GREMLIN Database
DUF763 - Protein of unknown function (DUF763)
PFAM: PF05559 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 312 (311)
Sequences: 3982 (2252)
Seq/√Len: 127.7
META: 0.924

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_D149_E3.7431.00
28_V40_F3.6611.00
54_G66_I3.3301.00
39_E42_R3.1411.00
118_Y122_L2.8191.00
97_K100_D2.8071.00
179_E203_E2.7631.00
37_R147_D2.6121.00
71_C141_S2.4901.00
40_F44_L2.4411.00
130_A265_L2.4001.00
203_E206_R2.3841.00
159_D162_R2.3791.00
14_R18_E2.3691.00
103_E117_V2.3561.00
180_E198_V2.3151.00
145_T149_E2.2991.00
179_E206_R2.1441.00
179_E200_R2.1421.00
31_I40_F2.1371.00
119_A123_S2.1121.00
197_L205_A2.1071.00
37_R145_T2.1011.00
100_D103_E2.0981.00
118_Y266_L2.0931.00
37_R146_D2.0691.00
260_D263_E2.0231.00
71_C143_I2.0071.00
259_R263_E2.0051.00
143_I153_V2.0001.00
197_L209_S1.9471.00
39_E43_R1.9391.00
112_D115_A1.9331.00
118_Y262_E1.9261.00
102_L144_V1.9061.00
24_G57_L1.8811.00
242_H245_V1.8721.00
26_A29_E1.8721.00
42_R172_E1.8601.00
180_E200_R1.8471.00
123_S152_V1.8381.00
233_H236_R1.8361.00
204_P288_A1.8261.00
232_H235_V1.8151.00
240_P243_H1.7871.00
201_E293_R1.7781.00
122_L266_L1.7731.00
25_R79_L1.7671.00
178_V206_R1.7491.00
277_A302_H1.7461.00
191_G194_I1.7301.00
119_A177_F1.7301.00
94_H97_K1.7171.00
35_Y286_Y1.6981.00
203_E207_K1.6821.00
209_S261_F1.6821.00
32_V40_F1.6651.00
215_E219_K1.6581.00
171_S174_V1.6561.00
197_L275_L1.6511.00
205_A279_A1.6321.00
187_G296_A1.6261.00
249_V253_A1.6121.00
135_F191_G1.6061.00
202_S205_A1.5731.00
270_V274_T1.5721.00
252_A268_E1.5661.00
75_K101_E1.5641.00
35_Y39_E1.5601.00
93_K96_R1.5571.00
100_D104_A1.5381.00
38_D147_D1.5361.00
40_F85_I1.5361.00
66_I70_V1.5241.00
211_D215_E1.5231.00
44_L143_I1.5021.00
234_D237_L1.5001.00
176_S179_E1.4991.00
241_A245_V1.4971.00
28_V32_V1.4761.00
32_V83_L1.4681.00
240_P245_V1.4621.00
151_A170_L1.4461.00
230_P233_H1.4401.00
179_E198_V1.4341.00
232_H236_R1.4101.00
104_A108_R1.3941.00
59_M69_S1.3941.00
212_L220_I1.3881.00
249_V270_V1.3831.00
230_P236_R1.3801.00
125_K129_A1.3731.00
158_N161_T1.3651.00
214_R257_Q1.3641.00
136_Q272_P1.3641.00
253_A267_L1.3601.00
28_V74_L1.3571.00
173_G183_T1.3551.00
283_E297_R1.3151.00
253_A270_V1.3081.00
17_F21_V1.3041.00
56_V281_V1.3021.00
135_F161_T1.2991.00
54_G70_V1.2981.00
149_E172_E1.2941.00
232_H237_L1.2921.00
87_V143_I1.2881.00
24_G53_F1.2831.00
202_S290_P1.2721.00
223_E227_L1.2641.00
241_A244_D1.2591.00
239_M243_H1.2491.00
