GREMLIN Database
DUF736 - Protein of unknown function (DUF736)
PFAM: PF05284 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 100 (96)
Sequences: 3901 (2038)
Seq/√Len: 208.0
META: 0.839

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_A66_L4.0271.00
71_D99_R2.8631.00
27_I68_V2.6301.00
42_R50_E2.4571.00
8_T11_G2.2491.00
33_K40_D2.1961.00
59_S63_R2.0421.00
56_K64_D1.8771.00
69_K80_Y1.8441.00
15_T24_K1.8401.00
58_T64_D1.7151.00
59_S62_G1.7081.00
17_R22_N1.6701.00
40_D56_K1.6651.00
54_A68_V1.6151.00
41_Y56_K1.6101.00
28_V44_F1.6081.00
71_D78_P1.5781.00
15_T22_N1.5661.00
83_L95_L1.5571.00
86_A94_A1.5381.00
86_A90_D1.5031.00
50_E53_A1.4991.00
16_I25_I1.4751.00
84_F96_I1.4751.00
57_K80_Y1.4641.00
35_S38_A1.4431.00
85_E91_G1.4311.00
13_T26_R1.4011.00
82_N96_I1.3941.00
20_T74_S1.3891.00
5_F83_L1.3461.00
57_K65_Y1.3291.00
25_I51_I1.3271.00
69_K78_P1.2991.00
33_K38_A1.2771.00
18_T72_D1.2381.00
93_Y96_I1.2241.00
68_V81_A1.2031.00
72_D75_F1.1991.00
41_Y66_L1.1901.00
56_K66_L1.1681.00
89_D92_G1.1671.00
27_I43_V1.1441.00
12_F66_L1.1401.00
20_T72_D1.1341.00
34_D38_A1.1091.00
6_T13_T1.0661.00
57_K67_S1.0651.00
85_E93_Y1.0381.00
44_F49_V1.0031.00
82_N98_S0.9931.00
44_F50_E0.9881.00
45_A49_V0.9761.00
7_K11_G0.9751.00
68_V95_L0.9480.99
44_F48_G0.9340.99
43_V68_V0.9290.99
63_R85_E0.9290.99
7_K12_F0.9270.99
88_E92_G0.9260.99
5_F95_L0.9130.99
85_E90_D0.9060.99
70_L79_I0.9040.99
8_T13_T0.9010.99
45_A51_I0.8950.99
43_V70_L0.8820.99
86_A89_D0.8820.99
7_K10_D0.8810.99
11_G29_P0.8740.99
30_N42_R0.8650.99
60_E63_R0.8550.99
5_F25_I0.8550.99
15_T25_I0.8510.99
88_E91_G0.8370.99
86_A92_G0.8340.99
35_S60_E0.7970.98
27_I83_L0.7920.98
84_F94_A0.7820.98
59_S65_Y0.7690.98
4_T7_K0.7610.98
53_A67_S0.7580.97
52_G55_W0.7410.97
23_A45_A0.7330.97
66_L82_N0.7320.97
5_F16_I0.7310.97
49_V74_S0.7190.96
27_I41_Y0.7040.96
27_I54_A0.6780.95
36_D67_S0.6760.95
38_A71_D0.6690.95
74_S79_I0.6680.95
18_T74_S0.6680.95
30_N33_K0.6540.94
23_A51_I0.6390.93
21_L74_S0.6390.93
76_P99_R0.6370.93
88_E94_A0.6350.93
26_R46_G0.6310.93
2_I71_D0.6270.93
94_A98_S0.6260.93
28_V31_E0.6250.93
19_L23_A0.6240.93
65_Y98_S0.6110.92
17_R51_I0.6070.92
57_K82_N0.5980.91
38_A69_K0.5970.91
61_E67_S0.5940.91
67_S80_Y0.5910.90
27_I66_L0.5830.90
21_L49_V0.5820.90
30_N38_A0.5800.90
27_I30_N0.5790.90
33_K41_Y0.5790.90
82_N93_Y0.5770.89
7_K29_P0.5760.89
89_D94_A0.5710.89
4_T8_T0.5670.89
64_D82_N0.5640.88
83_L93_Y0.5640.88
71_D76_P0.5630.88
79_I82_N0.5580.88
33_K36_D0.5570.88
80_Y93_Y0.5570.88
71_D77_A0.5560.88
78_P99_R0.5530.87
25_I43_V0.5410.86
55_W66_L0.5380.86
86_A93_Y0.5360.86
84_F93_Y0.5350.86
85_E94_A0.5320.85
24_K46_G0.5300.85
34_D77_A0.5270.85
18_T21_L0.5270.85
40_D55_W0.5260.85
12_F41_Y0.5140.83
18_T55_W0.5130.83
40_D66_L0.5110.83
72_D99_R0.5110.83
50_E57_K0.5070.82
34_D37_N0.5060.82
79_I97_W0.5060.82
21_L46_G0.5030.82
58_T65_Y0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p1wA 1 0.81 7.4 0.917 Contact Map
2qfpA 2 0.35 5.9 0.921 Contact Map
2nqaA 3 0.53 5.8 0.921 Contact Map
2dlgA 1 0.6 5.8 0.921 Contact Map
2r9fA 1 0.53 5.7 0.921 Contact Map
1fyhB 1 0.23 5.7 0.921 Contact Map
3bo6A 1 0.9 4.9 0.924 Contact Map
3kdfD 2 0.66 4.9 0.924 Contact Map
1xzwA 2 0.41 4 0.926 Contact Map
1qxpA 1 0.74 3.7 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.005 seconds.