GREMLIN Database
DUF748 - Domain of Unknown Function (DUF748)
PFAM: PF05359 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 152 (144)
Sequences: 32555 (25017)
Seq/√Len: 2084.8
META: 0.922

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_K111_E2.8001.00
51_D65_S2.6821.00
80_K109_D2.6271.00
32_D55_R2.5921.00
7_R38_T2.5471.00
7_R36_T2.5291.00
16_D29_T2.4511.00
18_T27_R2.3921.00
53_S63_S2.2771.00
9_A36_T2.2351.00
78_K109_D2.1521.00
63_S80_K2.1411.00
14_R29_T2.1381.00
83_G105_K2.0691.00
11_E34_N2.0661.00
76_D113_R2.0091.00
12_D32_D1.9851.00
107_S131_D1.9771.00
50_V66_G1.9051.00
38_T49_P1.8851.00
16_D27_R1.8671.00
65_S78_K1.8371.00
49_P67_T1.8311.00
55_R61_P1.7221.00
51_D63_S1.6661.00
111_E125_S1.6071.00
103_S132_D1.6021.00
47_P67_T1.5931.00
79_L110_L1.5921.00
14_R31_S1.5761.00
34_N53_S1.5741.00
5_I8_L1.5701.00
102_A136_G1.5241.00
85_D105_K1.4911.00
61_P82_K1.4911.00
54_A62_L1.4771.00
64_L77_L1.4611.00
35_L52_L1.4381.00
3_V42_T1.4361.00
81_L84_L1.4281.00
85_D88_P1.3771.00
113_R123_T1.3481.00
6_G39_N1.3281.00
50_V77_L1.3181.00
22_V92_Y1.3151.00
36_T51_D1.3051.00
56_L60_G1.2991.00
67_T76_D1.2861.00
102_A134_A1.2811.00
69_N72_P1.2781.00
77_L112_Y1.2751.00
110_L114_F1.2631.00
82_K107_S1.2511.00
10_L13_G1.2171.00
105_K132_D1.2171.00
26_F92_Y1.1911.00
110_L124_A1.1901.00
100_D136_G1.1871.00
90_Q94_P1.1791.00
20_R25_P1.1761.00
76_D111_E1.1661.00
83_G131_D1.1321.00
103_S134_A1.1251.00
12_D34_N1.1161.00
19_D92_Y1.1151.00
30_L54_A1.1091.00
9_A34_N1.1041.00
53_S61_P1.0981.00
107_S129_T1.0951.00
57_N88_P1.0841.00
4_S41_S1.0691.00
31_S55_R1.0651.00
109_D127_K1.0591.00
30_L56_L1.0591.00
17_F92_Y1.0431.00
124_A128_L1.0411.00
13_G33_L1.0271.00
38_T51_D1.0191.00
85_D103_S1.0151.00
47_P69_N0.9991.00
130_L133_L0.9981.00
94_P100_D0.9861.00
90_Q93_L0.9861.00
11_E36_T0.9771.00
43_L46_A0.9421.00
33_L54_A0.9381.00
75_A114_F0.9291.00
137_D140_E0.9191.00
66_G77_L0.9101.00
100_D138_K0.8821.00
134_A143_D0.8801.00
83_G107_S0.8741.00
24_P94_P0.8731.00
81_L108_L0.8721.00
29_T57_N0.8601.00
60_G84_L0.8491.00
37_L50_V0.8421.00
108_L112_Y0.8361.00
64_L68_L0.8321.00
40_L48_A0.8301.00
22_V26_F0.8291.00
2_P43_L0.8281.00
48_A68_L0.8231.00
16_D31_S0.8171.00
63_S82_K0.8101.00
84_L89_L0.8071.00
44_P47_P0.7971.00
115_A118_D0.7931.00
50_V64_L0.7891.00
37_L40_L0.7881.00
105_K131_D0.7851.00
99_L144_L0.7781.00
22_V25_P0.7741.00
82_K109_D0.7681.00
39_N49_P0.7661.00
