GREMLIN Database
AzlD - Branched-chain amino acid transport protein (AzlD)
PFAM: PF05437 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 99 (97)
Sequences: 26115 (16617)
Seq/√Len: 1687.2
META: 0.841

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_V94_V4.0691.00
52_L71_A3.4901.00
77_V90_A3.2931.00
83_N86_L2.9411.00
17_A21_L2.3411.00
76_L80_R2.2781.00
13_Y17_A2.1281.00
78_A87_T2.0011.00
77_V86_L1.9271.00
79_L82_R1.9221.00
70_A94_V1.7851.00
41_P45_A1.7681.00
73_V90_A1.7141.00
74_A91_G1.7071.00
33_R37_R1.6541.00
29_P32_V1.6021.00
82_R86_L1.5861.00
31_R34_R1.5391.00
74_A87_T1.5271.00
92_M96_A1.5251.00
70_A73_V1.5001.00
30_P33_R1.4441.00
23_L26_R1.4381.00
75_A79_L1.4281.00
6_L9_A1.4061.00
70_A95_L1.3941.00
64_G67_R1.3801.00
56_G59_L1.3301.00
45_A49_A1.3261.00
3_L7_G1.3231.00
69_A98_L1.3191.00
4_A8_M1.3181.00
30_P34_R1.3111.00
11_V15_T1.2881.00
34_R38_Y1.2861.00
65_D69_A1.2551.00
9_A13_Y1.2481.00
77_V81_R1.2331.00
55_P58_A1.2021.00
77_V82_R1.1941.00
81_R86_L1.1451.00
14_L18_L1.1271.00
76_L79_L1.1261.00
59_L62_S1.1181.00
66_A98_L1.1141.00
93_A97_L1.1081.00
83_N87_T1.0941.00
68_L72_A1.0841.00
70_A74_A1.0771.00
27_R33_R1.0561.00
15_T18_L1.0201.00
39_V43_V1.0141.00
6_L10_L1.0131.00
67_R95_L0.9921.00
2_W6_L0.9511.00
31_R35_A0.9411.00
12_T15_T0.9231.00
55_P67_R0.9231.00
11_V14_L0.9201.00
8_M11_V0.9111.00
42_A45_A0.8651.00
77_V80_R0.8581.00
39_V42_A0.8471.00
94_V97_L0.8441.00
77_V94_V0.8411.00
65_D68_L0.8361.00
53_L68_L0.8321.00
4_A7_G0.8281.00
28_L31_R0.8191.00
23_L28_L0.8141.00
7_G11_V0.8071.00
71_A74_A0.8051.00
18_L22_L0.8011.00
54_A57_G0.7991.00
88_I95_L0.7911.00
94_V98_L0.7841.00
10_L14_L0.7671.00
13_Y20_L0.7621.00
41_P44_L0.7611.00
51_A55_P0.7531.00
26_R33_R0.7491.00
89_V93_A0.7491.00
92_M95_L0.7251.00
86_L90_A0.7151.00
59_L65_D0.7041.00
10_L13_Y0.6981.00
60_A63_L0.6961.00
34_R37_R0.6691.00
40_P44_L0.6631.00
54_A59_L0.6621.00
73_V98_L0.6621.00
30_P37_R0.6601.00
56_G60_A0.6601.00
69_A72_A0.6601.00
66_A95_L0.6551.00
58_A62_S0.6521.00
61_L65_D0.6521.00
49_A53_L0.6511.00
59_L63_L0.6431.00
22_L25_R0.6431.00
55_P60_A0.6401.00
19_G22_L0.6401.00
46_A50_P0.6391.00
88_I92_M0.6281.00
28_L33_R0.6251.00
67_R71_A0.6241.00
57_G60_A0.6171.00
8_M15_T0.6141.00
8_M12_T0.6141.00
5_I9_A0.6071.00
20_L40_P0.6021.00
80_R83_N0.6011.00
72_A76_L0.6011.00
43_V50_P0.5981.00
3_L6_L0.5911.00
32_V36_L0.5841.00
72_A75_A0.5811.00
69_A94_V0.5771.00
66_A70_A0.5761.00
77_V87_T0.5751.00
73_V76_L0.5701.00
60_A64_G0.5701.00
42_A46_A0.5701.00
20_L23_L0.5691.00
91_G94_V0.5681.00
86_L93_A0.5661.00
93_A96_A0.5631.00
60_A65_D0.5621.00
9_A14_L0.5621.00
52_L68_L0.5601.00
90_A93_A0.5601.00
63_L67_R0.5531.00
91_G95_L0.5441.00
55_P59_L0.5431.00
44_L47_L0.5321.00
50_P71_A0.5271.00
15_T47_L0.5201.00
84_L88_I0.5191.00
38_Y42_A0.5161.00
50_P54_A0.5101.00
68_L71_A0.5071.00
77_V83_N0.5071.00
64_G68_L0.5051.00
2_W5_I0.5041.00
27_R30_P0.5021.00
28_L32_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.9192 5.7 0.869 Contact Map
5ajiA 3 0.9192 4.7 0.874 Contact Map
3lb6C 1 0 4.4 0.876 Contact Map
4tllB 2 0.2121 2.9 0.887 Contact Map
2ww9B 1 0.2727 2.8 0.888 Contact Map
3hd6A 3 0.8687 2.8 0.888 Contact Map
3b9wA 3 0.8384 2.6 0.889 Contact Map
2kluA 1 0.3333 2.6 0.889 Contact Map
3mp7B 1 0.2525 2.4 0.891 Contact Map
4hw9A 3 0.9192 2.2 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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