DUF763 - PFAM28P - GREMLIN Contacts

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DUF763 - Protein of unknown function (DUF763)

PFAM:	PF05559	Sequences: GIADLPLHGGRVPRWLFERMVRLGRAIVEAIVEEYGRDEFLRRLSDPFWFQAFGCVLGMDWHSSGITTSVCGALKRGLLEKELGIYVCGGKGKHSRKTPDELEAIGERLGLDGEALVYASRLSAKVDNAAVQDGFQLYHHSFIVTDDGEWAVVQQGMNDETRTARRYHWLSEGVKSFVEEPHTAIVGDNQGEKILNLVARESEPARKASLDLAREGPDKILRELRKLRMPAHHDVRLVMPAHHDVLGKVLAAAYERQPRDFEELLLLEGVGPRTLRALALVAEVIYGAPPSFRDPARFSFAHGGKDGHPFPV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	312 (311)
Sequences:	3982 (2252)
Seq/√Len:	127.7
META:	0.924

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
38_D	149_E	3.743	1.00
28_V	40_F	3.661	1.00
54_G	66_I	3.330	1.00
39_E	42_R	3.141	1.00
118_Y	122_L	2.819	1.00
97_K	100_D	2.807	1.00
179_E	203_E	2.763	1.00
37_R	147_D	2.612	1.00
71_C	141_S	2.490	1.00
40_F	44_L	2.441	1.00
130_A	265_L	2.400	1.00
203_E	206_R	2.384	1.00
159_D	162_R	2.379	1.00
14_R	18_E	2.369	1.00
103_E	117_V	2.356	1.00
180_E	198_V	2.315	1.00
145_T	149_E	2.299	1.00
179_E	206_R	2.144	1.00
179_E	200_R	2.142	1.00
31_I	40_F	2.137	1.00
119_A	123_S	2.112	1.00
197_L	205_A	2.107	1.00
37_R	145_T	2.101	1.00
100_D	103_E	2.098	1.00
118_Y	266_L	2.093	1.00
37_R	146_D	2.069	1.00
260_D	263_E	2.023	1.00
71_C	143_I	2.007	1.00
259_R	263_E	2.005	1.00
143_I	153_V	2.000	1.00
197_L	209_S	1.947	1.00
39_E	43_R	1.939	1.00
112_D	115_A	1.933	1.00
118_Y	262_E	1.926	1.00
102_L	144_V	1.906	1.00
24_G	57_L	1.881	1.00
242_H	245_V	1.872	1.00
26_A	29_E	1.872	1.00
42_R	172_E	1.860	1.00
180_E	200_R	1.847	1.00
123_S	152_V	1.838	1.00
233_H	236_R	1.836	1.00
204_P	288_A	1.826	1.00
232_H	235_V	1.815	1.00
240_P	243_H	1.787	1.00
201_E	293_R	1.778	1.00
122_L	266_L	1.773	1.00
25_R	79_L	1.767	1.00
178_V	206_R	1.749	1.00
277_A	302_H	1.746	1.00
191_G	194_I	1.730	1.00
119_A	177_F	1.730	1.00
94_H	97_K	1.717	1.00
35_Y	286_Y	1.698	1.00
203_E	207_K	1.682	1.00
209_S	261_F	1.682	1.00
32_V	40_F	1.665	1.00
215_E	219_K	1.658	1.00
171_S	174_V	1.656	1.00
197_L	275_L	1.651	1.00
205_A	279_A	1.632	1.00
187_G	296_A	1.626	1.00
249_V	253_A	1.612	1.00
135_F	191_G	1.606	1.00
202_S	205_A	1.573	1.00
270_V	274_T	1.572	1.00
252_A	268_E	1.566	1.00
75_K	101_E	1.564	1.00
35_Y	39_E	1.560	1.00
93_K	96_R	1.557	1.00
100_D	104_A	1.538	1.00
38_D	147_D	1.536	1.00
40_F	85_I	1.536	1.00
66_I	70_V	1.524	1.00
