GREMLIN Database
DUF732 - Protein of unknown function (DUF732)
PFAM: PF05305 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (91)
Sequences: 5473 (3840)
Seq/√Len: 402.5
META: 0.816

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_D93_Y3.2081.00
25_F81_F3.0081.00
22_D89_Y2.9521.00
28_A88_A2.4661.00
46_G89_Y2.4351.00
26_L43_I2.3111.00
22_D47_H2.1781.00
74_T77_Q2.0161.00
53_L86_V1.8561.00
25_F29_L1.8451.00
12_L15_P1.8441.00
28_A84_A1.8191.00
52_D62_V1.8101.00
50_C90_C1.7911.00
43_I89_Y1.6931.00
58_S61_D1.6911.00
26_L39_P1.6651.00
47_H89_Y1.5571.00
39_P42_A1.5381.00
86_V93_Y1.5341.00
20_P23_D1.5221.00
84_A88_A1.4191.00
9_A12_L1.3881.00
49_V82_V1.3571.00
32_A80_Y1.3271.00
43_I47_H1.3131.00
29_L34_I1.2891.00
57_A62_V1.2881.00
54_D92_Q1.2801.00
52_D57_A1.2551.00
83_G87_S1.2341.00
79_A83_G1.2101.00
38_S41_A1.2091.00
67_A75_P1.1931.00
32_A84_A1.1901.00
30_R39_P1.1901.00
48_A52_D1.1661.00
44_A48_A1.1661.00
57_A61_D1.1361.00
80_Y83_G1.1321.00
59_P82_V1.1201.00
30_R36_Y1.1151.00
75_P79_A1.1061.00
59_P86_V1.0701.00
28_A87_S1.0471.00
38_S42_A1.0431.00
49_V85_A1.0301.00
28_A31_A1.0081.00
36_Y42_A0.9731.00
52_D65_D0.9721.00
5_A9_A0.9631.00
64_A68_A0.9551.00
76_D80_Y0.9441.00
21_A88_A0.9421.00
76_D79_A0.9331.00
81_F84_A0.9221.00
66_V78_A0.8921.00
23_D27_A0.8771.00
21_A24_A0.8701.00
49_V81_F0.8471.00
28_A32_A0.8421.00
24_A88_A0.8411.00
64_A67_A0.8351.00
81_F85_A0.8301.00
5_A8_A0.8191.00
11_A14_A0.8091.00
7_A10_L0.8081.00
10_L15_P0.8051.00
51_D54_D0.7991.00
24_A27_A0.7961.00
26_L30_R0.7861.00
53_L82_V0.7841.00
45_A48_A0.7801.00
57_A65_D0.7791.00
7_A13_A0.7691.00
83_G86_V0.7561.00
4_A10_L0.7511.00
66_V81_F0.7471.00
29_L32_A0.7391.00
6_A9_A0.7371.00
27_A31_A0.7241.00
29_L33_G0.7191.00
10_L13_A0.7171.00
35_T77_Q0.7151.00
3_A9_A0.7121.00
59_P63_A0.7121.00
27_A30_R0.7091.00
53_L62_V0.7031.00
3_A8_A0.7021.00
23_D39_P0.6901.00
29_L42_A0.6891.00
7_A11_A0.6871.00
72_G78_A0.6810.99
49_V53_L0.6780.99
9_A15_P0.6770.99
73_L77_Q0.6770.99
59_P83_G0.6680.99
70_N73_L0.6590.99
41_A45_A0.6580.99
46_G85_A0.6440.99
73_L81_F0.6420.99
4_A9_A0.6340.99
11_A17_H0.6320.99
53_L93_Y0.6300.99
51_D55_A0.6200.99
42_A53_L0.6180.99
47_H51_D0.6140.99
6_A17_H0.6120.99
63_A67_A0.5900.99
26_L29_L0.5880.99
61_D65_D0.5860.98
14_A17_H0.5840.98
10_L18_A0.5810.98
8_A12_L0.5810.98
12_L17_H0.5790.98
13_A18_A0.5740.98
24_A28_A0.5710.98
65_D69_D0.5700.98
45_A71_P0.5570.98
35_T48_A0.5550.98
62_V66_V0.5500.98
30_R35_T0.5490.98
5_A12_L0.5420.97
77_Q80_Y0.5380.97
32_A36_Y0.5360.97
52_D55_A0.5270.97
64_A76_D0.5200.97
48_A57_A0.5190.97
48_A65_D0.5190.97
80_Y84_A0.5130.97
6_A10_L0.5110.96
29_L84_A0.5090.96
10_L14_A0.5030.96
32_A76_D0.5030.96
4_A7_A0.5000.96
3_A6_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h8oA 2 0.8105 3 0.894 Contact Map
1o17A 2 0.7263 2.7 0.897 Contact Map
3pdeA 2 0.8632 2.7 0.897 Contact Map
1brwA 2 0.7263 2.4 0.9 Contact Map
2dsjA 2 0.7263 2.4 0.9 Contact Map
1ml8A 2 0.8105 2.2 0.901 Contact Map
1wmwA 2 0.9895 2.1 0.902 Contact Map
4z9pA 1 0.7158 2.1 0.903 Contact Map
1vlaA 3 0.8316 2.1 0.903 Contact Map
1rtrA 2 0.8 2.1 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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