GREMLIN Database
ATP_synt_H - ATP synthase subunit H
PFAM: PF05493 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 62 (60)
Sequences: 941 (733)
Seq/√Len: 94.6
META: 0.561

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_Y52_M3.9381.00
49_L52_M2.7541.00
36_A40_C2.3321.00
2_L45_A2.0881.00
6_T9_F2.0861.00
48_Y53_N1.8611.00
17_P34_I1.7771.00
9_F12_L1.7481.00
33_V37_A1.7371.00
13_G37_A1.7321.00
43_M47_T1.6601.00
28_L32_L1.6451.00
6_T10_A1.5441.00
8_I12_L1.5291.00
13_G17_P1.4671.00
28_L39_C1.4361.00
13_G34_I1.3630.99
31_T35_L1.3630.99
7_I11_V1.3510.99
27_G30_R1.3300.99
3_I7_I1.2690.99
11_V15_V1.2450.99
5_G9_F1.2360.99
32_L36_A1.1960.98
9_F13_G1.1440.98
2_L52_M1.0880.97
34_I38_V1.0870.97
2_L37_A1.0620.96
37_A41_W1.0550.96
16_A20_V1.0220.95
42_L46_C1.0090.95
2_L5_G0.9570.93
28_L35_L0.9550.93
33_V40_C0.9470.93
32_L35_L0.9190.92
47_T56_I0.9140.92
6_T13_G0.9000.91
25_N28_L0.8980.91
17_P30_R0.8830.90
6_T41_W0.8760.90
50_A56_I0.8700.90
45_A49_L0.8590.89
4_I8_I0.8560.89
16_A19_F0.8070.86
11_V16_A0.7900.84
11_V20_V0.7820.84
25_N30_R0.7640.82
29_I47_T0.7540.82
54_P58_P0.7510.81
16_A43_M0.7380.80
35_L38_V0.7380.80
29_I50_A0.7360.80
43_M46_C0.7330.80
10_A14_I0.7270.79
38_V42_L0.7120.78
43_M49_L0.7070.77
4_I24_P0.6990.76
26_R30_R0.6970.76
30_R34_I0.6680.73
29_I56_I0.6670.73
46_C50_A0.6540.72
51_Q55_L0.6490.71
10_A60_L0.6470.71
21_P46_C0.6400.70
18_F39_C0.6260.68
6_T17_P0.6240.68
20_V23_G0.6240.68
35_L59_I0.6210.68
31_T50_A0.6190.67
18_F22_K0.6170.67
51_Q54_P0.6070.66
16_A33_V0.6070.66
7_I14_I0.6020.65
18_F23_G0.6010.65
8_I15_V0.5950.64
32_L39_C0.5930.64
47_T59_I0.5880.64
26_R49_L0.5850.63
41_W45_A0.5690.61
32_L47_T0.5650.60
15_V21_P0.5630.60
15_V19_F0.5570.59
5_G14_I0.5540.59
24_P27_G0.5470.58
27_G35_L0.5460.58
30_R37_A0.5210.54
49_L55_L0.5160.54
9_F15_V0.5110.53
41_W52_M0.5010.52
21_P60_L0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw6A 2 1 7.7 0.879 Contact Map
4e6zA 1 0 5.5 0.886 Contact Map
2l2tA 2 0.4839 4.7 0.89 Contact Map
4il3A 1 1 3.9 0.894 Contact Map
1zcdA 1 0.9194 3.6 0.896 Contact Map
2ks1B 1 0.4677 3.3 0.898 Contact Map
2mfrA 1 0.5645 3.1 0.9 Contact Map
3qbgA 3 1 3 0.9 Contact Map
2mofA 1 0.5 2.9 0.901 Contact Map
2jwaA 2 0.4516 2.8 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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