211_D	215_E	1.523	1.00
44_L	143_I	1.502	1.00
234_D	237_L	1.500	1.00
176_S	179_E	1.499	1.00
241_A	245_V	1.497	1.00
28_V	32_V	1.476	1.00
32_V	83_L	1.468	1.00
240_P	245_V	1.462	1.00
151_A	170_L	1.446	1.00
230_P	233_H	1.440	1.00
179_E	198_V	1.434	1.00
232_H	236_R	1.410	1.00
104_A	108_R	1.394	1.00
59_M	69_S	1.394	1.00
212_L	220_I	1.388	1.00
249_V	270_V	1.383	1.00
230_P	236_R	1.380	1.00
125_K	129_A	1.373	1.00
158_N	161_T	1.365	1.00
214_R	257_Q	1.364	1.00
136_Q	272_P	1.364	1.00
253_A	267_L	1.360	1.00
28_V	74_L	1.357	1.00
173_G	183_T	1.355	1.00
283_E	297_R	1.315	1.00
253_A	270_V	1.308	1.00
17_F	21_V	1.304	1.00
56_V	281_V	1.302	1.00
135_F	161_T	1.299	1.00
54_G	70_V	1.298	1.00
149_E	172_E	1.294	1.00
232_H	237_L	1.292	1.00
87_V	143_I	1.288	1.00
24_G	53_F	1.283	1.00
202_S	290_P	1.272	1.00
223_E	227_L	1.264	1.00
241_A	244_D	1.259	1.00
239_M	243_H	1.249	1.00
239_M	242_H	1.246	1.00
88_C	142_F	1.245	1.00
205_A	290_P	1.244	1.00
73_A	77_G	1.242	1.00
78_L	85_I	1.235	1.00
17_F	73_A	1.217	0.99
231_A	234_D	1.208	0.99
103_E	114_E	1.203	0.99
21_V	76_R	1.195	0.99
86_Y	146_D	1.182	0.99
204_P	207_K	1.181	0.99
135_F	163_T	1.172	0.99
220_I	250_L	1.161	0.99
208_A	282_A	1.159	0.99
104_A	107_E	1.159	0.99
86_Y	105_I	1.151	0.99
21_V	77_G	1.143	0.99
57_L	70_V	1.142	0.99
88_C	98_T	1.139	0.99
99_P	117_V	1.134	0.99
18_E	22_R	1.125	0.99
207_K	211_D	1.117	0.99
196_N	201_E	1.116	0.99
223_E	226_K	1.112	0.99
230_P	235_V	1.092	0.99
198_V	206_R	1.086	0.99
226_K	229_M	1.085	0.99
208_A	288_A	1.084	0.99
95_S	142_F	1.083	0.99
71_C	139_H	1.081	0.99
81_K	86_Y	1.080	0.99
270_V	275_L	1.079	0.99
38_D	145_T	1.078	0.99
85_I	145_T	1.072	0.99
48_F	184_A	1.069	0.99
29_E	83_L	1.067	0.99
29_E	33_E	1.053	0.98
55_C	62_H	1.044	0.98
44_L	153_V	1.044	0.98
233_H	237_L	1.042	0.98
196_N	199_A	1.038	0.98
17_F	76_R	1.034	0.98
113_G	117_V	1.034	0.98
59_M	66_I	1.032	0.98
21_V	24_G	1.032	0.98
213_A	253_A	1.019	0.98
132_Q	195_L	1.011	0.98
239_M	245_V	0.992	0.98
74_L	87_V	0.988	0.98
240_P	244_D	0.986	0.98
213_A	264_L	0.982	0.98
216_G	219_K	0.980	0.98
229_M	232_H	0.980	0.98
12_V	17_F	0.976	0.97
44_L	151_A	0.975	0.97
178_V	198_V	0.973	0.97
131_V	202_S	0.972	0.97
129_A	272_P	0.972	0.97
4_D	238_V	0.971	0.97
176_S	262_E	0.971	0.97
287_G	292_F	0.969	0.97
6_P	62_H	0.965	0.97
28_V	31_I	0.965	0.97
44_L	74_L	0.962	0.97
273_R	276_R	0.954	0.97
137_L	162_R	0.952	0.97
