315_K0.7510.31
24_P28_P0.7490.31
416_L419_Y0.7470.31
140_V151_E0.7440.31
315_K372_I0.7440.31
305_K321_S0.7440.31
195_L199_I0.7360.30
51_L72_F0.7340.30
33_S39_L0.7330.30
228_N231_V0.7330.30
289_T292_V0.7320.30
23_K31_D0.7310.30
309_S313_K0.7290.30
414_P419_Y0.7260.30
161_E229_E0.7260.30
295_L418_G0.7250.30
414_P418_G0.7220.29
112_P370_V0.7220.29
9_Y21_G0.7210.29
308_I408_L0.7210.29
233_E333_L0.7200.29
17_K28_P0.7200.29
146_L303_A0.7180.29
22_K26_P0.7180.29
4_R19_F0.7170.29
270_E387_D0.7160.29
218_W338_Y0.7150.29
3_L7_V0.7140.29
246_W335_I0.7140.29
18_Y39_L0.7120.29
103_V242_P0.7120.29
10_F18_Y0.7110.29
41_A179_L0.7090.29
364_I424_L0.7080.29
311_W324_S0.7080.29
161_E165_D0.7070.29
178_N241_S0.7070.29
234_L313_K0.7060.29
177_L403_L0.7040.28
247_K281_T0.7040.28
186_Y192_P0.7030.28
200_R411_V0.7030.28
221_R346_S0.7010.28
108_S124_A0.7000.28
285_L367_A0.6970.28
299_F310_F0.6970.28
405_F419_Y0.6960.28
270_E281_T0.6960.28
324_S415_L0.6950.28
195_L198_Y0.6950.28
167_I369_D0.6940.28
170_H408_L0.6930.28
11_I15_F0.6920.28
172_H300_E0.6920.28
392_E398_K0.6910.28
314_K332_Q0.6900.28
208_Y345_T0.6890.28
292_V342_N0.6860.27
314_K322_V0.6860.27
17_K21_G0.6850.27
76_D107_K0.6800.27
16_M21_G0.6790.27
275_K407_Y0.6790.27
106_T124_A0.6790.27
172_H416_L0.6790.27
102_H285_L0.6760.27
259_K415_L0.6750.27
350_L425_L0.6750.27
95_N250_L0.6690.27
269_S276_R0.6690.27
324_S406_K0.6690.27
247_K349_I0.6690.27
91_E98_T0.6670.26
392_E400_Y0.6660.26
111_S168_V0.6640.26
284_Y288_L0.6630.26
310_F389_H0.6630.26
394_E405_F0.6620.26
24_P378_G0.6580.26
24_P33_S0.6570.26
305_K415_L0.6570.26
164_K227_I0.6550.26
35_Y40_P0.6540.26
347_W351_I0.6520.26
56_Y137_K0.6520.26
4_R7_V0.6520.26
180_V349_I0.6520.26
24_P41_A0.6510.26
335_I346_S0.6500.26
55_V149_G0.6500.26
264_L379_S0.6490.25
27_C30_S0.6460.25
91_E232_T0.6460.25
111_S411_V0.6460.25
277_I282_N0.6440.25
65_L68_K0.6430.25
88_K243_L0.6430.25
57_L94_Q0.6420.25
34_C38_Y0.6420.25
172_H215_N0.6400.25
285_L324_S0.6400.25
67_W271_I0.6390.25
13_S18_Y0.6380.25
305_K420_A0.6370.25
400_Y405_F0.6370.25
30_S34_C0.6350.25
340_L361_A0.6350.25
132_T343_E0.6340.25
310_F353_Q0.6340.25
283_P287_G0.6340.25
52_D108_S0.6310.25
326_L358_L0.6300.24
387_D400_Y0.6290.24
401_D423_S0.6290.24
12_S17_K0.6260.24
2_I10_F0.6240.24
60_K212_L0.6240.24
174_N364_I0.6230.24
48_G95_N0.6230.24
73_T250_L0.6230.24
2_I20_F0.6210.24
11_I20_F0.6210.24
359_I362_W0.6200.24
285_L352_S0.6190.24
194_P197_Q0.6190.24
243_L356_G0.6180.24
12_S18_Y0.6170.24
98_T298_V0.6150.24
248_F394_E0.6150.24
257_S339_L0.6150.24
21_G28_P0.6150.24
157_E160_E0.6140.24
28_P39_L0.6140.24
297_S351_I0.6140.24
63_E355_I0.6130.24
275_K366_K0.6120.24
314_K360_E0.6100.23
123_K334_I0.6100.23
14_F21_G0.6080.23
69_E315_K0.6070.23
251_Y332_Q0.6060.23
7_V32_P0.6050.23
209_Y312_R0.6050.23
310_F398_K0.6040.23
4_R8_I0.6040.23
17_K41_A0.6040.23
328_N419_Y0.6030.23
180_V416_L0.6030.23
296_H362_W0.6030.23
269_S280_E0.6030.23
209_Y240_Y0.6030.23
305_K319_G0.6020.23
322_V380_L0.6010.23