52_L64_L0.7571.00
137_D144_L0.7511.00
136_G143_D0.7451.00
73_L76_D0.7431.00
17_F28_L0.7391.00
49_P65_S0.7351.00
99_L135_L0.7271.00
87_A90_Q0.7271.00
31_S57_N0.7231.00
18_T25_P0.7181.00
30_L33_L0.7151.00
90_Q100_D0.7141.00
65_S80_K0.7101.00
93_L97_L0.7081.00
54_A57_N0.7071.00
37_L48_A0.7061.00
120_P124_A0.7031.00
39_N46_A0.7031.00
62_L81_L0.7011.00
110_L126_G0.6961.00
69_N74_A0.6941.00
8_L35_L0.6921.00
17_F26_F0.6841.00
34_N51_D0.6831.00
86_L106_L0.6791.00
54_A58_G0.6771.00
110_L113_R0.6721.00
89_L93_L0.6691.00
41_S44_P0.6641.00
93_L101_L0.6551.00
124_A127_K0.6551.00
72_P75_A0.6541.00
39_N48_A0.6531.00
31_S58_G0.6531.00
28_L88_P0.6441.00
74_A113_R0.6421.00
88_P91_P0.6351.00
22_V91_P0.6341.00
32_D35_L0.6341.00
64_L79_L0.6331.00
2_P41_S0.6311.00
61_P64_L0.6291.00
4_S39_N0.6271.00
55_R59_G0.6241.00
108_L124_A0.6221.00
41_S46_A0.6171.00
60_G89_L0.6171.00
90_Q98_G0.6161.00
60_G88_P0.6141.00
87_A103_S0.6101.00
101_L133_L0.6081.00
49_P52_L0.6021.00
108_L128_L0.6021.00
115_A119_G0.6001.00
4_S43_L0.5981.00
77_L81_L0.5961.00
7_R39_N0.5891.00
37_L66_G0.5881.00
32_D53_S0.5821.00
44_P71_L0.5811.00
98_G138_K0.5771.00
10_L35_L0.5721.00
68_L73_L0.5711.00
137_D142_E0.5711.00
125_S128_L0.5651.00
95_K98_G0.5651.00
91_P94_P0.5641.00
28_L89_L0.5641.00
91_P96_Y0.5621.00
114_F120_P0.5601.00
140_E143_D0.5601.00
50_V54_A0.5581.00
75_A112_Y0.5561.00
28_L92_Y0.5551.00
68_L75_A0.5541.00
141_S144_L0.5481.00
22_V95_K0.5471.00
3_V40_L0.5471.00
115_A120_P0.5451.00
34_N37_L0.5451.00
90_Q97_L0.5441.00
58_G88_P0.5431.00
79_L108_L0.5421.00
68_L72_P0.5361.00
13_G32_D0.5361.00
73_L114_F0.5331.00
29_T58_G0.5321.00
2_P5_I0.5281.00
28_L57_N0.5271.00
21_S25_P0.5241.00
142_E145_L0.5241.00
118_D121_K0.5231.00
86_L93_L0.5191.00
87_A102_A0.5181.00
23_K95_K0.5161.00
48_A70_P0.5151.00
116_K121_K0.5121.00
59_G83_G0.5101.00
93_L96_Y0.5071.00
139_V144_L0.5071.00
94_P138_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kh9A 1 0.8421 11.3 0.891 Contact Map
1evlA 2 0.3355 6.4 0.903 Contact Map
1qf6A 1 0.3355 6.1 0.904 Contact Map
1vl4A 2 0.3882 3.7 0.913 Contact Map
3iklA 2 0.3092 3.6 0.914 Contact Map
4yguA 3 0.5855 3.3 0.916 Contact Map
1vpbA 2 0.4013 2.9 0.918 Contact Map
2mxaA 1 0.1382 2.7 0.919 Contact Map
3do6A 3 0.3355 2.6 0.92 Contact Map
2cfuA 2 0.5658 2.2 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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