205_A	282_A	0.947	0.97
25_R	77_G	0.941	0.97
131_V	185_I	0.941	0.97
222_R	226_K	0.939	0.97
8_H	62_H	0.935	0.97
80_E	86_Y	0.930	0.97
14_R	17_F	0.928	0.97
78_L	83_L	0.928	0.97
105_I	144_V	0.928	0.97
55_C	66_I	0.927	0.97
230_P	234_D	0.924	0.97
106_G	113_G	0.918	0.96
178_V	262_E	0.913	0.96
251_A	255_E	0.908	0.96
256_R	267_L	0.906	0.96
195_L	290_P	0.906	0.96
87_V	141_S	0.906	0.96
25_R	29_E	0.900	0.96
3_A	168_H	0.896	0.96
29_E	79_L	0.894	0.96
80_E	105_I	0.892	0.96
254_Y	257_Q	0.891	0.96
229_M	233_H	0.891	0.96
32_V	36_G	0.890	0.96
60_D	63_S	0.889	0.96
105_I	109_L	0.880	0.95
185_I	199_A	0.874	0.95
205_A	288_A	0.874	0.95
54_G	62_H	0.871	0.95
66_I	69_S	0.870	0.95
158_N	191_G	0.864	0.95
221_L	225_R	0.862	0.95
80_E	83_L	0.860	0.95
126_V	177_F	0.857	0.95
31_I	39_E	0.856	0.95
102_L	106_G	0.856	0.95
88_C	144_V	0.856	0.95
180_E	199_A	0.851	0.94
231_A	235_V	0.851	0.94
53_F	87_V	0.850	0.94
109_L	113_G	0.849	0.94
135_F	189_N	0.849	0.94
279_A	290_P	0.847	0.94
28_V	78_L	0.841	0.94
14_R	21_V	0.840	0.94
4_D	163_T	0.838	0.94
53_F	74_L	0.837	0.94
205_A	209_S	0.832	0.94
131_V	194_I	0.830	0.94
199_A	202_S	0.827	0.94
226_K	230_P	0.812	0.93
62_H	66_I	0.811	0.93
81_K	146_D	0.807	0.93
248_K	251_A	0.804	0.93
73_A	76_R	0.804	0.93
229_M	235_V	0.804	0.93
187_G	190_Q	0.801	0.92
53_F	70_V	0.794	0.92
115_A	119_A	0.794	0.92
42_R	170_L	0.789	0.92
71_C	87_V	0.785	0.92
231_A	236_R	0.782	0.92
116_L	142_F	0.782	0.92
5_L	8_H	0.781	0.92
16_L	19_R	0.780	0.91
201_E	291_S	0.780	0.91
292_F	297_R	0.780	0.91
126_V	176_S	0.776	0.91
8_H	306_D	0.768	0.91
187_G	194_I	0.767	0.91
27_I	56_V	0.765	0.91
3_A	48_F	0.764	0.91
49_W	52_A	0.763	0.91
122_L	177_F	0.763	0.91
281_V	285_I	0.761	0.90
86_Y	109_L	0.760	0.90
210_L	214_R	0.759	0.90
256_R	268_E	0.758	0.90
12_V	59_M	0.754	0.90
96_R	136_Q	0.752	0.90
197_L	261_F	0.752	0.90
211_D	214_R	0.751	0.90
105_I	111_L	0.750	0.90
94_H	99_P	0.750	0.90
217_P	254_Y	0.749	0.90
53_F	57_L	0.747	0.90
175_K	179_E	0.746	0.90
219_K	223_E	0.742	0.89
38_D	42_R	0.739	0.89
256_R	259_R	0.738	0.89
7_L	10_G	0.737	0.89
4_D	135_F	0.736	0.89
174_V	178_V	0.735	0.89
224_L	228_R	0.735	0.89
12_V	49_W	0.734	0.89
102_L	112_D	0.733	0.89
94_H	139_H	0.732	0.89
309_P	312_V	0.732	0.89
28_V	44_L	0.730	0.89
107_E	110_G	0.721	0.88
302_H	308_H	0.721	0.88
209_S	279_A	0.720	0.88
284_V	292_F	0.720	0.88
54_G	57_L	0.719	0.88
