GREMLIN Database
DUF723 - Protein of unknown function (DUF723)
PFAM: PF05265 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (55)
Sequences: 696 (651)
Seq/√Len: 87.8
META: 0.93

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_G29_T3.9821.00
8_A12_F3.6431.00
34_I40_E3.1781.00
32_T40_E3.0921.00
13_K17_G3.0261.00
21_L40_E2.1281.00
22_V31_V2.0901.00
32_T42_E1.9311.00
24_Y27_S1.6951.00
20_S34_I1.6651.00
9_I13_K1.6621.00
21_L32_T1.6481.00
25_K29_T1.5261.00
12_F17_G1.4740.99
9_I17_G1.3630.99
45_P48_H1.1870.98
56_C59_C1.1860.98
33_I43_Q1.1190.96
46_P49_H1.1030.96
19_Y33_I1.0970.96
14_E17_G0.9900.93
8_A13_K0.9890.93
7_E11_K0.9880.93
13_K18_D0.9560.92
50_L53_K0.9350.91
9_I12_F0.9190.90
38_H41_F0.9040.90
11_K15_K0.9010.89
53_K60_G0.8740.88
28_K47_N0.8730.88
33_I41_F0.8650.87
6_E10_K0.8550.87
12_F15_K0.8550.87
57_P60_G0.8280.85
12_F16_F0.8080.83
44_S47_N0.7980.83
36_P39_G0.7950.83
8_A17_G0.7900.82
47_N50_L0.7740.81
47_N51_K0.7700.80
40_E60_G0.7600.80
12_F33_I0.7500.79
6_E9_I0.7460.78
19_Y22_V0.7320.77
38_H42_E0.7090.75
44_S49_H0.6770.71
8_A16_F0.6750.71
39_G42_E0.6660.70
30_P42_E0.6520.68
27_S37_I0.6330.66
8_A11_K0.6320.66
12_F49_H0.6180.64
28_K37_I0.6140.64
55_G59_C0.6020.62
35_C56_C0.5840.60
21_L31_V0.5830.60
19_Y38_H0.5820.60
31_V41_F0.5790.59
28_K54_Y0.5790.59
23_E32_T0.5770.59
35_C39_G0.5670.58
28_K32_T0.5650.57
24_Y29_T0.5610.57
8_A15_K0.5610.57
14_E22_V0.5600.57
14_E42_E0.5490.55
33_I38_H0.5480.55
25_K40_E0.5450.55
31_V46_P0.5450.55
18_D23_E0.5420.54
54_Y60_G0.5410.54
9_I14_E0.5370.54
23_E58_K0.5340.53
35_C59_C0.5270.52
13_K16_F0.5220.52
43_Q54_Y0.5220.52
7_E37_I0.5190.51
26_G30_P0.5180.51
28_K46_P0.5150.51
7_E10_K0.5090.50
47_N52_S0.5020.49
18_D21_L0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u3eA 2 0.7833 65.3 0.789 Contact Map
1gh9A 1 0.45 50.1 0.808 Contact Map
3wwlA 1 0.4833 46.3 0.812 Contact Map
1yuzA 2 0.8833 40 0.819 Contact Map
2au3A 1 0.9667 38.2 0.821 Contact Map
2gviA 3 0.9833 26.6 0.835 Contact Map
4cgyA 1 0.4167 25.3 0.837 Contact Map
4aybP 1 0.4333 25.2 0.837 Contact Map
3i2dA 1 0.9 24.5 0.838 Contact Map
4qiwP 1 0.4 23.3 0.84 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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