76_D352_S0.5970.23
286_L296_H0.5970.23
32_P421_V0.5970.23
408_L420_A0.5970.23
7_V179_L0.5950.23
325_I413_Y0.5940.23
365_T369_D0.5920.23
192_P224_L0.5910.23
23_K421_V0.5890.22
300_E331_S0.5890.22
2_I38_Y0.5860.22
222_S277_I0.5850.22
148_G151_E0.5850.22
98_T130_P0.5840.22
6_F31_D0.5840.22
33_S151_E0.5830.22
275_K406_K0.5820.22
26_P30_S0.5810.22
216_D404_A0.5800.22
296_H319_G0.5800.22
308_I317_L0.5790.22
102_H134_Y0.5790.22
18_Y251_Y0.5780.22
58_S68_K0.5780.22
136_P170_H0.5780.22
130_P173_P0.5780.22
45_W325_I0.5780.22
325_I350_L0.5770.22
182_D244_S0.5740.22
45_W310_F0.5740.22
48_G51_L0.5740.22
303_A325_I0.5730.22
295_L324_S0.5720.22
41_A152_E0.5670.21
265_G272_D0.5660.21
126_H240_Y0.5640.21
353_Q406_K0.5640.21
90_P222_S0.5620.21
213_F255_D0.5620.21
361_A365_T0.5610.21
195_L234_L0.5600.21
4_R12_S0.5590.21
39_L358_L0.5570.21
409_S412_L0.5570.21
51_L168_V0.5560.21
333_L344_N0.5550.21
56_Y366_K0.5550.21
363_K414_P0.5530.21
145_N366_K0.5530.21
373_R386_E0.5520.21
255_D259_K0.5510.21
89_V147_L0.5500.21
2_I31_D0.5480.20
271_I308_I0.5480.20
314_K327_W0.5480.20
190_Q402_E0.5480.20
102_H147_L0.5470.20
16_M25_P0.5470.20
218_W400_Y0.5470.20
278_L412_L0.5460.20
56_Y311_W0.5460.20
345_T350_L0.5430.20
141_R250_L0.5430.20
27_C33_S0.5420.20
153_T425_L0.5420.20
257_S346_S0.5410.20
179_L243_L0.5390.20
226_P311_W0.5390.20
209_Y353_Q0.5390.20
310_F405_F0.5380.20
195_L253_S0.5380.20
28_P31_D0.5370.20
173_P404_A0.5370.20
108_S385_F0.5360.20
381_P421_V0.5340.20
93_V328_N0.5340.20
156_E164_K0.5330.20
154_E180_V0.5320.20
217_F275_K0.5310.20
145_N343_E0.5300.20
90_P104_F0.5300.20
22_K25_P0.5280.20
394_E416_L0.5280.20
174_N249_Q0.5280.20
25_P34_C0.5270.20
215_N342_N0.5260.20
71_N149_G0.5260.20
45_W268_G0.5250.19
247_K289_T0.5250.19
155_E374_R0.5230.19
364_I372_I0.5210.19
76_D252_A0.5210.19
202_T236_L0.5200.19
308_I323_R0.5190.19
222_S261_Q0.5190.19
165_D212_L0.5180.19
373_R381_P0.5170.19
86_T89_V0.5170.19
332_Q346_S0.5140.19
329_V342_N0.5130.19
172_H253_S0.5120.19
69_E81_R0.5120.19
243_L276_R0.5110.19
88_K306_N0.5110.19
236_L348_M0.5110.19
267_S413_Y0.5100.19
120_D139_K0.5100.19
208_Y315_K0.5090.19
77_W168_V0.5080.19
224_L410_Y0.5060.19
336_F408_L0.5050.19
138_K315_K0.5050.19
242_P323_R0.5030.19
200_R334_I0.5030.19
408_L412_L0.5020.18
220_L279_L0.5020.18
202_T207_W0.5020.18
98_T107_K0.5020.18
329_V405_F0.5020.18
261_Q369_D0.5010.18
83_I227_I0.5010.18
217_F220_L0.5010.18
181_P248_F0.5010.18
227_I243_L0.5010.18
125_V421_V0.5000.18
70_K372_I0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qncA 2 0.1925 37.9 0.974 Contact Map
4rngA 2 0.1948 26.5 0.976 Contact Map
4x5mA 2 0.216 24.8 0.976 Contact Map
3mk7C 2 0.1784 8.6 0.981 Contact Map
2v0pA 2 0.1948 2.8 0.985 Contact Map
1nkzB 1 0.0962 2.2 0.986 Contact Map
1z96A 1 0.0869 1.8 0.986 Contact Map
3oakC 1 0.0728 1.8 0.986 Contact Map
4xrpC 1 0.2019 1.7 0.986 Contact Map
1q2fA 1 0.0751 1.5 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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