238_V	243_H	0.717	0.88
307_G	312_V	0.715	0.88
35_Y	43_R	0.714	0.87
6_P	63_S	0.712	0.87
19_R	22_R	0.709	0.87
107_E	111_L	0.708	0.87
250_L	253_A	0.708	0.87
202_S	291_S	0.708	0.87
121_R	137_L	0.705	0.87
117_V	121_R	0.705	0.87
121_R	268_E	0.702	0.87
8_H	12_V	0.699	0.86
187_G	191_G	0.693	0.86
224_L	281_V	0.693	0.86
12_V	24_G	0.692	0.86
197_L	279_A	0.691	0.86
34_E	286_Y	0.689	0.86
30_A	285_I	0.688	0.85
185_I	201_E	0.687	0.85
28_V	53_F	0.686	0.85
247_G	251_A	0.686	0.85
199_A	291_S	0.685	0.85
58_G	63_S	0.684	0.85
283_E	298_F	0.683	0.85
238_V	245_V	0.681	0.85
86_Y	108_R	0.678	0.85
72_G	94_H	0.678	0.85
27_I	281_V	0.673	0.84
236_R	243_H	0.669	0.84
116_L	119_A	0.669	0.84
252_A	267_L	0.665	0.83
45_S	151_A	0.665	0.83
33_E	37_R	0.661	0.83
24_G	28_V	0.658	0.83
135_F	187_G	0.654	0.82
158_N	163_T	0.653	0.82
32_V	37_R	0.650	0.82
231_A	237_L	0.649	0.82
30_A	33_E	0.649	0.82
21_V	25_R	0.643	0.81
56_V	301_A	0.643	0.81
210_L	266_L	0.641	0.81
95_S	125_K	0.641	0.81
289_P	293_R	0.640	0.81
246_L	292_F	0.640	0.81
91_K	139_H	0.639	0.81
299_S	310_F	0.637	0.81
103_E	107_E	0.633	0.80
222_R	225_R	0.633	0.80
274_T	302_H	0.631	0.80
98_T	102_L	0.627	0.80
209_S	264_L	0.624	0.79
11_R	18_E	0.622	0.79
233_H	240_P	0.622	0.79
78_L	87_V	0.620	0.79
6_P	58_G	0.620	0.79
57_L	66_I	0.620	0.79
253_A	257_Q	0.618	0.79
215_E	223_E	0.617	0.79
207_K	214_R	0.617	0.79
263_E	266_L	0.617	0.79
205_A	275_L	0.615	0.78
128_N	136_Q	0.614	0.78
221_L	247_G	0.613	0.78
11_R	14_R	0.611	0.78
110_G	113_G	0.609	0.78
171_S	176_S	0.609	0.78
72_G	139_H	0.608	0.78
233_H	238_V	0.607	0.78
220_I	224_L	0.606	0.77
130_A	198_V	0.604	0.77
275_L	279_A	0.603	0.77
27_I	285_I	0.599	0.77
249_V	252_A	0.596	0.76
215_E	220_I	0.596	0.76
83_L	86_Y	0.594	0.76
253_A	264_L	0.592	0.76
246_L	273_R	0.592	0.76
237_L	240_P	0.592	0.76
45_S	149_E	0.590	0.76
7_L	13_P	0.589	0.75
75_K	94_H	0.587	0.75
128_N	272_P	0.587	0.75
8_H	63_S	0.586	0.75
87_V	101_E	0.585	0.75
196_N	291_S	0.584	0.75
281_V	310_F	0.584	0.75
20_M	23_L	0.584	0.75
48_F	186_V	0.582	0.75
69_S	187_G	0.582	0.75
130_A	261_F	0.582	0.75
238_V	244_D	0.579	0.74
212_L	219_K	0.578	0.74
22_R	30_A	0.578	0.74
126_V	178_V	0.578	0.74
238_V	242_H	0.576	0.74
216_G	222_R	0.575	0.74
195_L	269_G	0.575	0.74
12_V	69_S	0.575	0.74
21_V	73_A	0.574	0.74
283_E	290_P	0.573	0.73
175_K	200_R	0.572	0.73
46_D	49_W	0.571	0.73
216_G	254_Y	0.571	0.73
