GREMLIN Database
DUF772 - Transposase domain (DUF772)
PFAM: PF05598 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 73 (70)
Sequences: 43957 (19616)
Seq/√Len: 2344.6
META: 0.944

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_R53_H2.9311.00
30_A34_N2.4741.00
33_D36_A2.3261.00
24_D60_R2.2181.00
13_L31_L1.9931.00
17_Q27_L1.8071.00
35_L38_R1.7831.00
16_L37_F1.7471.00
22_L30_A1.6731.00
57_S61_K1.6521.00
13_L56_L1.6191.00
30_A37_F1.5391.00
31_L41_L1.5181.00
54_S58_R1.4801.00
67_E71_E1.4741.00
24_D57_S1.4031.00
20_Y37_F1.3651.00
10_L59_F1.3251.00
32_R50_V1.3171.00
26_E30_A1.2831.00
53_H57_S1.2641.00
5_Y9_L1.2601.00
28_E50_V1.2561.00
23_S26_E1.2431.00
15_L19_L1.2391.00
22_L26_E1.2361.00
13_L51_P1.2321.00
28_E32_R1.1831.00
54_S57_S1.1581.00
28_E53_H1.1571.00
29_E33_D1.1471.00
52_D55_T1.0931.00
9_L43_L1.0921.00
20_Y30_A1.0901.00
8_R12_K1.0871.00
55_T58_R1.0671.00
14_L56_L1.0671.00
30_A33_D1.0511.00
52_D58_R1.0221.00
22_L37_F1.0141.00
5_Y51_P1.0071.00
35_L45_L0.9931.00
13_L27_L0.9731.00
27_L56_L0.9711.00
10_L55_T0.9641.00
17_Q60_R0.9461.00
17_Q24_D0.9441.00
9_L42_G0.9401.00
6_P9_L0.9351.00
12_K40_F0.9331.00
38_R50_V0.9191.00
26_E29_E0.8971.00
12_K41_L0.8821.00
14_L17_Q0.8771.00
31_L50_V0.8751.00
68_E71_E0.8621.00
16_L20_Y0.8621.00
9_L41_L0.8591.00
20_Y33_D0.8581.00
58_R62_R0.8381.00
43_L46_D0.8271.00
29_E36_A0.7761.00
25_R54_S0.7691.00
38_R48_D0.7681.00
14_L60_R0.7681.00
13_L41_L0.7651.00
61_K64_G0.7651.00
22_L27_L0.7591.00
66_L69_L0.7461.00
7_P62_R0.7451.00
21_G26_E0.7241.00
58_R61_K0.7161.00
4_A7_P0.7141.00
66_L70_F0.7101.00
34_N37_F0.7061.00
35_L39_W0.7001.00
27_L37_F0.6961.00
61_K65_E0.6731.00
24_D56_L0.6721.00
5_Y55_T0.6691.00
43_L50_V0.6531.00
17_Q37_F0.6431.00
44_D48_D0.6311.00
28_E52_D0.6281.00
14_L66_L0.6281.00
20_Y29_E0.6261.00
31_L51_P0.6241.00
13_L28_E0.5891.00
32_R38_R0.5861.00
16_L36_A0.5731.00
67_E70_F0.5611.00
28_E56_L0.5461.00
59_F63_L0.5421.00
62_R65_E0.5401.00
55_T59_F0.5401.00
16_L41_L0.5341.00
57_S60_R0.5341.00
9_L12_K0.5291.00
28_E51_P0.5281.00
59_F62_R0.5231.00
42_G49_P0.5191.00
8_R42_G0.5131.00
63_L69_L0.5121.00
41_L50_V0.5051.00
5_Y10_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dyqA 5 0.726 28.5 0.819 Contact Map
2oqmA 3 0.9726 13.7 0.843 Contact Map
3uj3X 2 0 10.7 0.85 Contact Map
3p9aA 4 0.8493 9.5 0.854 Contact Map
3rziA 3 0.9589 8.8 0.856 Contact Map
2k27A 1 0.863 7.8 0.86 Contact Map
2ao9A 7 0.7534 7.8 0.86 Contact Map
1jkoC 1 0.6164 7.6 0.86 Contact Map
1pdnC 1 0.6849 7.5 0.861 Contact Map
5rubA 2 0.9315 7.1 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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