239_M242_H1.2461.00
88_C142_F1.2451.00
205_A290_P1.2441.00
73_A77_G1.2421.00
78_L85_I1.2351.00
17_F73_A1.2170.99
231_A234_D1.2080.99
103_E114_E1.2030.99
21_V76_R1.1950.99
86_Y146_D1.1820.99
204_P207_K1.1810.99
135_F163_T1.1720.99
220_I250_L1.1610.99
208_A282_A1.1590.99
104_A107_E1.1590.99
86_Y105_I1.1510.99
21_V77_G1.1430.99
57_L70_V1.1420.99
88_C98_T1.1390.99
99_P117_V1.1340.99
18_E22_R1.1250.99
207_K211_D1.1170.99
196_N201_E1.1160.99
223_E226_K1.1120.99
230_P235_V1.0920.99
198_V206_R1.0860.99
226_K229_M1.0850.99
208_A288_A1.0840.99
95_S142_F1.0830.99
71_C139_H1.0810.99
81_K86_Y1.0800.99
270_V275_L1.0790.99
38_D145_T1.0780.99
85_I145_T1.0720.99
48_F184_A1.0690.99
29_E83_L1.0670.99
29_E33_E1.0530.98
55_C62_H1.0440.98
44_L153_V1.0440.98
233_H237_L1.0420.98
196_N199_A1.0380.98
17_F76_R1.0340.98
113_G117_V1.0340.98
59_M66_I1.0320.98
21_V24_G1.0320.98
213_A253_A1.0190.98
132_Q195_L1.0110.98
239_M245_V0.9920.98
74_L87_V0.9880.98
240_P244_D0.9860.98
213_A264_L0.9820.98
216_G219_K0.9800.98
229_M232_H0.9800.98
12_V17_F0.9760.97
44_L151_A0.9750.97
178_V198_V0.9730.97
131_V202_S0.9720.97
129_A272_P0.9720.97
4_D238_V0.9710.97
176_S262_E0.9710.97
287_G292_F0.9690.97
6_P62_H0.9650.97
28_V31_I0.9650.97
44_L74_L0.9620.97
273_R276_R0.9540.97
137_L162_R0.9520.97
205_A282_A0.9470.97
25_R77_G0.9410.97
131_V185_I0.9410.97
222_R226_K0.9390.97
8_H62_H0.9350.97
80_E86_Y0.9300.97
14_R17_F0.9280.97
78_L83_L0.9280.97
105_I144_V0.9280.97
55_C66_I0.9270.97
230_P234_D0.9240.97
106_G113_G0.9180.96
178_V262_E0.9130.96
251_A255_E0.9080.96
256_R267_L0.9060.96
195_L290_P0.9060.96
87_V141_S0.9060.96
25_R29_E0.9000.96
3_A168_H0.8960.96
29_E79_L0.8940.96
80_E105_I0.8920.96
254_Y257_Q0.8910.96
229_M233_H0.8910.96
32_V36_G0.8900.96
60_D63_S0.8890.96
105_I109_L0.8800.95
185_I199_A0.8740.95
205_A288_A0.8740.95
54_G62_H0.8710.95
66_I69_S0.8700.95
158_N191_G0.8640.95
221_L225_R0.8620.95
80_E83_L0.8600.95
126_V177_F0.8570.95
31_I39_E0.8560.95
102_L106_G0.8560.95
88_C144_V0.8560.95
180_E199_A0.8510.94
231_A235_V0.8510.94
53_F87_V0.8500.94
109_L113_G0.8490.94
135_F189_N0.8490.94
279_A290_P0.8470.94
28_V78_L0.8410.94
14_R21_V0.8400.94
4_D163_T0.8380.94
53_F74_L0.8370.94
205_A209_S0.8320.94
131_V194_I0.8300.94
199_A202_S0.8270.94
226_K230_P0.8120.93
62_H66_I0.8110.93
81_K146_D0.8070.93
248_K251_A0.8040.93
73_A76_R0.8040.93
229_M235_V0.8040.93
187_G190_Q0.8010.92
53_F70_V0.7940.92
115_A119_A0.7940.92
42_R170_L0.7890.92
