GREMLIN Database
Fil_haemagg - Haemagluttinin repeat
PFAM: PF05594 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (69)
Sequences: 7345 (5901)
Seq/√Len: 710.4
META: 0.592

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_G75_L4.9031.00
29_S33_L2.3491.00
6_L10_A2.3101.00
30_G50_G2.2321.00
49_S53_L2.1971.00
65_G68_S2.1261.00
69_A75_L1.9301.00
23_Q41_D1.7671.00
60_L63_N1.7641.00
31_G51_G1.7471.00
32_G52_A1.6541.00
32_G51_G1.5841.00
43_N61_D1.5691.00
65_G69_A1.5681.00
19_L22_N1.5651.00
20_L23_Q1.4621.00
37_A40_L1.4341.00
19_L39_G1.4261.00
24_G44_G1.4001.00
28_S48_S1.3801.00
36_T56_T1.3591.00
69_A73_L1.3401.00
39_G59_S1.2831.00
37_A57_A1.2231.00
50_G70_Q1.2131.00
26_L46_T1.1491.00
5_A32_G1.1321.00
38_A58_A1.1021.00
23_Q43_N1.0791.00
61_D64_G1.0701.00
34_T54_T1.0521.00
5_A31_G1.0521.00
35_L47_L1.0351.00
60_L64_G1.0211.00
57_A63_N0.9891.00
37_A41_D0.9771.00
52_A55_L0.9521.00
20_L27_L0.9381.00
54_T57_A0.9281.00
57_A60_L0.9221.00
69_A72_D0.9151.00
53_L57_A0.9051.00
18_G39_G0.9001.00
8_V11_A0.8921.00
25_G29_S0.8741.00
9_N36_T0.8521.00
5_A8_V0.8401.00
21_N24_G0.8361.00
7_T34_T0.8311.00
3_A6_L0.8281.00
39_G58_A0.8281.00
34_T56_T0.8271.00
43_N62_N0.8151.00
4_G7_T0.7821.00
44_G64_G0.7771.00
68_S75_L0.7761.00
28_S50_G0.7751.00
36_T54_T0.7721.00
46_T66_T0.7661.00
52_A72_D0.7581.00
70_Q75_L0.7531.00
22_N42_N0.7521.00
67_I75_L0.7291.00
3_A30_G0.7251.00
6_L11_A0.7241.00
43_N64_G0.7191.00
55_L59_S0.7141.00
46_T50_G0.7091.00
32_G54_T0.7041.00
5_A10_A0.6981.00
40_L47_L0.6981.00
57_A69_A0.6981.00
38_A42_N0.6871.00
7_T10_A0.6771.00
48_S68_S0.6571.00
45_G55_L0.6471.00
4_G8_V0.6381.00
33_L53_L0.6311.00
40_L43_N0.6281.00
48_S70_Q0.6181.00
54_T74_D0.6091.00
46_T49_S0.6061.00
30_G34_T0.6061.00
49_S52_A0.6031.00
28_S46_T0.6011.00
23_Q27_L0.5991.00
3_A10_A0.5971.00
11_A39_G0.5961.00
29_S32_G0.5941.00
59_S63_N0.5901.00
23_Q42_N0.5801.00
4_G11_A0.5731.00
29_S49_S0.5701.00
65_G76_S0.5521.00
66_T69_A0.5361.00
19_L38_A0.5321.00
66_T70_Q0.5311.00
66_T72_D0.5301.00
54_T71_G0.5231.00
3_A29_S0.5121.00
43_N63_N0.5111.00
51_G71_G0.5030.99
32_G49_S0.5020.99
70_Q73_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rwrA 1 0.9351 81.6 0.621 Contact Map
4i84A 1 0.987 8.6 0.792 Contact Map
4peuA 1 0.9351 7.6 0.796 Contact Map
1wxrA 1 0.9481 6.6 0.802 Contact Map
3h09A 1 0.8831 4.8 0.815 Contact Map
2odlA 1 0.987 4.8 0.815 Contact Map
4nu3A 2 0.6883 4.4 0.818 Contact Map
3vn3A 1 0.6753 4.4 0.818 Contact Map
4mtkA 4 0.8961 3.6 0.826 Contact Map
4nuhA 1 0.6753 3.2 0.829 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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