GREMLIN Database
DUF751 - Protein of unknown function (DUF751)
PFAM: PF05421 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (60)
Sequences: 818 (502)
Seq/√Len: 64.8
META: 0.744

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_F54_T3.7231.00
33_N36_T3.4561.00
4_N7_R2.5541.00
12_F16_L2.3631.00
54_T59_L1.9851.00
34_P41_I1.9591.00
41_I45_I1.9141.00
22_V26_P1.8721.00
9_P12_F1.8211.00
5_V11_F1.7741.00
20_I24_L1.3640.97
56_R59_L1.3520.97
6_S9_P1.3430.97
33_N59_L1.3260.97
7_R11_F1.3010.96
19_L23_I1.2920.96
22_V28_K1.2510.95
11_F15_S1.1900.94
1_F4_N1.1900.94
20_I26_P1.1740.94
4_N10_R1.1490.93
10_R13_I1.1440.93
48_F53_F1.1320.92
49_I53_F1.1180.92
12_F15_S1.1000.91
31_L40_L1.0880.91
3_N7_R1.0780.90
27_L40_L1.0590.90
34_P37_A1.0580.90
3_N6_S1.0510.89
46_G49_I1.0450.89
4_N14_S1.0270.88
44_L50_F1.0230.88
34_P38_I1.0110.87
11_F14_S0.9790.86
53_F57_A0.9720.85
51_L55_L0.9700.85
5_V9_P0.9250.82
36_T41_I0.9220.82
4_N11_F0.8880.79
24_L45_I0.8730.78
10_R15_S0.8700.78
26_P32_K0.8600.77
15_S19_L0.8480.76
19_L22_V0.8200.74
31_L60_G0.8090.73
48_F51_L0.7940.71
8_Y28_K0.7890.71
14_S21_L0.7850.70
4_N13_I0.7790.70
8_Y27_L0.7760.70
32_K40_L0.7630.68
21_L25_E0.7580.68
14_S17_L0.7520.67
8_Y60_G0.7280.65
38_I41_I0.7030.62
42_G45_I0.6980.61
6_S12_F0.6960.61
7_R14_S0.6940.61
48_F52_Y0.6900.61
35_K39_A0.6780.59
55_L59_L0.6770.59
8_Y11_F0.6760.59
10_R31_L0.6750.59
33_N44_L0.6650.58
17_L47_G0.6340.54
16_L21_L0.6310.54
2_W19_L0.6280.53
43_A50_F0.6180.52
15_S22_V0.6090.51
52_Y60_G0.6060.51
9_P13_I0.5970.50
24_L28_K0.5850.48
22_V42_G0.5830.48
7_R12_F0.5730.47
1_F8_Y0.5720.47
19_L26_P0.5610.46
29_N33_N0.5610.46
50_F56_R0.5570.45
28_K31_L0.5540.45
41_I55_L0.5510.44
21_L30_L0.5510.44
17_L37_A0.5490.44
6_S10_R0.5470.44
23_I43_A0.5440.44
43_A46_G0.5280.42
35_K42_G0.5270.42
36_T40_L0.5240.41
22_V25_E0.5090.40
3_N34_P0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.9333 9.4 0.867 Contact Map
2nq2A 2 0.9667 8.7 0.87 Contact Map
2qi9A 2 0.9667 7.7 0.873 Contact Map
2zy9A 2 0.8833 2.8 0.898 Contact Map
2js7A 1 0.3333 2.6 0.899 Contact Map
3ar4A 1 1 2.5 0.9 Contact Map
1nmbN 1 0 2.4 0.9 Contact Map
1zauA 1 0.3333 2.2 0.902 Contact Map
2kogA 1 0.4667 2.2 0.903 Contact Map
3tiaA 3 0 2.2 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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