71_C87_V0.7850.92
231_A236_R0.7820.92
116_L142_F0.7820.92
5_L8_H0.7810.92
16_L19_R0.7800.91
201_E291_S0.7800.91
292_F297_R0.7800.91
126_V176_S0.7760.91
8_H306_D0.7680.91
187_G194_I0.7670.91
27_I56_V0.7650.91
3_A48_F0.7640.91
49_W52_A0.7630.91
122_L177_F0.7630.91
281_V285_I0.7610.90
86_Y109_L0.7600.90
210_L214_R0.7590.90
256_R268_E0.7580.90
12_V59_M0.7540.90
96_R136_Q0.7520.90
197_L261_F0.7520.90
211_D214_R0.7510.90
105_I111_L0.7500.90
94_H99_P0.7500.90
217_P254_Y0.7490.90
53_F57_L0.7470.90
175_K179_E0.7460.90
219_K223_E0.7420.89
38_D42_R0.7390.89
256_R259_R0.7380.89
7_L10_G0.7370.89
4_D135_F0.7360.89
174_V178_V0.7350.89
224_L228_R0.7350.89
12_V49_W0.7340.89
102_L112_D0.7330.89
94_H139_H0.7320.89
309_P312_V0.7320.89
28_V44_L0.7300.89
107_E110_G0.7210.88
302_H308_H0.7210.88
209_S279_A0.7200.88
284_V292_F0.7200.88
54_G57_L0.7190.88
238_V243_H0.7170.88
307_G312_V0.7150.88
35_Y43_R0.7140.87
6_P63_S0.7120.87
19_R22_R0.7090.87
107_E111_L0.7080.87
250_L253_A0.7080.87
202_S291_S0.7080.87
121_R137_L0.7050.87
117_V121_R0.7050.87
121_R268_E0.7020.87
8_H12_V0.6990.86
187_G191_G0.6930.86
224_L281_V0.6930.86
12_V24_G0.6920.86
197_L279_A0.6910.86
34_E286_Y0.6890.86
30_A285_I0.6880.85
185_I201_E0.6870.85
28_V53_F0.6860.85
247_G251_A0.6860.85
199_A291_S0.6850.85
58_G63_S0.6840.85
283_E298_F0.6830.85
238_V245_V0.6810.85
86_Y108_R0.6780.85
72_G94_H0.6780.85
27_I281_V0.6730.84
236_R243_H0.6690.84
116_L119_A0.6690.84
252_A267_L0.6650.83
45_S151_A0.6650.83
33_E37_R0.6610.83
24_G28_V0.6580.83
135_F187_G0.6540.82
158_N163_T0.6530.82
32_V37_R0.6500.82
231_A237_L0.6490.82
30_A33_E0.6490.82
21_V25_R0.6430.81
56_V301_A0.6430.81
210_L266_L0.6410.81
95_S125_K0.6410.81
289_P293_R0.6400.81
246_L292_F0.6400.81
91_K139_H0.6390.81
299_S310_F0.6370.81
103_E107_E0.6330.80
222_R225_R0.6330.80
274_T302_H0.6310.80
98_T102_L0.6270.80
209_S264_L0.6240.79
11_R18_E0.6220.79
233_H240_P0.6220.79
78_L87_V0.6200.79
6_P58_G0.6200.79
57_L66_I0.6200.79
253_A257_Q0.6180.79
215_E223_E0.6170.79
207_K214_R0.6170.79
263_E266_L0.6170.79
205_A275_L0.6150.78
128_N136_Q0.6140.78
221_L247_G0.6130.78
11_R14_R0.6110.78
110_G113_G0.6090.78
171_S176_S0.6090.78
72_G139_H0.6080.78
233_H238_V0.6070.78
220_I224_L0.6060.77
130_A198_V0.6040.77
275_L279_A0.6030.77
27_I285_I0.5990.77
249_V252_A0.5960.76
215_E220_I0.5960.76
83_L86_Y0.5940.76
253_A264_L0.5920.76
246_L273_R0.5920.76
237_L240_P0.5920.76
45_S149_E0.5900.76
7_L13_P0.5890.75
75_K94_H0.5870.75
