GREMLIN Database
DUF768 - Protein of unknown function (DUF768)
PFAM: PF05589 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (62)
Sequences: 865 (524)
Seq/√Len: 66.5
META: 0.892

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_K33_E2.4431.00
9_L53_V2.1111.00
19_P22_N2.1021.00
44_I48_E2.0901.00
3_E7_D2.0321.00
15_E33_E1.9801.00
46_A50_E1.9521.00
50_E54_G1.8731.00
9_L48_E1.7521.00
4_R48_E1.7421.00
16_N34_Q1.5390.99
15_E42_A1.4480.98
2_S39_A1.3670.98
8_F32_A1.3620.97
9_L49_I1.3390.97
7_D11_E1.3380.97
5_A9_L1.3250.97
35_C56_L1.2990.97
6_L52_E1.2590.96
6_L10_E1.2520.96
17_V22_N1.2440.96
28_A35_C1.2430.96
34_Q37_A1.2410.96
5_A8_F1.1800.94
28_A60_I1.1780.94
17_V20_T1.1630.94
34_Q38_D1.1340.93
18_P22_N1.1020.92
36_L40_A1.1010.92
28_A32_A1.0900.91
15_E18_P1.0750.91
21_A24_D1.0600.90
36_L46_A1.0550.90
16_N60_I1.0490.90
16_N41_A1.0430.89
47_E54_G1.0030.88
53_V59_F0.9760.86
11_E16_N0.9590.85
32_A45_S0.9090.82
27_R30_E0.9050.82
1_M5_A0.9000.81
8_F44_I0.8620.78
5_A52_E0.8570.78
11_E48_E0.8570.78
4_R10_E0.8500.77
11_E14_S0.8490.77
50_E61_L0.8380.76
13_I20_T0.8310.76
32_A47_E0.8270.75
5_A44_I0.8240.75
58_E61_L0.8070.74
18_P51_E0.7990.73
13_I60_I0.7960.73
2_S48_E0.7860.72
16_N30_E0.7850.72
17_V40_A0.7840.71
7_D45_S0.7790.71
55_D59_F0.7640.69
21_A27_R0.7600.69
13_I37_A0.7570.69
38_D41_A0.7450.68
19_P40_A0.7410.67
50_E56_L0.7400.67
19_P30_E0.7320.66
59_F62_D0.7280.66
25_I36_L0.7260.66
6_L54_G0.7220.65
32_A58_E0.7220.65
41_A51_E0.7150.64
8_F12_W0.7120.64
20_T30_E0.7120.64
31_L42_A0.6980.62
40_A50_E0.6920.62
56_L60_I0.6780.60
35_C50_E0.6780.60
16_N38_D0.6650.59
56_L59_F0.6590.58
10_E26_A0.6400.56
53_V58_E0.6360.55
21_A26_A0.6310.55
10_E14_S0.6220.54
13_I57_Y0.6070.52
48_E51_E0.6010.51
45_S52_E0.5960.51
25_I42_A0.5770.48
39_A54_G0.5760.48
28_A57_Y0.5750.48
45_S48_E0.5660.47
17_V31_L0.5640.47
17_V57_Y0.5490.45
26_A34_Q0.5440.45
53_V56_L0.5260.42
33_E53_V0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g5sA 1 0.3125 21.4 0.85 Contact Map
4ok9A 5 1 17.5 0.856 Contact Map
4xpxA 1 0.4688 12.4 0.865 Contact Map
1wpuA 6 0.9375 11.2 0.868 Contact Map
2m9xA 1 1 10.1 0.871 Contact Map
4p72A 2 0.7812 9.5 0.872 Contact Map
1exeA 2 0.5625 9.4 0.872 Contact Map
1p71A 2 0.5625 8.8 0.874 Contact Map
4p3vA 2 0.5625 8.5 0.875 Contact Map
1mulA 2 0.5625 8.4 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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