GREMLIN Database
UMP1 - Proteasome maturation factor UMP1
PFAM: PF05348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (114)
Sequences: 724 (565)
Seq/√Len: 52.9
META: 0.396

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_E32_K3.6041.00
65_V81_H3.5661.00
27_L30_R3.4841.00
46_L55_P3.1351.00
27_L31_L3.0571.00
80_L84_I2.7181.00
8_D11_R2.5741.00
94_F98_L2.4411.00
70_R77_S2.2371.00
15_R20_E2.1841.00
114_M118_L2.0591.00
66_S82_L2.0401.00
82_L86_T2.0361.00
109_D112_A1.9921.00
39_E62_R1.8070.99
83_D88_R1.7860.99
62_R82_L1.7520.99
70_R78_S1.6190.98
81_H84_I1.5800.98
7_H12_H1.5710.98
24_S28_E1.5270.97
58_L61_E1.5070.97
53_H57_R1.4970.97
99_N116_K1.4440.96
52_L55_P1.4330.96
28_E95_E1.4050.96
114_M117_K1.3910.96
50_Y54_A1.3840.95
115_E118_L1.3750.95
46_L60_M1.3050.94
14_L49_T1.2910.93
43_L55_P1.2810.93
62_R86_T1.2810.93
44_E48_R1.2540.92
27_L95_E1.2540.92
30_R34_W1.2510.92
39_E43_L1.2310.92
52_L56_L1.2250.91
70_R73_G1.2200.91
34_W37_T1.1870.90
92_I97_V1.1840.90
65_V68_V1.1610.89
84_I89_D1.1460.88
47_R55_P1.1300.88
80_L89_D1.1220.87
43_L62_R1.1210.87
14_L18_K1.1170.87
7_H15_R1.1160.87
20_E33_N1.0920.86
4_P53_H1.0750.85
102_E105_E1.0670.84
46_L58_L1.0500.83
17_L21_L1.0480.83
58_L97_V1.0270.82
57_R60_M1.0210.82
77_S99_N1.0130.81
61_E105_E1.0060.81
16_S53_H1.0040.81
9_T12_H0.9730.78
113_E117_K0.9660.78
44_E57_R0.9590.77
60_M89_D0.9450.76
71_L113_E0.9260.75
85_L89_D0.9250.75
100_D103_E0.9070.73
25_H28_E0.8990.73
101_P105_E0.8900.72
79_N83_D0.8800.71
55_P60_M0.8720.70
45_M49_T0.8620.70
64_I68_V0.8550.69
65_V82_L0.8470.68
98_L101_P0.8420.68
79_N88_R0.8400.68
34_W38_Q0.8350.67
63_K67_Q0.8270.66
46_L87_G0.8210.66
64_I109_D0.8140.65
59_Q93_D0.8040.64
88_R91_T0.7960.63
67_Q78_S0.7910.63
46_L53_H0.7910.63
111_H118_L0.7890.63
47_R85_L0.7830.62
53_H75_L0.7810.62
18_K50_Y0.7770.61
83_D97_V0.7760.61
71_L77_S0.7750.61
53_H62_R0.7730.61
95_E103_E0.7670.60
104_S107_M0.7660.60
38_Q42_K0.7610.60
53_H69_Q0.7580.60
56_L61_E0.7570.59
69_Q81_H0.7410.58
86_T90_E0.7390.58
70_R75_L0.7370.57
68_V72_P0.7360.57
49_T63_K0.7330.57
110_P116_K0.7330.57
21_L54_A0.7290.57
27_L65_V0.7280.56
43_L59_Q0.7260.56
25_H51_G0.7230.56
71_L110_P0.7230.56
47_R52_L0.7190.56
73_G105_E0.7180.55
39_E117_K0.7100.55
84_I91_T0.7080.54
92_I96_D0.7010.54
23_S87_G0.6960.53
36_A40_N0.6920.53
38_Q41_L0.6910.53
31_L37_T0.6810.52
42_K106_E0.6670.50
107_M110_P0.6670.50
65_V85_L0.6660.50
24_S99_N0.6600.49
52_L63_K0.6580.49
54_A57_R0.6520.48
6_L10_L0.6520.48
111_H114_M0.6510.48
13_G82_L0.6510.48
31_L34_W0.6460.48
19_S36_A0.6430.48
113_E118_L0.6350.47
5_G9_T0.6330.46
54_A69_Q0.6250.46
14_L20_E0.6230.45
107_M113_E0.6200.45
81_H110_P0.6160.45
30_R37_T0.6090.44
72_P75_L0.6050.44
58_L94_F0.6000.43
45_M112_A0.6000.43
80_L90_E0.5970.43
16_S20_E0.5970.43
24_S90_E0.5970.43
6_L9_T0.5950.43
33_N114_M0.5890.42
104_S108_P0.5880.42
16_S19_S0.5820.41
66_S114_M0.5780.41
94_F101_P0.5690.40
50_Y105_E0.5680.40
59_Q63_K0.5650.39
46_L49_T0.5650.39
100_D113_E0.5540.38
58_L62_R0.5460.38
28_E39_E0.5450.37
89_D102_E0.5440.37
26_P66_S0.5430.37
65_V87_G0.5420.37
21_L32_K0.5420.37
12_H17_L0.5410.37
56_L99_N0.5340.36
5_G8_D0.5290.36
25_H94_F0.5230.35
12_H77_S0.5230.35
105_E108_P0.5220.35
10_L13_G0.5220.35
13_G65_V0.5220.35
31_L46_L0.5200.35
18_K40_N0.5200.35
47_R65_V0.5190.35
36_A86_T0.5150.35
35_E86_T0.5150.35
68_V81_H0.5120.34
101_P104_S0.5110.34
41_L55_P0.5040.34
8_D12_H0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r07C 1 0.4237 4.4 0.937 Contact Map
2m4iA 1 0.4661 3.7 0.94 Contact Map
2e5aA 1 0.8729 3.3 0.941 Contact Map
3a7rA 1 0.8559 3.1 0.942 Contact Map
2gpvG 1 0.0593 2.9 0.943 Contact Map
1x9bA 1 0.2797 2.7 0.944 Contact Map
2iakA 3 0.5424 2.4 0.945 Contact Map
1v9nA 2 0.6271 2.4 0.945 Contact Map
4wzxE 1 0.1356 2.3 0.945 Contact Map
4ce4c 1 0.6186 2.1 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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