128_N272_P0.5870.75
8_H63_S0.5860.75
87_V101_E0.5850.75
196_N291_S0.5840.75
281_V310_F0.5840.75
20_M23_L0.5840.75
48_F186_V0.5820.75
69_S187_G0.5820.75
130_A261_F0.5820.75
238_V244_D0.5790.74
212_L219_K0.5780.74
22_R30_A0.5780.74
126_V178_V0.5780.74
238_V242_H0.5760.74
216_G222_R0.5750.74
195_L269_G0.5750.74
12_V69_S0.5750.74
21_V73_A0.5740.74
283_E290_P0.5730.73
175_K200_R0.5720.73
46_D49_W0.5710.73
216_G254_Y0.5710.73
292_F298_F0.5690.73
170_L174_V0.5690.73
12_V66_I0.5680.73
237_L243_H0.5670.73
236_R240_P0.5660.73
280_L300_F0.5650.72
9_G137_L0.5650.72
228_R232_H0.5650.72
305_K309_P0.5640.72
119_A180_E0.5610.72
212_L281_V0.5550.71
55_C59_M0.5550.71
258_P263_E0.5520.71
52_A55_C0.5520.71
106_G115_A0.5510.71
124_A154_Q0.5510.71
257_Q263_E0.5500.70
6_P55_C0.5500.70
15_W99_P0.5480.70
232_H240_P0.5470.70
247_G308_H0.5470.70
26_A33_E0.5430.69
223_E281_V0.5420.69
24_G29_E0.5420.69
13_P16_L0.5400.69
262_E282_A0.5400.69
143_I300_F0.5370.69
176_S279_A0.5370.69
10_G13_P0.5370.69
209_S258_P0.5370.69
229_M234_D0.5350.68
120_S140_H0.5340.68
60_D154_Q0.5340.68
252_A269_G0.5340.68
93_K97_K0.5330.68
137_L158_N0.5330.68
114_E203_E0.5320.68
180_E262_E0.5310.68
129_A137_L0.5310.68
54_G69_S0.5300.68
106_G109_L0.5300.68
69_S251_A0.5300.68
282_A289_P0.5300.68
70_V153_V0.5300.68
49_W53_F0.5270.67
61_W64_S0.5260.67
107_E113_G0.5260.67
12_V21_V0.5260.67
283_E289_P0.5250.67
129_A267_L0.5240.67
185_I196_N0.5230.67
131_V183_T0.5220.66
238_V241_A0.5190.66
17_F91_K0.5180.66
129_A209_S0.5180.66
81_K109_L0.5180.66
230_P237_L0.5180.66
101_E104_A0.5160.66
235_V240_P0.5160.66
257_Q267_L0.5150.65
117_V123_S0.5140.65
8_H304_G0.5130.65
262_E267_L0.5130.65
252_A256_R0.5120.65
200_R207_K0.5120.65
69_S91_K0.5100.65
202_S283_E0.5100.65
129_A275_L0.5090.65
133_D136_Q0.5070.64
103_E113_G0.5060.64
256_R263_E0.5060.64
31_I34_E0.5060.64
6_P72_G0.5060.64
45_S168_H0.5050.64
282_A285_I0.5050.64
56_V284_V0.5040.64
104_A222_R0.5040.64
169_W177_F0.5020.63
123_S137_L0.5000.63
279_A288_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kg2A 1 0.4583 79.4 0.969 Contact Map
2abkA 1 0.4455 77.4 0.969 Contact Map
2rhfA 1 0.2276 75.2 0.97 Contact Map
2dgzA 1 0.3397 68.7 0.971 Contact Map
2ma1A 1 0.2244 67.8 0.972 Contact Map
1keaA 2 0.4776 67 0.972 Contact Map
3n5nX 1 0.5288 66.6 0.972 Contact Map
3fspA 1 0.4487 59 0.973 Contact Map
2w40A 3 0.4071 57.6 0.973 Contact Map
4unfA 1 0.5032 57.2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.