292_F	298_F	0.569	0.73
170_L	174_V	0.569	0.73
12_V	66_I	0.568	0.73
237_L	243_H	0.567	0.73
236_R	240_P	0.566	0.73
280_L	300_F	0.565	0.72
9_G	137_L	0.565	0.72
228_R	232_H	0.565	0.72
305_K	309_P	0.564	0.72
119_A	180_E	0.561	0.72
212_L	281_V	0.555	0.71
55_C	59_M	0.555	0.71
258_P	263_E	0.552	0.71
52_A	55_C	0.552	0.71
106_G	115_A	0.551	0.71
124_A	154_Q	0.551	0.71
257_Q	263_E	0.550	0.70
6_P	55_C	0.550	0.70
15_W	99_P	0.548	0.70
232_H	240_P	0.547	0.70
247_G	308_H	0.547	0.70
26_A	33_E	0.543	0.69
223_E	281_V	0.542	0.69
24_G	29_E	0.542	0.69
13_P	16_L	0.540	0.69
262_E	282_A	0.540	0.69
143_I	300_F	0.537	0.69
176_S	279_A	0.537	0.69
10_G	13_P	0.537	0.69
209_S	258_P	0.537	0.69
229_M	234_D	0.535	0.68
120_S	140_H	0.534	0.68
60_D	154_Q	0.534	0.68
252_A	269_G	0.534	0.68
93_K	97_K	0.533	0.68
137_L	158_N	0.533	0.68
114_E	203_E	0.532	0.68
180_E	262_E	0.531	0.68
129_A	137_L	0.531	0.68
54_G	69_S	0.530	0.68
106_G	109_L	0.530	0.68
69_S	251_A	0.530	0.68
282_A	289_P	0.530	0.68
70_V	153_V	0.530	0.68
49_W	53_F	0.527	0.67
61_W	64_S	0.526	0.67
107_E	113_G	0.526	0.67
12_V	21_V	0.526	0.67
283_E	289_P	0.525	0.67
129_A	267_L	0.524	0.67
185_I	196_N	0.523	0.67
131_V	183_T	0.522	0.66
238_V	241_A	0.519	0.66
17_F	91_K	0.518	0.66
129_A	209_S	0.518	0.66
81_K	109_L	0.518	0.66
230_P	237_L	0.518	0.66
101_E	104_A	0.516	0.66
235_V	240_P	0.516	0.66
257_Q	267_L	0.515	0.65
117_V	123_S	0.514	0.65
8_H	304_G	0.513	0.65
262_E	267_L	0.513	0.65
252_A	256_R	0.512	0.65
200_R	207_K	0.512	0.65
69_S	91_K	0.510	0.65
202_S	283_E	0.510	0.65
129_A	275_L	0.509	0.65
133_D	136_Q	0.507	0.64
103_E	113_G	0.506	0.64
256_R	263_E	0.506	0.64
31_I	34_E	0.506	0.64
6_P	72_G	0.506	0.64
45_S	168_H	0.505	0.64
282_A	285_I	0.505	0.64
56_V	284_V	0.504	0.64
104_A	222_R	0.504	0.64
169_W	177_F	0.502	0.63
123_S	137_L	0.500	0.63
279_A	288_A	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1kg2A	1	0.4583	79.4	0.969	Contact Map
2abkA	1	0.4455	77.4	0.969	Contact Map
2rhfA	1	0.2276	75.2	0.97	Contact Map
2dgzA	1	0.3397	68.7	0.971	Contact Map
2ma1A	1	0.2244	67.8	0.972	Contact Map
1keaA	2	0.4776	67	0.972	Contact Map
3n5nX	1	0.5288	66.6	0.972	Contact Map
3fspA	1	0.4487	59	0.973	Contact Map
2w40A	3	0.4071	57.6	0.973	Contact Map
4unfA	1	0.5032	57.2	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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