GREMLIN Database
Phasin - Poly(hydroxyalcanoate) granule associated protein (phasin)
PFAM: PF05597 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (120)
Sequences: 3329 (2068)
Seq/√Len: 188.7
META: 0.914

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_F41_V3.5881.00
110_L114_V3.3951.00
20_L24_G2.8761.00
121_V124_L2.8121.00
88_F91_R2.7231.00
41_V44_G2.5371.00
116_E119_A2.1551.00
48_E52_R2.1391.00
118_T122_E2.1081.00
51_T54_A2.0811.00
58_K61_E1.9911.00
18_I26_F1.9511.00
65_K69_M1.9231.00
40_L44_G1.8871.00
113_R118_T1.8671.00
111_S118_T1.8301.00
87_V91_R1.7051.00
31_E43_E1.6651.00
92_V95_A1.6601.00
111_S121_V1.6091.00
111_S115_D1.6091.00
42_K46_K1.6071.00
70_A74_R1.5991.00
118_T121_V1.5961.00
97_N104_R1.5591.00
105_K108_D1.5151.00
37_F44_G1.5041.00
104_R108_D1.5011.00
112_A116_E1.4871.00
108_D111_S1.3981.00
43_E46_K1.3911.00
117_L121_V1.3751.00
69_M72_E1.3541.00
106_D111_S1.3411.00
85_E91_R1.3291.00
32_E35_K1.3211.00
111_S114_V1.3181.00
44_G48_E1.3061.00
43_E102_P1.3011.00
16_Q48_E1.2821.00
59_V63_R1.2791.00
116_E120_K1.2791.00
19_W23_L1.2501.00
33_G37_F1.2441.00
19_W25_A1.2321.00
18_I21_A1.1831.00
6_Q9_G1.1751.00
87_V92_V1.1711.00
89_E98_R1.1651.00
114_V117_L1.1551.00
42_K45_E1.1511.00
63_R67_E1.1321.00
28_K32_E1.1311.00
97_N103_T1.0901.00
53_K62_A1.0781.00
13_D17_Q1.0751.00
26_F30_Q1.0701.00
62_A71_G1.0621.00
25_A29_A1.0531.00
26_F37_F1.0521.00
108_D112_A1.0421.00
22_G33_G1.0271.00
84_L88_F1.0251.00
72_E76_K1.0141.00
107_I110_L1.0030.99
83_K87_V0.9910.99
30_Q43_E0.9830.99
76_K80_T0.9760.99
5_S9_G0.9760.99
110_L117_L0.9710.99
71_G74_R0.9550.99
45_E49_K0.9500.99
20_L27_A0.9410.99
26_F33_G0.9270.99
55_A61_E0.9140.99
91_R99_L0.9140.99
28_K31_E0.9080.99
24_G44_G0.8970.99
19_W33_G0.8930.99
89_E94_R0.8840.99
53_K57_E0.8730.99
37_F81_W0.8540.98
14_S26_F0.8450.98
16_Q20_L0.8450.98
60_E63_R0.8370.98
26_F32_E0.8320.98
10_A13_D0.8290.98
21_A25_A0.8170.98
120_K123_K0.8080.98
101_V111_S0.8080.98
83_K93_A0.8060.98
30_Q33_G0.7970.97
51_T55_A0.7910.97
40_L48_E0.7860.97
31_E34_G0.7810.97
67_E74_R0.7760.97
104_R107_I0.7740.97
35_K84_L0.7670.97
67_E70_A0.7630.97
88_F92_V0.7570.97
95_A102_P0.7560.97
77_A81_W0.7470.96
107_I111_S0.7470.96
56_E60_E0.7410.96
9_G13_D0.7410.96
115_D119_A0.7410.96
65_K70_A0.7380.96
88_F101_V0.7300.96
58_K63_R0.7280.96
115_D118_T0.7180.95
57_E60_E0.7180.95
7_L12_K0.7110.95
119_A123_K0.6990.95
20_L45_E0.6970.95
7_L10_A0.6920.94
27_A33_G0.6890.94
93_A97_N0.6890.94
33_G100_G0.6870.94
87_V95_A0.6810.94
48_E57_E0.6770.94
19_W26_F0.6660.93
12_K16_Q0.6620.93
90_D94_R0.6560.93
5_S8_A0.6470.92
19_W37_F0.6460.92
16_Q45_E0.6380.92
8_A11_V0.6370.91
31_E68_S0.6340.91
96_L101_V0.6290.91
17_Q43_E0.6280.91
72_E75_A0.6270.91
21_A24_G0.6250.91
62_A70_A0.6210.90
36_L42_K0.6200.90
46_K50_K0.6120.90
112_A115_D0.6100.90
57_E76_K0.6090.90
17_Q89_E0.6070.89
63_R80_T0.5910.88
64_G68_S0.5900.88
35_K77_A0.5830.87
66_V71_G0.5820.87
86_Q90_D0.5800.87
31_E36_L0.5730.87
28_K91_R0.5700.86
62_A115_D0.5690.86
6_Q111_S0.5660.86
61_E64_G0.5630.86
82_D87_V0.5630.86
24_G27_A0.5610.85
37_F47_L0.5580.85
66_V69_M0.5540.85
24_G41_V0.5540.85
45_E48_E0.5520.84
57_E63_R0.5510.84
54_A57_E0.5470.84
101_V107_I0.5460.84
23_L30_Q0.5460.84
26_F113_R0.5440.84
114_V121_V0.5430.83
53_K60_E0.5420.83
82_D88_F0.5370.83
29_A89_E0.5340.82
23_L94_R0.5330.82
92_V96_L0.5280.82
65_K80_T0.5270.82
52_R56_E0.5240.81
7_L11_V0.5240.81
64_G67_E0.5220.81
103_T107_I0.5190.81
55_A59_V0.5170.80
62_A65_K0.5120.80
32_E39_A0.5100.80
39_A46_K0.5100.80
23_L66_V0.5090.79
89_E100_G0.5080.79
104_R115_D0.5060.79
28_K55_A0.5010.78
23_L35_K0.5000.78
50_K71_G0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yy0A 6 0.296 55.5 0.861 Contact Map
3qprA 8 0.008 45.4 0.869 Contact Map
2lemA 1 0.992 41.5 0.872 Contact Map
3c9iA 5 0.832 41.3 0.872 Contact Map
3r2pA 2 0.912 34.1 0.878 Contact Map
1dipA 2 0.272 34.1 0.878 Contact Map
2a01A 1 0.992 32.2 0.879 Contact Map
3ci9A 5 0.384 28.5 0.883 Contact Map
1jcdA 3 0.192 28.1 0.883 Contact Map
3s84A 2 0.68 27.7 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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