GREMLIN Database
DUF760 - Protein of unknown function (DUF760)
PFAM: PF05542 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 84 (82)
Sequences: 1080 (560)
Seq/√Len: 61.9
META: 0.515

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_A32_N2.7071.00
22_S75_E2.5481.00
38_G42_P2.5301.00
32_N63_S2.4111.00
72_R75_E2.3491.00
21_A58_A2.1551.00
63_S67_T2.1151.00
49_T53_S1.9951.00
3_L7_Q1.9881.00
40_L46_F1.7620.99
30_E59_R1.7150.99
44_E48_V1.6750.99
40_L48_V1.6660.99
33_V75_E1.6550.99
58_A62_A1.6040.99
72_R79_E1.6020.99
5_Y8_S1.5600.99
26_L72_R1.5530.99
74_A79_E1.4510.98
34_Q39_G1.4330.98
32_N67_T1.3840.97
32_N64_A1.3820.97
43_S47_D1.3690.97
32_N70_F1.3560.97
20_P52_T1.3220.96
62_A70_F1.3150.96
30_E83_S1.2800.95
78_M82_R1.2550.95
12_E15_A1.2100.94
10_S13_T1.2070.94
35_G62_A1.1880.93
77_R80_L1.1640.92
21_A64_A1.1340.91
54_R57_L1.1000.90
79_E82_R1.0950.90
4_Q8_S1.0880.90
77_R81_E1.0790.89
24_E82_R1.0780.89
27_E48_V1.0760.89
67_T80_L1.0730.89
5_Y12_E1.0730.89
9_L17_L1.0550.88
28_A70_F1.0530.88
3_L6_V1.0530.88
13_T56_N1.0440.88
2_L5_Y1.0080.86
6_V51_T0.9780.84
38_G46_F0.9740.84
32_N73_N0.9730.84
42_P48_V0.9680.83
62_A71_L0.9560.83
29_M45_H0.9480.82
33_V37_L0.9460.82
40_L44_E0.9420.82
54_R60_L0.9360.81
43_S48_V0.9300.81
43_S46_F0.9210.80
8_S17_L0.9060.79
32_N36_L0.8930.78
61_L75_E0.8770.77
19_K52_T0.8660.76
71_L84_L0.8500.75
46_F50_I0.8480.74
27_E39_G0.8360.73
6_V9_L0.8300.73
28_A67_T0.7820.68
11_P15_A0.7790.68
36_L59_R0.7780.68
5_Y14_L0.7670.67
8_S13_T0.7610.66
6_V10_S0.7580.66
9_L75_E0.7460.65
17_L74_A0.7390.64
35_G67_T0.7270.63
27_E80_L0.7260.63
6_V11_P0.7260.63
42_P47_D0.7180.62
4_Q7_Q0.7080.61
5_Y18_S0.6980.60
42_P52_T0.6970.59
52_T74_A0.6930.59
6_V67_T0.6860.58
29_M71_L0.6840.58
29_M74_A0.6840.58
5_Y10_S0.6710.57
27_E30_E0.6510.54
71_L76_Q0.6510.54
66_M70_F0.6450.54
69_Y73_N0.6450.54
39_G83_S0.6400.53
56_N66_M0.6380.53
4_Q48_V0.6370.53
62_A78_M0.6330.52
46_F49_T0.6330.52
63_S70_F0.6280.52
70_F77_R0.6210.51
8_S58_A0.6200.51
58_A66_M0.6100.50
40_L43_S0.6100.50
22_S79_E0.6080.49
79_E83_S0.5980.48
21_A33_V0.5960.48
17_L28_A0.5920.48
28_A79_E0.5910.47
25_V72_R0.5890.47
64_A70_F0.5850.47
5_Y13_T0.5760.46
70_F76_Q0.5740.46
17_L20_P0.5710.45
11_P16_R0.5650.44
14_L18_S0.5640.44
61_L67_T0.5560.43
36_L82_R0.5440.42
77_R83_S0.5410.42
3_L80_L0.5380.41
53_S75_E0.5340.41
78_M81_E0.5240.40
54_R64_A0.5210.40
42_P46_F0.5200.40
29_M66_M0.5160.39
38_G48_V0.5080.38
33_V82_R0.5040.38
18_S78_M0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ub4A 2 0.4524 10.3 0.889 Contact Map
1cg5B 1 0.7857 9.4 0.891 Contact Map
3bomA 2 0.7976 9.3 0.891 Contact Map
1m1fA 2 0.4524 9.3 0.891 Contact Map
4ebaG 1 0 8.2 0.894 Contact Map
3d1kA 2 0.7976 7.8 0.894 Contact Map
4mzmA 2 0.4881 7.8 0.894 Contact Map
1outA 2 0.7976 7.1 0.896 Contact Map
1spgA 2 0.7976 7 0.897 Contact Map
3w3wA 1 0.6071 6.7 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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